Loperamide (hydrochloride)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.130573
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0817957
FAM13A family with sequence similarity 13, member A 0.0653636
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.054803
TSC22D2 TSC22 domain family, member 2 0.052838
NAMPT nicotinamide phosphoribosyltransferase 0.0528008
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0455137
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0417599
PDIA3 protein disulfide isomerase family A, member 3 0.0403742
BZW1 basic leucine zipper and W2 domains 1 0.0364094
ELL2 elongation factor, RNA polymerase II, 2 0.0352445
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0347872
USP3 ubiquitin specific peptidase 3 0.0328147
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0327046
TOP1 topoisomerase (DNA) I 0.0316832
HILPDA hypoxia inducible lipid droplet-associated 0.0303027
CCNY cyclin Y 0.0296941
GARS1 glycyl-tRNA synthetase 1 0.0274801
PDIA6 protein disulfide isomerase family A, member 6 0.0274404
EREG epiregulin 0.0266732
AKAP12 A kinase (PRKA) anchor protein 12 0.0266069
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0262727
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0255485
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0254497
HMGB2 high mobility group box 2 0.0241729
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0237449
ERRFI1 ERBB receptor feedback inhibitor 1 0.0236358
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0235041
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0227167
OGA O-GlcNAcase 0.0227082
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0226424
ATP13A3 ATPase type 13A3 0.0219083
H1-0 H1.0 linker histone 0.0213506
CANX calnexin 0.0212561
CDC73 cell division cycle 73 0.021079
RLF rearranged L-myc fusion 0.0209312
FNBP1L formin binding protein 1-like 0.0208392
KDM3A lysine (K)-specific demethylase 3A 0.0205114
HSPA8 heat shock 70kDa protein 8 0.020351
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.019999
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0197808
NRIP1 nuclear receptor interacting protein 1 0.0194319
MEF2A myocyte enhancer factor 2A 0.0192475
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0192061
PDIA4 protein disulfide isomerase family A, member 4 0.019164
RAB8B RAB8B, member RAS oncogene family 0.0190587
ZNF292 zinc finger protein 292 0.0189393
MARCHF6 membrane associated ring-CH-type finger 6 0.0183457
SH3KBP1 SH3-domain kinase binding protein 1 0.0179834
ASPH aspartate beta-hydroxylase 0.0177614
ANKRD11 ankyrin repeat domain 11 0.0169688
RAD21 RAD21 homolog (S. pombe) 0.0169498
YTHDC1 YTH domain containing 1 0.0165469
WSB1 WD repeat and SOCS box containing 1 0.0162483
PTBP2 polypyrimidine tract binding protein 2 0.0161384
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0158734
SERINC1 serine incorporator 1 0.0158136
TES testin LIM domain protein 0.0157092
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0156168
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0155566
OLA1 Obg-like ATPase 1 0.0154018
QKI QKI, KH domain containing, RNA binding 0.015398
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0153477
NUP58 nucleoporin 58 0.015283
NCKAP1 NCK-associated protein 1 0.0150562
YME1L1 YME1-like 1 ATPase 0.0150513
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.014711
ARRDC3 arrestin domain containing 3 0.0147094
MXI1 MAX interactor 1, dimerization protein 0.0146498
BIRC2 baculoviral IAP repeat containing 2 0.0136479
TFG TRK-fused gene 0.0131973
KIF5B kinesin family member 5B 0.0129202
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0126798
RIPK2 receptor-interacting serine-threonine kinase 2 0.0123315
FAM13B family with sequence similarity 13, member B 0.0122666
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0120762
UBA6 ubiquitin-like modifier activating enzyme 6 0.0120653
OSER1 oxidative stress responsive serine-rich 1 0.0120341
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.0119952
RAD23B RAD23 homolog B (S. cerevisiae) 0.0119652
TCEA1 transcription elongation factor A (SII), 1 0.0117646
TARS1 threonyl-tRNA synthetase 1 0.011693
CENPF centromere protein F, 350/400kDa 0.0115621
BIRC3 baculoviral IAP repeat containing 3 0.0115192
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0114524
PREPL prolyl endopeptidase-like 0.011348
SLMAP sarcolemma associated protein 0.0112971
MYH9 myosin, heavy chain 9, non-muscle 0.0112558
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0111942
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0111673
ZFC3H1 zinc finger, C3H1-type containing 0.0111124
FXR1 fragile X mental retardation, autosomal homolog 1 0.0110956
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.0110792
SUCO SUN domain containing ossification factor 0.0109932
RNF145 ring finger protein 145 0.0109479
PELI1 pellino E3 ubiquitin protein ligase 1 0.0108005
MATR3 matrin 3 0.0106535
