Lonafarnib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lonafarnib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

98 genes differentially expressed following the Lonafarnib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.131183
EGFR epidermal growth factor receptor 0.1143
FAT1 FAT atypical cadherin 1 0.0750086
RTN4 reticulon 4 0.0673746
RPS3 ribosomal protein S3 0.0645276
FNIP1 folliculin interacting protein 1 0.0619561
UBC ubiquitin C 0.0607799
ASPH aspartate beta-hydroxylase 0.055898
RAB7A RAB7A, member RAS oncogene family 0.0552735
ZNF292 zinc finger protein 292 0.0535378
RPL23 ribosomal protein L23 0.0534842
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0514934
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0507318
ANXA2 annexin A2 0.049818
NDRG1 N-myc downstream regulated 1 0.0433688
EFNA5 ephrin-A5 0.0429679
NUP58 nucleoporin 58 0.0417391
DSCAM Down syndrome cell adhesion molecule 0.0392923
KMT2E lysine (K)-specific methyltransferase 2E 0.036299
LDHA lactate dehydrogenase A 0.0329579
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0301359
ACTN4 actinin, alpha 4 0.0301305
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0231197
SPTBN1 spectrin, beta, non-erythrocytic 1 0.017112
TBC1D22A TBC1 domain family, member 22A 0.0170485
NAMPT nicotinamide phosphoribosyltransferase 0.0165678
PARD3 par-3 family cell polarity regulator 0.0160866
MT2A metallothionein 2A 0.0155414
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0147369
ANKRD11 ankyrin repeat domain 11 0.014458
TMSB10 thymosin beta 10 0.0139527
TXNRD1 thioredoxin reductase 1 0.0137097
PTPRM protein tyrosine phosphatase, receptor type, M 0.0133216
RBM39 RNA binding motif protein 39 0.0116163
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0113507
SLC38A1 solute carrier family 38, member 1 0.0112745
RLF rearranged L-myc fusion 0.0102099
ELL2 elongation factor, RNA polymerase II, 2 0.0102062
RPS27A ribosomal protein S27a 0.00974787
WAC WW domain containing adaptor with coiled-coil 0.00796951
MYO10 myosin X 0.00451717
BZW1 basic leucine zipper and W2 domains 1 0.00364882
TPT1 tumor protein, translationally-controlled 1 0.00164661
EEF2 eukaryotic translation elongation factor 2 0.00138834
PGK1 phosphoglycerate kinase 1 8.99068E-4
RPS6 ribosomal protein S6 7.19175E-4

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.120422
EXT1 exostosin glycosyltransferase 1 -0.118915
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.10788
HMGA2 high mobility group AT-hook 2 -0.103855
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0851514
VIM vimentin -0.0821329
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0738253
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0734058
TRIO trio Rho guanine nucleotide exchange factor -0.0708786
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0671323
EIF1 eukaryotic translation initiation factor 1 -0.0644287
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0572685
WSB1 WD repeat and SOCS box containing 1 -0.0565882
ZBTB20 zinc finger and BTB domain containing 20 -0.0557151
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0534833
PTK2 protein tyrosine kinase 2 -0.0515521
RPS8 ribosomal protein S8 -0.0510977
PDE4D phosphodiesterase 4D, cAMP-specific -0.0386353
RPL35A ribosomal protein L35a -0.0345037
FNDC3B fibronectin type III domain containing 3B -0.0321421
DST dystonin -0.0310106
IGF2 insulin-like growth factor 2 -0.0300308
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0280568
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0269048
AKAP12 A kinase (PRKA) anchor protein 12 -0.0262581
LMO7 LIM domain 7 -0.0251103
RPL19 ribosomal protein L19 -0.0247401
FTL ferritin, light polypeptide -0.0243155
JMJD1C jumonji domain containing 1C -0.0240651
ESYT2 extended synaptotagmin-like protein 2 -0.0237668
TM4SF1 transmembrane 4 L six family member 1 -0.0214715
ATXN1 ataxin 1 -0.0187995
PRELID2 PRELI domain containing 2 -0.018533
PTMA prothymosin, alpha -0.016408
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0161695
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0156156
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0152829
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0134623
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0125398
HLA-A major histocompatibility complex, class I, A -0.0124595
CCNI cyclin I -0.0123316
MCL1 myeloid cell leukemia 1 -0.0104943
PRKCA protein kinase C, alpha -0.0101106
FN1 fibronectin 1 -0.00841626
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.00756929
GPBP1 GC-rich promoter binding protein 1 -0.00643004
SETD5 SET domain containing 5 -0.00583894
MYO1E myosin IE -0.00496024
ENO1 enolase 1, (alpha) -0.00336515
PKM pyruvate kinase, muscle -0.00319922
RPL30 ribosomal protein L30 -0.00292345
RPS12 ribosomal protein S12 -0.00284525