Loperamide (hydrochloride)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0693156
FMNL2 formin-like 2 0.0537153
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0457528
HILPDA hypoxia inducible lipid droplet-associated 0.042091
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0390499
NEBL nebulette 0.0378232
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0347278
KMT2C lysine (K)-specific methyltransferase 2C 0.0339813
NUP58 nucleoporin 58 0.0309157
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0298775
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0288844
TRIO trio Rho guanine nucleotide exchange factor 0.0277904
KMT2E lysine (K)-specific methyltransferase 2E 0.0263303
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0253557
ATRN attractin 0.0236006
ZNF292 zinc finger protein 292 0.0231048
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.022858
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0227743
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0215723
NGLY1 N-glycanase 1 0.0213189
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0212639
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0203981
FXR1 fragile X mental retardation, autosomal homolog 1 0.0199954
PIAS2 protein inhibitor of activated STAT, 2 0.0197809
ATXN2 ataxin 2 0.0191062
SET SET nuclear proto-oncogene 0.0188332
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0185245
FAM13A family with sequence similarity 13, member A 0.0183956
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0182376
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0181549
KDM1A lysine (K)-specific demethylase 1A 0.0180064
FAM168A family with sequence similarity 168, member A 0.0171101
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0168354
TOP2B topoisomerase (DNA) II beta 180kDa 0.0164892
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0163618
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0162036
ESYT2 extended synaptotagmin-like protein 2 0.0159825
ZCCHC7 zinc finger, CCHC domain containing 7 0.0159734
PUS7 pseudouridylate synthase 7 (putative) 0.0159692
MXI1 MAX interactor 1, dimerization protein 0.0157916
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0157435
RNF145 ring finger protein 145 0.0156547
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0155179
CDC73 cell division cycle 73 0.015215
SEC63 SEC63 homolog (S. cerevisiae) 0.0149896
TBCD tubulin folding cofactor D 0.0149768
PDIA3 protein disulfide isomerase family A, member 3 0.0148141
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0146562
YEATS2 YEATS domain containing 2 0.0146316
CASC3 cancer susceptibility candidate 3 0.0144648
TBK1 TANK-binding kinase 1 0.0144633
HSPA8 heat shock 70kDa protein 8 0.0143246
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0143123
LDHA lactate dehydrogenase A 0.014311
EPN2 epsin 2 0.0140489
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0140051
HELZ helicase with zinc finger 0.0139419
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0139342
BRWD1 bromodomain and WD repeat domain containing 1 0.0138212
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0137188
PTK2 protein tyrosine kinase 2 0.0137109
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0137073
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0136463
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0135294
GIGYF2 GRB10 interacting GYF protein 2 0.0132369
DENR density-regulated protein 0.0131618
ZNF326 zinc finger protein 326 0.0130674
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0130259
NRG1 neuregulin 1 0.0128512
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.0125371
SCAF11 SR-related CTD-associated factor 11 0.0125067
SLK STE20-like kinase 0.0125018
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0124707
SSBP2 single-stranded DNA binding protein 2 0.0124584
SRRM1 serine/arginine repetitive matrix 1 0.0121973
RPS3A ribosomal protein S3A 0.0121596
RLF rearranged L-myc fusion 0.012103
ZMYM2 zinc finger, MYM-type 2 0.0120923
FNBP1L formin binding protein 1-like 0.0120483
KTN1 kinectin 1 (kinesin receptor) 0.0119586
ANKRD36 ankyrin repeat domain 36 0.0118361
GPBP1 GC-rich promoter binding protein 1 0.0118255
SREBF2 sterol regulatory element binding transcription factor 2 0.0117045
KDM6A lysine (K)-specific demethylase 6A 0.0116054
LARS1 leucyl-tRNA synthetase 1 0.0115803
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0115755
PGAP1 post-GPI attachment to proteins 1 0.0115313
SERBP1 SERPINE1 mRNA binding protein 1 0.0112732
RPS7 ribosomal protein S7 0.0112615
UBA6 ubiquitin-like modifier activating enzyme 6 0.0112478
WDR43 WD repeat domain 43 0.0111926
MDN1 MDN1, midasin homolog (yeast) 0.0111899
KIAA1671 KIAA1671 0.0111653
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0110257
OSBPL10 oxysterol binding protein-like 10 0.0109157
DHFR dihydrofolate reductase 0.0108706
