Lonafarnib_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lonafarnib perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lonafarnib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.205717
FNDC3B fibronectin type III domain containing 3B 0.0747183
CD44 CD44 molecule (Indian blood group) 0.0611535
AHNAK AHNAK nucleoprotein 0.0526351
IGFBP3 insulin-like growth factor binding protein 3 0.0495077
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0489788
SMAD3 SMAD family member 3 0.0464988
SMYD3 SET and MYND domain containing 3 0.045136
ANXA2 annexin A2 0.044952
BIRC3 baculoviral IAP repeat containing 3 0.0425835
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0414585
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0390456
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0385332
ANKRD28 ankyrin repeat domain 28 0.0358626
FMNL2 formin-like 2 0.035141
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0340726
LOC112694756 uncharaterized LOC112694756 0.0325512
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0321285
FNIP1 folliculin interacting protein 1 0.0313402
DSCAM Down syndrome cell adhesion molecule 0.0302554
CANX calnexin 0.0301024
MBNL2 muscleblind-like splicing regulator 2 0.0294291
PRKCA protein kinase C, alpha 0.0292555
MACF1 microtubule-actin crosslinking factor 1 0.0285513
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0275032
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0265658
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0255965
BHLHE40 basic helix-loop-helix family, member e40 0.0251073
ZSWIM6 zinc finger, SWIM-type containing 6 0.0249884
TRIO trio Rho guanine nucleotide exchange factor 0.0243568
ATXN1 ataxin 1 0.0240372
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0221077
PRELID2 PRELI domain containing 2 0.0217498
NT5E 5'-nucleotidase, ecto (CD73) 0.0215479
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.020944
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0207746
OSMR oncostatin M receptor 0.0207397
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0206075
JMJD1C jumonji domain containing 1C 0.0204778
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0203636
WAC WW domain containing adaptor with coiled-coil 0.0200286
EEF2 eukaryotic translation elongation factor 2 0.0196043
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0194244
NAP1L1 nucleosome assembly protein 1-like 1 0.0193913
TBC1D5 TBC1 domain family, member 5 0.0191725
ANO6 anoctamin 6 0.0191621
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0190135
IQGAP1 IQ motif containing GTPase activating protein 1 0.0186155
GLS2 glutaminase 2 (liver, mitochondrial) 0.0182146
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0181693
SVIL supervillin 0.0180732
SIK2 salt-inducible kinase 2 0.0180106
APLP2 amyloid beta (A4) precursor-like protein 2 0.0179725
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0178085
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0177394
NAMPT nicotinamide phosphoribosyltransferase 0.0175381
SAMD4A sterile alpha motif domain containing 4A 0.0174413
SQSTM1 sequestosome 1 0.0174384
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0173479
CALU calumenin 0.0170318
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0169723
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0167577
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0167558
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.01666
AHNAK2 AHNAK nucleoprotein 2 0.0166427
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0164987
ELL2 elongation factor, RNA polymerase II, 2 0.0164749
RORA RAR-related orphan receptor A 0.0164378
ZNF292 zinc finger protein 292 0.0164269
HOOK2 hook microtubule-tethering protein 2 0.0163931
MBNL1 muscleblind-like splicing regulator 1 0.0163657
TXNIP thioredoxin interacting protein 0.0157937
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0157581
AHCTF1 AT hook containing transcription factor 1 0.0155754
DTNA dystrobrevin, alpha 0.0155713
PICALM phosphatidylinositol binding clathrin assembly protein 0.0155346
ATP13A3 ATPase type 13A3 0.0155228
TRA2A transformer 2 alpha homolog (Drosophila) 0.015243
YAP1 Yes-associated protein 1 0.0152042
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0151963
ARL15 ADP-ribosylation factor-like 15 0.0150961
OXSR1 oxidative stress responsive 1 0.015078
NF1 neurofibromin 1 0.0150074
NUP98 nucleoporin 98kDa 0.0150073
TPI1 triosephosphate isomerase 1 0.0149216
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0149029
HELZ helicase with zinc finger 0.0148775
NDRG1 N-myc downstream regulated 1 0.0148534
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0146913
ENO1 enolase 1, (alpha) 0.0146577
KMT2E lysine (K)-specific methyltransferase 2E 0.0146132
YBX3 Y box binding protein 3 0.0146038
UBC ubiquitin C 0.0145583
ESYT2 extended synaptotagmin-like protein 2 0.0145331
MARCHF6 membrane associated ring-CH-type finger 6 0.014398
ITCH itchy E3 ubiquitin protein ligase 0.0143832
SPAG9 sperm associated antigen 9 0.014372
