Loperamide (hydrochloride)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in C32 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0507824
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0371681
CD109 CD109 molecule 0.0362539
HILPDA hypoxia inducible lipid droplet-associated 0.0355237
CDC73 cell division cycle 73 0.0346879
RNF145 ring finger protein 145 0.0337552
KMT2E lysine (K)-specific methyltransferase 2E 0.0284854
NUP58 nucleoporin 58 0.0209719
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0185506
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0183283
NAMPT nicotinamide phosphoribosyltransferase 0.0166087
HELZ helicase with zinc finger 0.0150044
ZNF292 zinc finger protein 292 0.0148564
RAB8B RAB8B, member RAS oncogene family 0.0144831
WDR43 WD repeat domain 43 0.0144744
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0141703
RAD23B RAD23 homolog B (S. cerevisiae) 0.0139485
PUM1 pumilio RNA-binding family member 1 0.0131997
XPO1 exportin 1 0.0123354
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0123063
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0122116
FNDC3B fibronectin type III domain containing 3B 0.0120387
FBXO7 F-box protein 7 0.0117748
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0116925
MIMS1 mitochondrial inner membrane scaffold 1 0.0114083
ATP13A3 ATPase type 13A3 0.0113281
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0112983
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0111297
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0110602
EPS8 epidermal growth factor receptor pathway substrate 8 0.0106212
PPME1 protein phosphatase methylesterase 1 0.0103305
NEK7 NIMA-related kinase 7 0.0102836
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.00998604
KDM6A lysine (K)-specific demethylase 6A 0.00994947
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0098282
RLF rearranged L-myc fusion 0.00978568
COPA coatomer protein complex, subunit alpha 0.00964163
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0095784
MKRN1 makorin ring finger protein 1 0.00956481
MRTFA myocardin related transcription factor A 0.00942279
DDIT4 DNA-damage-inducible transcript 4 0.00894092
RAD21 RAD21 homolog (S. pombe) 0.00886793
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.008734
LAMP2 lysosomal-associated membrane protein 2 0.00852827
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.00838064
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.00836492
KMT2C lysine (K)-specific methyltransferase 2C 0.00814187
CANX calnexin 0.00795707
KDM1A lysine (K)-specific demethylase 1A 0.00794051
ARRDC3 arrestin domain containing 3 0.00790522
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.00789952
PTPRJ protein tyrosine phosphatase, receptor type, J 0.00789669
TOP2B topoisomerase (DNA) II beta 180kDa 0.00783504
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00782696
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.00782029
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.00768205
SET SET nuclear proto-oncogene 0.00766421
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0075514
AMBRA1 autophagy/beclin-1 regulator 1 0.00747091
HOMER1 homer scaffolding protein 1 0.0072952
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.00719336
MIER1 mesoderm induction early response 1, transcriptional regulator 0.00719147
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0071723
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.00714137
WAC WW domain containing adaptor with coiled-coil 0.00712079
STOM stomatin 0.00711108
NCKAP1 NCK-associated protein 1 0.00709251
SCAF4 SR-related CTD-associated factor 4 0.00704405
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.00703599
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.00695397
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.00692063
SERINC1 serine incorporator 1 0.00677935
MXI1 MAX interactor 1, dimerization protein 0.00669532
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.00664999
UBA2 ubiquitin-like modifier activating enzyme 2 0.00663177
CCNT2 cyclin T2 0.00659873
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.00659515
GTF2I general transcription factor IIi 0.0065244
ARL8B ADP-ribosylation factor-like 8B 0.00650672
INSIG2 insulin induced gene 2 0.00643844
CNOT8 CCR4-NOT transcription complex, subunit 8 0.00635831
TRA2A transformer 2 alpha homolog (Drosophila) 0.00635046
FUBP1 far upstream element (FUSE) binding protein 1 0.00627305
PGK1 phosphoglycerate kinase 1 0.00625422
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.00624023
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0062059
SSBP2 single-stranded DNA binding protein 2 0.00619311
IWS1 IWS1 homolog (S. cerevisiae) 0.00615632
EIF3E eukaryotic translation initiation factor 3, subunit E 0.00612406
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00611579
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.00611474
ANXA5 annexin A5 0.00610127
