| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Loperamide (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.112538 |
| FTL | ferritin, light polypeptide | 0.104143 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0602303 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0586066 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0585176 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0535019 |
| RPS6 | ribosomal protein S6 | 0.0492324 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.0430158 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0409159 |
| RPL23 | ribosomal protein L23 | 0.0368756 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0354406 |
| GDF15 | growth differentiation factor 15 | 0.0352498 |
| RPS8 | ribosomal protein S8 | 0.0343361 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0341316 |
| GOLGA4 | golgin A4 | 0.0339734 |
| SPAG9 | sperm associated antigen 9 | 0.0334803 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0332877 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0326517 |
| RPL26 | ribosomal protein L26 | 0.0325235 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0321421 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0312083 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.030891 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.030345 |
| RPL35A | ribosomal protein L35a | 0.0299562 |
| CADM1 | cell adhesion molecule 1 | 0.0294072 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0290339 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0288603 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0283077 |
| DSTN | destrin (actin depolymerizing factor) | 0.0281969 |
| B2M | beta-2-microglobulin | 0.0280075 |
| CD70 | CD70 molecule | 0.0279695 |
| CAVIN1 | caveolae associated protein 1 | 0.0279679 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0277948 |
| USP3 | ubiquitin specific peptidase 3 | 0.0273438 |
| PRRC1 | proline-rich coiled-coil 1 | 0.027088 |
| ATP13A3 | ATPase type 13A3 | 0.0269702 |
| PTMA | prothymosin, alpha | 0.0269255 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0267774 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0267767 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0261721 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.026107 |
| DENND2B | DENN domain containing 2B | 0.0260312 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0260311 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.025504 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0254541 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0252862 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0248199 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0246851 |
| RPLP1 | ribosomal protein, large, P1 | 0.0246066 |
| RPLP0 | ribosomal protein, large, P0 | 0.0242024 |
| XPO1 | exportin 1 | 0.0239073 |
| MLEC | malectin | 0.0237911 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0233717 |
| RAB18 | RAB18, member RAS oncogene family | 0.0233213 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0231942 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0231488 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.023018 |
| RNF145 | ring finger protein 145 | 0.0229032 |
| SLMAP | sarcolemma associated protein | 0.0228662 |
| QKI | QKI, KH domain containing, RNA binding | 0.0228141 |
| RPS2 | ribosomal protein S2 | 0.0227932 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0227918 |
| ANXA5 | annexin A5 | 0.0225843 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0223721 |
| HMGB2 | high mobility group box 2 | 0.0222822 |
| CSTB | cystatin B (stefin B) | 0.0221653 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0220709 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.022025 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0212701 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0211496 |
| RPL7 | ribosomal protein L7 | 0.021125 |
| TPR | translocated promoter region, nuclear basket protein | 0.0210637 |
| MTDH | metadherin | 0.0210605 |
| PLK2 | polo-like kinase 2 | 0.0210595 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0210377 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0209267 |
| WDR43 | WD repeat domain 43 | 0.0209184 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0205883 |
| CANX | calnexin | 0.0202342 |
| RPLP2 | ribosomal protein, large, P2 | 0.0200572 |
| ADM | adrenomedullin | 0.0200228 |
| SEPTIN7 | septin 7 | 0.0200209 |
| RPS19 | ribosomal protein S19 | 0.0199229 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0198922 |
| AFTPH | aftiphilin | 0.019868 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0197341 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0195564 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0194905 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0193678 |
| RPS12 | ribosomal protein S12 | 0.0192201 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | 0.0191986 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0191609 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0191367 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0190391 |
| RPL12 | ribosomal protein L12 | 0.0189817 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0188579 |
| MTF2 | metal response element binding transcription factor 2 | 0.018751 |
| RPS20 | ribosomal protein S20 | 0.0187191 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0184639 |
