Lonafarnib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lonafarnib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Lonafarnib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0792997
PDE10A phosphodiesterase 10A 0.0735382
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0547212
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0544214
KYNU kynureninase 0.0513332
EEF2 eukaryotic translation elongation factor 2 0.0501923
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0493445
MCL1 myeloid cell leukemia 1 0.049057
SMOC1 SPARC related modular calcium binding 1 0.0432188
ESYT2 extended synaptotagmin-like protein 2 0.0418064
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0392513
PRELID2 PRELI domain containing 2 0.0385403
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0376306
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0350162
FNDC3A fibronectin type III domain containing 3A 0.0328285
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0326331
ANXA2 annexin A2 0.0323314
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0322153
SH3KBP1 SH3-domain kinase binding protein 1 0.0321678
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0320107
SMAD2 SMAD family member 2 0.0317514
PDLIM5 PDZ and LIM domain 5 0.0317296
TRIO trio Rho guanine nucleotide exchange factor 0.0309652
CXCL8 chemokine (C-X-C motif) ligand 8 0.0307973
ELL2 elongation factor, RNA polymerase II, 2 0.0306654
FTH1 ferritin, heavy polypeptide 1 0.0303806
SQSTM1 sequestosome 1 0.0300078
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0299393
PRKN parkin RBR E3 ubiquitin protein ligase 0.0297874
GRAMD1B GRAM domain containing 1B 0.0296436
HSPA8 heat shock 70kDa protein 8 0.0296065
PSD3 pleckstrin and Sec7 domain containing 3 0.0295999
FMNL2 formin-like 2 0.0292716
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0291844
CD44 CD44 molecule (Indian blood group) 0.0289641
PM20D1 peptidase M20 domain containing 1 0.0280666
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0276982
NDRG1 N-myc downstream regulated 1 0.0272484
EZR ezrin 0.0269406
FLNB filamin B, beta 0.026895
COL4A5 collagen, type IV, alpha 5 0.0264143
FNIP1 folliculin interacting protein 1 0.0262527
CTIF CBP80/20-dependent translation initiation factor 0.0262027
PTPRM protein tyrosine phosphatase, receptor type, M 0.0259842
ZSWIM6 zinc finger, SWIM-type containing 6 0.0258907
EXT1 exostosin glycosyltransferase 1 0.0255537
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0254521
DST dystonin 0.0244638
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0240685
CDH13 cadherin 13 0.0240276
AKAP13 A kinase (PRKA) anchor protein 13 0.0238893
ERRFI1 ERBB receptor feedback inhibitor 1 0.0233397
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0230821
TPM3 tropomyosin 3 0.0229253
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0228787
CTBP2 C-terminal binding protein 2 0.0227298
TGFBR1 transforming growth factor, beta receptor 1 0.0225349
AUTS2 autism susceptibility candidate 2 0.0222843
DGKD diacylglycerol kinase, delta 130kDa 0.0222057
AGTPBP1 ATP/GTP binding protein 1 0.0221785
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0218901
INTS6 integrator complex subunit 6 0.0217714
FAT1 FAT atypical cadherin 1 0.0216529
DENND1A DENN/MADD domain containing 1A 0.0212666
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0211654
RPS12 ribosomal protein S12 0.0210899
MYOF myoferlin 0.0210222
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0205988
P3H2 prolyl 3-hydroxylase 2 0.0204855
SRRM2 serine/arginine repetitive matrix 2 0.0203779
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0199338
NAP1L1 nucleosome assembly protein 1-like 1 0.0197542
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0195214
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0193907
FLNA filamin A, alpha 0.0189866
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0189579
INHBA inhibin, beta A 0.0189019
NT5C2 5'-nucleotidase, cytosolic II 0.018791
DDIT4 DNA-damage-inducible transcript 4 0.0187488
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0187329
LIMCH1 LIM and calponin homology domains 1 0.0184806
PYGL phosphorylase, glycogen, liver 0.0182936
CHL1 cell adhesion molecule L1-like 0.018041
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0179998
OXSR1 oxidative stress responsive 1 0.0178881
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0178589
CHD1 chromodomain helicase DNA binding protein 1 0.0177098
ASPH aspartate beta-hydroxylase 0.0174493
XYLT1 xylosyltransferase I 0.0174344
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0168634
IQGAP1 IQ motif containing GTPase activating protein 1 0.0167918
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0167354
HDAC4 histone deacetylase 4 0.0166631
GPC6 glypican 6 0.016494
DTNA dystrobrevin, alpha 0.0164406
SDK1 sidekick cell adhesion molecule 1 0.0163893
LOC112694756 uncharaterized LOC112694756 0.0163459
SPAG9 sperm associated antigen 9 0.0163447
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0162856
RAD51B RAD51 paralog B 0.016188

