Lonafarnib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lonafarnib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lonafarnib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.129182
NDRG1 N-myc downstream regulated 1 0.107797
CD44 CD44 molecule (Indian blood group) 0.107294
CLU clusterin 0.0773728
MYOF myoferlin 0.0740597
B2M beta-2-microglobulin 0.0733452
ENO1 enolase 1, (alpha) 0.0711066
MT2A metallothionein 2A 0.0683691
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0580248
EMP1 epithelial membrane protein 1 0.0513232
TMSB4X thymosin beta 4, X-linked 0.0477363
STC1 stanniocalcin 1 0.04639
RPS6 ribosomal protein S6 0.0460306
MBNL2 muscleblind-like splicing regulator 2 0.045304
AHNAK AHNAK nucleoprotein 0.0449755
LDHA lactate dehydrogenase A 0.0443931
LOC112694756 uncharaterized LOC112694756 0.0430551
MBNL1 muscleblind-like splicing regulator 1 0.0427592
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0423466
PGK1 phosphoglycerate kinase 1 0.0411817
RPS8 ribosomal protein S8 0.0411191
CAV1 caveolin 1, caveolae protein, 22kDa 0.0406259
TPT1 tumor protein, translationally-controlled 1 0.0398348
ANXA2 annexin A2 0.0386382
TMSB10 thymosin beta 10 0.0376184
BHLHE40 basic helix-loop-helix family, member e40 0.0373945
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0373394
S100A10 S100 calcium binding protein A10 0.037188
DSTN destrin (actin depolymerizing factor) 0.0360236
IFITM3 interferon induced transmembrane protein 3 0.0358234
TGM2 transglutaminase 2 0.03484
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0347211
IFITM1 interferon induced transmembrane protein 1 0.0343696
LMNA lamin A/C 0.0342991
TRIO trio Rho guanine nucleotide exchange factor 0.0341171
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0340479
NAMPT nicotinamide phosphoribosyltransferase 0.0331123
HLA-B major histocompatibility complex, class I, B 0.0330686
SMAD3 SMAD family member 3 0.032752
RPS13 ribosomal protein S13 0.0321077
SRRM2 serine/arginine repetitive matrix 2 0.0316872
KIAA1217 KIAA1217 0.031352
RPS21 ribosomal protein S21 0.0311432
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0311267
KTN1 kinectin 1 (kinesin receptor) 0.0310197
RPLP2 ribosomal protein, large, P2 0.0304791
FOXP1 forkhead box P1 0.0302582
PTMA prothymosin, alpha 0.0298632
KMT2E lysine (K)-specific methyltransferase 2E 0.0296547
RPL11 ribosomal protein L11 0.0294611
RPL37 ribosomal protein L37 0.0292412
ARRDC3 arrestin domain containing 3 0.0292206
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.029145
RPLP1 ribosomal protein, large, P1 0.0287618
GNAS GNAS complex locus 0.028596
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0283524
HLA-E major histocompatibility complex, class I, E 0.0280719
KRT17 keratin 17, type I 0.0280523
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0279533
FN1 fibronectin 1 0.0274123
CUL4B cullin 4B 0.0274118
RPL12 ribosomal protein L12 0.0273105
ANKRD33B ankyrin repeat domain 33B 0.0272903
CD99 CD99 molecule 0.0272464
DOK5 docking protein 5 0.0269879
RPL19 ribosomal protein L19 0.0269102
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0268712
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0267694
S100A6 S100 calcium binding protein A6 0.0265677
EIF1 eukaryotic translation initiation factor 1 0.0264752
NRG1 neuregulin 1 0.0263171
RPL7A ribosomal protein L7a 0.0261318
EEF2 eukaryotic translation elongation factor 2 0.0261033
RPS19 ribosomal protein S19 0.025745
CANX calnexin 0.0257399
YBX3 Y box binding protein 3 0.0257118
RACK1 receptor for activated C kinase 1 0.0254688
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0254383
RPS3 ribosomal protein S3 0.0251385
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0249408
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0245215
PLEC plectin 0.0243171
HLA-A major histocompatibility complex, class I, A 0.024241
RPS12 ribosomal protein S12 0.0242165
ANXA1 annexin A1 0.0237423
ANGPTL4 angiopoietin-like 4 0.0236396
GOLGA4 golgin A4 0.023363
ESYT2 extended synaptotagmin-like protein 2 0.0232996
RPLP0 ribosomal protein, large, P0 0.0228422
RPL5 ribosomal protein L5 0.0226829
RPL8 ribosomal protein L8 0.0226819
FTH1 ferritin, heavy polypeptide 1 0.0226209
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0223904
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0223451
RPL30 ribosomal protein L30 0.0222954
KLF5 Kruppel-like factor 5 (intestinal) 0.0220746
S100A2 S100 calcium binding protein A2 0.0220069
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0218216
TXNIP thioredoxin interacting protein 0.0217365
APLP2 amyloid beta (A4) precursor-like protein 2 0.0216663

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.123062
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0885648
ANO1 anoctamin 1, calcium activated chloride channel -0.03909
