| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0543574 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.044624 |
| VMP1 | vacuole membrane protein 1 | 0.0411962 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0397566 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0386706 |
| VEGFA | vascular endothelial growth factor A | 0.0341396 |
| DTNA | dystrobrevin, alpha | 0.0330968 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0321102 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0300887 |
| CEP250 | centrosomal protein 250kDa | 0.0299798 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0292665 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.027529 |
| NDRG1 | N-myc downstream regulated 1 | 0.0242306 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0241587 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0240934 |
| TMEM165 | transmembrane protein 165 | 0.0234557 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0230531 |
| MCL1 | myeloid cell leukemia 1 | 0.0219509 |
| SCFD1 | sec1 family domain containing 1 | 0.0218795 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0217596 |
| CCNL1 | cyclin L1 | 0.0213614 |
| SET | SET nuclear proto-oncogene | 0.0206583 |
| ZNF292 | zinc finger protein 292 | 0.0200691 |
| PNN | pinin, desmosome associated protein | 0.0194861 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0194352 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0191909 |
| PLSCR2 | phospholipid scramblase 2 | 0.0191399 |
| SP100 | SP100 nuclear antigen | 0.018645 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0182417 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0180857 |
| USP53 | ubiquitin specific peptidase 53 | 0.0179921 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0179364 |
| ANLN | anillin, actin binding protein | 0.0179206 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.017902 |
| KIF16B | kinesin family member 16B | 0.0177672 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0177377 |
| PRELID2 | PRELI domain containing 2 | 0.0176957 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0169814 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0169124 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.0168207 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0165247 |
| MYO1B | myosin IB | 0.0164819 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0161382 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0158387 |
| PLSCR1 | phospholipid scramblase 1 | 0.015684 |
| CCNY | cyclin Y | 0.015512 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0154737 |
| USO1 | USO1 vesicle transport factor | 0.0154658 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0147617 |
| MCU | mitochondrial calcium uniporter | 0.0146763 |
| YAP1 | Yes-associated protein 1 | 0.014648 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0145827 |
| DSPP | dentin sialophosphoprotein | 0.0145732 |
| YEATS2 | YEATS domain containing 2 | 0.0145504 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0139274 |
| RAD51B | RAD51 paralog B | 0.0136005 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0134001 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0133861 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0133842 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0132389 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0132203 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0131769 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0130736 |
| ZNF395 | zinc finger protein 395 | 0.013069 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.012989 |
| TPM3 | tropomyosin 3 | 0.0129438 |
| SRP54 | signal recognition particle 54kDa | 0.0128944 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | 0.0125728 |
| FAM13A | family with sequence similarity 13, member A | 0.012445 |
| BBX | bobby sox homolog (Drosophila) | 0.012367 |
| TSC22D2 | TSC22 domain family, member 2 | 0.012362 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0122342 |
| SETD5 | SET domain containing 5 | 0.0122203 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | 0.0121779 |
| ADAR | adenosine deaminase, RNA-specific | 0.0121712 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0121266 |
| FNIP1 | folliculin interacting protein 1 | 0.0121202 |
| CD24 | CD24 molecule | 0.01212 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0120334 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0120125 |
| TPD52 | tumor protein D52 | 0.0120072 |
| ECT2 | epithelial cell transforming 2 | 0.0119489 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0119369 |
| ZNF148 | zinc finger protein 148 | 0.0118958 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0118387 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0118096 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0117321 |
| RPL21 | ribosomal protein L21 | 0.0116992 |
| ST8SIA6 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 | 0.0116022 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0115619 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.011547 |
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | 0.0115037 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0113102 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0112732 |
| PANK3 | pantothenate kinase 3 | 0.0111926 |
| ZNF207 | zinc finger protein 207 | 0.0111479 |
| FAM219A | family with sequence similarity 219, member A | 0.0111155 |
| NUP58 | nucleoporin 58 | 0.0110762 |
