Loperamide (hydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.190633
TMSB10 thymosin beta 10 0.117981
VIM vimentin 0.105652
PTMA prothymosin, alpha 0.0960369
BAIAP2L1 BAI1-associated protein 2-like 1 0.0785261
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0783789
LMO7 LIM domain 7 0.0659454
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0655094
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0580399
S100A10 S100 calcium binding protein A10 0.0568719
TPT1 tumor protein, translationally-controlled 1 0.054249
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0525375
EZR ezrin 0.0519767
LDHA lactate dehydrogenase A 0.0519166
PSD3 pleckstrin and Sec7 domain containing 3 0.0495207
S100A6 S100 calcium binding protein A6 0.0491156
EIF1 eukaryotic translation initiation factor 1 0.0483711
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0462242
ITGA6 integrin, alpha 6 0.0457263
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0452175
PTPRR protein tyrosine phosphatase, receptor type, R 0.0435365
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0419417
ARHGAP42 Rho GTPase activating protein 42 0.0414618
EMP1 epithelial membrane protein 1 0.0407576
PGK1 phosphoglycerate kinase 1 0.0386752
VCAN versican 0.0379665
RPS3 ribosomal protein S3 0.0373171
B2M beta-2-microglobulin 0.037218
EPS8 epidermal growth factor receptor pathway substrate 8 0.0370699
DSG2 desmoglein 2 0.0348872
MYOF myoferlin 0.0343242
UBC ubiquitin C 0.0338687
S100A4 S100 calcium binding protein A4 0.0337953
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0334013
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0333679
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0330979
ACTG1 actin gamma 1 0.0317254
JMJD1C jumonji domain containing 1C 0.0311664
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0310417
BZW1 basic leucine zipper and W2 domains 1 0.0309611
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0303438
PERP PERP, TP53 apoptosis effector 0.0302348
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 0.0301721
ITPRID2 ITPR interacting domain containing 2 0.0301078
SQSTM1 sequestosome 1 0.029077
KLF6 Kruppel-like factor 6 0.0287902
CD2AP CD2-associated protein 0.0283215
AHNAK AHNAK nucleoprotein 0.0281472
LOC112694756 uncharaterized LOC112694756 0.0280026
RAD21 RAD21 homolog (S. pombe) 0.0277286
ESYT2 extended synaptotagmin-like protein 2 0.0276688
RPL12 ribosomal protein L12 0.0269631
KTN1 kinectin 1 (kinesin receptor) 0.0269012
KDM3A lysine (K)-specific demethylase 3A 0.0268603
LAMA4 laminin, alpha 4 0.0266838
KRT18 keratin 18, type I 0.0265172
OGA O-GlcNAcase 0.0262815
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0260956
DSTN destrin (actin depolymerizing factor) 0.0259265
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0258589
ADAM9 ADAM metallopeptidase domain 9 0.0257448
RPL37A ribosomal protein L37a 0.0254092
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0253312
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.025299
EPCAM epithelial cell adhesion molecule 0.0252597
TOP1 topoisomerase (DNA) I 0.0250148
EGFR epidermal growth factor receptor 0.0248709
PPARG peroxisome proliferator-activated receptor gamma 0.024745
RIOK3 RIO kinase 3 0.0246996
ARHGAP5 Rho GTPase activating protein 5 0.0246882
PLAUR plasminogen activator, urokinase receptor 0.0246719
ERRFI1 ERBB receptor feedback inhibitor 1 0.0245913
FAM107B family with sequence similarity 107, member B 0.0242045
RPS8 ribosomal protein S8 0.0239973
SDC4 syndecan 4 0.0239161
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0237392
RPS13 ribosomal protein S13 0.0237299
SLC38A2 solute carrier family 38, member 2 0.0236727
RPLP0 ribosomal protein, large, P0 0.0235443
S100A11 S100 calcium binding protein A11 0.0229647
TRA2A transformer 2 alpha homolog (Drosophila) 0.022604
RPL23 ribosomal protein L23 0.0225729
NEK7 NIMA-related kinase 7 0.0221598
RPS6 ribosomal protein S6 0.0220171
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.0220122
RPL31 ribosomal protein L31 0.0219948
RACK1 receptor for activated C kinase 1 0.0218333
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0218277
RPS27A ribosomal protein S27a 0.0218013
ENO1 enolase 1, (alpha) 0.0216323
FTL ferritin, light polypeptide 0.0211978
CSTB cystatin B (stefin B) 0.021114
RPS12 ribosomal protein S12 0.0210208
COL17A1 collagen, type XVII, alpha 1 0.0209822
RPL11 ribosomal protein L11 0.0208646
DSCAM Down syndrome cell adhesion molecule 0.0207874
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0207622
TMEM41B transmembrane protein 41B 0.020639
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0205853
TMSB4X thymosin beta 4, X-linked 0.0204762

decreased expression

Symbol Name Standardized Value
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0842341
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0710447
TRRAP transformation/transcription domain-associated protein -0.043458
