| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lonafarnib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lonafarnib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.18024 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.166911 |
| FN1 | fibronectin 1 | 0.152531 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.14206 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.135701 |
| ACTG1 | actin gamma 1 | 0.10408 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.100561 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0960461 |
| LAMB3 | laminin, beta 3 | 0.0936249 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0838551 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0771507 |
| AHNAK | AHNAK nucleoprotein | 0.0771491 |
| FNDC3B | fibronectin type III domain containing 3B | 0.075815 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0734213 |
| PTK2 | protein tyrosine kinase 2 | 0.068794 |
| UBC | ubiquitin C | 0.0650149 |
| ANXA2 | annexin A2 | 0.0632602 |
| TMSB4X | thymosin beta 4, X-linked | 0.0629819 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.060309 |
| CANX | calnexin | 0.0602427 |
| LAMC2 | laminin, gamma 2 | 0.0594393 |
| LDHA | lactate dehydrogenase A | 0.0582537 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0580588 |
| SQSTM1 | sequestosome 1 | 0.057176 |
| ARRDC3 | arrestin domain containing 3 | 0.0563794 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0554215 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0542065 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0537395 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0518695 |
| LMO7 | LIM domain 7 | 0.0503941 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0484456 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0483762 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0478034 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0473708 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0463314 |
| NAV2 | neuron navigator 2 | 0.0449734 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0442782 |
| ENO1 | enolase 1, (alpha) | 0.0435489 |
| CSTB | cystatin B (stefin B) | 0.0420096 |
| ASPH | aspartate beta-hydroxylase | 0.0414251 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0411356 |
| ADAR | adenosine deaminase, RNA-specific | 0.0410568 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0409242 |
| PGK1 | phosphoglycerate kinase 1 | 0.0408925 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0399605 |
| CD2AP | CD2-associated protein | 0.0392191 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.039103 |
| FAM13A | family with sequence similarity 13, member A | 0.0390193 |
| RAD21 | RAD21 homolog (S. pombe) | 0.03841 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0381337 |
| CTSB | cathepsin B | 0.0377268 |
| SDC4 | syndecan 4 | 0.0374662 |
| DSPP | dentin sialophosphoprotein | 0.0365962 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0363401 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0362659 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0361489 |
| F11R | F11 receptor | 0.0359032 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0357289 |
| PLEC | plectin | 0.0356356 |
| VEGFA | vascular endothelial growth factor A | 0.0347702 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0345352 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0343284 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0338384 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0331321 |
| SLC38A1 | solute carrier family 38, member 1 | 0.032429 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0321249 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0316043 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0314442 |
| MYO6 | myosin VI | 0.031009 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0309176 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0308199 |
| DSG2 | desmoglein 2 | 0.0307726 |
| TOP1 | topoisomerase (DNA) I | 0.0297577 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0297453 |
| GOLGA4 | golgin A4 | 0.0297121 |
| PLAU | plasminogen activator, urokinase | 0.0296097 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0295993 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0292346 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.029183 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0291618 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0291391 |
| IRF6 | interferon regulatory factor 6 | 0.0289254 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0288897 |
| SBF2 | SET binding factor 2 | 0.0286867 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0286855 |
| STEAP4 | STEAP family member 4 | 0.028639 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.028228 |
| TXNRD1 | thioredoxin reductase 1 | 0.0282054 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0281348 |
| CDCP1 | CUB domain containing protein 1 | 0.0278926 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.027414 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0272793 |
| S100A6 | S100 calcium binding protein A6 | 0.0272681 |
| MXD1 | MAX dimerization protein 1 | 0.0271597 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0271267 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0269199 |
| HLA-A | major histocompatibility complex, class I, A | 0.0267328 |
| SMAD3 | SMAD family member 3 | 0.0265753 |
| CALU | calumenin | 0.0265356 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0264592 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZC3H3 | zinc finger CCCH-type containing 3 | -0.0270289 |
