Loperamide (hydrochloride)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.136921
ELL2 elongation factor, RNA polymerase II, 2 0.113239
FAM13A family with sequence similarity 13, member A 0.0849227
ERRFI1 ERBB receptor feedback inhibitor 1 0.0765033
SPAG9 sperm associated antigen 9 0.0604734
NUP58 nucleoporin 58 0.0473676
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0458753
ZNF292 zinc finger protein 292 0.0447116
USP3 ubiquitin specific peptidase 3 0.0425665
HILPDA hypoxia inducible lipid droplet-associated 0.0413901
MIMS1 mitochondrial inner membrane scaffold 1 0.0412919
STC1 stanniocalcin 1 0.040629
ATP13A3 ATPase type 13A3 0.039112
RLF rearranged L-myc fusion 0.0388054
HELZ helicase with zinc finger 0.0372497
NAMPT nicotinamide phosphoribosyltransferase 0.0366776
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0353826
RNF145 ring finger protein 145 0.0350021
RNMT RNA (guanine-7-) methyltransferase 0.0348286
OGA O-GlcNAcase 0.0343527
WDR45B WD repeat domain 45B 0.0331012
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0326568
GOLGA4 golgin A4 0.0316817
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0309104
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0308775
PGK1 phosphoglycerate kinase 1 0.030169
RNF24 ring finger protein 24 0.0293002
CANX calnexin 0.028778
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0267295
NGLY1 N-glycanase 1 0.0266395
CD109 CD109 molecule 0.0266077
KMT2E lysine (K)-specific methyltransferase 2E 0.0265521
BHLHE40 basic helix-loop-helix family, member e40 0.0262783
FAM162A family with sequence similarity 162, member A 0.0256572
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0254907
UBA6 ubiquitin-like modifier activating enzyme 6 0.0254222
TFG TRK-fused gene 0.0251749
KDM3A lysine (K)-specific demethylase 3A 0.0249363
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0246859
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0240868
CHD1 chromodomain helicase DNA binding protein 1 0.0240106
LCORL ligand dependent nuclear receptor corepressor-like 0.0233403
TAC4 tachykinin 4 (hemokinin) 0.023148
DDIT4 DNA-damage-inducible transcript 4 0.0226195
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0225354
WAC WW domain containing adaptor with coiled-coil 0.0224962
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0222936
INSIG2 insulin induced gene 2 0.0221613
NPEPPS aminopeptidase puromycin sensitive 0.0217529
FNDC3B fibronectin type III domain containing 3B 0.0216851
QKI QKI, KH domain containing, RNA binding 0.021538
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0213643
ARRDC3 arrestin domain containing 3 0.0207558
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0206879
TOP2B topoisomerase (DNA) II beta 180kDa 0.0206321
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0203741
ADAM17 ADAM metallopeptidase domain 17 0.0200866
HMGB2 high mobility group box 2 0.0200632
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0198463
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0193586
SEC23A Sec23 homolog A (S. cerevisiae) 0.0192135
ARID4B AT rich interactive domain 4B (RBP1-like) 0.019033
RAB8B RAB8B, member RAS oncogene family 0.0189768
AFF4 AF4/FMR2 family, member 4 0.0189317
SETD5 SET domain containing 5 0.0188021
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0187312
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0183661
CLINT1 clathrin interactor 1 0.0181857
SUCO SUN domain containing ossification factor 0.0181459
TSC22D2 TSC22 domain family, member 2 0.0177647
HDAC3 histone deacetylase 3 0.0175482
MARCHF6 membrane associated ring-CH-type finger 6 0.0174848
MIS18BP1 MIS18 binding protein 1 0.0174047
PTMA prothymosin, alpha 0.0172417
FXR1 fragile X mental retardation, autosomal homolog 1 0.0172119
KMT2C lysine (K)-specific methyltransferase 2C 0.017205
PUM2 pumilio RNA-binding family member 2 0.017106
SRP54 signal recognition particle 54kDa 0.0168103
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0167654
HOOK2 hook microtubule-tethering protein 2 0.0167506
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0167388
TPX2 TPX2, microtubule-associated 0.0166364
PDIA3 protein disulfide isomerase family A, member 3 0.0166265
PICALM phosphatidylinositol binding clathrin assembly protein 0.0165738
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0163546
AMPD3 adenosine monophosphate deaminase 3 0.0163004
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0162607
SEC24A SEC24 family member A 0.016241
TFRC transferrin receptor 0.0162023
ZFC3H1 zinc finger, C3H1-type containing 0.0161178
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0160235
MATR3 matrin 3 0.0159608
CASC3 cancer susceptibility candidate 3 0.015952
NOP58 NOP58 ribonucleoprotein 0.0156837
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0155371
RICTOR RPTOR independent companion of MTOR, complex 2 0.0154526
