| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.144918 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0654615 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0620643 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0518432 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0515414 |
| RPS6 | ribosomal protein S6 | 0.0481531 |
| PTMA | prothymosin, alpha | 0.047118 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0444968 |
| VEGFA | vascular endothelial growth factor A | 0.0414606 |
| SPAG9 | sperm associated antigen 9 | 0.0406027 |
| FTL | ferritin, light polypeptide | 0.0404445 |
| SQLE | squalene epoxidase | 0.0392512 |
| ARRDC3 | arrestin domain containing 3 | 0.0390696 |
| RPS2 | ribosomal protein S2 | 0.0366906 |
| B2M | beta-2-microglobulin | 0.0366251 |
| ATP13A3 | ATPase type 13A3 | 0.0357893 |
| GOLGA4 | golgin A4 | 0.0343213 |
| ZNF292 | zinc finger protein 292 | 0.0336365 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.033635 |
| CADM1 | cell adhesion molecule 1 | 0.0332458 |
| RLF | rearranged L-myc fusion | 0.0315313 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0315295 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0313734 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0311809 |
| RNF145 | ring finger protein 145 | 0.0300935 |
| RPS8 | ribosomal protein S8 | 0.0298455 |
| MT1X | metallothionein 1X | 0.0279221 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0276225 |
| DSTN | destrin (actin depolymerizing factor) | 0.0274947 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0270257 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.026956 |
| RPL7 | ribosomal protein L7 | 0.0256459 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0255694 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0253944 |
| QKI | QKI, KH domain containing, RNA binding | 0.0246824 |
| MRTFA | myocardin related transcription factor A | 0.0246443 |
| RPL37A | ribosomal protein L37a | 0.0236827 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0233384 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0232304 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0232275 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0231976 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0228421 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0227646 |
| TMF1 | TATA element modulatory factor 1 | 0.0227222 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0224659 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0220457 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0220448 |
| USP3 | ubiquitin specific peptidase 3 | 0.0218545 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0212156 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0210367 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0210204 |
| RPL23 | ribosomal protein L23 | 0.0209025 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.020832 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0207965 |
| RPS12 | ribosomal protein S12 | 0.0205907 |
| SETD5 | SET domain containing 5 | 0.0202763 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0201024 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0200006 |
| ADM | adrenomedullin | 0.0199816 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0197248 |
| RYBP | RING1 and YY1 binding protein | 0.0196842 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0195807 |
| RPS3 | ribosomal protein S3 | 0.019249 |
| RPS19 | ribosomal protein S19 | 0.0190403 |
| XPO1 | exportin 1 | 0.01897 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0188492 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0188132 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0187834 |
| RASA2 | RAS p21 protein activator 2 | 0.018739 |
| SRP54 | signal recognition particle 54kDa | 0.0186713 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0183805 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0181525 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0181159 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0176462 |
| CLINT1 | clathrin interactor 1 | 0.0175963 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0175962 |
| MSN | moesin | 0.0175886 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0175849 |
| TFG | TRK-fused gene | 0.0175488 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0175454 |
| MATR3 | matrin 3 | 0.0172443 |
| MTDH | metadherin | 0.0171023 |
| S100A9 | S100 calcium binding protein A9 | 0.0169544 |
| FNBP1L | formin binding protein 1-like | 0.0167559 |
| RYK | receptor-like tyrosine kinase | 0.0166102 |
| HELZ | helicase with zinc finger | 0.0165651 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0163509 |
| TPX2 | TPX2, microtubule-associated | 0.0162935 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0159643 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.015938 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0159184 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.01588 |
| ECT2 | epithelial cell transforming 2 | 0.0157458 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0155173 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0154359 |
| PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | 0.0153995 |
| FAM162A | family with sequence similarity 162, member A | 0.0152992 |
| RIOK3 | RIO kinase 3 | 0.0152953 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0152952 |
