| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.132172 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.069207 |
| PTMA | prothymosin, alpha | 0.0556672 |
| MT2A | metallothionein 2A | 0.0438698 |
| GOLGA4 | golgin A4 | 0.0418681 |
| CALR | calreticulin | 0.0371139 |
| XPO1 | exportin 1 | 0.0331503 |
| CANX | calnexin | 0.0324163 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0321192 |
| RPL37A | ribosomal protein L37a | 0.0320226 |
| SET | SET nuclear proto-oncogene | 0.0309143 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.030868 |
| PGK1 | phosphoglycerate kinase 1 | 0.0298476 |
| TXNIP | thioredoxin interacting protein | 0.0290308 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0288416 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0283045 |
| FTL | ferritin, light polypeptide | 0.0277713 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0275948 |
| TMSB4X | thymosin beta 4, X-linked | 0.0274391 |
| MT1E | metallothionein 1E | 0.026616 |
| RPL23 | ribosomal protein L23 | 0.0263371 |
| SRP54 | signal recognition particle 54kDa | 0.0255136 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0251594 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0239696 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0236718 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0230935 |
| SBF2 | SET binding factor 2 | 0.0229447 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0229369 |
| NUP58 | nucleoporin 58 | 0.0228685 |
| RNF145 | ring finger protein 145 | 0.021968 |
| TMSB10 | thymosin beta 10 | 0.0215339 |
| TMF1 | TATA element modulatory factor 1 | 0.0214705 |
| PKM | pyruvate kinase, muscle | 0.0214563 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0210395 |
| ENO1 | enolase 1, (alpha) | 0.0209842 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0207305 |
| SPAG9 | sperm associated antigen 9 | 0.020712 |
| HDGF | hepatoma-derived growth factor | 0.0206772 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0203233 |
| TPR | translocated promoter region, nuclear basket protein | 0.0201339 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0201325 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0198017 |
| S100A9 | S100 calcium binding protein A9 | 0.0197236 |
| SEPTIN7 | septin 7 | 0.0189955 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0187478 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0187353 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0186941 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0186057 |
| RPS3 | ribosomal protein S3 | 0.0185231 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0184614 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0180617 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.01782 |
| RPL36 | ribosomal protein L36 | 0.0176737 |
| RPS12 | ribosomal protein S12 | 0.0173149 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0172118 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0169263 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0169028 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0168624 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0166724 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0165256 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0164025 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0163846 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0163259 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.016316 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0163061 |
| LDHA | lactate dehydrogenase A | 0.0158496 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0157107 |
| ATXN2 | ataxin 2 | 0.0154133 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.015314 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0153037 |
| TPM4 | tropomyosin 4 | 0.0152745 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0152568 |
| RACK1 | receptor for activated C kinase 1 | 0.0151289 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0150451 |
| FNBP1L | formin binding protein 1-like | 0.0148722 |
| RPL27A | ribosomal protein L27a | 0.0148066 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0147252 |
| HELZ | helicase with zinc finger | 0.0147223 |
| ZNF292 | zinc finger protein 292 | 0.0146607 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0145938 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.014593 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0145736 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0144535 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0142371 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0142216 |
| TPI1 | triosephosphate isomerase 1 | 0.0141164 |
| NUCB2 | nucleobindin 2 | 0.0141004 |
| EPHA4 | EPH receptor A4 | 0.0140245 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0139692 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0138897 |
| CD109 | CD109 molecule | 0.0138662 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0137639 |
| RIOK3 | RIO kinase 3 | 0.0137602 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | 0.013651 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.013636 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0133957 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0133677 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0133423 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0133399 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0133373 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.144517 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0848706 |
| TXNRD1 | thioredoxin reductase 1 | -0.0804922 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0629178 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0624115 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.062325 |
| TP63 | tumor protein p63 | -0.0614871 |
| DST | dystonin | -0.0464656 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0421337 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0404724 |
| JMJD1C | jumonji domain containing 1C | -0.0403145 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0390076 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0381614 |
| CD44 | CD44 molecule (Indian blood group) | -0.035693 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0345747 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0333499 |
| PDE10A | phosphodiesterase 10A | -0.0329486 |
| VMP1 | vacuole membrane protein 1 | -0.0327095 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0320491 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0318984 |
| EGR1 | early growth response 1 | -0.0311126 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0283173 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0275146 |
| RASAL2 | RAS protein activator like 2 | -0.026513 |
| CAPRIN2 | caprin family member 2 | -0.0265006 |
| EMP1 | epithelial membrane protein 1 | -0.0249689 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0236806 |
| RTN4 | reticulon 4 | -0.0230966 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0227899 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0226506 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0226037 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0219924 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0218545 |
| ACTG1 | actin gamma 1 | -0.0217661 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0216993 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0213636 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0212357 |
| RUNX1 | runt-related transcription factor 1 | -0.0210399 |
| VIM | vimentin | -0.0209403 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0208368 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0207552 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0207193 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0206644 |
| KLF6 | Kruppel-like factor 6 | -0.0204155 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0203211 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0200715 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0199201 |
| ZNF217 | zinc finger protein 217 | -0.0198486 |
| FUS | FUS RNA binding protein | -0.0193653 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.019097 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0187658 |
| ERBIN | erbb2 interacting protein | -0.0186065 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0185723 |
| FLNB | filamin B, beta | -0.0185511 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0184462 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0180846 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0180121 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0178277 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0176612 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0173372 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0170526 |
| AHNAK | AHNAK nucleoprotein | -0.0167773 |
| EZR | ezrin | -0.0167482 |
| YBX3 | Y box binding protein 3 | -0.0164617 |
| SQSTM1 | sequestosome 1 | -0.0164586 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0164064 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0163335 |
| H1-0 | H1.0 linker histone | -0.0163271 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0163202 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0162771 |
| MKI67 | marker of proliferation Ki-67 | -0.0162362 |
| ANXA1 | annexin A1 | -0.0162079 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0161441 |
| USP34 | ubiquitin specific peptidase 34 | -0.0160095 |
| CCNL1 | cyclin L1 | -0.0159927 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0159323 |
| OSMR | oncostatin M receptor | -0.0159236 |
| PLSCR1 | phospholipid scramblase 1 | -0.0158823 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.015805 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0157294 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0155793 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | -0.0150102 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0148952 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0148267 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0148248 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0145198 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0145064 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0144392 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0143265 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0140264 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0139227 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0137798 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0137764 |
| RPS24 | ribosomal protein S24 | -0.0136447 |
| SGMS2 | sphingomyelin synthase 2 | -0.0136093 |
| CENPF | centromere protein F, 350/400kDa | -0.0134246 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0131683 |
| LPIN1 | lipin 1 | -0.0130815 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0127914 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.012787 |
