| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lonafarnib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lonafarnib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.186555 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.167838 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0940243 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0870236 |
| GRAMD1B | GRAM domain containing 1B | 0.0823447 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0784638 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0643548 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0584714 |
| TXNRD1 | thioredoxin reductase 1 | 0.0582727 |
| TPM3 | tropomyosin 3 | 0.0581434 |
| YBX3 | Y box binding protein 3 | 0.0567946 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0470754 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0450424 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0449961 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0441519 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0417136 |
| TPI1 | triosephosphate isomerase 1 | 0.0413608 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0412636 |
| ADAR | adenosine deaminase, RNA-specific | 0.0399607 |
| AHNAK | AHNAK nucleoprotein | 0.0377074 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0349904 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0345115 |
| ATP11A | ATPase, class VI, type 11A | 0.0343907 |
| ACTG1 | actin gamma 1 | 0.0328739 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0308974 |
| VIM | vimentin | 0.0305141 |
| ENO1 | enolase 1, (alpha) | 0.0292986 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0291691 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0290193 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0288911 |
| RTN4 | reticulon 4 | 0.028868 |
| KRT18 | keratin 18, type I | 0.0286894 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0280862 |
| UBC | ubiquitin C | 0.0279896 |
| TLN1 | talin 1 | 0.0276763 |
| VMP1 | vacuole membrane protein 1 | 0.0275605 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0268296 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0267953 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0262606 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0261372 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0259556 |
| STC1 | stanniocalcin 1 | 0.0258875 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0253757 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0252988 |
| JMJD1C | jumonji domain containing 1C | 0.0252361 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0245073 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0241787 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0241495 |
| EGR1 | early growth response 1 | 0.0241305 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0240181 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0238485 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0230853 |
| POTEF | POTE ankyrin domain family, member F | 0.0230072 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0229746 |
| COPA | coatomer protein complex, subunit alpha | 0.0226782 |
| CLTC | clathrin, heavy chain (Hc) | 0.0225895 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0224785 |
| SPAG9 | sperm associated antigen 9 | 0.0224689 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0223562 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0219411 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0218411 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0217522 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0215931 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0215741 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0212047 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0207439 |
| CCND2 | cyclin D2 | 0.0205297 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0202603 |
| XPO1 | exportin 1 | 0.0202205 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0201274 |
| H1-0 | H1.0 linker histone | 0.020081 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0200683 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0200452 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0197796 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0197148 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0193954 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 0.0192552 |
| YBX1 | Y box binding protein 1 | 0.0191972 |
| RRM2 | ribonucleotide reductase M2 | 0.0191886 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.019083 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0190587 |
| CDK17 | cyclin-dependent kinase 17 | 0.0189411 |
| TUBA1B | tubulin, alpha 1b | 0.0187331 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0185398 |
| TMEM41B | transmembrane protein 41B | 0.0184312 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0182365 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0181382 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0180151 |
| MMP12 | matrix metallopeptidase 12 | 0.0180059 |
| ANXA5 | annexin A5 | 0.0179774 |
| CANX | calnexin | 0.0179404 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0178735 |
| PKM | pyruvate kinase, muscle | 0.0178316 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0177554 |
| DSPP | dentin sialophosphoprotein | 0.01767 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0174018 |
| DST | dystonin | 0.0168973 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0166406 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0164736 |
