Loperamide (hydrochloride)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UGCG UDP-glucose ceramide glucosyltransferase 0.105708
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0803684
FTL ferritin, light polypeptide 0.0730402
GOLGA4 golgin A4 0.0486936
UBA6 ubiquitin-like modifier activating enzyme 6 0.0473263
NUP58 nucleoporin 58 0.0458255
B2M beta-2-microglobulin 0.0428647
ZNF841 zinc finger protein 841 0.0402328
KMT2E lysine (K)-specific methyltransferase 2E 0.0373641
ZNF292 zinc finger protein 292 0.0369028
SPAG9 sperm associated antigen 9 0.035784
ADM adrenomedullin 0.0343597
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0340173
KTN1 kinectin 1 (kinesin receptor) 0.0303887
MT2A metallothionein 2A 0.0303824
SET SET nuclear proto-oncogene 0.0302003
TMF1 TATA element modulatory factor 1 0.0272295
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 0.0270395
MSN moesin 0.026061
RPS2 ribosomal protein S2 0.0257423
ARRDC3 arrestin domain containing 3 0.025417
RIOK3 RIO kinase 3 0.0253311
RLF rearranged L-myc fusion 0.0248077
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.024803
ESYT2 extended synaptotagmin-like protein 2 0.0243495
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0232142
RAB6A RAB6A, member RAS oncogene family 0.0228569
RAB8B RAB8B, member RAS oncogene family 0.0226978
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0226474
SRP54 signal recognition particle 54kDa 0.022448
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0223722
DENND4C DENN/MADD domain containing 4C 0.0222221
TPD52 tumor protein D52 0.022133
HILPDA hypoxia inducible lipid droplet-associated 0.0220784
RNF145 ring finger protein 145 0.021671
UBQLN1 ubiquilin 1 0.0215724
RPL21 ribosomal protein L21 0.0211992
KMT2C lysine (K)-specific methyltransferase 2C 0.0208668
BRD2 bromodomain containing 2 0.0204836
USP3 ubiquitin specific peptidase 3 0.0197339
RAB18 RAB18, member RAS oncogene family 0.0196478
ACBD3 acyl-CoA binding domain containing 3 0.0195691
SUCO SUN domain containing ossification factor 0.0193829
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0193531
MXI1 MAX interactor 1, dimerization protein 0.0188909
FXR1 fragile X mental retardation, autosomal homolog 1 0.0187526
NAV2 neuron navigator 2 0.0186876
NGLY1 N-glycanase 1 0.0184184
BHLHE40 basic helix-loop-helix family, member e40 0.0183088
NCKAP1 NCK-associated protein 1 0.018231
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0182081
TPM3 tropomyosin 3 0.0181412
PRPF4B pre-mRNA processing factor 4B 0.017928
AKAP12 A kinase (PRKA) anchor protein 12 0.0177845
ELL2 elongation factor, RNA polymerase II, 2 0.0177278
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0176645
PDS5B PDS5 cohesin associated factor B 0.0176229
H1-4 H1.4 linker histone, cluster member 0.0175476
HELZ helicase with zinc finger 0.0172031
SLMAP sarcolemma associated protein 0.0169079
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0168403
CKAP5 cytoskeleton associated protein 5 0.0167122
NOP58 NOP58 ribonucleoprotein 0.0166271
KDM6A lysine (K)-specific demethylase 6A 0.0165292
WSB1 WD repeat and SOCS box containing 1 0.0165159
CCNL1 cyclin L1 0.0164785
RYBP RING1 and YY1 binding protein 0.0164523
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0164168
PNN pinin, desmosome associated protein 0.0162715
OPTN optineurin 0.0161654
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0159713
TSC22D2 TSC22 domain family, member 2 0.01574
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 0.0156149
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0155318
RSRC2 arginine/serine-rich coiled-coil 2 0.0154979
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0153307
MEF2A myocyte enhancer factor 2A 0.0150813
IRS2 insulin receptor substrate 2 0.0150517
TPX2 TPX2, microtubule-associated 0.0150022
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0149724
USP12 ubiquitin specific peptidase 12 0.0148743
ADAM9 ADAM metallopeptidase domain 9 0.014846
NUP153 nucleoporin 153kDa 0.0147148
ELP2 elongator acetyltransferase complex subunit 2 0.0147136
SLTM SAFB-like, transcription modulator 0.0146939
CHD1 chromodomain helicase DNA binding protein 1 0.0146383
SCAF11 SR-related CTD-associated factor 11 0.0145057
FNBP4 formin binding protein 4 0.0144848
NAP1L1 nucleosome assembly protein 1-like 1 0.0144131
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0143752
RBM27 RNA binding motif protein 27 0.0143042
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0143024
SRRM1 serine/arginine repetitive matrix 1 0.0142242
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.014093
GOLT1B golgi transport 1B 0.0139561
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0138754
QKI QKI, KH domain containing, RNA binding 0.0138537
KIF5B kinesin family member 5B 0.0138528
RNMT RNA (guanine-7-) methyltransferase 0.0138348
DSTN destrin (actin depolymerizing factor) 0.0137342

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.220355
EXT1 exostosin glycosyltransferase 1 -0.219143
