Loperamide (hydrochloride)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.115452
TRIO trio Rho guanine nucleotide exchange factor 0.0930672
MEF2A myocyte enhancer factor 2A 0.0787943
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0655215
ITCH itchy E3 ubiquitin protein ligase 0.060189
SQLE squalene epoxidase 0.0529757
CANX calnexin 0.0483696
MTSS1 metastasis suppressor 1 0.044949
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0440291
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0417622
FLNB filamin B, beta 0.0393777
PTMA prothymosin, alpha 0.0377793
OGA O-GlcNAcase 0.0376812
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0369354
RAI14 retinoic acid induced 14 0.0363812
SPAG9 sperm associated antigen 9 0.0355851
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0347878
PGK1 phosphoglycerate kinase 1 0.0347457
PLS3 plastin 3 0.0341084
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0336169
KRT17 keratin 17, type I 0.0323073
ESYT2 extended synaptotagmin-like protein 2 0.031462
KRT6A keratin 6A, type II 0.030651
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0286139
SUCO SUN domain containing ossification factor 0.028572
GOLGA4 golgin A4 0.0283409
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0281615
PDIA3 protein disulfide isomerase family A, member 3 0.0279302
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0279123
RICTOR RPTOR independent companion of MTOR, complex 2 0.0277143
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.027311
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0272402
KDM3A lysine (K)-specific demethylase 3A 0.0268544
PDLIM5 PDZ and LIM domain 5 0.0267741
NAV2 neuron navigator 2 0.0265235
SLC35F3 solute carrier family 35, member F3 0.0260145
SLMAP sarcolemma associated protein 0.0259448
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.02509
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0232004
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0230208
COPA coatomer protein complex, subunit alpha 0.0229542
KDM6A lysine (K)-specific demethylase 6A 0.0229149
LMO7 LIM domain 7 0.022722
SRP54 signal recognition particle 54kDa 0.0221242
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0218355
LAMC2 laminin, gamma 2 0.0215304
SQSTM1 sequestosome 1 0.021434
GRB10 growth factor receptor-bound protein 10 0.0212387
HELZ helicase with zinc finger 0.020856
CDC73 cell division cycle 73 0.0207263
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0203174
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 0.0200014
SULF1 sulfatase 1 0.0199697
PICALM phosphatidylinositol binding clathrin assembly protein 0.019738
ABI3BP ABI family, member 3 (NESH) binding protein 0.0197043
SLK STE20-like kinase 0.0196334
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0194765
COPB1 coatomer protein complex, subunit beta 1 0.0194073
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0193237
MYH9 myosin, heavy chain 9, non-muscle 0.019179
NUP58 nucleoporin 58 0.0190046
BZW1 basic leucine zipper and W2 domains 1 0.0189619
RBM39 RNA binding motif protein 39 0.0188467
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.018289
LMAN1 lectin, mannose-binding, 1 0.0181416
ALCAM activated leukocyte cell adhesion molecule 0.0179482
PPARG peroxisome proliferator-activated receptor gamma 0.0176169
ZFC3H1 zinc finger, C3H1-type containing 0.0176147
SKIC3 SKI3 subunit of superkiller complex 0.0175668
HLA-E major histocompatibility complex, class I, E 0.0174347
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0173795
VCL vinculin 0.0169272
RLF rearranged L-myc fusion 0.0169094
KMT2C lysine (K)-specific methyltransferase 2C 0.0168934
TNIP1 TNFAIP3 interacting protein 1 0.0166736
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0166496
TTC3 tetratricopeptide repeat domain 3 0.016624
TMEM165 transmembrane protein 165 0.0165509
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0163834
MARCHF6 membrane associated ring-CH-type finger 6 0.0162672
CAVIN1 caveolae associated protein 1 0.0162608
PRRC2C proline-rich coiled-coil 2C 0.0162114
KDM5B lysine (K)-specific demethylase 5B 0.0161932
RAB6A RAB6A, member RAS oncogene family 0.0161324
TFG TRK-fused gene 0.0159355
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0159257
ZEB1 zinc finger E-box binding homeobox 1 0.0158701
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0158478
ANXA1 annexin A1 0.0155992
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0155697
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.015569
FNDC3A fibronectin type III domain containing 3A 0.0154638
USP3 ubiquitin specific peptidase 3 0.0154052
AKAP13 A kinase (PRKA) anchor protein 13 0.0153761
TMF1 TATA element modulatory factor 1 0.0152903
MXI1 MAX interactor 1, dimerization protein 0.0152733
SEC63 SEC63 homolog (S. cerevisiae) 0.015226
