Loperamide (hydrochloride)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0515353
ERRFI1 ERBB receptor feedback inhibitor 1 0.0512401
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0455313
RNF149 ring finger protein 149 0.0446753
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0423364
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0400457
STK39 serine threonine kinase 39 0.0358111
FNIP1 folliculin interacting protein 1 0.034282
MEF2A myocyte enhancer factor 2A 0.0332247
ZMYM2 zinc finger, MYM-type 2 0.0325086
PTEN phosphatase and tensin homolog 0.032157
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0309934
BCLAF1 BCL2-associated transcription factor 1 0.0275033
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0274687
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0259564
NPEPPS aminopeptidase puromycin sensitive 0.0258559
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0256952
ZNF148 zinc finger protein 148 0.0255703
ADAM10 ADAM metallopeptidase domain 10 0.0244404
TPR translocated promoter region, nuclear basket protein 0.0240082
GRK3 G protein-coupled receptor kinase 3 0.0238901
PGK1 phosphoglycerate kinase 1 0.0234235
RBM26 RNA binding motif protein 26 0.0231313
GOLGA4 golgin A4 0.0225139
NCOA2 nuclear receptor coactivator 2 0.0222711
EHF ets homologous factor 0.0222074
TRIO trio Rho guanine nucleotide exchange factor 0.0213999
PRELID2 PRELI domain containing 2 0.021193
SORBS1 sorbin and SH3 domain containing 1 0.0210803
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0210134
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0208971
YEATS2 YEATS domain containing 2 0.0205762
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0203913
ARHGAP32 Rho GTPase activating protein 32 0.0202472
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0199999
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0199601
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0197426
PTBP3 polypyrimidine tract binding protein 3 0.0196547
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0195181
HELZ helicase with zinc finger 0.0194135
ESYT2 extended synaptotagmin-like protein 2 0.0192942
CENPF centromere protein F, 350/400kDa 0.0192788
CD46 CD46 molecule, complement regulatory protein 0.0191127
ZDHHC20 zinc finger, DHHC-type containing 20 0.0189709
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0188864
RREB1 ras responsive element binding protein 1 0.018721
PUM2 pumilio RNA-binding family member 2 0.0182021
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0180253
ARRDC3 arrestin domain containing 3 0.0179792
KDM2A lysine (K)-specific demethylase 2A 0.0176839
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0173382
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0172859
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0172438
ARHGAP12 Rho GTPase activating protein 12 0.0171392
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0171314
SECISBP2L SECIS binding protein 2-like 0.0171202
PIAS1 protein inhibitor of activated STAT, 1 0.016827
XRN1 5'-3' exoribonuclease 1 0.016657
TENT2 terminal nucleotidyltransferase 2 0.0165594
PHKB phosphorylase kinase, beta 0.0164619
UBAC2 UBA domain containing 2 0.0159447
PANK3 pantothenate kinase 3 0.0158919
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.015661
TCEA1 transcription elongation factor A (SII), 1 0.0156049
MXI1 MAX interactor 1, dimerization protein 0.0154988
R3HCC1L R3H domain and coiled-coil containing 1-like 0.0154422
EPB41 erythrocyte membrane protein band 4.1 0.0154253
MCTP2 multiple C2 domains, transmembrane 2 0.015064
NKTR natural killer cell triggering receptor 0.0150628
AKAP11 A kinase (PRKA) anchor protein 11 0.0150331
CAND1 cullin-associated and neddylation-dissociated 1 0.0150046
STAG2 stromal antigen 2 0.0149966
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0148572
KMT5B lysine methyltransferase 5B 0.0147594
EFR3A EFR3 homolog A (S. cerevisiae) 0.014618
FAM13A family with sequence similarity 13, member A 0.0144545
LBR lamin B receptor 0.0144534
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0144311
SETD5 SET domain containing 5 0.014386
SNX1 sorting nexin 1 0.0143799
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0143395
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0142492
TFG TRK-fused gene 0.0142329
BACE2 beta-site APP-cleaving enzyme 2 0.0140962
ZFC3H1 zinc finger, C3H1-type containing 0.0139641
WDR26 WD repeat domain 26 0.013928
SCOC short coiled-coil protein 0.013879
SIN3A SIN3 transcription regulator family member A 0.0137774
SAMD4A sterile alpha motif domain containing 4A 0.0135582
MAML2 mastermind-like 2 (Drosophila) 0.0135409
PTBP2 polypyrimidine tract binding protein 2 0.0134979
GRAMD2B GRAM domain containing 2B 0.0134827
BRWD3 bromodomain and WD repeat domain containing 3 0.013433
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0133837
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0133352
