Loperamide (hydrochloride)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.131006
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.116597
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.101538
HILPDA hypoxia inducible lipid droplet-associated 0.0750943
CANX calnexin 0.0707122
COL6A3 collagen, type VI, alpha 3 0.0643919
CXCL8 chemokine (C-X-C motif) ligand 8 0.0596722
IGFBP3 insulin-like growth factor binding protein 3 0.0594092
FAM13A family with sequence similarity 13, member A 0.0569596
AKAP12 A kinase (PRKA) anchor protein 12 0.0457699
DST dystonin 0.0414974
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0410371
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0402224
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.040151
PDIA3 protein disulfide isomerase family A, member 3 0.0388291
CADM1 cell adhesion molecule 1 0.0387522
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0367575
ERRFI1 ERBB receptor feedback inhibitor 1 0.0365027
TRIO trio Rho guanine nucleotide exchange factor 0.0334321
ATP13A3 ATPase type 13A3 0.0285222
HELZ helicase with zinc finger 0.0282119
SPAG9 sperm associated antigen 9 0.0279152
EGFR epidermal growth factor receptor 0.0277831
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0264914
MXI1 MAX interactor 1, dimerization protein 0.0264315
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0261989
LCORL ligand dependent nuclear receptor corepressor-like 0.0257392
CALD1 caldesmon 1 0.0252265
TRA2A transformer 2 alpha homolog (Drosophila) 0.0243493
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0236236
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0236125
NUP58 nucleoporin 58 0.0235412
KMT2C lysine (K)-specific methyltransferase 2C 0.0232146
TIMP3 TIMP metallopeptidase inhibitor 3 0.0230462
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0228301
HSPA8 heat shock 70kDa protein 8 0.0227195
ZNF841 zinc finger protein 841 0.0226926
INHBA inhibin, beta A 0.0219357
TPM3 tropomyosin 3 0.0217481
USP37 ubiquitin specific peptidase 37 0.0216962
MIMS1 mitochondrial inner membrane scaffold 1 0.0216124
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0215666
SEC24A SEC24 family member A 0.0214612
MAP2K1 mitogen-activated protein kinase kinase 1 0.0209223
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0207159
TTC3 tetratricopeptide repeat domain 3 0.0206761
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0203977
RAB8B RAB8B, member RAS oncogene family 0.0203208
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.020189
LMAN1 lectin, mannose-binding, 1 0.0199214
TNIP1 TNFAIP3 interacting protein 1 0.0197345
PDIA6 protein disulfide isomerase family A, member 6 0.0197127
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0193682
AFF4 AF4/FMR2 family, member 4 0.0192501
APP amyloid beta (A4) precursor protein 0.0191467
GOLGA4 golgin A4 0.0189137
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0185156
COPA coatomer protein complex, subunit alpha 0.0184825
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0184271
SRP54 signal recognition particle 54kDa 0.0182374
CHD1 chromodomain helicase DNA binding protein 1 0.018132
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0178789
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0176599
RAI1 retinoic acid induced 1 0.017381
PHF3 PHD finger protein 3 0.0171624
TMEM39A transmembrane protein 39A 0.0171404
GRB10 growth factor receptor-bound protein 10 0.0168008
SAMD4A sterile alpha motif domain containing 4A 0.0167922
SEC23A Sec23 homolog A (S. cerevisiae) 0.016679
YEATS2 YEATS domain containing 2 0.0164784
USP3 ubiquitin specific peptidase 3 0.0161776
TNS3 tensin 3 0.016169
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0160688
SET SET nuclear proto-oncogene 0.0159551
NFE2L1 nuclear factor, erythroid 2-like 1 0.0157905
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0156319
ZNF292 zinc finger protein 292 0.0155241
ESYT2 extended synaptotagmin-like protein 2 0.0155189
MEF2A myocyte enhancer factor 2A 0.0153294
KDM3A lysine (K)-specific demethylase 3A 0.015305
TMF1 TATA element modulatory factor 1 0.0152391
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0152307
OGA O-GlcNAcase 0.0151373
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0151175
MMP12 matrix metallopeptidase 12 0.0151027
ADAM17 ADAM metallopeptidase domain 17 0.0149963
ASPH aspartate beta-hydroxylase 0.0146135
MACF1 microtubule-actin crosslinking factor 1 0.0145621
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0144356
MYO1B myosin IB 0.0143925
SUCO SUN domain containing ossification factor 0.0143556
RAB1A RAB1A, member RAS oncogene family 0.0143417
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0141034
