Lonafarnib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lonafarnib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lonafarnib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0798589
GMDS GDP-mannose 4,6-dehydratase 0.0601795
EXT1 exostosin glycosyltransferase 1 0.0535838
FAT1 FAT atypical cadherin 1 0.0501808
MYO1E myosin IE 0.0448657
LMO7 LIM domain 7 0.0406166
LPP LIM domain containing preferred translocation partner in lipoma 0.0385032
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0369173
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0360182
MBNL1 muscleblind-like splicing regulator 1 0.0349456
NEBL nebulette 0.0328691
PTPRK protein tyrosine phosphatase, receptor type, K 0.0325136
HSPA8 heat shock 70kDa protein 8 0.0323343
CADPS Ca++-dependent secretion activator 0.0310111
AFF1 AF4/FMR2 family, member 1 0.02998
TPT1 tumor protein, translationally-controlled 1 0.0293777
AHNAK AHNAK nucleoprotein 0.0271871
PRELID2 PRELI domain containing 2 0.0268045
MYO5B myosin VB 0.0265737
CCSER1 coiled-coil serine-rich protein 1 0.0265304
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0262465
ATXN1 ataxin 1 0.0253378
TRPS1 trichorhinophalangeal syndrome I 0.0245352
FHIT fragile histidine triad 0.0245076
PATJ PATJ crumbs cell polarity complex component 0.0244171
FNDC3B fibronectin type III domain containing 3B 0.0240854
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0240337
TTC3 tetratricopeptide repeat domain 3 0.0236511
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.023268
PARD3B par-3 family cell polarity regulator beta 0.0228706
ZSWIM6 zinc finger, SWIM-type containing 6 0.0227416
ITGA6 integrin, alpha 6 0.0225816
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0223283
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0223131
MED13 mediator complex subunit 13 0.0221847
ALCAM activated leukocyte cell adhesion molecule 0.0221631
MBNL2 muscleblind-like splicing regulator 2 0.0220405
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0220278
MACF1 microtubule-actin crosslinking factor 1 0.0215407
NDRG1 N-myc downstream regulated 1 0.021427
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0209161
SVIL supervillin 0.0209113
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0206692
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.020515
ZBTB20 zinc finger and BTB domain containing 20 0.0204977
SAMD4A sterile alpha motif domain containing 4A 0.0204333
SMYD3 SET and MYND domain containing 3 0.0203009
SRRM2 serine/arginine repetitive matrix 2 0.0196455
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0196196
ARHGAP21 Rho GTPase activating protein 21 0.0195859
PSD3 pleckstrin and Sec7 domain containing 3 0.0193714
VEGFA vascular endothelial growth factor A 0.0192028
BTBD9 BTB (POZ) domain containing 9 0.0191382
SLC38A2 solute carrier family 38, member 2 0.0189728
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0189047
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0183929
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0183776
GRB10 growth factor receptor-bound protein 10 0.0181996
AKAP13 A kinase (PRKA) anchor protein 13 0.0181129
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0177816
TGFBR3 transforming growth factor, beta receptor III 0.0176013
TPD52 tumor protein D52 0.0175945
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0174836
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.017174
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0171726
SAMD5 sterile alpha motif domain containing 5 0.0171203
PDZD8 PDZ domain containing 8 0.0170038
DIAPH2 diaphanous-related formin 2 0.0169983
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.016938
PDLIM5 PDZ and LIM domain 5 0.016858
KLF6 Kruppel-like factor 6 0.0164928
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0161131
MARCHF3 membrane associated ring-CH-type finger 3 0.0160996
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0160491
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0160472
KDM4C lysine (K)-specific demethylase 4C 0.0160154
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0156436
PTPRB protein tyrosine phosphatase, receptor type, B 0.0155527
ASPH aspartate beta-hydroxylase 0.0154286
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0153183
BACE2 beta-site APP-cleaving enzyme 2 0.0153142
USP53 ubiquitin specific peptidase 53 0.0151934
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0149635
EZR ezrin 0.0148939
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0147661
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0147358
UNC13B unc-13 homolog B (C. elegans) 0.014601
ARHGAP26 Rho GTPase activating protein 26 0.0145952
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0145026
FRMD5 FERM domain containing 5 0.0144236
FBXL17 F-box and leucine-rich repeat protein 17 0.014386
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0141749
FBXO11 F-box protein 11 0.0140812
NALF1 NALCN channel auxiliary factor 1 0.0140537
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0139889
ANKRD11 ankyrin repeat domain 11 0.0139076