| ATP13A3 | ATPase type 13A3 | 0.0109952 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0109433 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL19 | ribosomal protein L19 | -0.135805 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -0.115799 |
| LASP1 | LIM and SH3 protein 1 | -0.106441 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.103378 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0896693 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0895641 |
| CDK12 | cyclin-dependent kinase 12 | -0.0885542 |
| RPL23 | ribosomal protein L23 | -0.0791704 |
| CCND1 | cyclin D1 | -0.0783737 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0761971 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0740657 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0690847 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0683414 |
| ASPH | aspartate beta-hydroxylase | -0.0631356 |
| ACTG1 | actin gamma 1 | -0.0608361 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.057057 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0564395 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0558238 |
| AHNAK | AHNAK nucleoprotein | -0.0522048 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0514038 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0473064 |
| TMSB10 | thymosin beta 10 | -0.0445999 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0425182 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0423199 |
| CCNI | cyclin I | -0.0422914 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0421644 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.0415326 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0388746 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0379986 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0373625 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0369873 |
| TC2N | tandem C2 domains, nuclear | -0.0368383 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0352039 |
| SMYD3 | SET and MYND domain containing 3 | -0.0346382 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0336618 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0330765 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0325276 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0325163 |
| ANXA2 | annexin A2 | -0.0324417 |
| SLC38A1 | solute carrier family 38, member 1 | -0.032356 |
| ZNF217 | zinc finger protein 217 | -0.0322705 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0322154 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0318032 |
| GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | -0.0310622 |
| NCOA6 | nuclear receptor coactivator 6 | -0.0299465 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0295796 |
| SDC4 | syndecan 4 | -0.0287712 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0284142 |
| IER3 | immediate early response 3 | -0.0280793 |
| PTMA | prothymosin, alpha | -0.0278954 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0275877 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0275372 |
| S100A9 | S100 calcium binding protein A9 | -0.0271115 |
| RPL35A | ribosomal protein L35a | -0.026932 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0268091 |
| S100A8 | S100 calcium binding protein A8 | -0.0260413 |
| SEPTIN9 | septin 9 | -0.0259881 |
| GNAS | GNAS complex locus | -0.0250364 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.0248569 |
| TMC5 | transmembrane channel-like 5 | -0.0248364 |
| RRBP1 | ribosome binding protein 1 | -0.0246537 |
| KRT19 | keratin 19, type I | -0.0242961 |
| TMSB4X | thymosin beta 4, X-linked | -0.0241999 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0237748 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0236384 |
| LMNA | lamin A/C | -0.0235612 |
| KRT18 | keratin 18, type I | -0.0234402 |
| SMIM14 | small integral membrane protein 14 | -0.0231924 |
| HDLBP | high density lipoprotein binding protein | -0.0229055 |
| PGK1 | phosphoglycerate kinase 1 | -0.0227685 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0224349 |
| CADPS2 | Ca++-dependent secretion activator 2 | -0.0221388 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0221244 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0219043 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0217717 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.0217702 |
| KRT7 | keratin 7, type II | -0.0216069 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0215095 |
| NTN4 | netrin 4 | -0.0214559 |
| TP53INP2 | tumor protein p53 inducible nuclear protein 2 | -0.0209766 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0209579 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0209069 |
| DUSP4 | dual specificity phosphatase 4 | -0.0208934 |
| RPLP1 | ribosomal protein, large, P1 | -0.0207393 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0205881 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0204762 |
| YPEL2 | yippee-like 2 (Drosophila) | -0.0200587 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0200261 |
| FAT1 | FAT atypical cadherin 1 | -0.0199121 |
| ITGB6 | integrin, beta 6 | -0.0198837 |
| MBD4 | methyl-CpG binding domain protein 4 | -0.0197688 |
| ACTN4 | actinin, alpha 4 | -0.0196683 |
| RPL8 | ribosomal protein L8 | -0.0194249 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0193068 |
| CUX1 | cut-like homeobox 1 | -0.0190364 |
| LOC112694756 | uncharaterized LOC112694756 | -0.018937 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0188998 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0188348 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0187314 |
| FADS2 | fatty acid desaturase 2 | -0.0187147 |
