Lonafarnib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lonafarnib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lonafarnib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0749994
CAPRIN2 caprin family member 2 0.0724927
DST dystonin 0.0644062
RUNX1 runt-related transcription factor 1 0.0563531
PSD3 pleckstrin and Sec7 domain containing 3 0.0514681
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0462696
MACF1 microtubule-actin crosslinking factor 1 0.0434415
TRIO trio Rho guanine nucleotide exchange factor 0.0412252
HDAC9 histone deacetylase 9 0.0409683
ERRFI1 ERBB receptor feedback inhibitor 1 0.0395656
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.039469
INTS6 integrator complex subunit 6 0.0360502
NPAS2 neuronal PAS domain protein 2 0.035343
ZSWIM6 zinc finger, SWIM-type containing 6 0.0340281
CD44 CD44 molecule (Indian blood group) 0.033032
ZDHHC14 zinc finger, DHHC-type containing 14 0.0325718
NEK10 NIMA-related kinase 10 0.0316781
SDK1 sidekick cell adhesion molecule 1 0.0298276
APP amyloid beta (A4) precursor protein 0.0298182
BCAR3 breast cancer anti-estrogen resistance 3 0.029592
HOMER1 homer scaffolding protein 1 0.0294879
RAB7A RAB7A, member RAS oncogene family 0.0293048
AHNAK AHNAK nucleoprotein 0.0289778
ZBTB38 zinc finger and BTB domain containing 38 0.0285572
RPL31 ribosomal protein L31 0.0277889
CSMD3 CUB and Sushi multiple domains 3 0.0274599
HSPA8 heat shock 70kDa protein 8 0.0270574
EEF2 eukaryotic translation elongation factor 2 0.0268129
FNIP1 folliculin interacting protein 1 0.0267989
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0262781
CMIP c-Maf inducing protein 0.026216
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0258496
ADARB1 adenosine deaminase, RNA-specific, B1 0.0252908
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0236674
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0235047
MCTP1 multiple C2 domains, transmembrane 1 0.023248
AEBP2 AE binding protein 2 0.0229597
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0229346
GLS2 glutaminase 2 (liver, mitochondrial) 0.0226395
TSC22D1 TSC22 domain family, member 1 0.0224225
RCOR1 REST corepressor 1 0.0217801
DENND1A DENN/MADD domain containing 1A 0.0217614
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.021603
SPAG9 sperm associated antigen 9 0.02142
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0211148
SLC39A10 solute carrier family 39 (zinc transporter), member 10 0.0210672
JMJD1C jumonji domain containing 1C 0.0207464
ZEB1 zinc finger E-box binding homeobox 1 0.0207322
KDM4C lysine (K)-specific demethylase 4C 0.0202721
TM4SF1 transmembrane 4 L six family member 1 0.0201164
ARRDC3 arrestin domain containing 3 0.0196598
MYOF myoferlin 0.0195684
BICD1 bicaudal D homolog 1 (Drosophila) 0.0193065
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0191468
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0190252
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0188565
MCL1 myeloid cell leukemia 1 0.0184718
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0184447
PRELID2 PRELI domain containing 2 0.0184344
EHBP1 EH domain binding protein 1 0.0181683
SDCCAG8 serologically defined colon cancer antigen 8 0.018048
LOXL2 lysyl oxidase-like 2 0.017868
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0174106
DOCK1 dedicator of cytokinesis 1 0.0174018
PODXL podocalyxin-like 0.0173979
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0169055
EGFR epidermal growth factor receptor 0.0168957
ZMIZ1 zinc finger, MIZ-type containing 1 0.0168581
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0168075
ANK2 ankyrin 2, neuronal 0.0166794
NAV2 neuron navigator 2 0.0166116
LYST lysosomal trafficking regulator 0.016531
LRRC49 leucine rich repeat containing 49 0.0165137
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0163788
ZFAND3 zinc finger, AN1-type domain 3 0.0163292
RPS8 ribosomal protein S8 0.0162473
TRIP12 thyroid hormone receptor interactor 12 0.0162076
RPL26 ribosomal protein L26 0.0160516
PDE10A phosphodiesterase 10A 0.0160388
RASA2 RAS p21 protein activator 2 0.0160064
WDR27 WD repeat domain 27 0.0158939
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0158634
IARS1 isoleucyl-tRNA synthetase 1 0.015217
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0151991
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0150856
LPP LIM domain containing preferred translocation partner in lipoma 0.014889
CFLAR CASP8 and FADD-like apoptosis regulator 0.0147173
SMAD3 SMAD family member 3 0.0147079
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0145201
CADM2 cell adhesion molecule 2 0.0145179
BIRC3 baculoviral IAP repeat containing 3 0.0144067
NBAS neuroblastoma amplified sequence 0.0141582
PYGL phosphorylase, glycogen, liver 0.0141119
RPL4 ribosomal protein L4 0.0140251
RPL28 ribosomal protein L28 0.0139126
SOD2 superoxide dismutase 2, mitochondrial 0.0138438
TTC17 tetratricopeptide repeat domain 17 0.0138398
RPS25 ribosomal protein S25 0.0136998