| SEPTIN7 | septin 7 | 0.0152938 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.513883 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.226464 |
| COL1A1 | collagen, type I, alpha 1 | -0.199827 |
| COL6A3 | collagen, type VI, alpha 3 | -0.194217 |
| CDH13 | cadherin 13 | -0.113229 |
| EXT1 | exostosin glycosyltransferase 1 | -0.103937 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.102529 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.084646 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0823786 |
| CD44 | CD44 molecule (Indian blood group) | -0.0812799 |
| FBN1 | fibrillin 1 | -0.073345 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0728362 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0721987 |
| COL5A1 | collagen, type V, alpha 1 | -0.066609 |
| AHNAK | AHNAK nucleoprotein | -0.0665822 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0658327 |
| ASPH | aspartate beta-hydroxylase | -0.0622686 |
| GLIS3 | GLIS family zinc finger 3 | -0.0615101 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0614458 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0590344 |
| HMGA2 | high mobility group AT-hook 2 | -0.0588085 |
| OSMR | oncostatin M receptor | -0.0562415 |
| NAV1 | neuron navigator 1 | -0.0517446 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0507267 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0487048 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0470821 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0468913 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0456527 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0436433 |
| VCL | vinculin | -0.0433367 |
| COL1A2 | collagen, type I, alpha 2 | -0.0432084 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0428454 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0397373 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0371504 |
| PRELID2 | PRELI domain containing 2 | -0.0370005 |
| TMSB10 | thymosin beta 10 | -0.0366421 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0364866 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0361743 |
| TPM4 | tropomyosin 4 | -0.0346324 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0340445 |
| LOXL2 | lysyl oxidase-like 2 | -0.0340266 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0337289 |
| NRP1 | neuropilin 1 | -0.0328437 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0326411 |
| ATXN1 | ataxin 1 | -0.0323313 |
| SMYD3 | SET and MYND domain containing 3 | -0.0315974 |
| RRBP1 | ribosome binding protein 1 | -0.0312061 |
| PLEC | plectin | -0.0306635 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0298294 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0293395 |
| CLIC4 | chloride intracellular channel 4 | -0.0292829 |
| CNTN5 | contactin 5 | -0.0287709 |
| ACTG1 | actin gamma 1 | -0.0287236 |
| EGR1 | early growth response 1 | -0.0287072 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.028453 |
| INHBA | inhibin, beta A | -0.0280127 |
| IL6ST | interleukin 6 signal transducer | -0.0279626 |
| UBC | ubiquitin C | -0.0269598 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0267324 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0266802 |
| RIGI | RNA sensor RIG-I | -0.0263585 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0263284 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0261237 |
| CALD1 | caldesmon 1 | -0.0257358 |
| HDLBP | high density lipoprotein binding protein | -0.0257171 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0256759 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0251578 |
| LOX | lysyl oxidase | -0.0250319 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0248795 |
| FAT1 | FAT atypical cadherin 1 | -0.0247707 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0244137 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0240436 |
| CALU | calumenin | -0.0239293 |
| COL3A1 | collagen, type III, alpha 1 | -0.0237115 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0231487 |
| CPQ | carboxypeptidase Q | -0.0227219 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0227094 |
| HLA-B | major histocompatibility complex, class I, B | -0.0224784 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0223869 |
| HMCN1 | hemicentin 1 | -0.0223173 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0222377 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0220433 |
| IL6 | interleukin 6 | -0.022034 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0219707 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0218338 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0215321 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0212096 |
| FLNA | filamin A, alpha | -0.0208434 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0206182 |
| PALLD | palladin, cytoskeletal associated protein | -0.0203712 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0203188 |
| FAM20C | family with sequence similarity 20, member C | -0.020141 |
| EBF1 | early B-cell factor 1 | -0.0198782 |
| TENM3 | teneurin transmembrane protein 3 | -0.0196795 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0193944 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0192149 |
| RASAL2 | RAS protein activator like 2 | -0.0191786 |
| FOXP1 | forkhead box P1 | -0.019177 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0191737 |
| NREP | neuronal regeneration related protein | -0.0189471 |