PIGR polymeric immunoglobulin receptor 0.0138404
CLCN3 chloride channel, voltage-sensitive 3 0.0137559
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0135976
TES testin LIM domain protein 0.0135581

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0690868
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0584728
TNS4 tensin 4 -0.0426102
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0359474
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0335444
TXNRD1 thioredoxin reductase 1 -0.0305933
NPSR1 neuropeptide S receptor 1 -0.0295133
TMSB10 thymosin beta 10 -0.0281686
IFIH1 interferon induced with helicase C domain 1 -0.0230684
PDE4B phosphodiesterase 4B, cAMP-specific -0.0216435
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0206216
CENPF centromere protein F, 350/400kDa -0.0201117
YBX1 Y box binding protein 1 -0.0200826
HDAC9 histone deacetylase 9 -0.0198713
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0192555
FTH1 ferritin, heavy polypeptide 1 -0.0189264
S100P S100 calcium binding protein P -0.0179156
RPLP1 ribosomal protein, large, P1 -0.0176945
RNF43 ring finger protein 43 -0.0172799
FERMT1 fermitin family member 1 -0.0171602
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -0.0168939
HMGA1 high mobility group AT-hook 1 -0.0168835
PRSS3 protease, serine, 3 -0.0163614
KLF3 Kruppel-like factor 3 (basic) -0.0163446
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.016314
FOSL1 FOS-like antigen 1 -0.0159946
S100A6 S100 calcium binding protein A6 -0.0151829
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0149759
WDR43 WD repeat domain 43 -0.0148159
RPS19 ribosomal protein S19 -0.0144745
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0140841
INSIG1 insulin induced gene 1 -0.014002
POTEF POTE ankyrin domain family, member F -0.0138743
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0138316
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0134261
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0132723
RPL12 ribosomal protein L12 -0.0129885
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0126236
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0126218
RPL35 ribosomal protein L35 -0.0126213
EXOC1 exocyst complex component 1 -0.0125891
PNISR PNN-interacting serine/arginine-rich protein -0.0124073
RPL11 ribosomal protein L11 -0.0121804
EGR1 early growth response 1 -0.0120691
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0120584
VIM vimentin -0.0115946
PCDHB16 protocadherin beta 16 -0.0115862
CENPE centromere protein E, 312kDa -0.0112894
MKI67 marker of proliferation Ki-67 -0.0112559
ZMYND8 zinc finger, MYND-type containing 8 -0.0112525
SREBF2 sterol regulatory element binding transcription factor 2 -0.0112438
KRT19 keratin 19, type I -0.0112298
ITGB4 integrin, beta 4 -0.0111542
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.010753
LGALS4 lectin, galactoside-binding, soluble, 4 -0.0107277
KTN1 kinectin 1 (kinesin receptor) -0.0107053
DERA deoxyribose-phosphate aldolase (putative) -0.0105709
ZFR zinc finger RNA binding protein -0.0105537
B2M beta-2-microglobulin -0.0105352
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0104783
BCL2L1 BCL2-like 1 -0.0103727
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0102908
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0102822
CKAP2 cytoskeleton associated protein 2 -0.0102302
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.01015
H1-0 H1.0 linker histone -0.0101468
FTL ferritin, light polypeptide -0.0100981
GOLGA4 golgin A4 -0.0100294
KRT18 keratin 18, type I -0.00997139
PLAUR plasminogen activator, urokinase receptor -0.00987966
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.00979676
RPL36 ribosomal protein L36 -0.00975003
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.00970678
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.00969384
SMC4 structural maintenance of chromosomes 4 -0.0096471
HMGB2 high mobility group box 2 -0.00961002
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.00958965
ASTN2 astrotactin 2 -0.00940176
PKM pyruvate kinase, muscle -0.00936156
UBA6 ubiquitin-like modifier activating enzyme 6 -0.00933588
PGK1 phosphoglycerate kinase 1 -0.00927715
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0091987
ATP13A3 ATPase type 13A3 -0.00911779
RPL8 ribosomal protein L8 -0.00909687
CD46 CD46 molecule, complement regulatory protein -0.00890204
GCC2 GRIP and coiled-coil domain containing 2 -0.0088566
RPLP2 ribosomal protein, large, P2 -0.00881095
TCERG1 transcription elongation regulator 1 -0.00879842
UBB ubiquitin B -0.00877417
HMGB1 high mobility group box 1 -0.00876402
OLA1 Obg-like ATPase 1 -0.00870683
GPSM2 G-protein signaling modulator 2 -0.0085441
AVL9 AVL9 homolog (S. cerevisiase) -0.00852406
LDHA lactate dehydrogenase A -0.00849842
RAD21 RAD21 homolog (S. pombe) -0.00843616
RNF149 ring finger protein 149 -0.00834946
XPC xeroderma pigmentosum, complementation group C -0.00833846
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.00832863
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.00815995
RBM39 RNA binding motif protein 39 -0.00813325