HMGB2 high mobility group box 2 0.00607748
TFG TRK-fused gene 0.00606838
SLMAP sarcolemma associated protein 0.0060109
TOP1 topoisomerase (DNA) I 0.00600262
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.00598425
KIF5B kinesin family member 5B 0.00587677
OSBPL9 oxysterol binding protein-like 9 0.00585512
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00584132

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.358059
FN1 fibronectin 1 -0.152983
VIM vimentin -0.0984169
GPC6 glypican 6 -0.0793455
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0765672
NDRG1 N-myc downstream regulated 1 -0.0703779
MT2A metallothionein 2A -0.0646042
FMN1 formin 1 -0.0566437
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0541302
ACTG1 actin gamma 1 -0.0538742
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0534231
IFI16 interferon, gamma-inducible protein 16 -0.0476171
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0459775
TMSB10 thymosin beta 10 -0.0452815
HLA-B major histocompatibility complex, class I, B -0.0436722
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0428387
EGR1 early growth response 1 -0.0414052
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0351409
LOC112694756 uncharaterized LOC112694756 -0.034377
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0323373
NLGN1 neuroligin 1 -0.0310125
RPLP1 ribosomal protein, large, P1 -0.0302274
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0298302
TNNC1 troponin C type 1 (slow) -0.028625
ATXN1 ataxin 1 -0.027739
ZBTB20 zinc finger and BTB domain containing 20 -0.0271574
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0267377
ICAM1 intercellular adhesion molecule 1 -0.0257074
LMNA lamin A/C -0.0252948
ASPH aspartate beta-hydroxylase -0.0242378
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0240382
IER3 immediate early response 3 -0.0239658
BACE2 beta-site APP-cleaving enzyme 2 -0.0239075
IFRD1 interferon-related developmental regulator 1 -0.0238613
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0231458
NPAS2 neuronal PAS domain protein 2 -0.0229755
WWTR1 WW domain containing transcription regulator 1 -0.0225233
FUS FUS RNA binding protein -0.0225003
IGFBP3 insulin-like growth factor binding protein 3 -0.0223873
ZMYND8 zinc finger, MYND-type containing 8 -0.0223785
NPC1 Niemann-Pick disease, type C1 -0.0222496
TBC1D22A TBC1 domain family, member 22A -0.0214306
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0209625
NAV1 neuron navigator 1 -0.0207929
TPT1 tumor protein, translationally-controlled 1 -0.0205441
TAGLN2 transgelin 2 -0.020505
TM4SF1 transmembrane 4 L six family member 1 -0.0204794
PCDH7 protocadherin 7 -0.0202275
RPS8 ribosomal protein S8 -0.0199511
POTEF POTE ankyrin domain family, member F -0.0195978
PTMA prothymosin, alpha -0.0194698
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0193148
OSMR oncostatin M receptor -0.0189739
RAB7A RAB7A, member RAS oncogene family -0.0188846
AHNAK AHNAK nucleoprotein -0.0187397
RPL35A ribosomal protein L35a -0.0182924
SFTPA2 surfactant protein A2 -0.018292
EXOC4 exocyst complex component 4 -0.0178043
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0177233
VGF VGF nerve growth factor inducible -0.0174409
PARVB parvin, beta -0.0171199
SMYD3 SET and MYND domain containing 3 -0.0170178
CTSD cathepsin D -0.0169838
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0166834
VDAC1 voltage-dependent anion channel 1 -0.0166792
ACTN1 actinin, alpha 1 -0.0165934
ACTN4 actinin, alpha 4 -0.0165887
CALD1 caldesmon 1 -0.016304
PAX3 paired box 3 -0.0162166
PKM pyruvate kinase, muscle -0.016186
CUX1 cut-like homeobox 1 -0.0160724
LOC102724023 ES1 protein homolog, mitochondrial -0.0159144
ZSWIM6 zinc finger, SWIM-type containing 6 -0.015849
PTCHD4 patched domain containing 4 -0.0158089
VCL vinculin -0.0155231
SDC2 syndecan 2 -0.0154529
CALU calumenin -0.0153448
PDE10A phosphodiesterase 10A -0.0153316
CABIN1 calcineurin binding protein 1 -0.0151895
RPS6 ribosomal protein S6 -0.0151564
S100A10 S100 calcium binding protein A10 -0.0150942
RPS19 ribosomal protein S19 -0.0150699
PTPRM protein tyrosine phosphatase, receptor type, M -0.0149549
FRMD4A FERM domain containing 4A -0.0148988
COL19A1 collagen, type XIX, alpha 1 -0.0147956
ANKRD12 ankyrin repeat domain 12 -0.0147678
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0146516
NCOA7 nuclear receptor coactivator 7 -0.0146034
ENO2 enolase 2 (gamma, neuronal) -0.0145521
UBC ubiquitin C -0.0144865
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0144734
LAMB1 laminin, beta 1 -0.0144629
WDPCP WD repeat containing planar cell polarity effector -0.0144304
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0144207
IGF2 insulin-like growth factor 2 -0.0143723
MYO1E myosin IE -0.0141963
BABAM2 BRISC and BRCA1 A complex member 2 -0.014114
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0140474
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0139437
PTPRG protein tyrosine phosphatase, receptor type, G -0.0138886