| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lonafarnib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lonafarnib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.159427 |
| SLTM | SAFB-like, transcription modulator | 0.0630727 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0595113 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0582946 |
| NDRG1 | N-myc downstream regulated 1 | 0.05173 |
| GRAMD1B | GRAM domain containing 1B | 0.0507278 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0500962 |
| FAM13A | family with sequence similarity 13, member A | 0.0476774 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0452503 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0447175 |
| ENO1 | enolase 1, (alpha) | 0.0407835 |
| MT2A | metallothionein 2A | 0.0386785 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0375865 |
| CES1 | carboxylesterase 1 | 0.0350776 |
| STC1 | stanniocalcin 1 | 0.0345107 |
| RUNX1 | runt-related transcription factor 1 | 0.0334627 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0334613 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0306568 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0301452 |
| SEC61G | Sec61 gamma subunit | 0.0292512 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0289924 |
| SPAG9 | sperm associated antigen 9 | 0.0286997 |
| ARRDC3 | arrestin domain containing 3 | 0.0278039 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0269432 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0262027 |
| RPS3 | ribosomal protein S3 | 0.0261445 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0254388 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0252899 |
| AHNAK | AHNAK nucleoprotein | 0.024825 |
| SMAD3 | SMAD family member 3 | 0.0237999 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0229054 |
| AGO2 | argonaute RISC catalytic component 2 | 0.022832 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0226841 |
| TOP1 | topoisomerase (DNA) I | 0.0224562 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0218815 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0216176 |
| RPS8 | ribosomal protein S8 | 0.0214334 |
| ANXA2 | annexin A2 | 0.0211044 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0208668 |
| CANX | calnexin | 0.0205342 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0202715 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0201542 |
| MCL1 | myeloid cell leukemia 1 | 0.0200731 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0198011 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0196337 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0196099 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0195885 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0195427 |
| DTNA | dystrobrevin, alpha | 0.0195218 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0193717 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0192831 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0191619 |
| TMEM45B | transmembrane protein 45B | 0.0189487 |
| LAMB3 | laminin, beta 3 | 0.0189323 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0188155 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0187363 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0186876 |
| JMJD1C | jumonji domain containing 1C | 0.0186796 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0184911 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0181942 |
| MYOF | myoferlin | 0.0180242 |
| HELZ | helicase with zinc finger | 0.0179051 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0175933 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0173869 |
| AREG | amphiregulin | 0.0171275 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0171238 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0169301 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0168259 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0166103 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0164858 |
| NPTN | neuroplastin | 0.0161018 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0160243 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0159543 |
| UBC | ubiquitin C | 0.0159384 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0158855 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0158237 |
| UVRAG | UV radiation resistance associated | 0.0157624 |
| PYGL | phosphorylase, glycogen, liver | 0.0156963 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0156563 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0156497 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0155376 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0155134 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0154113 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0153409 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0152342 |
| OGA | O-GlcNAcase | 0.0152283 |
| PGK1 | phosphoglycerate kinase 1 | 0.0151339 |
| PLEC | plectin | 0.01513 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.014962 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0149134 |
| RPL37A | ribosomal protein L37a | 0.0148405 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0148016 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0144838 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0144142 |
| ANKRD37 | ankyrin repeat domain 37 | 0.0143969 |
| ATP13A3 | ATPase type 13A3 | 0.0141419 |
| CSNK1E | casein kinase 1, epsilon | 0.014106 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0139118 |