| RPS19 | ribosomal protein S19 | -0.026603 |
| RPLP2 | ribosomal protein, large, P2 | -0.0252111 |
| RPS23 | ribosomal protein S23 | -0.0237759 |
| RPS29 | ribosomal protein S29 | -0.0233346 |
| RPL35A | ribosomal protein L35a | -0.0211826 |
| HMGA1 | high mobility group AT-hook 1 | -0.0205576 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.018397 |
| RPL9 | ribosomal protein L9 | -0.0180375 |
| YBX1 | Y box binding protein 1 | -0.0164526 |
| RPS10 | ribosomal protein S10 | -0.0150978 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0148121 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0144896 |
| RPS8 | ribosomal protein S8 | -0.0140489 |
| RPL37A | ribosomal protein L37a | -0.0140083 |
| TMSB10 | thymosin beta 10 | -0.0136983 |
| RPS13 | ribosomal protein S13 | -0.0134281 |
| RPS3 | ribosomal protein S3 | -0.013318 |
| RPL12 | ribosomal protein L12 | -0.012162 |
| RPS21 | ribosomal protein S21 | -0.0118648 |
| RPL36 | ribosomal protein L36 | -0.0118441 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0108295 |
| RPL38 | ribosomal protein L38 | -0.0107795 |
| FTL | ferritin, light polypeptide | -0.0102706 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0102201 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.00995305 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0096524 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.00953547 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | -0.00943617 |
| RPS15 | ribosomal protein S15 | -0.00932107 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.00920693 |
| RPL8 | ribosomal protein L8 | -0.00907223 |
| RPL23 | ribosomal protein L23 | -0.00900913 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.00895947 |
| RCAN3 | RCAN family member 3 | -0.00894181 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.00880424 |
| RPS14 | ribosomal protein S14 | -0.0085137 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.00835714 |
| TBCA | tubulin folding cofactor A | -0.00833006 |
| VCL | vinculin | -0.00830085 |
| EREG | epiregulin | -0.00829223 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.00829202 |
| GSTP1 | glutathione S-transferase pi 1 | -0.00824754 |
| RPS6 | ribosomal protein S6 | -0.00818286 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.00808966 |
| HMGB1 | high mobility group box 1 | -0.00805857 |
| DENND1A | DENN/MADD domain containing 1A | -0.00800985 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.00794879 |
| RPS17 | ribosomal protein S17 | -0.00756375 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.00754747 |
| SCEL | sciellin | -0.00750115 |
| RPS27 | ribosomal protein S27 | -0.00742736 |
| RPL28 | ribosomal protein L28 | -0.00740396 |
| PFN1 | profilin 1 | -0.00739029 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | -0.00723919 |
| CTBP2 | C-terminal binding protein 2 | -0.00719564 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.00713302 |
| STMN1 | stathmin 1 | -0.0071023 |
| TPM1 | tropomyosin 1 (alpha) | -0.00693855 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.00689462 |
| MRPL33 | mitochondrial ribosomal protein L33 | -0.00683288 |
| RPL35 | ribosomal protein L35 | -0.00680066 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.00676939 |
| TTLL11 | tubulin tyrosine ligase-like family member 11 | -0.0066969 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.00668774 |
| RPL13A | ribosomal protein L13a | -0.00664773 |
| POTEF | POTE ankyrin domain family, member F | -0.00664594 |
| RANBP1 | RAN binding protein 1 | -0.00661398 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.00646871 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.0064496 |
| LDHB | lactate dehydrogenase B | -0.00643467 |
| DOP1B | DOP1 leucine zipper like protein B | -0.00639869 |
| ATP5MK | ATP synthase membrane subunit k | -0.00629815 |
| S100A9 | S100 calcium binding protein A9 | -0.00621598 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.00621507 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | -0.0061576 |
| EGR1 | early growth response 1 | -0.00615485 |
| PABPC4 | poly(A) binding protein, cytoplasmic 4 (inducible form) | -0.00614759 |
| AHCTF1 | AT hook containing transcription factor 1 | -0.00609287 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.00603375 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.00601736 |
| MT2A | metallothionein 2A | -0.00600989 |
| DEK | DEK proto-oncogene | -0.00600792 |
| RPS11 | ribosomal protein S11 | -0.00599798 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.00592667 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | -0.00587397 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.00582715 |
| GALC | galactosylceramidase | -0.00582168 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.00575764 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | -0.005744 |
| RPL27 | ribosomal protein L27 | -0.00571953 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.00571446 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.00556856 |
| C19ORF33 | chromosome 19 open reading frame 33 | -0.00555486 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.00553317 |
| ARF4 | ADP-ribosylation factor 4 | -0.00551896 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.00542689 |
| BRF1 | BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit | -0.0054197 |
| ABHD5 | abhydrolase domain containing 5 | -0.00541909 |
| ECI1 | enoyl-CoA delta isomerase 1 | -0.0053935 |