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0140431
TMEM41B transmembrane protein 41B 0.0140253
CCNY cyclin Y 0.0139221
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0137381
CCDC47 coiled-coil domain containing 47 0.0135573
SETD5 SET domain containing 5 0.0134565
SFXN1 sideroflexin 1 0.013373

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.561958
FTL ferritin, light polypeptide -0.148479
MT2A metallothionein 2A -0.142002
TMSB10 thymosin beta 10 -0.0910662
NDRG1 N-myc downstream regulated 1 -0.0663607
EGR1 early growth response 1 -0.0653779
RPLP1 ribosomal protein, large, P1 -0.061993
VIM vimentin -0.0613723
LOC112694756 uncharaterized LOC112694756 -0.0520492
RPL28 ribosomal protein L28 -0.0486023
PKM pyruvate kinase, muscle -0.0475623
RPL35A ribosomal protein L35a -0.0474719
RPS6 ribosomal protein S6 -0.0460335
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0417641
RPLP2 ribosomal protein, large, P2 -0.0378822
RPS8 ribosomal protein S8 -0.0357632
HLA-B major histocompatibility complex, class I, B -0.0350684
ENO2 enolase 2 (gamma, neuronal) -0.0342511
RPS19 ribosomal protein S19 -0.033617
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0315605
TXNRD1 thioredoxin reductase 1 -0.0308896
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0303399
ZBTB20 zinc finger and BTB domain containing 20 -0.029159
RPS16 ribosomal protein S16 -0.0288835
VDAC1 voltage-dependent anion channel 1 -0.0282747
RPL34 ribosomal protein L34 -0.0279255
RPS23 ribosomal protein S23 -0.0276943
TGFBI transforming growth factor, beta-induced, 68kDa -0.0273312
CD44 CD44 molecule (Indian blood group) -0.0271643
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0263559
FTH1 ferritin, heavy polypeptide 1 -0.0262222
EIF1 eukaryotic translation initiation factor 1 -0.0258679
RPS11 ribosomal protein S11 -0.0252997
RPL13A ribosomal protein L13a -0.0252627
TIMP1 TIMP metallopeptidase inhibitor 1 -0.025008
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0243904
RPL36 ribosomal protein L36 -0.0243897
RPS13 ribosomal protein S13 -0.0240793
SLC38A2 solute carrier family 38, member 2 -0.023962
RPL19 ribosomal protein L19 -0.023667
RPL32 ribosomal protein L32 -0.0234035
MAP1B microtubule-associated protein 1B -0.0229202
RPL31 ribosomal protein L31 -0.0228832
POTEF POTE ankyrin domain family, member F -0.0225315
ATXN1 ataxin 1 -0.0225275
WWTR1 WW domain containing transcription regulator 1 -0.0223302
RPL23 ribosomal protein L23 -0.0222535
CYB5R3 cytochrome b5 reductase 3 -0.0216568
HMGA1 high mobility group AT-hook 1 -0.0216343
RPL37A ribosomal protein L37a -0.0215432
PDE4D phosphodiesterase 4D, cAMP-specific -0.0213933
RPL12 ribosomal protein L12 -0.0209217
MT1X metallothionein 1X -0.0206181
ACTN4 actinin, alpha 4 -0.020615
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0205479
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0203605
RPL9 ribosomal protein L9 -0.0202509
EEF2 eukaryotic translation elongation factor 2 -0.0202246
RPL38 ribosomal protein L38 -0.0200429
RPS20 ribosomal protein S20 -0.0200303
RPL8 ribosomal protein L8 -0.0197605
RPL37 ribosomal protein L37 -0.0194794
PFN1 profilin 1 -0.0194134
KPNB1 karyopherin (importin) beta 1 -0.0192633
SEC61G Sec61 gamma subunit -0.0188267
NPC1 Niemann-Pick disease, type C1 -0.0184992
GLIS3 GLIS family zinc finger 3 -0.0184087
TXNIP thioredoxin interacting protein -0.0177542
TUBA1B tubulin, alpha 1b -0.0175982
FOSL1 FOS-like antigen 1 -0.0173521
LMNA lamin A/C -0.0172208
BRD2 bromodomain containing 2 -0.0171293
BPTF bromodomain PHD finger transcription factor -0.0170261
RPS14 ribosomal protein S14 -0.0169068
KTN1 kinectin 1 (kinesin receptor) -0.0167217
RPS21 ribosomal protein S21 -0.0164608
SMYD3 SET and MYND domain containing 3 -0.0163669
FN1 fibronectin 1 -0.0162524
HLA-C major histocompatibility complex, class I, C -0.0162303
ATP5F1B ATP synthase F1 subunit beta -0.0159722
RRBP1 ribosome binding protein 1 -0.0158388
EXOC6B exocyst complex component 6B -0.0155073
CD99 CD99 molecule -0.0154921
RPS5 ribosomal protein S5 -0.0154465
RPS4X ribosomal protein S4, X-linked -0.0154122
ACTG1 actin gamma 1 -0.0153601
GLCCI1 glucocorticoid induced 1 -0.01536
RPS10 ribosomal protein S10 -0.0152935
HLA-A major histocompatibility complex, class I, A -0.0152569
DEK DEK proto-oncogene -0.0150902
MCL1 myeloid cell leukemia 1 -0.0148035
SMC4 structural maintenance of chromosomes 4 -0.0144383
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.014428
NDUFA4 NDUFA4, mitochondrial complex associated -0.0144211
RNF216 ring finger protein 216 -0.0142359
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.01418
ATN1 atrophin 1 -0.0141685
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0141197
RTN4 reticulon 4 -0.0141064
STC1 stanniocalcin 1 -0.0140992