ARHGAP5 Rho GTPase activating protein 5 0.013678
RPS24 ribosomal protein S24 0.0135098

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.102629
PTMA prothymosin, alpha -0.0714451
VIM vimentin -0.0632301
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0489115
KTN1 kinectin 1 (kinesin receptor) -0.0435758
DLG1 discs, large homolog 1 (Drosophila) -0.0402543
WSB1 WD repeat and SOCS box containing 1 -0.0382456
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.038213
POTEF POTE ankyrin domain family, member F -0.0374071
RAI1 retinoic acid induced 1 -0.0338709
WARS1 tryptophanyl-tRNA synthetase 1 -0.0291943
ZMYND8 zinc finger, MYND-type containing 8 -0.0286562
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0281377
MT1E metallothionein 1E -0.0279423
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.027789
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0276098
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0263423
SLK STE20-like kinase -0.0263344
ESYT2 extended synaptotagmin-like protein 2 -0.0241154
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0238511
EZR ezrin -0.022944
TPM4 tropomyosin 4 -0.0221641
COL5A2 collagen, type V, alpha 2 -0.0216432
CENPF centromere protein F, 350/400kDa -0.0215241
SRGN serglycin -0.0210686
SEPTIN7 septin 7 -0.0210062
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0208677
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0206523
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0205088
SMC4 structural maintenance of chromosomes 4 -0.0201854
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0200768
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.019841
ANLN anillin, actin binding protein -0.0197964
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0196985
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.019573
YBX1 Y box binding protein 1 -0.0193508
GOLGA4 golgin A4 -0.0189148
MKI67 marker of proliferation Ki-67 -0.0188711
CALD1 caldesmon 1 -0.0179137
HILPDA hypoxia inducible lipid droplet-associated -0.0178224
MEF2A myocyte enhancer factor 2A -0.0177066
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.017521
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0173895
KPNB1 karyopherin (importin) beta 1 -0.0172534
IFI6 interferon, alpha-inducible protein 6 -0.0171617
PDIA3 protein disulfide isomerase family A, member 3 -0.0170788
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0167581
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0166621
DEK DEK proto-oncogene -0.0166444
RIGI RNA sensor RIG-I -0.016515
ENO1 enolase 1, (alpha) -0.0160971
B2M beta-2-microglobulin -0.0160646
PLIN2 perilipin 2 -0.015907
MYADM myeloid-associated differentiation marker -0.0159064
TMEM123 transmembrane protein 123 -0.0157464
TPR translocated promoter region, nuclear basket protein -0.0155954
LDHA lactate dehydrogenase A -0.0155858
EFNA5 ephrin-A5 -0.0153615
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0152407
NPEPPS aminopeptidase puromycin sensitive -0.0152081
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0151447
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0150217
XPO1 exportin 1 -0.0148417
FNBP4 formin binding protein 4 -0.0147469
NUCB2 nucleobindin 2 -0.0147317
RBM39 RNA binding motif protein 39 -0.0146912
ANKRD26 ankyrin repeat domain 26 -0.0146901
RPL35 ribosomal protein L35 -0.0146454
ZNF148 zinc finger protein 148 -0.0146447
CEP350 centrosomal protein 350kDa -0.014484
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0143724
AKAP10 A kinase (PRKA) anchor protein 10 -0.0143694
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0142164
AKAP9 A kinase (PRKA) anchor protein 9 -0.0141148
KLHL24 kelch-like family member 24 -0.0139193
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0138958
SCAF11 SR-related CTD-associated factor 11 -0.0138493
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0137019
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0136679
KIF20B kinesin family member 20B -0.0136666
ZNF292 zinc finger protein 292 -0.0136262
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0135969
BRD4 bromodomain containing 4 -0.0135804
TMSB10 thymosin beta 10 -0.0135352
KDM5B lysine (K)-specific demethylase 5B -0.0134823
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0133271
GLG1 golgi glycoprotein 1 -0.0132899
CALR calreticulin -0.0132572
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0131791
GCLM glutamate-cysteine ligase, modifier subunit -0.0131524
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0130783
MTF2 metal response element binding transcription factor 2 -0.0130226
FOSL1 FOS-like antigen 1 -0.0129328
FAM162A family with sequence similarity 162, member A -0.012879
IFITM1 interferon induced transmembrane protein 1 -0.0126283
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0125015
HLA-A major histocompatibility complex, class I, A -0.0124968
EPHA4 EPH receptor A4 -0.0124732
ADGRG6 adhesion G protein-coupled receptor G6 -0.0124149
ARL4C ADP-ribosylation factor-like 4C -0.0121911