Loperamide (hydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.152359
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.131114
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.120567
ENO1 enolase 1, (alpha) 0.111319
FTL ferritin, light polypeptide 0.111113
PTMA prothymosin, alpha 0.110943
ASPH aspartate beta-hydroxylase 0.107215
TMSB10 thymosin beta 10 0.103329
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0981583
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0954035
TPT1 tumor protein, translationally-controlled 1 0.0889268
LDHA lactate dehydrogenase A 0.0820426
ALCAM activated leukocyte cell adhesion molecule 0.0789328
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0781131
B2M beta-2-microglobulin 0.0765502
TPM4 tropomyosin 4 0.0733581
RPS6 ribosomal protein S6 0.0716517
RPS8 ribosomal protein S8 0.0703912
TOP2A topoisomerase (DNA) II alpha 170kDa 0.064044
RPL23 ribosomal protein L23 0.059774
LAMB3 laminin, beta 3 0.059415
RPL12 ribosomal protein L12 0.0574035
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0556352
RPL35A ribosomal protein L35a 0.0555131
ACTG1 actin gamma 1 0.055306
AHNAK AHNAK nucleoprotein 0.0539659
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0533969
CCND1 cyclin D1 0.0518429
RPS19 ribosomal protein S19 0.0490399
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0488068
S100A10 S100 calcium binding protein A10 0.0482742
RPL19 ribosomal protein L19 0.0481051
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0475383
CANX calnexin 0.0467751
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0463294
EIF1 eukaryotic translation initiation factor 1 0.0447627
RPL31 ribosomal protein L31 0.0437938
RPLP0 ribosomal protein, large, P0 0.0433028
MKI67 marker of proliferation Ki-67 0.0432608
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0432118
TMSB4X thymosin beta 4, X-linked 0.0428451
S100A9 S100 calcium binding protein A9 0.0427407
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0422317
TPI1 triosephosphate isomerase 1 0.042007
PRELID2 PRELI domain containing 2 0.0414044
RPLP1 ribosomal protein, large, P1 0.0412046
KRT7 keratin 7, type II 0.0402613
RPL34 ribosomal protein L34 0.0394104
RPS27A ribosomal protein S27a 0.0392401
SET SET nuclear proto-oncogene 0.0390468
RACK1 receptor for activated C kinase 1 0.038793
AKAP12 A kinase (PRKA) anchor protein 12 0.0387595
ANXA2 annexin A2 0.0386501
PGK1 phosphoglycerate kinase 1 0.0386347
PKM pyruvate kinase, muscle 0.0385287
S100A6 S100 calcium binding protein A6 0.0375403
NDRG1 N-myc downstream regulated 1 0.0374774
LAMC2 laminin, gamma 2 0.0372788
RPS3 ribosomal protein S3 0.0371281
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0369886
SQSTM1 sequestosome 1 0.0369694
RPL7A ribosomal protein L7a 0.0366824
DSG2 desmoglein 2 0.0365455
RPS14 ribosomal protein S14 0.0363758
RPL11 ribosomal protein L11 0.0359222
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0355194
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0353156
RPLP2 ribosomal protein, large, P2 0.0327626
RPL32 ribosomal protein L32 0.0322121
CD44 CD44 molecule (Indian blood group) 0.0321685
RPS12 ribosomal protein S12 0.0319758
ZFP36L1 ZFP36 ring finger protein-like 1 0.0319531
RPL26 ribosomal protein L26 0.0312876
ERRFI1 ERBB receptor feedback inhibitor 1 0.03099
KTN1 kinectin 1 (kinesin receptor) 0.030869
RPL37A ribosomal protein L37a 0.0302435
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.030099
RPL35 ribosomal protein L35 0.0299333
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0290721
FHIT fragile histidine triad 0.0289486
ANXA1 annexin A1 0.0288953
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0288623
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0284185
DEK DEK proto-oncogene 0.028384
EZR ezrin 0.0282627
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0281438
SEPTIN7 septin 7 0.0281428
CBX3 chromobox homolog 3 0.0281341
VCAN versican 0.0279126
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0278027
PDIA3 protein disulfide isomerase family A, member 3 0.0277805
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0274962
ANLN anillin, actin binding protein 0.0274102
IQGAP1 IQ motif containing GTPase activating protein 1 0.0273724
PAX8 paired box 8 0.0272085
RPS24 ribosomal protein S24 0.0269693
RPS17 ribosomal protein S17 0.0265967
CALR calreticulin 0.026537
VCL vinculin 0.0264811
RPS13 ribosomal protein S13 0.0260049

decreased expression

Symbol Name Standardized Value
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0288647
ANKRD10 ankyrin repeat domain 10 -0.024014
FTH1 ferritin, heavy polypeptide 1 -0.0206686
WWC1 WW and C2 domain containing 1 -0.0203849
CCNL1 cyclin L1 -0.0191154
ANKRD28 ankyrin repeat domain 28 -0.0189017
KDM6A lysine (K)-specific demethylase 6A -0.0185987
