Lonafarnib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lonafarnib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lonafarnib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH10 cadherin 10, type 2 (T2-cadherin) 0.13709
COL11A1 collagen, type XI, alpha 1 0.098329
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0980684
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0889498
VIM vimentin 0.088866
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0808796
PCLO piccolo presynaptic cytomatrix protein 0.0806475
COL5A2 collagen, type V, alpha 2 0.0798239
CADM2 cell adhesion molecule 2 0.0792342
COL3A1 collagen, type III, alpha 1 0.0568837
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0545662
ADGRL2 adhesion G protein-coupled receptor L2 0.0524217
PARD3B par-3 family cell polarity regulator beta 0.0521119
AHNAK AHNAK nucleoprotein 0.0517885
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0512734
TENM3 teneurin transmembrane protein 3 0.0496841
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0467302
PEG10 paternally expressed 10 0.0462354
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0455778
H1-0 H1.0 linker histone 0.0429501
SMYD3 SET and MYND domain containing 3 0.0426761
TRIO trio Rho guanine nucleotide exchange factor 0.0416102
MEIS2 Meis homeobox 2 0.0407857
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0407585
RAD51B RAD51 paralog B 0.039828
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0370213
ACTG1 actin gamma 1 0.0357022
SRRM2 serine/arginine repetitive matrix 2 0.0348538
RPS16 ribosomal protein S16 0.0341919
PGK1 phosphoglycerate kinase 1 0.0333445
DST dystonin 0.0323509
PCDH9 protocadherin 9 0.0313257
PLPP1 phospholipid phosphatase 1 0.0305486
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0293396
ENO1 enolase 1, (alpha) 0.0283773
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0282726
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0281543
NSUN6 NOP2/Sun domain family, member 6 0.0280681
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0280459
CALR calreticulin 0.0273758
PCDH7 protocadherin 7 0.0271428
RASAL2 RAS protein activator like 2 0.0267237
JMJD1C jumonji domain containing 1C 0.0266533
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0266107
LYST lysosomal trafficking regulator 0.0257989
HDAC9 histone deacetylase 9 0.0253564
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0251028
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0250461
PHF21A PHD finger protein 21A 0.0249503
SLIT2 slit homolog 2 (Drosophila) 0.0248551
LRMDA leucine rich melanocyte differentiation associated 0.0247737
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0246922
TMSB10 thymosin beta 10 0.0244819
NEBL nebulette 0.0244211
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.024047
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0239294
SCAF11 SR-related CTD-associated factor 11 0.0237689
ITGAV integrin, alpha V 0.023432
KMT2C lysine (K)-specific methyltransferase 2C 0.0232088
FOXG1 forkhead box G1 0.0230642
ZC3H12B zinc finger CCCH-type containing 12B 0.0230362
DMD dystrophin 0.0230049
FOXP2 forkhead box P2 0.0228048
NBEAL1 neurobeachin-like 1 0.0228015
FBXO17 F-box protein 17 0.0223717
FNDC3B fibronectin type III domain containing 3B 0.0222099
COL1A2 collagen, type I, alpha 2 0.0220528
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0218589
TCF12 transcription factor 12 0.0217163
ZCCHC7 zinc finger, CCHC domain containing 7 0.0213352
LDHA lactate dehydrogenase A 0.0212007
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0210881
PTMA prothymosin, alpha 0.0210814
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0210721
AKAP9 A kinase (PRKA) anchor protein 9 0.0209798
PCDH18 protocadherin 18 0.0206596
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0206359
SNX6 sorting nexin 6 0.0206127
PROS1 protein S (alpha) 0.0200141
DARS1 aspartyl-tRNA synthetase 1 0.019922
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0198119
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0193881
TAS2R14 taste receptor, type 2, member 14 0.0193824
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0191263
NSD3 nuclear receptor binding SET domain protein 3 0.0189735
PBX3 pre-B-cell leukemia homeobox 3 0.0189317
ZFAND3 zinc finger, AN1-type domain 3 0.0187993
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0185761
LARP1 La ribonucleoprotein domain family, member 1 0.0185708
RAB31 RAB31, member RAS oncogene family 0.0184304
POU3F2 POU class 3 homeobox 2 0.0182619
RPL30 ribosomal protein L30 0.0181369
PDIA6 protein disulfide isomerase family A, member 6 0.0180532
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0179565
NUMB numb homolog (Drosophila) 0.0179002
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0178584
CALU calumenin 0.0177849
EEF2 eukaryotic translation elongation factor 2 0.017693
PDIA3 protein disulfide isomerase family A, member 3 0.0176279
COG5 component of oligomeric golgi complex 5 0.0175451

decreased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 -0.0666295