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0371058
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0364181
PDLIM5 PDZ and LIM domain 5 -0.0338365
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0315306
SLC35F3 solute carrier family 35, member F3 -0.029766
HMGA2 high mobility group AT-hook 2 -0.02968
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0280675
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0273503
PLS3 plastin 3 -0.0268651
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0255653
PSD3 pleckstrin and Sec7 domain containing 3 -0.0244228
PDE4D phosphodiesterase 4D, cAMP-specific -0.0236871
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0230971
RCOR1 REST corepressor 1 -0.0228975
RIGI RNA sensor RIG-I -0.022728
THSD4 thrombospondin, type I, domain containing 4 -0.0224634
DPYD dihydropyrimidine dehydrogenase -0.0213224
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0208919
EGFR epidermal growth factor receptor -0.0200336
DGKH diacylglycerol kinase, eta -0.0193055
LAMC2 laminin, gamma 2 -0.019011
INTS6 integrator complex subunit 6 -0.0184451
LAMA5 laminin, alpha 5 -0.0181377
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0175841
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0173403
BCAR3 breast cancer anti-estrogen resistance 3 -0.0164177
GRB10 growth factor receptor-bound protein 10 -0.0159654
SETX senataxin -0.0159397
SOX5 SRY (sex determining region Y)-box 5 -0.0151956
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0150609
COL4A5 collagen, type IV, alpha 5 -0.014704
MPRIP myosin phosphatase Rho interacting protein -0.0146765
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0144845
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0143819
ZEB1 zinc finger E-box binding homeobox 1 -0.0140871
UTRN utrophin -0.0140437
SYN3 synapsin III -0.0138681
KLF12 Kruppel-like factor 12 -0.0138378
ANKRD11 ankyrin repeat domain 11 -0.0138359
TNS3 tensin 3 -0.013679
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0135121
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0127249
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 -0.0127014
EXOC4 exocyst complex component 4 -0.0126562
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0125617
SPIRE1 spire-type actin nucleation factor 1 -0.0124607
MECOM MDS1 and EVI1 complex locus -0.0122857
CUX1 cut-like homeobox 1 -0.0121039
NCKAP5 NCK-associated protein 5 -0.0120854
ZC3H12C zinc finger CCCH-type containing 12C -0.0120059
ZMYND8 zinc finger, MYND-type containing 8 -0.0119949
CDK13 cyclin-dependent kinase 13 -0.0119424
DENND1A DENN/MADD domain containing 1A -0.0119223
PALLD palladin, cytoskeletal associated protein -0.0118588
IARS1 isoleucyl-tRNA synthetase 1 -0.0118429
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0118274
KIAA1549L KIAA1549-like -0.011819
ABI3BP ABI family, member 3 (NESH) binding protein -0.0112275
FLG filaggrin -0.0111792
CADM2 cell adhesion molecule 2 -0.0111524
WDFY2 WD repeat and FYVE domain containing 2 -0.0107841
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0105252
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0104846
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0104745
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0104228
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.01034
SESTD1 SEC14 and spectrin domains 1 -0.0103223
FRMD6 FERM domain containing 6 -0.010244
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0101723
NEBL nebulette -0.010135
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.00991551
CTBP2 C-terminal binding protein 2 -0.00990914
HDAC9 histone deacetylase 9 -0.00986577
C4BPB complement component 4 binding protein, beta -0.00977951
FRAS1 Fraser extracellular matrix complex subunit 1 -0.00971393
IFI44 interferon-induced protein 44 -0.00965947
LRP1B low density lipoprotein receptor-related protein 1B -0.00956713
PLXNA2 plexin A2 -0.00952234
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.00949782
PATJ PATJ crumbs cell polarity complex component -0.00938048
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 -0.00916111
CSMD2 CUB and Sushi multiple domains 2 -0.00914161
WARS1 tryptophanyl-tRNA synthetase 1 -0.00909765
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.00897258
CORO2A coronin, actin binding protein, 2A -0.00876886
AFF3 AF4/FMR2 family, member 3 -0.00876616
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0086333
RNF217 ring finger protein 217 -0.00850502
MOSMO modulator of smoothened -0.0084646
DHFR dihydrofolate reductase -0.00829817
ZCCHC7 zinc finger, CCHC domain containing 7 -0.00825789
ARF4 ADP-ribosylation factor 4 -0.00821338
FMNL2 formin-like 2 -0.0081696
DMXL1 Dmx-like 1 -0.00811974
TJP1 tight junction protein 1 -0.00810358
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.008093
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.00804376