NALF1 NALCN channel auxiliary factor 1 -0.209461
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.174401
CD44 CD44 molecule (Indian blood group) -0.139107
AHNAK AHNAK nucleoprotein -0.118746
IGFBP3 insulin-like growth factor binding protein 3 -0.117712
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.110552
GLIS3 GLIS family zinc finger 3 -0.101685
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0890423
HLA-B major histocompatibility complex, class I, B -0.0856739
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0810118
TRIO trio Rho guanine nucleotide exchange factor -0.0804414
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0774359
FTH1 ferritin, heavy polypeptide 1 -0.0753504
FLNB filamin B, beta -0.0748659
ERBIN erbb2 interacting protein -0.0721122
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0713981
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0712209
SLIT2 slit homolog 2 (Drosophila) -0.0635017
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0624946
PHACTR1 phosphatase and actin regulator 1 -0.0619869
ANXA2 annexin A2 -0.0615608
OSMR oncostatin M receptor -0.0564481
COL5A1 collagen, type V, alpha 1 -0.0560961
F3 coagulation factor III (thromboplastin, tissue factor) -0.0560157
SLC12A8 solute carrier family 12, member 8 -0.0536433
ENO1 enolase 1, (alpha) -0.0527737
ACTG1 actin gamma 1 -0.0522947
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0514397
LOC112694756 uncharaterized LOC112694756 -0.0508308
VEGFC vascular endothelial growth factor C -0.0491669
ZBTB20 zinc finger and BTB domain containing 20 -0.0475999
DIAPH3 diaphanous-related formin 3 -0.0471909
FNDC3B fibronectin type III domain containing 3B -0.0470304
PODXL podocalyxin-like -0.045592
TMSB10 thymosin beta 10 -0.0448817
PTPRG protein tyrosine phosphatase, receptor type, G -0.0448338
PTK2 protein tyrosine kinase 2 -0.043845
ASPH aspartate beta-hydroxylase -0.0438338
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0438227
FLNA filamin A, alpha -0.0427514
LPP LIM domain containing preferred translocation partner in lipoma -0.0427374
SMYD3 SET and MYND domain containing 3 -0.0420009
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0413667
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0409096
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0408286
TUBB tubulin, beta class I -0.0401911
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0398786
ABI3BP ABI family, member 3 (NESH) binding protein -0.039815
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0396598
LDHA lactate dehydrogenase A -0.0396585
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0393728
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0389423
CCBE1 collagen and calcium binding EGF domains 1 -0.0388448
INTS6 integrator complex subunit 6 -0.0383246
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0382871
UBC ubiquitin C -0.0379646
PTPRF protein tyrosine phosphatase, receptor type, F -0.0379048
ACTN1 actinin, alpha 1 -0.037888
TXNRD1 thioredoxin reductase 1 -0.0378089
PRRC2B proline-rich coiled-coil 2B -0.0377683
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.037571
MAP1B microtubule-associated protein 1B -0.0373888
DLG1 discs, large homolog 1 (Drosophila) -0.0373571
PLCB4 phospholipase C, beta 4 -0.0371664
VCL vinculin -0.0367475
RAD51B RAD51 paralog B -0.0365873
HEG1 heart development protein with EGF-like domains 1 -0.0363566
FOXP1 forkhead box P1 -0.0360487
HLA-C major histocompatibility complex, class I, C -0.0353356
DST dystonin -0.0351609
TENM3 teneurin transmembrane protein 3 -0.0344745
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0342554
ZNF804A zinc finger protein 804A -0.0338994
DPYD dihydropyrimidine dehydrogenase -0.033579
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0331607
RAB7A RAB7A, member RAS oncogene family -0.0327956
NSD2 nuclear receptor binding SET domain protein 2 -0.0327498
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0325503
VIM vimentin -0.0324222
PTPRK protein tyrosine phosphatase, receptor type, K -0.0323172
RALY RALY heterogeneous nuclear ribonucleoprotein -0.032063
ACTN4 actinin, alpha 4 -0.0317699
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0317089
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0316983
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0311914
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0306476
WNT5B wingless-type MMTV integration site family, member 5B -0.0306039
SAMD4A sterile alpha motif domain containing 4A -0.0302686
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0293294
MAP4 microtubule-associated protein 4 -0.02923
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.029034
FHIT fragile histidine triad -0.0288204
NAV1 neuron navigator 1 -0.0286476
VGLL3 vestigial-like family member 3 -0.0278781
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.027804
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0276967
RAI14 retinoic acid induced 14 -0.0275271
PARD3B par-3 family cell polarity regulator beta -0.0273675