MYO10 myosin X -0.038047
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0371185
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0299143
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0294971
KCTD16 potassium channel tetramerization domain containing 16 -0.0271098
CHD1 chromodomain helicase DNA binding protein 1 -0.0251324
YBX1 Y box binding protein 1 -0.0243965
RLF rearranged L-myc fusion -0.023868
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0238387
ADAM9 ADAM metallopeptidase domain 9 -0.023308
GPC3 glypican 3 -0.0226449
ADGRV1 adhesion G protein-coupled receptor V1 -0.0223218
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0222498
QKI QKI, KH domain containing, RNA binding -0.0212254
USP53 ubiquitin specific peptidase 53 -0.021152
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0207405
PGAP1 post-GPI attachment to proteins 1 -0.0205558
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0201719
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0200716
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0198679
WASL Wiskott-Aldrich syndrome-like -0.019616
SFRP4 secreted frizzled-related protein 4 -0.018629
FNDC3A fibronectin type III domain containing 3A -0.0185517
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0181957
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0181738
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0181418
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0180489
CALCR calcitonin receptor -0.0180295
AFF1 AF4/FMR2 family, member 1 -0.01782
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0177325
FUBP1 far upstream element (FUSE) binding protein 1 -0.01773
MED13L mediator complex subunit 13-like -0.0176736
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0175624
BMPR1A bone morphogenetic protein receptor, type IA -0.0174667
RBM39 RNA binding motif protein 39 -0.0171809
RAB30 RAB30, member RAS oncogene family -0.0170096
TBC1D12 TBC1 domain family, member 12 -0.0168225
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0165882
RNF145 ring finger protein 145 -0.0158949
CCNL1 cyclin L1 -0.0157096
NAMPT nicotinamide phosphoribosyltransferase -0.0155806
KMT2E lysine (K)-specific methyltransferase 2E -0.0155645
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.01546
SFPQ splicing factor proline/glutamine-rich -0.0154502
TOP1 topoisomerase (DNA) I -0.0154226
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0154102
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0153225
ADGRB3 adhesion G protein-coupled receptor B3 -0.0152488
RHEB Ras homolog enriched in brain -0.0151728
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0151131
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0150578
KDM6A lysine (K)-specific demethylase 6A -0.0150433
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 -0.0145108
ANKRD33B ankyrin repeat domain 33B -0.014417
WDR43 WD repeat domain 43 -0.0143781
PRRC2C proline-rich coiled-coil 2C -0.0142982
RPS10 ribosomal protein S10 -0.0142009
WTAP Wilms tumor 1 associated protein -0.0140378
TPM1 tropomyosin 1 (alpha) -0.0139897
CAMTA1 calmodulin binding transcription activator 1 -0.0139381
MAST2 microtubule associated serine/threonine kinase 2 -0.0139222
RBM20 RNA binding motif protein 20 -0.0138936
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0136859
FNBP1L formin binding protein 1-like -0.0136073
USP3 ubiquitin specific peptidase 3 -0.0135439
MMP1 matrix metallopeptidase 1 -0.0133873
ANKRD11 ankyrin repeat domain 11 -0.0132933
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -0.0132767
HDAC2 histone deacetylase 2 -0.013143
RTN4 reticulon 4 -0.013142
FAM168B family with sequence similarity 168, member B -0.0130634
NELL2 NEL-like 2 (chicken) -0.0130022
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.012957
TCP1 t-complex 1 -0.0129457
NRXN1 neurexin 1 -0.0128258
CCNYL1 cyclin Y-like 1 -0.0126883
PUM1 pumilio RNA-binding family member 1 -0.01248
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0124332
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0123911
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0123897
HBP1 HMG-box transcription factor 1 -0.0123499
MT2A metallothionein 2A -0.0123145
MCTP1 multiple C2 domains, transmembrane 1 -0.0123049
PTBP2 polypyrimidine tract binding protein 2 -0.0122883
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0122755
MATR3 matrin 3 -0.0122224
RPLP2 ribosomal protein, large, P2 -0.0121769
GLCCI1 glucocorticoid induced 1 -0.0121232
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -0.0119228
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0119169
RAB10 RAB10, member RAS oncogene family -0.0118387
ARHGAP32 Rho GTPase activating protein 32 -0.0118004
NCKAP1 NCK-associated protein 1 -0.0117537
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0117492
RFX7 regulatory factor X, 7 -0.0117195
SREBF2 sterol regulatory element binding transcription factor 2 -0.0116997
KANK1 KN motif and ankyrin repeat domains 1 -0.0116903
H1-4 H1.4 linker histone, cluster member -0.0116889
FRY furry homolog (Drosophila) -0.0116044