Lonafarnib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lonafarnib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lonafarnib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZFAND3 zinc finger, AN1-type domain 3 0.0753095
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0734601
TPD52 tumor protein D52 0.0607011
RBM39 RNA binding motif protein 39 0.052515
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0468558
FTH1 ferritin, heavy polypeptide 1 0.04675
USP3 ubiquitin specific peptidase 3 0.0466471
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0444482
ZNF292 zinc finger protein 292 0.0441661
WAC WW domain containing adaptor with coiled-coil 0.043136
APP amyloid beta (A4) precursor protein 0.0428267
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0413664
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0407407
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0405142
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0403249
MACF1 microtubule-actin crosslinking factor 1 0.0401209
RICTOR RPTOR independent companion of MTOR, complex 2 0.0396686
TRIO trio Rho guanine nucleotide exchange factor 0.0394968
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0382187
SOD2 superoxide dismutase 2, mitochondrial 0.0358628
NCKAP1 NCK-associated protein 1 0.0357902
PUM1 pumilio RNA-binding family member 1 0.0356981
TM4SF1 transmembrane 4 L six family member 1 0.0346243
PARD3 par-3 family cell polarity regulator 0.0339976
RAB1A RAB1A, member RAS oncogene family 0.0333217
SPAG9 sperm associated antigen 9 0.033201
KDM3A lysine (K)-specific demethylase 3A 0.0329908
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0327332
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0322848
MARCHF6 membrane associated ring-CH-type finger 6 0.0322616
RNF145 ring finger protein 145 0.031974
EEF2 eukaryotic translation elongation factor 2 0.0315236
EIF1 eukaryotic translation initiation factor 1 0.0313907
FMNL2 formin-like 2 0.0311272
WDR43 WD repeat domain 43 0.0307063
RBM25 RNA binding motif protein 25 0.0304272
FNDC3B fibronectin type III domain containing 3B 0.0303608
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0302235
FNBP1L formin binding protein 1-like 0.0301012
PUM2 pumilio RNA-binding family member 2 0.0299746
ELL2 elongation factor, RNA polymerase II, 2 0.0298164
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0293888
PTK2 protein tyrosine kinase 2 0.029224
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0291835
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.028963
ABI1 abl-interactor 1 0.0284402
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0282345
NOP58 NOP58 ribonucleoprotein 0.0281984
CXCL8 chemokine (C-X-C motif) ligand 8 0.0275016
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0272877
TFG TRK-fused gene 0.0272688
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0270732
HSPA8 heat shock 70kDa protein 8 0.0269672
AHNAK AHNAK nucleoprotein 0.0267345
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0263819
UGCG UDP-glucose ceramide glucosyltransferase 0.0261466
NEK7 NIMA-related kinase 7 0.0261051
SIK3 SIK family kinase 3 0.0260724
TRA2A transformer 2 alpha homolog (Drosophila) 0.0260413
KMT2E lysine (K)-specific methyltransferase 2E 0.025891
MATR3 matrin 3 0.0252911
YME1L1 YME1-like 1 ATPase 0.0252513
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0252186
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0251126
ADAM17 ADAM metallopeptidase domain 17 0.0248429
CYRIB CYFIP related Rac1 interactor B 0.0241508
CCNL1 cyclin L1 0.0241283
ZNF207 zinc finger protein 207 0.0239915
HELZ helicase with zinc finger 0.0239758
IFRD1 interferon-related developmental regulator 1 0.0237513
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0236874
RTN4 reticulon 4 0.02359
EIF4A2 eukaryotic translation initiation factor 4A2 0.0234554
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0234444
ANKRD11 ankyrin repeat domain 11 0.0231025
GRAMD1B GRAM domain containing 1B 0.0230215
JAK1 Janus kinase 1 0.0229023
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0228876
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0228362
NUP58 nucleoporin 58 0.0225403
QKI QKI, KH domain containing, RNA binding 0.0223531
NAP1L1 nucleosome assembly protein 1-like 1 0.0223123
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0220426
ADAM9 ADAM metallopeptidase domain 9 0.021996
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0219757
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0218124
AKAP12 A kinase (PRKA) anchor protein 12 0.021682
CDC73 cell division cycle 73 0.0216558
NAMPT nicotinamide phosphoribosyltransferase 0.0216247
FXR1 fragile X mental retardation, autosomal homolog 1 0.0215569
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0211094
FAM107B family with sequence similarity 107, member B 0.0210758
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0209568