CSNK1A1 casein kinase 1, alpha 1 0.0143673
FBXL7 F-box and leucine-rich repeat protein 7 0.0143078
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.014252

decreased expression

Symbol Name Standardized Value
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0328357
HMGA2 high mobility group AT-hook 2 -0.0325218
TMSB10 thymosin beta 10 -0.0299258
RIGI RNA sensor RIG-I -0.023037
DNER delta/notch-like EGF repeat containing -0.0193867
MT2A metallothionein 2A -0.0180278
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0177274
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0159555
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.015584
TPM4 tropomyosin 4 -0.01553
RPL9 ribosomal protein L9 -0.0154704
FTL ferritin, light polypeptide -0.0146378
BTG1 B-cell translocation gene 1, anti-proliferative -0.0137716
POTEF POTE ankyrin domain family, member F -0.0133788
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.012518
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.012487
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0120846
TEX14 testis expressed 14 -0.0119351
EFNA5 ephrin-A5 -0.0118265
LMO7 LIM domain 7 -0.011612
PSEN1 presenilin 1 -0.0115188
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0111546
RPLP2 ribosomal protein, large, P2 -0.0109517
ATG7 autophagy related 7 -0.0107999
PCED1B PC-esterase domain containing 1B -0.010631
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0105889
TIMP1 TIMP metallopeptidase inhibitor 1 -0.010362
OASL 2'-5'-oligoadenylate synthetase-like -0.0103422
RPL38 ribosomal protein L38 -0.00995588
PTS 6-pyruvoyltetrahydropterin synthase -0.00992719
SLC35F3 solute carrier family 35, member F3 -0.00991894
CALD1 caldesmon 1 -0.00985784
TM4SF1 transmembrane 4 L six family member 1 -0.00985061
RPL34 ribosomal protein L34 -0.00982087
RPS14 ribosomal protein S14 -0.00969912
WARS1 tryptophanyl-tRNA synthetase 1 -0.00962071
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.00946863
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.00930113
UHMK1 U2AF homology motif (UHM) kinase 1 -0.00926805
RBM39 RNA binding motif protein 39 -0.00909297
RPS6 ribosomal protein S6 -0.00889451
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.00881026
RPL12 ribosomal protein L12 -0.00865726
NLK nemo-like kinase -0.00823804
PRRC2B proline-rich coiled-coil 2B -0.00823588
PTPRK protein tyrosine phosphatase, receptor type, K -0.00819677
PODXL podocalyxin-like -0.00814814
CAVIN1 caveolae associated protein 1 -0.0080902
NRG1 neuregulin 1 -0.0080144
RPL37A ribosomal protein L37a -0.0079987
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.00795065
KNOP1 lysine-rich nucleolar protein 1 -0.00789518
CCDC82 coiled-coil domain containing 82 -0.00789349
EGR1 early growth response 1 -0.00785371
KLF6 Kruppel-like factor 6 -0.00785166
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.00776039
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0077536
MAML3 mastermind-like 3 (Drosophila) -0.00773743
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.00765861
PHEX phosphate regulating endopeptidase homolog, X-linked -0.00764449
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.00763215
TMSB4X thymosin beta 4, X-linked -0.00745127
RPS25 ribosomal protein S25 -0.00742742
ZC3H3 zinc finger CCCH-type containing 3 -0.00739866
SEC13 SEC13 homolog (S. cerevisiae) -0.00738588
SEC62 SEC62 homolog (S. cerevisiae) -0.00729587
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.00728826
AK1 adenylate kinase 1 -0.0072734
EIF5B eukaryotic translation initiation factor 5B -0.00724635
RPS29 ribosomal protein S29 -0.00720112
HMGA1 high mobility group AT-hook 1 -0.00719054
BCL2L1 BCL2-like 1 -0.00699544
UNC13A unc-13 homolog A (C. elegans) -0.00688888
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.00687055
MMP24OS MMP24 opposite strand -0.00683451
RPL35A ribosomal protein L35a -0.00682216
ACTG1 actin gamma 1 -0.00678416
SOS2 son of sevenless homolog 2 (Drosophila) -0.00675076
SLC38A6 solute carrier family 38, member 6 -0.0067466
S100A10 S100 calcium binding protein A10 -0.0067374
RPS12 ribosomal protein S12 -0.00673265
LAMB1 laminin, beta 1 -0.00670905
FERMT2 fermitin family member 2 -0.00669047
THBS1 thrombospondin 1 -0.00662652
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0066132
RPS19 ribosomal protein S19 -0.00654585
PRKACB protein kinase, cAMP-dependent, catalytic, beta -0.00653131
TPP2 tripeptidyl peptidase II -0.0065189
KLF3 Kruppel-like factor 3 (basic) -0.00650464
HSPB1 heat shock 27kDa protein 1 -0.00648662
CD63 CD63 molecule -0.00642637
ENOSF1 enolase superfamily member 1 -0.00638918
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.00638303
INO80D INO80 complex subunit D -0.00633609
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.00633317
SERF2 small EDRK-rich factor 2 -0.0063275
PLCB4 phospholipase C, beta 4 -0.00630688
LIMA1 LIM domain and actin binding 1 -0.00627101
MAML2 mastermind-like 2 (Drosophila) -0.00625013
NME7 NME/NM23 family member 7 -0.00620119