| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.117364 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102286 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0832113 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0792783 |
| USP3 | ubiquitin specific peptidase 3 | 0.0788435 |
| SPAG9 | sperm associated antigen 9 | 0.0720307 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0601529 |
| HELZ | helicase with zinc finger | 0.0578331 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0567475 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0531447 |
| FTL | ferritin, light polypeptide | 0.052081 |
| GOLGA4 | golgin A4 | 0.0478493 |
| NUP58 | nucleoporin 58 | 0.0463894 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0457367 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0423989 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0408241 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0387361 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0382392 |
| FMNL2 | formin-like 2 | 0.0382311 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0358198 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0341803 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0339364 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0339251 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0328445 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0318705 |
| ECT2 | epithelial cell transforming 2 | 0.0315705 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0305673 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0301549 |
| WDR43 | WD repeat domain 43 | 0.029607 |
| SRP54 | signal recognition particle 54kDa | 0.028932 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0287986 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0286927 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0282929 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0282246 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0281995 |
| IPO7 | importin 7 | 0.0281708 |
| SET | SET nuclear proto-oncogene | 0.028093 |
| RPS2 | ribosomal protein S2 | 0.0280835 |
| KLF6 | Kruppel-like factor 6 | 0.0279208 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0275629 |
| TFG | TRK-fused gene | 0.0273453 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0272872 |
| STC1 | stanniocalcin 1 | 0.0264486 |
| SETD5 | SET domain containing 5 | 0.0264136 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0263274 |
| KCTD9 | potassium channel tetramerization domain containing 9 | 0.0262883 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0262572 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0262055 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.026094 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0255818 |
| SUCO | SUN domain containing ossification factor | 0.0253665 |
| ATP13A3 | ATPase type 13A3 | 0.0251004 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0246082 |
| NGLY1 | N-glycanase 1 | 0.0245316 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0241882 |
| MT1X | metallothionein 1X | 0.0241858 |
| HDGF | hepatoma-derived growth factor | 0.0239988 |
| PCBP2 | poly(rC) binding protein 2 | 0.0239819 |
| NAV2 | neuron navigator 2 | 0.0237937 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0231278 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0231082 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0230917 |
| PFN1 | profilin 1 | 0.0229815 |
| FAM13A | family with sequence similarity 13, member A | 0.0226462 |
| MATR3 | matrin 3 | 0.0226047 |
| FRMD6 | FERM domain containing 6 | 0.0219924 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0215666 |
| FLNB | filamin B, beta | 0.0214279 |
| RPLP0 | ribosomal protein, large, P0 | 0.0213615 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0213126 |
| QKI | QKI, KH domain containing, RNA binding | 0.0211852 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0209769 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0209226 |
| EREG | epiregulin | 0.0209061 |
| USP37 | ubiquitin specific peptidase 37 | 0.0207136 |
| ANXA5 | annexin A5 | 0.0205159 |
| ZNF207 | zinc finger protein 207 | 0.0205087 |
| OLA1 | Obg-like ATPase 1 | 0.0203482 |
| WDR45B | WD repeat domain 45B | 0.0203279 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0203145 |
| ZNF292 | zinc finger protein 292 | 0.0201269 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.0200826 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0196697 |
| CDC73 | cell division cycle 73 | 0.0191184 |
| YBX1 | Y box binding protein 1 | 0.0190373 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0189749 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0189292 |
| CASC3 | cancer susceptibility candidate 3 | 0.018916 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0188118 |
| CANX | calnexin | 0.0187587 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0187447 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0186306 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0184686 |
| RPL26 | ribosomal protein L26 | 0.0184575 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0183912 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0183243 |
| RPL23 | ribosomal protein L23 | 0.0182816 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0181043 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0180452 |