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0209069
SLMAP sarcolemma associated protein 0.020528
TLK1 tousled-like kinase 1 0.0204744
PCBP2 poly(rC) binding protein 2 0.0203997
ERRFI1 ERBB receptor feedback inhibitor 1 0.0201948
AKAP13 A kinase (PRKA) anchor protein 13 0.0201812
RAD21 RAD21 homolog (S. pombe) 0.0200955

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0714471
MT2A metallothionein 2A -0.0507997
EGR1 early growth response 1 -0.0492678
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0475187
THSD4 thrombospondin, type I, domain containing 4 -0.0457222
EGFR epidermal growth factor receptor -0.0402252
IGF2 insulin-like growth factor 2 -0.0389345
CMIP c-Maf inducing protein -0.0368862
TPM4 tropomyosin 4 -0.0346773
TMSB10 thymosin beta 10 -0.0342953
BICC1 BicC family RNA binding protein 1 -0.0339862
ACTG1 actin gamma 1 -0.0338151
LDHA lactate dehydrogenase A -0.0328323
VIM vimentin -0.0326945
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0325671
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0322358
NEGR1 neuronal growth regulator 1 -0.0315284
TPM1 tropomyosin 1 (alpha) -0.0310467
DOCK5 dedicator of cytokinesis 5 -0.0301467
POTEF POTE ankyrin domain family, member F -0.0289427
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0282561
ZBTB20 zinc finger and BTB domain containing 20 -0.0255073
IGFBP4 insulin-like growth factor binding protein 4 -0.02534
VCL vinculin -0.0250689
EFNA5 ephrin-A5 -0.0242942
SLC38A2 solute carrier family 38, member 2 -0.024162
PDE4D phosphodiesterase 4D, cAMP-specific -0.0240199
SMOC1 SPARC related modular calcium binding 1 -0.0240034
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0239646
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0219794
EHBP1 EH domain binding protein 1 -0.0215698
IGFBP3 insulin-like growth factor binding protein 3 -0.0209028
RASAL2 RAS protein activator like 2 -0.0200193
KYNU kynureninase -0.0196335
OSMR oncostatin M receptor -0.0196026
USP34 ubiquitin specific peptidase 34 -0.018652
HMGA2 high mobility group AT-hook 2 -0.0185345
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0180031
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0179504
BICD1 bicaudal D homolog 1 (Drosophila) -0.0170724
ACTN1 actinin, alpha 1 -0.0169563
PKM pyruvate kinase, muscle -0.0169506
NTN4 netrin 4 -0.0169246
FTL ferritin, light polypeptide -0.016891
S100A6 S100 calcium binding protein A6 -0.0167738
PM20D1 peptidase M20 domain containing 1 -0.0166297
HMGA1 high mobility group AT-hook 1 -0.0164449
GLIS3 GLIS family zinc finger 3 -0.0163393
HDAC9 histone deacetylase 9 -0.0161571
SLC35F3 solute carrier family 35, member F3 -0.0160504
UTRN utrophin -0.0159138
SVIL supervillin -0.0156953
DST dystonin -0.0156522
MAML3 mastermind-like 3 (Drosophila) -0.0153805
MSRB3 methionine sulfoxide reductase B3 -0.015177
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0151166
PDLIM5 PDZ and LIM domain 5 -0.0145664
NAV3 neuron navigator 3 -0.0143892
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0127323
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0124682
RSU1 Ras suppressor protein 1 -0.0124572
TGM2 transglutaminase 2 -0.0124324
BPTF bromodomain PHD finger transcription factor -0.0123992
TTC28 tetratricopeptide repeat domain 28 -0.012383
BASP1 brain abundant, membrane attached signal protein 1 -0.0123347
TNS3 tensin 3 -0.0123281
SKIL SKI-like proto-oncogene -0.0119406
P3H2 prolyl 3-hydroxylase 2 -0.0119329
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0117515
CALD1 caldesmon 1 -0.0115283
SETX senataxin -0.0111556
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0111177
TAS2R14 taste receptor, type 2, member 14 -0.0110473
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0110293
THBS1 thrombospondin 1 -0.0109248
PRKCA protein kinase C, alpha -0.0109244
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0109132
ATM ATM serine/threonine kinase -0.0108465
FOXP1 forkhead box P1 -0.0108003
PFN1 profilin 1 -0.0107065
KAT6B K(lysine) acetyltransferase 6B -0.0106159
MFF mitochondrial fission factor -0.0105678
ZNF644 zinc finger protein 644 -0.0104771
ANTXR1 anthrax toxin receptor 1 -0.0104454
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0103465
PCNX4 pecanex 4 -0.0103212
KLF6 Kruppel-like factor 6 -0.0103203
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0102951
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0101668
PATJ PATJ crumbs cell polarity complex component -0.0100555
RAB31 RAB31, member RAS oncogene family -0.00982476
CUX1 cut-like homeobox 1 -0.00980985
LIMA1 LIM domain and actin binding 1 -0.0098035
MYO1E myosin IE -0.00976362
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.00965772
TRIP11 thyroid hormone receptor interactor 11 -0.00952336
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.00949874
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.00948968
NNMT nicotinamide N-methyltransferase -0.00947927
NLK nemo-like kinase -0.00941239