UBA2 ubiquitin-like modifier activating enzyme 2 0.0154439
ECT2 epithelial cell transforming 2 0.0153144
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0152725
CLEC1B C-type lectin domain family 1, member B 0.0152249

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.336978
VIM vimentin -0.178343
COL5A1 collagen, type V, alpha 1 -0.129971
IGF2 insulin-like growth factor 2 -0.123121
NDRG1 N-myc downstream regulated 1 -0.117566
HMGA2 high mobility group AT-hook 2 -0.116385
CD44 CD44 molecule (Indian blood group) -0.112535
NAV1 neuron navigator 1 -0.107545
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.101271
FN1 fibronectin 1 -0.0975494
CDH13 cadherin 13 -0.0887501
TMSB10 thymosin beta 10 -0.0838494
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0766467
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0732547
GLIS3 GLIS family zinc finger 3 -0.070091
COL6A1 collagen, type VI, alpha 1 -0.0689662
EXT1 exostosin glycosyltransferase 1 -0.0686165
ACTG1 actin gamma 1 -0.065541
MT2A metallothionein 2A -0.0624341
MYO10 myosin X -0.062145
COL6A3 collagen, type VI, alpha 3 -0.0614758
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0590858
NALF1 NALCN channel auxiliary factor 1 -0.0584737
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0568386
EGR1 early growth response 1 -0.0508307
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0480728
RAI14 retinoic acid induced 14 -0.0477781
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0476357
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.04658
P4HB prolyl 4-hydroxylase, beta polypeptide -0.046509
ZBTB20 zinc finger and BTB domain containing 20 -0.0458407
TPT1 tumor protein, translationally-controlled 1 -0.04459
ASPH aspartate beta-hydroxylase -0.0430092
CCND1 cyclin D1 -0.041348
EGFR epidermal growth factor receptor -0.0407247
MAML3 mastermind-like 3 (Drosophila) -0.0396306
AHNAK AHNAK nucleoprotein -0.0393462
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0392057
COL6A2 collagen, type VI, alpha 2 -0.0383992
RPS6 ribosomal protein S6 -0.0376724
ATXN1 ataxin 1 -0.0375996
CLMP CXADR-like membrane protein -0.036621
AFF3 AF4/FMR2 family, member 3 -0.036176
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0338941
FMN1 formin 1 -0.0334881
BICD1 bicaudal D homolog 1 (Drosophila) -0.0332326
POTEF POTE ankyrin domain family, member F -0.0325945
ANKRD12 ankyrin repeat domain 12 -0.0324365
DST dystonin -0.0319309
RPLP1 ribosomal protein, large, P1 -0.0318863
TAS2R14 taste receptor, type 2, member 14 -0.0312719
TUBB6 tubulin, beta 6 class V -0.0312698
PRKCA protein kinase C, alpha -0.0309408
RRBP1 ribosome binding protein 1 -0.0306514
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0302333
DOCK5 dedicator of cytokinesis 5 -0.0300143
FRMD4A FERM domain containing 4A -0.0294911
EFNA5 ephrin-A5 -0.0285597
NAV2 neuron navigator 2 -0.0285592
LPP LIM domain containing preferred translocation partner in lipoma -0.0282026
PRELID2 PRELI domain containing 2 -0.027894
SEPTIN9 septin 9 -0.0278191
PLEC plectin -0.0273817
RAD51B RAD51 paralog B -0.0272949
BPTF bromodomain PHD finger transcription factor -0.027236
FLNA filamin A, alpha -0.0270915
SMYD3 SET and MYND domain containing 3 -0.0269065
ARHGAP22 Rho GTPase activating protein 22 -0.0263543
ACTN4 actinin, alpha 4 -0.0263411
TPM1 tropomyosin 1 (alpha) -0.0262454
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0262364
ENO2 enolase 2 (gamma, neuronal) -0.026196
ENO1 enolase 1, (alpha) -0.026117
TENM2 teneurin transmembrane protein 2 -0.0257546
CCDC91 coiled-coil domain containing 91 -0.0256491
MAP4 microtubule-associated protein 4 -0.0254103
DIAPH2 diaphanous-related formin 2 -0.0252736
LAMB3 laminin, beta 3 -0.0252718
RPL35A ribosomal protein L35a -0.0250236
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0250142
ETV6 ets variant 6 -0.024921
ANTXR1 anthrax toxin receptor 1 -0.0247916
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0246299
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0245516
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0245024
PRSS23 protease, serine, 23 -0.0244625
MPRIP myosin phosphatase Rho interacting protein -0.0244436
GRB10 growth factor receptor-bound protein 10 -0.0243996
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.024318
HMGA1 high mobility group AT-hook 1 -0.0241611
OSMR oncostatin M receptor -0.0240325
WNK1 WNK lysine deficient protein kinase 1 -0.0237997
FER fer (fps/fes related) tyrosine kinase -0.0236874
HM13 histocompatibility (minor) 13 -0.0232998
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0231479
RPL9 ribosomal protein L9 -0.0230737
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0229721
CUX1 cut-like homeobox 1 -0.0228629
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0226439
MBD5 methyl-CpG binding domain protein 5 -0.0225723