| TPD52 | tumor protein D52 | 0.0138733 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0138045 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.054801 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0337343 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0274177 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0231484 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0190046 |
| EGR1 | early growth response 1 | -0.0177046 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0165801 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0164999 |
| ACTG1 | actin gamma 1 | -0.015769 |
| CST3 | cystatin C | -0.0145499 |
| LMO7 | LIM domain 7 | -0.0145268 |
| KRT7 | keratin 7, type II | -0.0139087 |
| LDHA | lactate dehydrogenase A | -0.0138384 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0131242 |
| HMGA1 | high mobility group AT-hook 1 | -0.0122904 |
| MCU | mitochondrial calcium uniporter | -0.0106762 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0102643 |
| PERP | PERP, TP53 apoptosis effector | -0.0102565 |
| CAV2 | caveolin 2 | -0.0100978 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.00972764 |
| VCL | vinculin | -0.00960744 |
| TPM4 | tropomyosin 4 | -0.00957527 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.00937363 |
| TNS3 | tensin 3 | -0.00930005 |
| KRT19 | keratin 19, type I | -0.00902036 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.00894089 |
| CCND1 | cyclin D1 | -0.00884101 |
| POTEF | POTE ankyrin domain family, member F | -0.00845206 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.007497 |
| PCED1B | PC-esterase domain containing 1B | -0.00748254 |
| PRKCA | protein kinase C, alpha | -0.00715535 |
| GM2A | GM2 ganglioside activator | -0.00709576 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0069008 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.00689205 |
| RCOR1 | REST corepressor 1 | -0.00686515 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00684599 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.00681248 |
| RIN2 | Ras and Rab interactor 2 | -0.00676278 |
| MGAT4C | MGAT4 family, member C | -0.00674569 |
| EHBP1 | EH domain binding protein 1 | -0.00668934 |
| RAB27B | RAB27B, member RAS oncogene family | -0.00643888 |
| OSMR | oncostatin M receptor | -0.00620846 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.00602019 |
| PKM | pyruvate kinase, muscle | -0.00601932 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.00593387 |
| FAM114A1 | family with sequence similarity 114, member A1 | -0.0058668 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.00583029 |
| DOCK9 | dedicator of cytokinesis 9 | -0.00582704 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.00579829 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.00578557 |
| S100A10 | S100 calcium binding protein A10 | -0.00561387 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.00559604 |
| TAOK3 | TAO kinase 3 | -0.00555195 |
| CHML | choroideremia-like (Rab escort protein 2) | -0.00546089 |
| AGR2 | anterior gradient 2 | -0.00545378 |
| EFNA5 | ephrin-A5 | -0.00536563 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.00532849 |
| S100A11 | S100 calcium binding protein A11 | -0.00526426 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0052552 |
| DSPP | dentin sialophosphoprotein | -0.00510688 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.00510358 |
| CLMN | calmin (calponin-like, transmembrane) | -0.00503681 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.00491541 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.00479706 |
| NEBL | nebulette | -0.00477429 |
| DENND5B | DENN/MADD domain containing 5B | -0.00476439 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.00475659 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.00470954 |
| EBF1 | early B-cell factor 1 | -0.00458995 |
| MDFIC | MyoD family inhibitor domain containing | -0.00458314 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.00451254 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.00450947 |
| KRT18 | keratin 18, type I | -0.00448614 |
| DNER | delta/notch-like EGF repeat containing | -0.00444452 |
| DENND1B | DENN/MADD domain containing 1B | -0.00440575 |
| GNAS | GNAS complex locus | -0.00439146 |
| RIOK3 | RIO kinase 3 | -0.00430296 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00423121 |
| SMIM14 | small integral membrane protein 14 | -0.00422719 |
| SH3D19 | SH3 domain containing 19 | -0.00419142 |
| NALCN | sodium leak channel, non selective | -0.00417228 |
| GOLGA3 | golgin A3 | -0.00414105 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.00412009 |
| ITGA6 | integrin, alpha 6 | -0.00410571 |
| BMP7 | bone morphogenetic protein 7 | -0.00409578 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00408026 |
| PDLIM5 | PDZ and LIM domain 5 | -0.00400117 |
| SDC1 | syndecan 1 | -0.00399915 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.00398758 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00397642 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.00397483 |
| KRT8 | keratin 8, type II | -0.00396379 |
| SRPRA | SRP receptor subunit alpha | -0.00396223 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0039193 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.00388849 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.00388752 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0038767 |
| JUP | junction plakoglobin | -0.00385652 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.00383793 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.00378774 |