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.0591532
TMSB10 thymosin beta 10 -0.0576092
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0482507
NALF1 NALCN channel auxiliary factor 1 -0.0431613
SMYD3 SET and MYND domain containing 3 -0.0424792
PTMA prothymosin, alpha -0.0419006
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0414565
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0395485
GDA guanine deaminase -0.0377739
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0367064
COL5A2 collagen, type V, alpha 2 -0.0366135
VIM vimentin -0.0335766
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0327325
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0326874
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0287743
PBX1 pre-B-cell leukemia homeobox 1 -0.0281433
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.026702
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0249768
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0243142
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0242937
SCN3A sodium channel, voltage gated, type III alpha subunit -0.022759
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0221863
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0217194
S100A6 S100 calcium binding protein A6 -0.0212242
PTGR1 prostaglandin reductase 1 -0.0206455
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0200551
FTL ferritin, light polypeptide -0.0195881
RTN1 reticulon 1 -0.0190575
ZMYND8 zinc finger, MYND-type containing 8 -0.0188411
BCAS3 breast carcinoma amplified sequence 3 -0.0186981
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0186338
NRCAM neuronal cell adhesion molecule -0.0179604
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0178705
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0177184
RPS24 ribosomal protein S24 -0.0172613
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.017073
ADGRB3 adhesion G protein-coupled receptor B3 -0.0168587
CENPF centromere protein F, 350/400kDa -0.0163964
KIAA0825 KIAA0825 -0.015965
TFPI2 tissue factor pathway inhibitor 2 -0.015859
NEK7 NIMA-related kinase 7 -0.0157439
TXNRD1 thioredoxin reductase 1 -0.0150257
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0149846
LAMB1 laminin, beta 1 -0.014923
SRPK2 SRSF protein kinase 2 -0.0148755
NCOA7 nuclear receptor coactivator 7 -0.0148556
RPLP1 ribosomal protein, large, P1 -0.0143546
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0142567
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0140736
GNAS GNAS complex locus -0.0139652
NCAM2 neural cell adhesion molecule 2 -0.0138001
MAML2 mastermind-like 2 (Drosophila) -0.0134046
TPM4 tropomyosin 4 -0.0133019
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0131331
CTSL cathepsin L -0.0130527
WSB1 WD repeat and SOCS box containing 1 -0.0130503
NCKAP5 NCK-associated protein 5 -0.0130127
DPYD dihydropyrimidine dehydrogenase -0.0126844
ATAD1 ATPase family, AAA domain containing 1 -0.0126345
PCBP3 poly(rC) binding protein 3 -0.0125004
IFIH1 interferon induced with helicase C domain 1 -0.0124132
TMX4 thioredoxin-related transmembrane protein 4 -0.0122136
TBC1D19 TBC1 domain family, member 19 -0.0120765
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0118843
ISG15 ISG15 ubiquitin-like modifier -0.0117468
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0115258
RIGI RNA sensor RIG-I -0.0112969
AFG2A AFG2 AAA ATPase homolog A -0.0111797
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0111203
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0110979
PDE7B phosphodiesterase 7B -0.0110787
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0109717
RPL35A ribosomal protein L35a -0.010852
WARS1 tryptophanyl-tRNA synthetase 1 -0.0107951
HLA-B major histocompatibility complex, class I, B -0.0107772
OASL 2'-5'-oligoadenylate synthetase-like -0.0107627
PDE4D phosphodiesterase 4D, cAMP-specific -0.0106725
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0106293
QPCT glutaminyl-peptide cyclotransferase -0.0106061
RBM47 RNA binding motif protein 47 -0.0105945
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0103413
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.010118
PDE1A phosphodiesterase 1A, calmodulin-dependent -0.00999575
VCL vinculin -0.00983279
GCC2 GRIP and coiled-coil domain containing 2 -0.00978082
AOPEP aminopeptidase O (putative) -0.0097247
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.00971144
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.00965771
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -0.00943097
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0093959
FRMD4B FERM domain containing 4B -0.00936221
RBM39 RNA binding motif protein 39 -0.00924736
STXBP5 syntaxin binding protein 5 (tomosyn) -0.00923816
TBXT T-box transcription factor T -0.00923645
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.00912124
STEAP1B STEAP family member 1B -0.00903652
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.00902241
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.00891861
ETV1 ets variant 1 -0.00890888
SRGN serglycin -0.00888888