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0131777
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.0131568
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0130658
TMF1 TATA element modulatory factor 1 0.012998
KLHL24 kelch-like family member 24 0.0129579

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.191098
LMO7 LIM domain 7 -0.1822
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18083
EGR1 early growth response 1 -0.153256
TPT1 tumor protein, translationally-controlled 1 -0.141556
HLA-B major histocompatibility complex, class I, B -0.125454
LCN2 lipocalin 2 -0.121589
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0926834
GCLC glutamate-cysteine ligase, catalytic subunit -0.0922513
RAB7A RAB7A, member RAS oncogene family -0.0832473
MYO1E myosin IE -0.0820537
ANXA2 annexin A2 -0.0761707
IFI6 interferon, alpha-inducible protein 6 -0.0745092
RNF213 ring finger protein 213 -0.0706848
PKM pyruvate kinase, muscle -0.0701718
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0691415
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0667206
AHI1 Abelson helper integration site 1 -0.0664627
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0653144
LOC112694756 uncharaterized LOC112694756 -0.0621655
INTS6 integrator complex subunit 6 -0.0620256
C6ORF132 chromosome 6 open reading frame 132 -0.0615692
SQSTM1 sequestosome 1 -0.0608255
RRBP1 ribosome binding protein 1 -0.0590787
RPL35A ribosomal protein L35a -0.0590596
IRF1 interferon regulatory factor 1 -0.0584842
RIGI RNA sensor RIG-I -0.0555577
TMC5 transmembrane channel-like 5 -0.0537242
ACTG1 actin gamma 1 -0.0535579
NDRG1 N-myc downstream regulated 1 -0.0529621
EZR ezrin -0.0527585
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0527333
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0522238
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0517768
CALR calreticulin -0.0515606
FTL ferritin, light polypeptide -0.0514739
LOC102724023 ES1 protein homolog, mitochondrial -0.0513931
EXT1 exostosin glycosyltransferase 1 -0.051286
HLA-C major histocompatibility complex, class I, C -0.0512503
ACTN4 actinin, alpha 4 -0.0511742
RPS6 ribosomal protein S6 -0.0504911
JUN jun proto-oncogene -0.0490245
IFI27 interferon, alpha-inducible protein 27 -0.0483189
MX1 MX dynamin-like GTPase 1 -0.0471166
MX2 MX dynamin-like GTPase 2 -0.0471003
RPLP1 ribosomal protein, large, P1 -0.0470563
MORF4L2 mortality factor 4 like 2 -0.0448055
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0446455
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0443363
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0441286
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0437242
EIF1 eukaryotic translation initiation factor 1 -0.0434571
RPL34 ribosomal protein L34 -0.0431832
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0429837
TMSB10 thymosin beta 10 -0.0423729
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0411884
RPL11 ribosomal protein L11 -0.0411194
RPL19 ribosomal protein L19 -0.0403689
EPSTI1 epithelial stromal interaction 1 (breast) -0.0397375
UBC ubiquitin C -0.0390929
PLSCR1 phospholipid scramblase 1 -0.0384811
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0378385
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0373476
TRIM2 tripartite motif containing 2 -0.0372925
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0366843
RPL38 ribosomal protein L38 -0.0357504
AREG amphiregulin -0.0357415
RPL37 ribosomal protein L37 -0.0355022
EPHB2 EPH receptor B2 -0.0354141
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0354095
PERP PERP, TP53 apoptosis effector -0.035332
GMDS GDP-mannose 4,6-dehydratase -0.035164
BLZF1 basic leucine zipper nuclear factor 1 -0.0350901
S100A10 S100 calcium binding protein A10 -0.0347051
TJP1 tight junction protein 1 -0.0343489
SLC38A1 solute carrier family 38, member 1 -0.034042
RPS24 ribosomal protein S24 -0.0331639
HLA-A major histocompatibility complex, class I, A -0.0324677
VMP1 vacuole membrane protein 1 -0.0323301
MUC13 mucin 13, cell surface associated -0.0322266
RPL28 ribosomal protein L28 -0.0321855
MCL1 myeloid cell leukemia 1 -0.0319225
RPS19 ribosomal protein S19 -0.0313573
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0304374
RPL23 ribosomal protein L23 -0.0301336
ADIPOR2 adiponectin receptor 2 -0.0299799
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0296497
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0292837
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.029212
CLDN4 claudin 4 -0.0291232
SP100 SP100 nuclear antigen -0.0287657
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0285287
RPS8 ribosomal protein S8 -0.0284
RPL26 ribosomal protein L26 -0.0282857
S100P S100 calcium binding protein P -0.0281569
H1-0 H1.0 linker histone -0.0279937
UGDH UDP-glucose 6-dehydrogenase -0.027938
ATF6 activating transcription factor 6 -0.0278522
NAMPT nicotinamide phosphoribosyltransferase -0.027845
GOLGB1 golgin B1 -0.0277382