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0171867
WDR43 WD repeat domain 43 -0.0167278
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -0.0156062
TFG TRK-fused gene -0.015218
AFDN afadin, adherens junction formation factor -0.0141905
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.013711
PUM2 pumilio RNA-binding family member 2 -0.0136534
ORC4 origin recognition complex, subunit 4 -0.0136425
FOXJ3 forkhead box J3 -0.0135225
PRRC2B proline-rich coiled-coil 2B -0.0132413
MON2 MON2 homolog (S. cerevisiae) -0.013108
ZNF644 zinc finger protein 644 -0.0129397
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0123669
TAPBP TAP binding protein (tapasin) -0.0122323
FLNA filamin A, alpha -0.0121546
LAMA5 laminin, alpha 5 -0.0119385
EWSR1 EWS RNA-binding protein 1 -0.0119059
PHKB phosphorylase kinase, beta -0.0118275
AGRN agrin -0.0118226
TSC22D2 TSC22 domain family, member 2 -0.0115115
GPC5 glypican 5 -0.011347
RBM33 RNA binding motif protein 33 -0.0112155
WAC WW domain containing adaptor with coiled-coil -0.0110354
AHCTF1 AT hook containing transcription factor 1 -0.0109669
MEF2A myocyte enhancer factor 2A -0.0109294
RFX7 regulatory factor X, 7 -0.0108881
JAZF1 JAZF zinc finger 1 -0.010477
MTMR3 myotubularin related protein 3 -0.0104425
GPHN gephyrin -0.0104114
FAM168B family with sequence similarity 168, member B -0.010241
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0100828
PIAS2 protein inhibitor of activated STAT, 2 -0.00966232
MPRIP myosin phosphatase Rho interacting protein -0.00964226
DOCK3 dedicator of cytokinesis 3 -0.00963315
RANBP17 RAN binding protein 17 -0.00961502
PRRC2A proline-rich coiled-coil 2A -0.00952721
USP3 ubiquitin specific peptidase 3 -0.0093946
LENG8 leukocyte receptor cluster (LRC) member 8 -0.0093798
UBP1 upstream binding protein 1 (LBP-1a) -0.00919078
RICTOR RPTOR independent companion of MTOR, complex 2 -0.00914446
BRD4 bromodomain containing 4 -0.00903354
TNRC6A trinucleotide repeat containing 6A -0.00899476
ZNF207 zinc finger protein 207 -0.00898343
AMBRA1 autophagy/beclin-1 regulator 1 -0.00886953
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0088467
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.00877755
UBE3A ubiquitin protein ligase E3A -0.00876055
ANKRD17 ankyrin repeat domain 17 -0.0084706
CAPN1 calpain 1, (mu/I) large subunit -0.008416
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00835762
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.00834452
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.00833693
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.00828529
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.00825519
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.00824474
STRN3 striatin, calmodulin binding protein 3 -0.0082207
SCAF4 SR-related CTD-associated factor 4 -0.00816725
EVI5 ecotropic viral integration site 5 -0.00811364
NRIP1 nuclear receptor interacting protein 1 -0.00811167
ATN1 atrophin 1 -0.00804949
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.00801255
GATAD2B GATA zinc finger domain containing 2B -0.00798211
STK33 serine/threonine kinase 33 -0.00791318
KMT2D lysine (K)-specific methyltransferase 2D -0.00789896
TMEM39A transmembrane protein 39A -0.00787107
ATP11B ATPase, class VI, type 11B -0.00784884
PTBP2 polypyrimidine tract binding protein 2 -0.00781677
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.00781344
MAP2K4 mitogen-activated protein kinase kinase 4 -0.00781116
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -0.00774466
RNASE3 ribonuclease, RNase A family, 3 -0.0077385
NDFIP1 Nedd4 family interacting protein 1 -0.00769701
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.00767686
GTPBP1 GTP binding protein 1 -0.00759193
EPS8 epidermal growth factor receptor pathway substrate 8 -0.00756256
KCMF1 potassium channel modulatory factor 1 -0.007502
NUP214 nucleoporin 214kDa -0.00749452
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.00742178
MIDEAS mitotic deacetylase associated SANT domain protein -0.00742038
AUH AU RNA binding protein/enoyl-CoA hydratase -0.00734049
VPS26C VPS26 endosomal protein sorting factor C -0.00732396
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.00727494
HMGXB3 HMG box domain containing 3 -0.00723834
TULP4 tubby like protein 4 -0.00720179
NCOR2 nuclear receptor corepressor 2 -0.00719171
USP24 ubiquitin specific peptidase 24 -0.00713396
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.00708118
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -0.00705214
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 -0.00698383
ARL8B ADP-ribosylation factor-like 8B -0.00686632
LRP12 low density lipoprotein receptor-related protein 12 -0.00684644
VWA8 von Willebrand factor A domain containing 8 -0.00681869
EIF4E eukaryotic translation initiation factor 4E -0.00681642