| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Loperamide (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0802677 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0680121 |
| GOLGA4 | golgin A4 | 0.0583469 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0378881 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0353908 |
| FTL | ferritin, light polypeptide | 0.035023 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0303314 |
| SQSTM1 | sequestosome 1 | 0.0288752 |
| TMF1 | TATA element modulatory factor 1 | 0.0274466 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0257788 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0241135 |
| COG6 | component of oligomeric golgi complex 6 | 0.0223204 |
| SUCO | SUN domain containing ossification factor | 0.0219043 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0217096 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0216265 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0212585 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0212167 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0211863 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0208782 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0208213 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0207889 |
| FDPS | farnesyl diphosphate synthase | 0.0205762 |
| SRP54 | signal recognition particle 54kDa | 0.0205715 |
| VMP1 | vacuole membrane protein 1 | 0.0204363 |
| ZNF292 | zinc finger protein 292 | 0.0204221 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0197619 |
| TMEM41B | transmembrane protein 41B | 0.0197207 |
| WDR26 | WD repeat domain 26 | 0.0192711 |
| CDK19 | cyclin-dependent kinase 19 | 0.0189081 |
| INSIG2 | insulin induced gene 2 | 0.0187965 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0179166 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0178567 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0177703 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0176307 |
| ZNF638 | zinc finger protein 638 | 0.0175719 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.017567 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0175567 |
| PRELID2 | PRELI domain containing 2 | 0.017315 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.017073 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0169236 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0168728 |
| GOLGB1 | golgin B1 | 0.0167716 |
| CCDC186 | coiled-coil domain containing 186 | 0.0165423 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0165363 |
| KIAA1217 | KIAA1217 | 0.0164625 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0164063 |
| ARF4 | ADP-ribosylation factor 4 | 0.0159864 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0159187 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0158949 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0158645 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0157183 |
| CCNG2 | cyclin G2 | 0.0156413 |
| SEC24A | SEC24 family member A | 0.0153705 |
| FAM117B | family with sequence similarity 117, member B | 0.0153485 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0151304 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0149247 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0149124 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0148206 |
| RPL21 | ribosomal protein L21 | 0.0147797 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0146622 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0144657 |
| RIOK3 | RIO kinase 3 | 0.0143289 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0142971 |
| ZNF654 | zinc finger protein 654 | 0.0141581 |
| UFM1 | ubiquitin-fold modifier 1 | 0.0139619 |
| OGA | O-GlcNAcase | 0.0139134 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0138785 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0137082 |
| RPL23 | ribosomal protein L23 | 0.0135563 |
| RNF24 | ring finger protein 24 | 0.0134992 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0134595 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 0.013389 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0133627 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.01335 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0132479 |
| PHF3 | PHD finger protein 3 | 0.0132168 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0131962 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0131519 |
| TMEM39A | transmembrane protein 39A | 0.0130746 |
| TBC1D23 | TBC1 domain family, member 23 | 0.0130582 |
| ATF4 | activating transcription factor 4 | 0.0130214 |
| SEC24D | SEC24 family member D | 0.0129344 |
| CCNL1 | cyclin L1 | 0.0129342 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0129059 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0126619 |
| ARFGEF3 | ARFGEF family member 3 | 0.0124887 |
| SPAG9 | sperm associated antigen 9 | 0.0123053 |
| NBAS | neuroblastoma amplified sequence | 0.0122984 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0122216 |
| NEBL | nebulette | 0.0120204 |
| MCL1 | myeloid cell leukemia 1 | 0.0119319 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0119089 |
| TFG | TRK-fused gene | 0.0117142 |
| UBAP1 | ubiquitin associated protein 1 | 0.0116237 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0115855 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0114896 |
| PGM3 | phosphoglucomutase 3 | 0.0114637 |
| YTHDC1 | YTH domain containing 1 | 0.0112201 |