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.010628
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0106033
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0105124

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.228676
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.198525
NDRG1 N-myc downstream regulated 1 -0.174439
TMSB10 thymosin beta 10 -0.168635
HLA-B major histocompatibility complex, class I, B -0.143053
IGFBP3 insulin-like growth factor binding protein 3 -0.105265
ACTG1 actin gamma 1 -0.104266
LAMB3 laminin, beta 3 -0.0963673
HLA-A major histocompatibility complex, class I, A -0.0785296
EIF1 eukaryotic translation initiation factor 1 -0.073509
HMGA1 high mobility group AT-hook 1 -0.0710482
LOC112694756 uncharaterized LOC112694756 -0.0646241
KRT19 keratin 19, type I -0.0626506
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0618945
SAMD4A sterile alpha motif domain containing 4A -0.0618658
JUP junction plakoglobin -0.0608199
PKM pyruvate kinase, muscle -0.0602669
MAML2 mastermind-like 2 (Drosophila) -0.0582018
B2M beta-2-microglobulin -0.0574375
F3 coagulation factor III (thromboplastin, tissue factor) -0.0571063
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0542491
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.053608
EGR1 early growth response 1 -0.0498447
FLNB filamin B, beta -0.0488837
MUC4 mucin 4, cell surface associated -0.0487222
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0471911
HSPG2 heparan sulfate proteoglycan 2 -0.0468691
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0463755
MYO1E myosin IE -0.0461181
PATJ PATJ crumbs cell polarity complex component -0.0454057
TRIO trio Rho guanine nucleotide exchange factor -0.0452796
RPLP1 ribosomal protein, large, P1 -0.0452541
FTL ferritin, light polypeptide -0.0450156
LASP1 LIM and SH3 protein 1 -0.0449859
RPS29 ribosomal protein S29 -0.0434964
ISG15 ISG15 ubiquitin-like modifier -0.0431059
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0424867
KLF6 Kruppel-like factor 6 -0.0423214
CLDN4 claudin 4 -0.0413121
CD2AP CD2-associated protein -0.0412743
RPL35A ribosomal protein L35a -0.0409435
TGM2 transglutaminase 2 -0.0396361
MT1X metallothionein 1X -0.0391812
ACTN4 actinin, alpha 4 -0.0389421
ERBIN erbb2 interacting protein -0.0379553
RAB7A RAB7A, member RAS oncogene family -0.0379467
ALCAM activated leukocyte cell adhesion molecule -0.0374761
BACE2 beta-site APP-cleaving enzyme 2 -0.0374516
EFNA5 ephrin-A5 -0.0372862
LMNA lamin A/C -0.0363738
PRKCA protein kinase C, alpha -0.0355603
IFITM1 interferon induced transmembrane protein 1 -0.0354969
UBC ubiquitin C -0.034559
RPS21 ribosomal protein S21 -0.0344559
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0343742
EHBP1 EH domain binding protein 1 -0.0343104
IFI27 interferon, alpha-inducible protein 27 -0.0340766
ZBTB20 zinc finger and BTB domain containing 20 -0.033934
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0337121
RPS19 ribosomal protein S19 -0.0335033
RASAL2 RAS protein activator like 2 -0.0334981
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.033446
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0333098
DUSP5 dual specificity phosphatase 5 -0.0330029
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0328985
LPP LIM domain containing preferred translocation partner in lipoma -0.032879
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0325454
CP ceruloplasmin (ferroxidase) -0.0322639
RNF213 ring finger protein 213 -0.0319521
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0319218
AGRN agrin -0.031825
RRBP1 ribosome binding protein 1 -0.0316929
TAPBP TAP binding protein (tapasin) -0.0313713
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.031121
RBM47 RNA binding motif protein 47 -0.0309179
HLA-E major histocompatibility complex, class I, E -0.030897
JMJD1C jumonji domain containing 1C -0.030454
RCOR1 REST corepressor 1 -0.0297499
LMO7 LIM domain 7 -0.0296724
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.02966
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0296579
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.0296275
SYNRG synergin, gamma -0.0292169
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0290834
LOC102724023 ES1 protein homolog, mitochondrial -0.0290347
SVIL supervillin -0.0289556
LAMA4 laminin, alpha 4 -0.0287742
RPS23 ribosomal protein S23 -0.0285717
NCOR2 nuclear receptor corepressor 2 -0.0285561
CDCP1 CUB domain containing protein 1 -0.0282779
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0281131
VIM vimentin -0.0280157
PPARD peroxisome proliferator-activated receptor delta -0.027967
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.027842
TXNIP thioredoxin interacting protein -0.0278409
OSMR oncostatin M receptor -0.0276845
SMAD3 SMAD family member 3 -0.0275951
SEC31A SEC31 homolog A (S. cerevisiae) -0.0273009
STRN3 striatin, calmodulin binding protein 3 -0.0269329
BCL2L1 BCL2-like 1 -0.0268301