| CRY1 | cryptochrome circadian clock 1 | 0.0164619 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.045187 |
| TMSB10 | thymosin beta 10 | -0.0450579 |
| PTMA | prothymosin, alpha | -0.0413685 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0378829 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0349977 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0304975 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0300834 |
| RPL35A | ribosomal protein L35a | -0.029869 |
| RYR3 | ryanodine receptor 3 | -0.0271646 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0253766 |
| RPL37A | ribosomal protein L37a | -0.025251 |
| RPS24 | ribosomal protein S24 | -0.0227531 |
| RBM39 | RNA binding motif protein 39 | -0.0223177 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0214367 |
| RPS29 | ribosomal protein S29 | -0.0212095 |
| RPL31 | ribosomal protein L31 | -0.0206993 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0205693 |
| RPS3 | ribosomal protein S3 | -0.0204668 |
| AEBP2 | AE binding protein 2 | -0.0204561 |
| RPL26 | ribosomal protein L26 | -0.0197501 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.0195635 |
| FTL | ferritin, light polypeptide | -0.0191202 |
| IER3 | immediate early response 3 | -0.0189701 |
| RBM25 | RNA binding motif protein 25 | -0.0186535 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0177842 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0175463 |
| HMGA2 | high mobility group AT-hook 2 | -0.0175018 |
| RPLP2 | ribosomal protein, large, P2 | -0.0166828 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0166029 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0165213 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0162422 |
| FMN1 | formin 1 | -0.0161986 |
| RPS19 | ribosomal protein S19 | -0.0159814 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.015876 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0156791 |
| RPS27A | ribosomal protein S27a | -0.0153871 |
| LRRC23 | leucine rich repeat containing 23 | -0.0153323 |
| RCC1 | regulator of chromosome condensation 1 | -0.0152099 |
| RPL34 | ribosomal protein L34 | -0.0151998 |
| RPLP1 | ribosomal protein, large, P1 | -0.0147484 |
| RPL11 | ribosomal protein L11 | -0.0145927 |
| RYK | receptor-like tyrosine kinase | -0.0144572 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0142898 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0142703 |
| RPS10 | ribosomal protein S10 | -0.0139535 |
| TBC1D22A | TBC1 domain family, member 22A | -0.013949 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0138839 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0138751 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.013705 |
| RPL9 | ribosomal protein L9 | -0.0133749 |
| THOC2 | THO complex 2 | -0.0128241 |
| MCL1 | myeloid cell leukemia 1 | -0.0127626 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0119629 |
| RPS15 | ribosomal protein S15 | -0.0119363 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0119051 |
| ST3GAL3 | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 | -0.0118885 |
| RPL37 | ribosomal protein L37 | -0.0118789 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0113572 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0112559 |
| RPS13 | ribosomal protein S13 | -0.0112261 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0111769 |
| NOP58 | NOP58 ribonucleoprotein | -0.0108452 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0108292 |
| NEK10 | NIMA-related kinase 10 | -0.0107586 |
| NEMF | nuclear export mediator factor | -0.0105852 |
| RPL38 | ribosomal protein L38 | -0.0105072 |
| ZNF207 | zinc finger protein 207 | -0.0104247 |
| ARMH4 | armadillo like helical domain containing 4 | -0.0103799 |
| RPS21 | ribosomal protein S21 | -0.0101977 |
| RPS6 | ribosomal protein S6 | -0.0100815 |
| CAVIN1 | caveolae associated protein 1 | -0.0100804 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0100002 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.00996787 |
| MYH15 | myosin, heavy chain 15 | -0.00980927 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.00975444 |
| RPL36 | ribosomal protein L36 | -0.00975294 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.00971843 |
| DENND1A | DENN/MADD domain containing 1A | -0.00964016 |
| EGFR | epidermal growth factor receptor | -0.0095373 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.00946588 |
| ATXN1 | ataxin 1 | -0.00943105 |
| SEM1 | SEM1 26S proteasome subunit | -0.00942277 |
| PTK2 | protein tyrosine kinase 2 | -0.00940189 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0093905 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.00937813 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.00932348 |
| SNX14 | sorting nexin 14 | -0.00927657 |
| FNDC3B | fibronectin type III domain containing 3B | -0.00919751 |
| GPATCH2L | G patch domain containing 2-like | -0.00918935 |
| PPHLN1 | periphilin 1 | -0.00912279 |
| STPG4 | sperm-tail PG-rich repeat containing 4 | -0.00911053 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.00898146 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.00892681 |
| RPL36A | ribosomal protein L36a | -0.00891285 |
| ENOSF1 | enolase superfamily member 1 | -0.00885747 |
| USP34 | ubiquitin specific peptidase 34 | -0.00883275 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.00877261 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.00874161 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.00874124 |
| RPS25 | ribosomal protein S25 | -0.00865385 |
