| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.113051 |
| FAM13A | family with sequence similarity 13, member A | 0.075146 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0568771 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0556357 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0451688 |
| HELZ | helicase with zinc finger | 0.0422799 |
| DST | dystonin | 0.0351589 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.031497 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0313804 |
| SPAG9 | sperm associated antigen 9 | 0.0299048 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0298343 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0288066 |
| OGA | O-GlcNAcase | 0.0287962 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0284318 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0274571 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0261898 |
| MEF2A | myocyte enhancer factor 2A | 0.0254653 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0248782 |
| COL3A1 | collagen, type III, alpha 1 | 0.0246889 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0242499 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0238851 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0235627 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.023531 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0234779 |
| ENAH | enabled homolog (Drosophila) | 0.0226431 |
| WDR45B | WD repeat domain 45B | 0.022278 |
| KIF5B | kinesin family member 5B | 0.022003 |
| ZNF292 | zinc finger protein 292 | 0.0219079 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0216854 |
| AHR | aryl hydrocarbon receptor | 0.0214206 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.020816 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0208033 |
| HMGB2 | high mobility group box 2 | 0.0206846 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0204773 |
| LPIN1 | lipin 1 | 0.0202844 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0201737 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0200673 |
| NEK7 | NIMA-related kinase 7 | 0.0198667 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0198634 |
| NCKAP1 | NCK-associated protein 1 | 0.0198493 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | 0.0198484 |
| RIOK3 | RIO kinase 3 | 0.0197838 |
| TOP1 | topoisomerase (DNA) I | 0.0196701 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0196261 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0193789 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0193541 |
| SRP54 | signal recognition particle 54kDa | 0.0193538 |
| LMNA | lamin A/C | 0.0191178 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0190689 |
| SLMAP | sarcolemma associated protein | 0.0186422 |
| CCDC47 | coiled-coil domain containing 47 | 0.0185102 |
| SAFB | scaffold attachment factor B | 0.0184147 |
| ANXA2 | annexin A2 | 0.0183509 |
| SEPTIN7 | septin 7 | 0.0183041 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0181966 |
| RLF | rearranged L-myc fusion | 0.0181123 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0177914 |
| APP | amyloid beta (A4) precursor protein | 0.0176523 |
| CLINT1 | clathrin interactor 1 | 0.0175926 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0175903 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0174283 |
| XPO1 | exportin 1 | 0.0174075 |
| CDC27 | cell division cycle 27 | 0.0172502 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0172343 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.017166 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0171476 |
| ABI2 | abl-interactor 2 | 0.0170714 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0169476 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.016945 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0169436 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0168907 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.0168059 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0166472 |
| CANX | calnexin | 0.0166449 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.016512 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.016493 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0163998 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.016366 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0162725 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0160034 |
| AFDN | afadin, adherens junction formation factor | 0.0159106 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0157866 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0155993 |
| FOXK2 | forkhead box K2 | 0.0155067 |
| DENND4C | DENN/MADD domain containing 4C | 0.015407 |
| SUCO | SUN domain containing ossification factor | 0.0153413 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.015304 |
| RGS5 | regulator of G-protein signaling 5 | 0.0152813 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.014984 |
| OXSR1 | oxidative stress responsive 1 | 0.0149353 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0148569 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0148168 |
| SERINC1 | serine incorporator 1 | 0.0148038 |
| RNF145 | ring finger protein 145 | 0.0147648 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0147093 |
| GLG1 | golgi glycoprotein 1 | 0.0145843 |
| SETD5 | SET domain containing 5 | 0.0145237 |
| UBQLN1 | ubiquilin 1 | 0.014503 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0143622 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0142962 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.297901 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.119455 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0785518 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0754893 |
| LSAMP | limbic system-associated membrane protein | -0.0732512 |
| NRG1 | neuregulin 1 | -0.0540282 |
| ACTG1 | actin gamma 1 | -0.0494192 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0475034 |
| SYT1 | synaptotagmin I | -0.0473161 |
| VCL | vinculin | -0.0460853 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0447919 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0443521 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0433895 |
| CADM2 | cell adhesion molecule 2 | -0.0432139 |
| RPS6 | ribosomal protein S6 | -0.042885 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0427325 |
| COL1A1 | collagen, type I, alpha 1 | -0.0400852 |
| MEIS2 | Meis homeobox 2 | -0.0391308 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0379765 |
| CRH | corticotropin releasing hormone | -0.0378428 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0377681 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.036631 |
| BPTF | bromodomain PHD finger transcription factor | -0.0366009 |
| FMN1 | formin 1 | -0.0361515 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0361161 |
| TMSB10 | thymosin beta 10 | -0.0332735 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0328674 |
| RNF213 | ring finger protein 213 | -0.0319109 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0313519 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0309277 |
| RPL35A | ribosomal protein L35a | -0.0307759 |
| MAPK10 | mitogen-activated protein kinase 10 | -0.0304738 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0296238 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0286816 |
| CENPF | centromere protein F, 350/400kDa | -0.0286476 |
| ZNF804A | zinc finger protein 804A | -0.0284843 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.028463 |
| TLE4 | transducin-like enhancer of split 4 | -0.0283988 |
| RPS29 | ribosomal protein S29 | -0.028391 |
| EGR1 | early growth response 1 | -0.0282896 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0279236 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.02791 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0274786 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0271895 |
| CDK12 | cyclin-dependent kinase 12 | -0.0271761 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0259435 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0258096 |
| KLHL13 | kelch-like family member 13 | -0.0257121 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0254447 |
| GLCCI1 | glucocorticoid induced 1 | -0.0251426 |
| PCDH9 | protocadherin 9 | -0.0240624 |
| DNM3 | dynamin 3 | -0.0239145 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0236187 |
| PCNX4 | pecanex 4 | -0.0231189 |
| TBX2 | T-box 2 | -0.0226194 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.0225765 |
| ZFHX3 | zinc finger homeobox 3 | -0.022212 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.0220626 |
| NREP | neuronal regeneration related protein | -0.0219393 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0218487 |
| ANGPT1 | angiopoietin 1 | -0.0218376 |
| ZNF609 | zinc finger protein 609 | -0.0218312 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0217475 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0215446 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0213505 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0212326 |
| MED13 | mediator complex subunit 13 | -0.0209938 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0203099 |
| RPS14 | ribosomal protein S14 | -0.0202475 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0202116 |
| SIK2 | salt-inducible kinase 2 | -0.0197305 |
| DPH6 | diphthamine biosynthesis 6 | -0.0195563 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0194469 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0192893 |
| ZNF644 | zinc finger protein 644 | -0.0192432 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0192215 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0192164 |
| UNC5C | unc-5 homolog C (C. elegans) | -0.0191557 |
| HDAC8 | histone deacetylase 8 | -0.0188586 |
| RPL31 | ribosomal protein L31 | -0.018252 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0182052 |
| TENM1 | teneurin transmembrane protein 1 | -0.0182043 |
| RPS4X | ribosomal protein S4, X-linked | -0.0180926 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0180824 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0180815 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0180798 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0178319 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0177726 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0177438 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0176885 |
| GPC6 | glypican 6 | -0.0176722 |
| PHF14 | PHD finger protein 14 | -0.0175067 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.0174417 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0173478 |
| IFI44L | interferon-induced protein 44-like | -0.0172073 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0171979 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0171641 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0171257 |
| DIAPH2 | diaphanous-related formin 2 | -0.0169216 |
| TULP4 | tubby like protein 4 | -0.0169041 |