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0152122
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0152096
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0151014

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.163749
NDRG1 N-myc downstream regulated 1 -0.107346
MT2A metallothionein 2A -0.0832885
TMSB10 thymosin beta 10 -0.0625072
IFITM1 interferon induced transmembrane protein 1 -0.0547148
OSMR oncostatin M receptor -0.0493031
IFITM3 interferon induced transmembrane protein 3 -0.0485289
B2M beta-2-microglobulin -0.0467287
HLA-B major histocompatibility complex, class I, B -0.0459135
RPS6 ribosomal protein S6 -0.0438623
RPS19 ribosomal protein S19 -0.0409447
CYB5R3 cytochrome b5 reductase 3 -0.040678
POTEF POTE ankyrin domain family, member F -0.0404283
RPLP2 ribosomal protein, large, P2 -0.0392692
PLAT plasminogen activator, tissue -0.0386985
FOXP1 forkhead box P1 -0.0373197
MBNL1 muscleblind-like splicing regulator 1 -0.0366813
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0363352
LOC112694756 uncharaterized LOC112694756 -0.0361373
RPLP1 ribosomal protein, large, P1 -0.0360484
IGF2 insulin-like growth factor 2 -0.0359347
RPS21 ribosomal protein S21 -0.0346296
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0344634
IGFBP4 insulin-like growth factor binding protein 4 -0.0339085
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.031801
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0311139
CEMIP cell migration inducing protein, hyaluronan binding -0.0308309
BCL2L1 BCL2-like 1 -0.0305453
RPL8 ribosomal protein L8 -0.0288299
IFI6 interferon, alpha-inducible protein 6 -0.0287917
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0282295
CD44 CD44 molecule (Indian blood group) -0.0281725
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0269457
RPL11 ribosomal protein L11 -0.026716
RPS13 ribosomal protein S13 -0.0262718
RPL35A ribosomal protein L35a -0.026264
SLC38A2 solute carrier family 38, member 2 -0.026152
IFI16 interferon, gamma-inducible protein 16 -0.0257198
GNAS GNAS complex locus -0.0256456
YBX3 Y box binding protein 3 -0.0251697
FTH1 ferritin, heavy polypeptide 1 -0.0247601
RPL12 ribosomal protein L12 -0.0237963
CLU clusterin -0.0237857
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0237724
FTL ferritin, light polypeptide -0.0236665
TGM2 transglutaminase 2 -0.0235495
ACTN4 actinin, alpha 4 -0.0235235
RPL32 ribosomal protein L32 -0.0231705
PDE4D phosphodiesterase 4D, cAMP-specific -0.0231607
RPS23 ribosomal protein S23 -0.0230285
H1-0 H1.0 linker histone -0.0228048
RPL9 ribosomal protein L9 -0.022576
S100A10 S100 calcium binding protein A10 -0.0225505
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0221256
CMIP c-Maf inducing protein -0.0220695
TNS4 tensin 4 -0.0220526
ANKRD12 ankyrin repeat domain 12 -0.0216344
RPL37 ribosomal protein L37 -0.021164
MRPS6 mitochondrial ribosomal protein S6 -0.02112
RPS15 ribosomal protein S15 -0.0210985
RPL36 ribosomal protein L36 -0.0206929
RPL30 ribosomal protein L30 -0.0206394
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.0205824
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.020408
PKM pyruvate kinase, muscle -0.0202457
CNRIP1 cannabinoid receptor interacting protein 1 -0.0202017
RPL7A ribosomal protein L7a -0.0200451
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0200319
PRELID2 PRELI domain containing 2 -0.0199194
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0198301
ATP5F1E ATP synthase F1 subunit epsilon -0.019811
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0194864
EPHA2 EPH receptor A2 -0.0192817
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0192814
RPS29 ribosomal protein S29 -0.0191191
ZNFX1 zinc finger, NFX1-type containing 1 -0.0191185
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0190984
MDK midkine (neurite growth-promoting factor 2) -0.0188293
DOK5 docking protein 5 -0.0187314
FOXO1 forkhead box O1 -0.0184842
SMAD3 SMAD family member 3 -0.0183618
DUSP4 dual specificity phosphatase 4 -0.018287
TPT1 tumor protein, translationally-controlled 1 -0.0181665
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.017586
RPL35 ribosomal protein L35 -0.0175118
EGR1 early growth response 1 -0.0175099
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0174898
ITGB4 integrin, beta 4 -0.0173953
SYNJ2 synaptojanin 2 -0.0172078
LAMA5 laminin, alpha 5 -0.0171781
CNTNAP3 contactin associated protein-like 3 -0.0170208
RPL19 ribosomal protein L19 -0.0170189
RALGDS ral guanine nucleotide dissociation stimulator -0.0169827
IFI27 interferon, alpha-inducible protein 27 -0.0169786
CST3 cystatin C -0.0168477
ACTG1 actin gamma 1 -0.0168033
RPS4X ribosomal protein S4, X-linked -0.0165899
RPS8 ribosomal protein S8 -0.0165447
MAML2 mastermind-like 2 (Drosophila) -0.0164942
JAG1 jagged 1 -0.0164728