| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0952686 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0818574 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0700474 |
| MT2A | metallothionein 2A | 0.0636285 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.062926 |
| TF | transferrin | 0.0628515 |
| ENO1 | enolase 1, (alpha) | 0.0534175 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0516578 |
| APOB | apolipoprotein B | 0.0470032 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0388961 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0367134 |
| RPS6 | ribosomal protein S6 | 0.0363898 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0358685 |
| AFDN | afadin, adherens junction formation factor | 0.0324261 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0303081 |
| RPS8 | ribosomal protein S8 | 0.0296938 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0291516 |
| RPL11 | ribosomal protein L11 | 0.028702 |
| DSPP | dentin sialophosphoprotein | 0.0284753 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0282664 |
| RPS12 | ribosomal protein S12 | 0.0262935 |
| RPL37A | ribosomal protein L37a | 0.0261367 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0260162 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0252324 |
| RPL23 | ribosomal protein L23 | 0.0250972 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0245286 |
| FTL | ferritin, light polypeptide | 0.0237963 |
| TRIM26 | tripartite motif containing 26 | 0.0234725 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0226904 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0224801 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0224556 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0223156 |
| FNDC3B | fibronectin type III domain containing 3B | 0.022275 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0221601 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0221217 |
| RPLP1 | ribosomal protein, large, P1 | 0.0220747 |
| GOLGA4 | golgin A4 | 0.0217267 |
| CPE | carboxypeptidase E | 0.0213813 |
| GPC3 | glypican 3 | 0.0206641 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0196335 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0194288 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0193043 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0192441 |
| KIF5B | kinesin family member 5B | 0.0188365 |
| APOE | apolipoprotein E | 0.0187622 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0181609 |
| CANX | calnexin | 0.0181341 |
| PTMA | prothymosin, alpha | 0.0170042 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.016992 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0166704 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0165653 |
| RPLP0 | ribosomal protein, large, P0 | 0.0165585 |
| RPS19 | ribosomal protein S19 | 0.0161986 |
| ZNF292 | zinc finger protein 292 | 0.0160953 |
| SPAG9 | sperm associated antigen 9 | 0.0160261 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0159404 |
| RPS3 | ribosomal protein S3 | 0.0158513 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.015795 |
| RPL35A | ribosomal protein L35a | 0.0155642 |
| RPS27A | ribosomal protein S27a | 0.0150403 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0148484 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0146298 |
| PHF3 | PHD finger protein 3 | 0.0144397 |
| INSIG2 | insulin induced gene 2 | 0.014408 |
| GDF15 | growth differentiation factor 15 | 0.0143703 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0142129 |
| SET | SET nuclear proto-oncogene | 0.0140402 |
| TOP1 | topoisomerase (DNA) I | 0.0139687 |
| LDHA | lactate dehydrogenase A | 0.0139633 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0138611 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0137932 |
| RLF | rearranged L-myc fusion | 0.0137246 |
| RPL10A | ribosomal protein L10a | 0.0136173 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0135727 |
| APOA1 | apolipoprotein A-I | 0.0135069 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0134077 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0132565 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0132267 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0131508 |
| OGA | O-GlcNAcase | 0.0128663 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0127835 |
| RPL5 | ribosomal protein L5 | 0.0127708 |
| WDR45B | WD repeat domain 45B | 0.0127573 |
| RACK1 | receptor for activated C kinase 1 | 0.0127526 |
| RBM25 | RNA binding motif protein 25 | 0.0126395 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0126095 |
| RPL26 | ribosomal protein L26 | 0.0125287 |
| RPL12 | ribosomal protein L12 | 0.0124429 |
| SDC4 | syndecan 4 | 0.0123928 |
| RPLP2 | ribosomal protein, large, P2 | 0.0123612 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0123028 |
| RPL31 | ribosomal protein L31 | 0.0121273 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.012119 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0119509 |
| RAB1A | RAB1A, member RAS oncogene family | 0.011929 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0117864 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0117383 |
| HELZ | helicase with zinc finger | 0.0117225 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.011641 |
| MATR3 | matrin 3 | 0.0113461 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.681293 |