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0432299
FLNB filamin B, beta -0.0409338
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0404246
PMM2 phosphomannomutase 2 -0.0387002
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0379902
PPARD peroxisome proliferator-activated receptor delta -0.0362292
THSD4 thrombospondin, type I, domain containing 4 -0.0348486
PARD3 par-3 family cell polarity regulator -0.0341841
EXT1 exostosin glycosyltransferase 1 -0.0339988
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0309306
CLMP CXADR-like membrane protein -0.0299381
MCL1 myeloid cell leukemia 1 -0.0291849
BMP6 bone morphogenetic protein 6 -0.0267356
FMNL2 formin-like 2 -0.0243534
PDLIM5 PDZ and LIM domain 5 -0.0243163
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0237958
INTS6 integrator complex subunit 6 -0.0236871
NDRG1 N-myc downstream regulated 1 -0.0236315
HDAC9 histone deacetylase 9 -0.0231637
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.0225493
RASAL2 RAS protein activator like 2 -0.0223824
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0213349
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0208053
DOCK5 dedicator of cytokinesis 5 -0.0204814
ZHX2 zinc fingers and homeoboxes 2 -0.0204498
LARP4B La ribonucleoprotein domain family, member 4B -0.0202743
TGM2 transglutaminase 2 -0.0202446
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0200505
MSN moesin -0.0195474
USP34 ubiquitin specific peptidase 34 -0.0195112
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0191414
NABP1 nucleic acid binding protein 1 -0.019074
TRIP12 thyroid hormone receptor interactor 12 -0.018572
AK1 adenylate kinase 1 -0.0181803
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0180222
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0173886
MYO5B myosin VB -0.0172699
HMGA2 high mobility group AT-hook 2 -0.0171769
AHRR aryl-hydrocarbon receptor repressor -0.0170391
UBAP2 ubiquitin associated protein 2 -0.0169363
TGFA transforming growth factor, alpha -0.0168196
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0167331
EFNB2 ephrin-B2 -0.016583
SAMD4A sterile alpha motif domain containing 4A -0.0163086
SLC35F3 solute carrier family 35, member F3 -0.0163013
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0162089
EFNA5 ephrin-A5 -0.0161631
GRB10 growth factor receptor-bound protein 10 -0.0161173
SEC16A SEC16 homolog A (S. cerevisiae) -0.0159293
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0159212
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0157852
MXD1 MAX dimerization protein 1 -0.0154788
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0154219
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0149297
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0149285
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0147506
MAML2 mastermind-like 2 (Drosophila) -0.0145708
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0145293
LAMA5 laminin, alpha 5 -0.0145167
EGR1 early growth response 1 -0.0142241
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0141513
BLZF1 basic leucine zipper nuclear factor 1 -0.0138072
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.0137447
FLNA filamin A, alpha -0.0137089
SETX senataxin -0.013591
NUP98 nucleoporin 98kDa -0.0133987
ANTXR2 anthrax toxin receptor 2 -0.0133492
NDEL1 nudE neurodevelopment protein 1-like 1 -0.0133109
LPP LIM domain containing preferred translocation partner in lipoma -0.0132643
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0132524
MPRIP myosin phosphatase Rho interacting protein -0.0132487
DIAPH2 diaphanous-related formin 2 -0.0131569
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.013141
SVIL supervillin -0.0130344
GREB1L growth regulation by estrogen in breast cancer-like -0.0127177
PDCD6 programmed cell death 6 -0.0126815
SEC31A SEC31 homolog A (S. cerevisiae) -0.0125515
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0124874
SCFD2 sec1 family domain containing 2 -0.012214
SEC23IP SEC23 interacting protein -0.0121872
GRAMD2B GRAM domain containing 2B -0.0121541
RAB7A RAB7A, member RAS oncogene family -0.011985
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0119408
HOMER1 homer scaffolding protein 1 -0.0118428
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.011831
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0118124
ZMIZ1 zinc finger, MIZ-type containing 1 -0.011737
ZNF83 zinc finger protein 83 -0.0116978
GTDC1 glycosyltransferase-like domain containing 1 -0.0116963
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0115455
TLN1 talin 1 -0.011535
RNF216 ring finger protein 216 -0.0115314
EVI5 ecotropic viral integration site 5 -0.0114416
NAV3 neuron navigator 3 -0.0113561
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0112147
CCDC91 coiled-coil domain containing 91 -0.0110497
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0109426