PDS5B PDS5 cohesin associated factor B 0.0108541
INSIG2 insulin induced gene 2 0.0108383
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0108003
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0107836

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.155964
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0852875
IFI6 interferon, alpha-inducible protein 6 -0.0740715
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0703112
RAD51B RAD51 paralog B -0.0660135
RPLP1 ribosomal protein, large, P1 -0.0634065
RPS6 ribosomal protein S6 -0.060605
EGR1 early growth response 1 -0.0605449
RPS8 ribosomal protein S8 -0.0584123
ACTG1 actin gamma 1 -0.0559042
PDE4D phosphodiesterase 4D, cAMP-specific -0.052633
ADGRG6 adhesion G protein-coupled receptor G6 -0.0520718
RPL11 ribosomal protein L11 -0.051218
RPLP2 ribosomal protein, large, P2 -0.0504272
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0483684
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0473513
RPS19 ribosomal protein S19 -0.0460154
TMSB10 thymosin beta 10 -0.0453293
RPL28 ribosomal protein L28 -0.0446354
TPT1 tumor protein, translationally-controlled 1 -0.0443053
RPS24 ribosomal protein S24 -0.0430707
PTMA prothymosin, alpha -0.0426158
RPS21 ribosomal protein S21 -0.0415596
RPS29 ribosomal protein S29 -0.0412838
RPL34 ribosomal protein L34 -0.0394896
SOX4 SRY (sex determining region Y)-box 4 -0.0394663
NALF1 NALCN channel auxiliary factor 1 -0.0393132
RPL9 ribosomal protein L9 -0.0392364
VCL vinculin -0.0381744
GNAS GNAS complex locus -0.0365537
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0364544
RPL23 ribosomal protein L23 -0.0360586
MYL12B myosin, light chain 12B, regulatory -0.0357225
RPS11 ribosomal protein S11 -0.0345318
RPL36 ribosomal protein L36 -0.0343134
RPL19 ribosomal protein L19 -0.0342555
B2M beta-2-microglobulin -0.0330641
RPS15 ribosomal protein S15 -0.0329111
RPL26 ribosomal protein L26 -0.0320704
RPL12 ribosomal protein L12 -0.0319947
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0318052
TMEM41B transmembrane protein 41B -0.0315248
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0314555
RPL32 ribosomal protein L32 -0.0314345
ISG15 ISG15 ubiquitin-like modifier -0.031407
RPS23 ribosomal protein S23 -0.0313807
RPS4X ribosomal protein S4, X-linked -0.0313354
JMJD1C jumonji domain containing 1C -0.0308935
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0308657
EXT1 exostosin glycosyltransferase 1 -0.0301135
RIGI RNA sensor RIG-I -0.03001
TOX thymocyte selection-associated high mobility group box -0.0297502
HMGB1 high mobility group box 1 -0.0296428
FUS FUS RNA binding protein -0.0295738
RPL37A ribosomal protein L37a -0.0295073
RPL31 ribosomal protein L31 -0.0293535
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0293054
ZC3H12B zinc finger CCCH-type containing 12B -0.029057
RPL5 ribosomal protein L5 -0.0286304
RPS3 ribosomal protein S3 -0.0281654
FBXL7 F-box and leucine-rich repeat protein 7 -0.0279218
NPAS3 neuronal PAS domain protein 3 -0.0276017
HLA-B major histocompatibility complex, class I, B -0.0272444
RPL37 ribosomal protein L37 -0.0271317
MBD5 methyl-CpG binding domain protein 5 -0.0268879
NFIA nuclear factor I/A -0.0267687
MT2A metallothionein 2A -0.0266367
RPLP0 ribosomal protein, large, P0 -0.0262712
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -0.0261991
SHROOM3 shroom family member 3 -0.0252645
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0251401
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0246291
MLIP muscular LMNA-interacting protein -0.024565
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0244053
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0241914
PNISR PNN-interacting serine/arginine-rich protein -0.0239796
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0238955
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0238673
RPL7A ribosomal protein L7a -0.0237326
SMYD3 SET and MYND domain containing 3 -0.0235406
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0235078
TENM3 teneurin transmembrane protein 3 -0.0233633
VMP1 vacuole membrane protein 1 -0.0232194
RPL13A ribosomal protein L13a -0.0231337
FTL ferritin, light polypeptide -0.0230363
DEK DEK proto-oncogene -0.0228232
RPS27A ribosomal protein S27a -0.0227641
RPS5 ribosomal protein S5 -0.0223947
RPL35A ribosomal protein L35a -0.0223774
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0222592
ATG10 autophagy related 10 -0.0217103
RPL8 ribosomal protein L8 -0.0216639
ZNFX1 zinc finger, NFX1-type containing 1 -0.0214631
RBBP6 retinoblastoma binding protein 6 -0.0214074
PRRC2B proline-rich coiled-coil 2B -0.0213929
CARD18 caspase recruitment domain family, member 18 -0.0213168
H1-0 H1.0 linker histone -0.0211692
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0210923
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0210025
RAP1B RAP1B, member of RAS oncogene family -0.0207591