| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.121621 |
| AREG | amphiregulin | 0.105661 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0761392 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.070909 |
| RPL23 | ribosomal protein L23 | 0.0577658 |
| KIF5B | kinesin family member 5B | 0.0548095 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.044951 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0441504 |
| NEK7 | NIMA-related kinase 7 | 0.0398961 |
| TPI1 | triosephosphate isomerase 1 | 0.0385287 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0352532 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0351223 |
| MGAT4C | MGAT4 family, member C | 0.0347215 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0344223 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0336342 |
| XPO1 | exportin 1 | 0.0332578 |
| OXR1 | oxidation resistance 1 | 0.0329337 |
| EDN1 | endothelin 1 | 0.0325728 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0312556 |
| RPS3 | ribosomal protein S3 | 0.0309455 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0307603 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0296415 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0296249 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0293251 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.028729 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0282443 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0279721 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.027686 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.0266913 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0266385 |
| RNF145 | ring finger protein 145 | 0.0265148 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.0265109 |
| FTL | ferritin, light polypeptide | 0.026407 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0263504 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.026262 |
| SPAG9 | sperm associated antigen 9 | 0.025729 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0254996 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0254558 |
| TNPO1 | transportin 1 | 0.0253871 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0253657 |
| USP15 | ubiquitin specific peptidase 15 | 0.0252651 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0250313 |
| PLK2 | polo-like kinase 2 | 0.024756 |
| NCKAP1 | NCK-associated protein 1 | 0.0247156 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0246313 |
| TFG | TRK-fused gene | 0.0244329 |
| GASK1B | golgi associated kinase 1B | 0.0243418 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0241582 |
| MED13L | mediator complex subunit 13-like | 0.0239609 |
| WDR43 | WD repeat domain 43 | 0.0239395 |
| RPS7 | ribosomal protein S7 | 0.0231153 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0230479 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0225402 |
| RPL19 | ribosomal protein L19 | 0.0224943 |
| RLF | rearranged L-myc fusion | 0.0224298 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0222857 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0221046 |
| SET | SET nuclear proto-oncogene | 0.0219439 |
| HMGB2 | high mobility group box 2 | 0.0219065 |
| CLDND1 | claudin domain containing 1 | 0.0216459 |
| MATR3 | matrin 3 | 0.021627 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0215845 |
| MPG | N-methylpurine-DNA glycosylase | 0.021351 |
| RPL26 | ribosomal protein L26 | 0.0210003 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.020636 |
| CLDN1 | claudin 1 | 0.0206251 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0205752 |
| PHF3 | PHD finger protein 3 | 0.0203331 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0199635 |
| SERINC1 | serine incorporator 1 | 0.0199468 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0198743 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0197931 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0197385 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.019606 |
| RACK1 | receptor for activated C kinase 1 | 0.0196001 |
| YBX3 | Y box binding protein 3 | 0.0195181 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0194489 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0193901 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0193014 |
| TPR | translocated promoter region, nuclear basket protein | 0.0191764 |
| GOLGA4 | golgin A4 | 0.0191225 |
| YBX1 | Y box binding protein 1 | 0.0189912 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0189839 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0188458 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0188449 |
| THOC1 | THO complex 1 | 0.0188166 |
| CPOX | coproporphyrinogen oxidase | 0.0187733 |
| ETNK1 | ethanolamine kinase 1 | 0.0187159 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0186191 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0184603 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0184336 |
| OGA | O-GlcNAcase | 0.0183964 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0181723 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0181698 |
| IPMK | inositol polyphosphate multikinase | 0.0181679 |
| S100A6 | S100 calcium binding protein A6 | 0.0181247 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0180026 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0179977 |
| RPLP0 | ribosomal protein, large, P0 | 0.0179211 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0178441 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.203634 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.117709 |
| NLGN1 | neuroligin 1 | -0.116392 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0755972 |
| ACTG1 | actin gamma 1 | -0.0739922 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.071534 |
| HMGA2 | high mobility group AT-hook 2 | -0.0712468 |
| EHBP1 | EH domain binding protein 1 | -0.0702516 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0676915 |
| EGR1 | early growth response 1 | -0.0663241 |
| YAP1 | Yes-associated protein 1 | -0.0569862 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0569065 |
| NHSL1 | NHS-like 1 | -0.0542237 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0490241 |
| MMP12 | matrix metallopeptidase 12 | -0.0481798 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0439862 |
| JMJD1C | jumonji domain containing 1C | -0.0436599 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0425215 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0414852 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.041026 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0400297 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.038728 |
| CMIP | c-Maf inducing protein | -0.0373717 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0370997 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0368383 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0347625 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0323937 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0323528 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0322225 |
| PCDH7 | protocadherin 7 | -0.0317043 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0312555 |
| ASPH | aspartate beta-hydroxylase | -0.0306046 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0298929 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0295305 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0291347 |
| RASAL2 | RAS protein activator like 2 | -0.0291107 |
| BPTF | bromodomain PHD finger transcription factor | -0.0286254 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0286117 |
| VIM | vimentin | -0.0285676 |
| RTN4 | reticulon 4 | -0.028129 |
| MAP1B | microtubule-associated protein 1B | -0.0280887 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0280085 |
| CUX1 | cut-like homeobox 1 | -0.0256844 |
| BCHE | butyrylcholinesterase | -0.0250407 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0250002 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0248888 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0248375 |
| ANK2 | ankyrin 2, neuronal | -0.0247476 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0244678 |
| USP34 | ubiquitin specific peptidase 34 | -0.0244335 |
| PDGFC | platelet derived growth factor C | -0.0242895 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0240204 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0236751 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0236611 |
| R3HDM2 | R3H domain containing 2 | -0.023403 |
| TPM4 | tropomyosin 4 | -0.0228357 |
| EXOC4 | exocyst complex component 4 | -0.0219709 |
| TUBA1B | tubulin, alpha 1b | -0.0214776 |
| SETX | senataxin | -0.0211555 |
| MKI67 | marker of proliferation Ki-67 | -0.0209375 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0208348 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0208072 |
| BRD4 | bromodomain containing 4 | -0.0206787 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0205868 |
| RAD51B | RAD51 paralog B | -0.0205024 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.0204882 |
| GCG | glucagon | -0.0204307 |
| MTAP | methylthioadenosine phosphorylase | -0.0204077 |
| NABP1 | nucleic acid binding protein 1 | -0.0203444 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0203363 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0203142 |
| CCN2 | cellular communication network factor 2 | -0.0202949 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0201747 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0201022 |
| WWOX | WW domain containing oxidoreductase | -0.0200883 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0199494 |
| ATP9A | ATPase, class II, type 9A | -0.0199299 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0197818 |
| ZNF804A | zinc finger protein 804A | -0.0195587 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0194051 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0193608 |
| NEBL | nebulette | -0.0192923 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0192336 |
| FUS | FUS RNA binding protein | -0.0191497 |
| COMMD10 | COMM domain containing 10 | -0.0191453 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0189654 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0189012 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0187596 |
| GOLT1A | golgi transport 1A | -0.018756 |
| ZNF638 | zinc finger protein 638 | -0.0187085 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0184695 |
| MTCL1 | microtubule crosslinking factor 1 | -0.0184491 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0183733 |
| PHF14 | PHD finger protein 14 | -0.0183113 |
| AHNAK | AHNAK nucleoprotein | -0.0183064 |
| KSR2 | kinase suppressor of ras 2 | -0.0180047 |
| ADIPOR2 | adiponectin receptor 2 | -0.0179525 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0179468 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0178989 |
| FADS2 | fatty acid desaturase 2 | -0.0178731 |
