| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lonafarnib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lonafarnib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.212458 |
| IGF2 | insulin-like growth factor 2 | 0.212399 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.161017 |
| FN1 | fibronectin 1 | 0.136138 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.121119 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.115656 |
| C3 | complement component 3 | 0.101559 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0960348 |
| SVIL | supervillin | 0.0950458 |
| DSPP | dentin sialophosphoprotein | 0.092861 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0867546 |
| ENO1 | enolase 1, (alpha) | 0.0613887 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0578156 |
| MT2A | metallothionein 2A | 0.0560487 |
| VEGFA | vascular endothelial growth factor A | 0.0514757 |
| APOB | apolipoprotein B | 0.0496584 |
| FAT1 | FAT atypical cadherin 1 | 0.0477049 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0448203 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0420233 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0412777 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0406754 |
| AHNAK | AHNAK nucleoprotein | 0.0406117 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0405999 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0396743 |
| FRMD5 | FERM domain containing 5 | 0.0381007 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0380435 |
| BCL2L1 | BCL2-like 1 | 0.0375576 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0360072 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.034785 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0338668 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0335323 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0323809 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0323788 |
| GRB10 | growth factor receptor-bound protein 10 | 0.032023 |
| DST | dystonin | 0.0308894 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.03065 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0305695 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0304945 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.030188 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0293632 |
| SMAD3 | SMAD family member 3 | 0.0288518 |
| FAM107B | family with sequence similarity 107, member B | 0.0285912 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0285537 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0281156 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0279221 |
| FOXP1 | forkhead box P1 | 0.0274742 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0266798 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0264238 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0250646 |
| ITGB5 | integrin, beta 5 | 0.0246323 |
| KIAA1217 | KIAA1217 | 0.0245238 |
| KRT8 | keratin 8, type II | 0.0243254 |
| NDRG1 | N-myc downstream regulated 1 | 0.0239278 |
| ATXN1 | ataxin 1 | 0.0235704 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0234148 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0231819 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0213955 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0212932 |
| CCN2 | cellular communication network factor 2 | 0.0206991 |
| FLNB | filamin B, beta | 0.0206775 |
| KYNU | kynureninase | 0.0200609 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0200555 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0199078 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0195794 |
| FLNA | filamin A, alpha | 0.0193294 |
| SEPTIN9 | septin 9 | 0.0190177 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0186761 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0185547 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0185388 |
| CTSB | cathepsin B | 0.0181552 |
| RAD51B | RAD51 paralog B | 0.0181038 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0180117 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0179312 |
| RTN4 | reticulon 4 | 0.017565 |
| ITGAV | integrin, alpha V | 0.0175309 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0169689 |
| TNS1 | tensin 1 | 0.0168318 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0167731 |
| RPS12 | ribosomal protein S12 | 0.0165637 |
| PLEC | plectin | 0.0163063 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0162582 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.0162121 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0160598 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.015988 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0158951 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0156432 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0154356 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0153924 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0152459 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.014908 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0147996 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0147491 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.014692 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0146839 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.014649 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0145665 |
| MRTFA | myocardin related transcription factor A | 0.014461 |
| ACTN4 | actinin, alpha 4 | 0.0144545 |
| TCIM | transcriptional and immune response regulator | 0.0144439 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0143335 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CP | ceruloplasmin (ferroxidase) | -0.0617914 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0507042 |
| PLIN2 | perilipin 2 | -0.0498851 |
| FNDC3B | fibronectin type III domain containing 3B | -0.046383 |
| RPS24 | ribosomal protein S24 | -0.0440601 |
| APOA2 | apolipoprotein A-II | -0.0439238 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0433968 |
| GPC3 | glypican 3 | -0.0359677 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0357893 |
| NPR2 | natriuretic peptide receptor 2 | -0.0340079 |
| TMSB10 | thymosin beta 10 | -0.0338252 |
| RBM39 | RNA binding motif protein 39 | -0.0315777 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0302252 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0295416 |
| RPS6 | ribosomal protein S6 | -0.0286042 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0281147 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0275247 |
| FTL | ferritin, light polypeptide | -0.0264615 |
| RPLP1 | ribosomal protein, large, P1 | -0.0256373 |
| HMGA1 | high mobility group AT-hook 1 | -0.0242188 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0237545 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.023512 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0234293 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0227044 |
| AHSG | alpha-2-HS-glycoprotein | -0.0220379 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0220214 |
| APOE | apolipoprotein E | -0.0214986 |
| LYZ | lysozyme | -0.0211267 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0204282 |
| WDR45B | WD repeat domain 45B | -0.0200352 |
| PERP | PERP, TP53 apoptosis effector | -0.0197399 |
| TMEM123 | transmembrane protein 123 | -0.0193809 |
| RPL31 | ribosomal protein L31 | -0.0191498 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0187318 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0174363 |
| GNAS | GNAS complex locus | -0.017315 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0162797 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0156292 |
| RPL23 | ribosomal protein L23 | -0.0154296 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0151069 |
| GLG1 | golgi glycoprotein 1 | -0.0146656 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0146272 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0146234 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0145468 |
| RPS23 | ribosomal protein S23 | -0.0142407 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0140234 |
| HDLBP | high density lipoprotein binding protein | -0.0139938 |
| PTMA | prothymosin, alpha | -0.0138074 |
| IER3 | immediate early response 3 | -0.0136942 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -0.0136303 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0134829 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0134428 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0133527 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0133004 |
| RPS19 | ribosomal protein S19 | -0.0130252 |
| RPS16 | ribosomal protein S16 | -0.0129587 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0126157 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0124909 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0122843 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0122154 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0120527 |
| RBM25 | RNA binding motif protein 25 | -0.0119064 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0119039 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0117731 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0117006 |
| RPL9 | ribosomal protein L9 | -0.011546 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0114758 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0113681 |
| NGLY1 | N-glycanase 1 | -0.0113452 |
| RPL12 | ribosomal protein L12 | -0.0113166 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.011107 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0110475 |
| RPL34 | ribosomal protein L34 | -0.0110308 |
| HMGA2 | high mobility group AT-hook 2 | -0.0109827 |
| RPS21 | ribosomal protein S21 | -0.0107649 |
| SRPK1 | SRSF protein kinase 1 | -0.0107074 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0106785 |
| RPS14 | ribosomal protein S14 | -0.0106397 |
| RPL4 | ribosomal protein L4 | -0.0105431 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0104942 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0103194 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0102634 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0101286 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0101073 |
| DOK6 | docking protein 6 | -0.010104 |
| MYO6 | myosin VI | -0.0101031 |
| STK17A | serine/threonine kinase 17a | -0.0100658 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.00997742 |
| INSIG2 | insulin induced gene 2 | -0.0099048 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.00990298 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.00986043 |
| LDHA | lactate dehydrogenase A | -0.00981071 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0097872 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.00971598 |
| TRIM26 | tripartite motif containing 26 | -0.00966876 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00957704 |
| MATR3 | matrin 3 | -0.00953837 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.009474 |
| RPL32 | ribosomal protein L32 | -0.00945915 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.00945835 |