| C3 | complement component 3 | -0.0522332 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0402703 |
| EHBP1 | EH domain binding protein 1 | -0.0337872 |
| FN1 | fibronectin 1 | -0.0305515 |
| GPC6 | glypican 6 | -0.0296767 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0271385 |
| FRMD5 | FERM domain containing 5 | -0.0201899 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0184794 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0182061 |
| ATXN1 | ataxin 1 | -0.018187 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0166598 |
| ITGAV | integrin, alpha V | -0.0165667 |
| HMGA1 | high mobility group AT-hook 1 | -0.015628 |
| EGR1 | early growth response 1 | -0.0154643 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0150661 |
| RNF213 | ring finger protein 213 | -0.014895 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0140509 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0134161 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0133221 |
| ASPH | aspartate beta-hydroxylase | -0.0128674 |
| VCL | vinculin | -0.0124112 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0123333 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.012108 |
| RIGI | RNA sensor RIG-I | -0.0120975 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0119266 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0112949 |
| ATP10A | ATPase, class V, type 10A | -0.0111746 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0102808 |
| DST | dystonin | -0.0101559 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.00972612 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.00966028 |
| PRKCA | protein kinase C, alpha | -0.00948877 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.00929919 |
| SEPTIN9 | septin 9 | -0.00913982 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.00904581 |
| NHSL1 | NHS-like 1 | -0.00893996 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.00886802 |
| FOXP1 | forkhead box P1 | -0.00869383 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.00853906 |
| RUNX1 | runt-related transcription factor 1 | -0.00847386 |
| FAT1 | FAT atypical cadherin 1 | -0.00843539 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.00834678 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00822605 |
| MX2 | MX dynamin-like GTPase 2 | -0.00809884 |
| CMIP | c-Maf inducing protein | -0.00789402 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0077789 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.00776099 |
| TNS3 | tensin 3 | -0.00764344 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.00752139 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.00743371 |
| CNKSR3 | CNKSR family member 3 | -0.00736082 |
| COL27A1 | collagen, type XXVII, alpha 1 | -0.00711287 |
| ZNF644 | zinc finger protein 644 | -0.00710381 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.00704802 |
| APOA2 | apolipoprotein A-II | -0.00703139 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.00702834 |
| TXNRD1 | thioredoxin reductase 1 | -0.00700836 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.00686753 |
| PTCHD4 | patched domain containing 4 | -0.00670084 |
| NABP1 | nucleic acid binding protein 1 | -0.00665811 |
| LAP3 | leucine aminopeptidase 3 | -0.00664196 |
| PLSCR1 | phospholipid scramblase 1 | -0.00660339 |
| TMEM123 | transmembrane protein 123 | -0.00639558 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0063923 |
| AHNAK | AHNAK nucleoprotein | -0.00635203 |
| ACTG1 | actin gamma 1 | -0.00631006 |
| ITGA1 | integrin, alpha 1 | -0.00623891 |
| FUS | FUS RNA binding protein | -0.00619785 |
| INTS6 | integrator complex subunit 6 | -0.00619773 |
| GLIS3 | GLIS family zinc finger 3 | -0.00611162 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.00601096 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.00600619 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.00599267 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.00596094 |
| FLNA | filamin A, alpha | -0.00592658 |
| DISC1 | disrupted in schizophrenia 1 | -0.00587448 |
| FAM107B | family with sequence similarity 107, member B | -0.0058369 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.00581946 |
| NINL | ninein-like | -0.00580954 |
| RASAL2 | RAS protein activator like 2 | -0.00580795 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0057778 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.00573094 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0057023 |
| RAD51B | RAD51 paralog B | -0.00569315 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.00564258 |
| CUX1 | cut-like homeobox 1 | -0.00562869 |
| FKTN | fukutin | -0.00561923 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.005618 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.00560463 |
| FERMT1 | fermitin family member 1 | -0.00560164 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.00560067 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | -0.00552405 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -0.00552225 |
| EXOC4 | exocyst complex component 4 | -0.005503 |
| HDAC4 | histone deacetylase 4 | -0.00545643 |
| SMAD3 | SMAD family member 3 | -0.00540219 |
| SP100 | SP100 nuclear antigen | -0.00538782 |
| KYNU | kynureninase | -0.00536102 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.00533071 |
