| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lonafarnib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lonafarnib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.137872 |
| KYNU | kynureninase | 0.0960945 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0955474 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0848145 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0807965 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0768033 |
| SVIL | supervillin | 0.0741344 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0666972 |
| ATP11A | ATPase, class VI, type 11A | 0.0638552 |
| LMO7 | LIM domain 7 | 0.0633136 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0628125 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0583018 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0582912 |
| EGR1 | early growth response 1 | 0.0580644 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0575471 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0574325 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0564732 |
| SMAD3 | SMAD family member 3 | 0.0554368 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0554359 |
| MYO1E | myosin IE | 0.053336 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0523838 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0520774 |
| GPHN | gephyrin | 0.0495614 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0477856 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0477225 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0438092 |
| EGFR | epidermal growth factor receptor | 0.043621 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0435449 |
| CALR | calreticulin | 0.0433946 |
| PTK2 | protein tyrosine kinase 2 | 0.0433725 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0413379 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0410901 |
| ANXA2 | annexin A2 | 0.0404831 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0404388 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0404104 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0399742 |
| DTNA | dystrobrevin, alpha | 0.0397807 |
| C3 | complement component 3 | 0.0393132 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0389694 |
| CNKSR3 | CNKSR family member 3 | 0.038786 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0383173 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 0.0379288 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0370271 |
| SEPTIN9 | septin 9 | 0.0367353 |
| SNX9 | sorting nexin 9 | 0.0366323 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0363892 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.036132 |
| RPS8 | ribosomal protein S8 | 0.035647 |
| MYO5B | myosin VB | 0.0356306 |
| SETD2 | SET domain containing 2 | 0.035586 |
| CMIP | c-Maf inducing protein | 0.035301 |
| ERBIN | erbb2 interacting protein | 0.0352786 |
| FNIP1 | folliculin interacting protein 1 | 0.035268 |
| ANKRD37 | ankyrin repeat domain 37 | 0.0350358 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0347963 |
| FHIT | fragile histidine triad | 0.0342209 |
| PCM1 | pericentriolar material 1 | 0.0338131 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0330444 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0329439 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.032689 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0323592 |
| ITGB4 | integrin, beta 4 | 0.0322096 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0321359 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0321193 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0320133 |
| LAMB3 | laminin, beta 3 | 0.0319991 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0319688 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0319332 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0318552 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0314419 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0313255 |
| VMP1 | vacuole membrane protein 1 | 0.0312797 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0311915 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0308877 |
| POMP | proteasome maturation protein | 0.0304431 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0303247 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0301673 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0300877 |
| WAC | WW domain containing adaptor with coiled-coil | 0.029984 |
| GOLGA4 | golgin A4 | 0.0298188 |
| TJP1 | tight junction protein 1 | 0.0296826 |
| JUN | jun proto-oncogene | 0.0294935 |
| LAMC2 | laminin, gamma 2 | 0.0292683 |
| SQSTM1 | sequestosome 1 | 0.0288756 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0286721 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0285148 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0279347 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0272413 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.027188 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0271791 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.026829 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0265149 |
| RUNX1 | runt-related transcription factor 1 | 0.0264955 |
| AHNAK | AHNAK nucleoprotein | 0.0264529 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0262865 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0262386 |
| H3-3B | H3.3 histone B | 0.0260534 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0260469 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0258 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.025602 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.153325 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0802867 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.075074 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0678067 |
| PEG10 | paternally expressed 10 | -0.0584719 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0544435 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0510951 |
| RIGI | RNA sensor RIG-I | -0.0474304 |
| SMYD3 | SET and MYND domain containing 3 | -0.0472565 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0468945 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0465789 |
| TXNIP | thioredoxin interacting protein | -0.0464503 |
| CDC42 | cell division cycle 42 | -0.0464144 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0444659 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.043493 |
| MTSS1 | metastasis suppressor 1 | -0.0430763 |
| XRN1 | 5'-3' exoribonuclease 1 | -0.0430339 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0426887 |
| SEC24D | SEC24 family member D | -0.0423483 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.041809 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0413259 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0409468 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0407083 |
| DOCK7 | dedicator of cytokinesis 7 | -0.0403591 |
| MXD1 | MAX dimerization protein 1 | -0.0396888 |
| VIM | vimentin | -0.039441 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.0388141 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0387299 |
| ATRN | attractin | -0.0384436 |
| DOCK9 | dedicator of cytokinesis 9 | -0.038358 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0381286 |
| AUTS2 | autism susceptibility candidate 2 | -0.0378619 |
| WASF2 | WAS protein family, member 2 | -0.0378057 |
| TMSB10 | thymosin beta 10 | -0.0377204 |
| EP300 | E1A binding protein p300 | -0.0374818 |
| YBX3 | Y box binding protein 3 | -0.0374247 |
| NDRG1 | N-myc downstream regulated 1 | -0.0374105 |
| TVP23C-CDRT4 | TVP23C-CDRT4 readthrough | -0.0373774 |
| MORF4L1 | mortality factor 4 like 1 | -0.0371009 |
| TMEM87A | transmembrane protein 87A | -0.0369197 |
| BPTF | bromodomain PHD finger transcription factor | -0.0369192 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0366323 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0365599 |
| RASAL2 | RAS protein activator like 2 | -0.0364626 |
| HOOK3 | hook microtubule-tethering protein 3 | -0.0364453 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.03638 |
| SDC4 | syndecan 4 | -0.0362487 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | -0.0361519 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0361369 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.036117 |
| HMBOX1 | homeobox containing 1 | -0.0358988 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0358569 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0357763 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0354546 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.035449 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0350352 |
| TPM4 | tropomyosin 4 | -0.0348447 |
| SRP54 | signal recognition particle 54kDa | -0.0347361 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.034505 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0343511 |
| NBEA | neurobeachin | -0.0337655 |
| NUMB | numb homolog (Drosophila) | -0.0337085 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0335841 |
| WDR45B | WD repeat domain 45B | -0.0334819 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0334046 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0332896 |
| CCNI | cyclin I | -0.0331423 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0330768 |
| LNPEP | leucyl/cystinyl aminopeptidase | -0.0330759 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0330109 |
| FMN1 | formin 1 | -0.032394 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0322385 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0318632 |
| CCDC186 | coiled-coil domain containing 186 | -0.0317527 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | -0.0316542 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0316108 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0315991 |
| PRKCA | protein kinase C, alpha | -0.0315946 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0313027 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.031239 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0309871 |
| KIAA1671 | KIAA1671 | -0.0309801 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0308718 |
| TMEM41B | transmembrane protein 41B | -0.0306649 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0305439 |
| RAB3GAP2 | RAB3 GTPase activating protein subunit 2 (non-catalytic) | -0.0304822 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | -0.0303653 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0302379 |
| CEP350 | centrosomal protein 350kDa | -0.0302252 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.030099 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0297594 |
| PKP4 | plakophilin 4 | -0.0293446 |
| RPL34 | ribosomal protein L34 | -0.0292392 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0291417 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0290582 |
| ATG14 | autophagy related 14 | -0.0287475 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0286717 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0286688 |
| TANK | TRAF family member-associated NFKB activator | -0.0285339 |
| FBXO34 | F-box protein 34 | -0.0285337 |