| RAB8B | RAB8B, member RAS oncogene family | 0.018388 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FRMD4A | FERM domain containing 4A | -0.1506 |
| GPC6 | glypican 6 | -0.0966186 |
| CD44 | CD44 molecule (Indian blood group) | -0.0911788 |
| EXT1 | exostosin glycosyltransferase 1 | -0.088427 |
| GLIS3 | GLIS family zinc finger 3 | -0.0769524 |
| ASPH | aspartate beta-hydroxylase | -0.0646759 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0608731 |
| TXNRD1 | thioredoxin reductase 1 | -0.0602862 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0516009 |
| UBC | ubiquitin C | -0.0505543 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0496749 |
| SMAD3 | SMAD family member 3 | -0.049307 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0472438 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0470448 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0466657 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0451716 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0425834 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0419817 |
| RNF213 | ring finger protein 213 | -0.041478 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0405343 |
| EHBP1 | EH domain binding protein 1 | -0.0404652 |
| VCL | vinculin | -0.0402337 |
| OSMR | oncostatin M receptor | -0.0400777 |
| FAT1 | FAT atypical cadherin 1 | -0.0400637 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0391398 |
| TMSB10 | thymosin beta 10 | -0.0385735 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0380265 |
| EFNA5 | ephrin-A5 | -0.0374878 |
| AHNAK | AHNAK nucleoprotein | -0.0362275 |
| NAV2 | neuron navigator 2 | -0.0355928 |
| CMIP | c-Maf inducing protein | -0.034979 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0337064 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.033229 |
| EXOC4 | exocyst complex component 4 | -0.0325201 |
| LOXL2 | lysyl oxidase-like 2 | -0.0324403 |
| ETV6 | ets variant 6 | -0.0324079 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.032286 |
| FUS | FUS RNA binding protein | -0.0322781 |
| MX1 | MX dynamin-like GTPase 1 | -0.0320812 |
| KYNU | kynureninase | -0.0314576 |
| NRP1 | neuropilin 1 | -0.0306553 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0299741 |
| CA12 | carbonic anhydrase XII | -0.0299201 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0297005 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0296694 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0289617 |
| EGFR | epidermal growth factor receptor | -0.0285609 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0285509 |
| TNS3 | tensin 3 | -0.0282992 |
| CALU | calumenin | -0.0278751 |
| NDRG1 | N-myc downstream regulated 1 | -0.0278419 |
| TUSC3 | tumor suppressor candidate 3 | -0.0272888 |
| MYO1E | myosin IE | -0.0268051 |
| CP | ceruloplasmin (ferroxidase) | -0.0266581 |
| PRKCA | protein kinase C, alpha | -0.0266029 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0263589 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0263157 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0263155 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0260595 |
| ACTN4 | actinin, alpha 4 | -0.0259687 |
| RRBP1 | ribosome binding protein 1 | -0.0258714 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0256208 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0252364 |
| CUX1 | cut-like homeobox 1 | -0.0251422 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0248181 |
| APP | amyloid beta (A4) precursor protein | -0.0247365 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0247199 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.024593 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0243606 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.024254 |
| FLNA | filamin A, alpha | -0.0236828 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0236624 |
| FAM20C | family with sequence similarity 20, member C | -0.0235428 |
| SMYD3 | SET and MYND domain containing 3 | -0.02278 |
| RUNX1 | runt-related transcription factor 1 | -0.0227757 |
| CDCP1 | CUB domain containing protein 1 | -0.0224688 |
| NF1 | neurofibromin 1 | -0.0222078 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0221316 |
| STK17A | serine/threonine kinase 17a | -0.0219747 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0215159 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0210007 |
| CADPS2 | Ca++-dependent secretion activator 2 | -0.0209501 |
| HLA-B | major histocompatibility complex, class I, B | -0.0208065 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0208035 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0206874 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0203384 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0200825 |
| SEPTIN9 | septin 9 | -0.0200478 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0198811 |
| IFI44L | interferon-induced protein 44-like | -0.019814 |
| FAM107B | family with sequence similarity 107, member B | -0.0195782 |
| RAI14 | retinoic acid induced 14 | -0.0193554 |
| COL5A1 | collagen, type V, alpha 1 | -0.019339 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -0.0191564 |
| DGKI | diacylglycerol kinase, iota | -0.0191461 |
| TPM1 | tropomyosin 1 (alpha) | -0.0190848 |
| BPTF | bromodomain PHD finger transcription factor | -0.0190115 |
| APOL1 | apolipoprotein L, 1 | -0.0188973 |
| TLN1 | talin 1 | -0.0187276 |
| PTH2R | parathyroid hormone 2 receptor | -0.018699 |