| TOP1 | topoisomerase (DNA) I | 0.0179009 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.177736 |
| EFNA5 | ephrin-A5 | -0.0879778 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0699861 |
| EHBP1 | EH domain binding protein 1 | -0.0633558 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.061403 |
| CMIP | c-Maf inducing protein | -0.0596023 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0580313 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0538938 |
| PDE10A | phosphodiesterase 10A | -0.0529296 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0528485 |
| RNF213 | ring finger protein 213 | -0.0509598 |
| OSMR | oncostatin M receptor | -0.0498517 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0480079 |
| TNS3 | tensin 3 | -0.0437996 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0436819 |
| ACTG1 | actin gamma 1 | -0.0389849 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0386855 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0384196 |
| TMSB10 | thymosin beta 10 | -0.0378326 |
| NRP1 | neuropilin 1 | -0.0370491 |
| BICC1 | BicC family RNA binding protein 1 | -0.034975 |
| ACTN4 | actinin, alpha 4 | -0.03483 |
| GOLGB1 | golgin B1 | -0.0346732 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0345404 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0330937 |
| GLIS3 | GLIS family zinc finger 3 | -0.0326728 |
| TXNRD1 | thioredoxin reductase 1 | -0.0321193 |
| TCF12 | transcription factor 12 | -0.0319203 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0316866 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0311181 |
| VIM | vimentin | -0.0310569 |
| KRT81 | keratin 81, type II | -0.0305132 |
| FOXP1 | forkhead box P1 | -0.0303977 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0288688 |
| BMERB1 | bMERB domain containing 1 | -0.0287815 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.027193 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0270515 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0270313 |
| CA12 | carbonic anhydrase XII | -0.02585 |
| RRBP1 | ribosome binding protein 1 | -0.0257634 |
| SP100 | SP100 nuclear antigen | -0.0254218 |
| KYNU | kynureninase | -0.0252803 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0252065 |
| HLA-B | major histocompatibility complex, class I, B | -0.0245917 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0244514 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0242611 |
| RPS29 | ribosomal protein S29 | -0.0240895 |
| RIN2 | Ras and Rab interactor 2 | -0.0240116 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0238585 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0233939 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0233648 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0233574 |
| RIGI | RNA sensor RIG-I | -0.0231765 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0228153 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0226954 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0225661 |
| MYO9A | myosin IXA | -0.0224934 |
| BPTF | bromodomain PHD finger transcription factor | -0.0223139 |
| RAD51B | RAD51 paralog B | -0.0221526 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0218163 |
| RAI14 | retinoic acid induced 14 | -0.0217393 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0217125 |
| TAOK3 | TAO kinase 3 | -0.021669 |
| ETV6 | ets variant 6 | -0.0216502 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0215417 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0215093 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0213971 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0213849 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0209272 |
| MAP4 | microtubule-associated protein 4 | -0.0209179 |
| RPS19 | ribosomal protein S19 | -0.0207875 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0206789 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0203916 |
| LMNA | lamin A/C | -0.0200441 |
| DST | dystonin | -0.019969 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0199555 |
| SFTPA2 | surfactant protein A2 | -0.0199107 |
| RPL31 | ribosomal protein L31 | -0.0198735 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0197427 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0197286 |
| PMP22 | peripheral myelin protein 22 | -0.019622 |
| ZNF609 | zinc finger protein 609 | -0.0195722 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0195633 |
| ANXA4 | annexin A4 | -0.0195348 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0195062 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.019449 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0194037 |
| CUX1 | cut-like homeobox 1 | -0.0193818 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0193232 |
| HDAC8 | histone deacetylase 8 | -0.0193042 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0192806 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0192293 |
| AOPEP | aminopeptidase O (putative) | -0.0192258 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0192149 |
| DNAAF9 | dynein axonemal assembly factor 9 | -0.0192024 |
| EXOC6B | exocyst complex component 6B | -0.0190459 |
| GPC6 | glypican 6 | -0.0190248 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0188311 |
| CDK12 | cyclin-dependent kinase 12 | -0.0187989 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0187517 |
