| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.137492 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.118551 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.106033 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.101191 |
| FAT1 | FAT atypical cadherin 1 | 0.0920333 |
| PKP2 | plakophilin 2 | 0.0818442 |
| MYOF | myoferlin | 0.0798982 |
| TXNRD1 | thioredoxin reductase 1 | 0.0780723 |
| ITGA6 | integrin, alpha 6 | 0.0637297 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0634922 |
| SHROOM3 | shroom family member 3 | 0.0602044 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0585176 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0566303 |
| PLAC8 | placenta-specific 8 | 0.0529106 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0520141 |
| WWC1 | WW and C2 domain containing 1 | 0.051571 |
| MKI67 | marker of proliferation Ki-67 | 0.0511171 |
| PRELID2 | PRELI domain containing 2 | 0.0502189 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0493522 |
| RPL23 | ribosomal protein L23 | 0.0457869 |
| KIF5B | kinesin family member 5B | 0.0452414 |
| CENPF | centromere protein F, 350/400kDa | 0.0430033 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0428339 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0422652 |
| PCDHB16 | protocadherin beta 16 | 0.0417711 |
| FOXP1 | forkhead box P1 | 0.0411822 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0410099 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0406024 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0395264 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | 0.039453 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0394073 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0393246 |
| PTMA | prothymosin, alpha | 0.0390955 |
| GOLGA4 | golgin A4 | 0.0389144 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0387912 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0385097 |
| VCL | vinculin | 0.0380577 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0373923 |
| TRIM2 | tripartite motif containing 2 | 0.0373356 |
| FLNB | filamin B, beta | 0.0371533 |
| SQSTM1 | sequestosome 1 | 0.0365342 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0360105 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0359514 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0358918 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0351265 |
| EREG | epiregulin | 0.0351039 |
| RPLP0 | ribosomal protein, large, P0 | 0.0339718 |
| LIMA1 | LIM domain and actin binding 1 | 0.0335072 |
| ASPH | aspartate beta-hydroxylase | 0.0334424 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0333914 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0331679 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0317064 |
| TRIM31 | tripartite motif containing 31 | 0.0316123 |
| CCPG1 | cell cycle progression 1 | 0.0312869 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0305965 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0304804 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0304266 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.030129 |
| RPL12 | ribosomal protein L12 | 0.030123 |
| ABHD17C | abhydrolase domain containing 17C | 0.0298875 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.0297615 |
| PRSS3 | protease, serine, 3 | 0.029456 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0292319 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.029183 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.0290694 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0290466 |
| GDF15 | growth differentiation factor 15 | 0.0289827 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | 0.0289668 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0289079 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0288215 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0285976 |
| RPS19 | ribosomal protein S19 | 0.0283913 |
| RBM39 | RNA binding motif protein 39 | 0.0281957 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.0280139 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0276393 |
| AREG | amphiregulin | 0.0276092 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.027523 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0274403 |
| EPCAM | epithelial cell adhesion molecule | 0.0273694 |
| TLN2 | talin 2 | 0.02733 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0273119 |
| MYO1D | myosin ID | 0.0272219 |
| ZNF292 | zinc finger protein 292 | 0.0271551 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0271073 |
| ENO1 | enolase 1, (alpha) | 0.0270424 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0269679 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0266868 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0265459 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0263538 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0263205 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0262844 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0262224 |
| YBX3 | Y box binding protein 3 | 0.026134 |
| HMGB2 | high mobility group box 2 | 0.0260972 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0260335 |
| FOXO1 | forkhead box O1 | 0.0260068 |
| RNF145 | ring finger protein 145 | 0.0260002 |
| ETNK1 | ethanolamine kinase 1 | 0.0256785 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0256551 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0255365 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.12799 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0998902 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0764763 |
| FRMD5 | FERM domain containing 5 | -0.0754163 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0737475 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0651672 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0611805 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0570045 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.052097 |
| INTS6 | integrator complex subunit 6 | -0.05119 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0506446 |
| PKM | pyruvate kinase, muscle | -0.0479125 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0471008 |
| NPSR1 | neuropeptide S receptor 1 | -0.042285 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0417989 |
| RCOR1 | REST corepressor 1 | -0.0401781 |
| SVIL | supervillin | -0.0398377 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0390607 |
| SPINK13 | serine peptidase inhibitor, Kazal type 13 (putative) | -0.0386336 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0376732 |
| MYO5B | myosin VB | -0.037 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0359769 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0356746 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0327058 |
| EGFR | epidermal growth factor receptor | -0.0325185 |
| POTEF | POTE ankyrin domain family, member F | -0.0318909 |
| ITGB4 | integrin, beta 4 | -0.0312641 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | -0.0299157 |
| MCU | mitochondrial calcium uniporter | -0.0294271 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0291513 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.029106 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0286606 |
| CLIC5 | chloride intracellular channel 5 | -0.0284742 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0283256 |
| FOXO3 | forkhead box O3 | -0.0282247 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0281358 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0274913 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.027463 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0273795 |
| DIAPH1 | diaphanous-related formin 1 | -0.0266353 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0264571 |
| UBAP2 | ubiquitin associated protein 2 | -0.0263705 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.026063 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0259116 |
| ACTN4 | actinin, alpha 4 | -0.0254153 |
| STK39 | serine threonine kinase 39 | -0.0254097 |
| NABP1 | nucleic acid binding protein 1 | -0.0251376 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0251163 |
| CAV2 | caveolin 2 | -0.0249006 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0247906 |
| ZNF83 | zinc finger protein 83 | -0.024455 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -0.0243958 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.023925 |
| RPL34 | ribosomal protein L34 | -0.0236559 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0235682 |
| HLA-B | major histocompatibility complex, class I, B | -0.0233969 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0233377 |
| FBXO11 | F-box protein 11 | -0.0232288 |
| DSG3 | desmoglein 3 | -0.0232152 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0230064 |
| MXD1 | MAX dimerization protein 1 | -0.0228002 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0227778 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0224671 |
| HMGA1 | high mobility group AT-hook 1 | -0.0223914 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0221257 |
| RPL35A | ribosomal protein L35a | -0.0219979 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.0218795 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0217733 |
| TPM4 | tropomyosin 4 | -0.0216058 |
| DENND1A | DENN/MADD domain containing 1A | -0.0210856 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0208372 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0208173 |
| RREB1 | ras responsive element binding protein 1 | -0.0208046 |
| CTBP2 | C-terminal binding protein 2 | -0.0204958 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0204571 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0201934 |
| RPL28 | ribosomal protein L28 | -0.0200009 |
| TRAM1 | translocation associated membrane protein 1 | -0.0194334 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.019333 |
| DSG2 | desmoglein 2 | -0.019291 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0191842 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | -0.0190379 |
| CUX1 | cut-like homeobox 1 | -0.0190233 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0189607 |
| RPL37A | ribosomal protein L37a | -0.0189139 |
| PALLD | palladin, cytoskeletal associated protein | -0.0188889 |
| NDRG1 | N-myc downstream regulated 1 | -0.0187834 |
| RPS23 | ribosomal protein S23 | -0.0187371 |
| COBL | cordon-bleu WH2 repeat protein | -0.018556 |
| NPTN | neuroplastin | -0.0182397 |
| ABLIM1 | actin binding LIM protein 1 | -0.0181989 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0181097 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0180872 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0180786 |
| LRRC23 | leucine rich repeat containing 23 | -0.0180441 |
| RPS8 | ribosomal protein S8 | -0.0178158 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.017716 |
| CCND1 | cyclin D1 | -0.0176506 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0176434 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0174756 |