| NFXL1 | nuclear transcription factor, X-box binding-like 1 | 0.0109406 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0109211 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | -0.352307 |
| AHNAK | AHNAK nucleoprotein | -0.258448 |
| PTMA | prothymosin, alpha | -0.187318 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.129285 |
| TMSB10 | thymosin beta 10 | -0.0953243 |
| MKI67 | marker of proliferation Ki-67 | -0.0877444 |
| NDRG1 | N-myc downstream regulated 1 | -0.0860614 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0695975 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0673837 |
| KRT18 | keratin 18, type I | -0.0645126 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0600821 |
| PKM | pyruvate kinase, muscle | -0.0585728 |
| SERINC5 | serine incorporator 5 | -0.0536518 |
| KRT8 | keratin 8, type II | -0.0529169 |
| MSI2 | musashi RNA-binding protein 2 | -0.051351 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0496079 |
| FHIT | fragile histidine triad | -0.0489653 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.047809 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0472602 |
| ACTG1 | actin gamma 1 | -0.0455489 |
| TPM4 | tropomyosin 4 | -0.0437959 |
| ENO1 | enolase 1, (alpha) | -0.0436816 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0431422 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0411566 |
| WWOX | WW domain containing oxidoreductase | -0.0404555 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0399872 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0394046 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.038876 |
| DIAPH3 | diaphanous-related formin 3 | -0.0387311 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0384557 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0384497 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0384198 |
| MED13L | mediator complex subunit 13-like | -0.0381632 |
| CADPS | Ca++-dependent secretion activator | -0.0380879 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0377388 |
| POTEF | POTE ankyrin domain family, member F | -0.0374348 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0372586 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0368349 |
| TUBA1B | tubulin, alpha 1b | -0.0365808 |
| TUBB | tubulin, beta class I | -0.0365556 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0365528 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0358457 |
| FRMD5 | FERM domain containing 5 | -0.035329 |
| CCND1 | cyclin D1 | -0.0351228 |
| KPNB1 | karyopherin (importin) beta 1 | -0.034718 |
| APP | amyloid beta (A4) precursor protein | -0.0345027 |
| TENM3 | teneurin transmembrane protein 3 | -0.0344379 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0343791 |
| FUS | FUS RNA binding protein | -0.0339304 |
| RAD51B | RAD51 paralog B | -0.0328595 |
| ZNRF3 | zinc and ring finger 3 | -0.0328304 |
| H1-0 | H1.0 linker histone | -0.0327192 |
| HMGA2 | high mobility group AT-hook 2 | -0.0322175 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0311711 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0305627 |
| PARD3 | par-3 family cell polarity regulator | -0.0302738 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0293503 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0289616 |
| EGFR | epidermal growth factor receptor | -0.0287397 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0283677 |
| TPI1 | triosephosphate isomerase 1 | -0.0283257 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0277895 |
| HELLS | helicase, lymphoid-specific | -0.0276307 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0276291 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0268824 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0268479 |
| CTBP2 | C-terminal binding protein 2 | -0.0267731 |
| SH3BP4 | SH3-domain binding protein 4 | -0.0267585 |
| ACTN4 | actinin, alpha 4 | -0.0267553 |
| SMYD3 | SET and MYND domain containing 3 | -0.026673 |
| EHBP1 | EH domain binding protein 1 | -0.0263133 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.025721 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0255909 |
| RRM2 | ribonucleotide reductase M2 | -0.0252516 |
| DIAPH2 | diaphanous-related formin 2 | -0.0248881 |
| CUX1 | cut-like homeobox 1 | -0.0248689 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0242949 |
| DEK | DEK proto-oncogene | -0.0242245 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0241727 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0240629 |
| HMGB1 | high mobility group box 1 | -0.023886 |
| ITGB4 | integrin, beta 4 | -0.0236134 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0234233 |
| MYO1D | myosin ID | -0.023314 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0231419 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.0230709 |
| LDHA | lactate dehydrogenase A | -0.023061 |
| LMNA | lamin A/C | -0.0229806 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0228396 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0227631 |
| VCL | vinculin | -0.0227307 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0226629 |
| PLEC | plectin | -0.0226461 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0226216 |
| PGK1 | phosphoglycerate kinase 1 | -0.022578 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.022511 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0223296 |
| PTK2 | protein tyrosine kinase 2 | -0.0222648 |
| ZFHX3 | zinc finger homeobox 3 | -0.0222451 |
| BPTF | bromodomain PHD finger transcription factor | -0.0222384 |
