Loperamide (hydrochloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0996529
FAM13A family with sequence similarity 13, member A 0.049836
SLTM SAFB-like, transcription modulator 0.0473754
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0423973
LAMA4 laminin, alpha 4 0.0385124
MKI67 marker of proliferation Ki-67 0.0379059
CES1 carboxylesterase 1 0.0335475
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.033197
TXNRD1 thioredoxin reductase 1 0.0300451
GCLC glutamate-cysteine ligase, catalytic subunit 0.0293679
NAMPT nicotinamide phosphoribosyltransferase 0.0285235
SPAG9 sperm associated antigen 9 0.0280859
NGLY1 N-glycanase 1 0.0245757
TES testin LIM domain protein 0.024527
FTH1 ferritin, heavy polypeptide 1 0.0240918
ZC3H11A zinc finger CCCH-type containing 11A 0.0238661
CXCL8 chemokine (C-X-C motif) ligand 8 0.0232942
ZNF292 zinc finger protein 292 0.0232785
ELL2 elongation factor, RNA polymerase II, 2 0.0231038
JMJD1C jumonji domain containing 1C 0.0230402
ARRDC3 arrestin domain containing 3 0.0225101
OSMR oncostatin M receptor 0.0223774
ERRFI1 ERBB receptor feedback inhibitor 1 0.0218365
TSC22D2 TSC22 domain family, member 2 0.0216582
NPC1 Niemann-Pick disease, type C1 0.0212398
GRAMD1B GRAM domain containing 1B 0.0206533
KDM2A lysine (K)-specific demethylase 2A 0.020234
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0198878
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0188466
ZNF638 zinc finger protein 638 0.0186557
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0177262
ADAM9 ADAM metallopeptidase domain 9 0.0176488
YTHDC1 YTH domain containing 1 0.0175842
FRY furry homolog (Drosophila) 0.0172842
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0166259
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0163237
SON SON DNA binding protein 0.0163077
RAB27B RAB27B, member RAS oncogene family 0.0162525
CCNL1 cyclin L1 0.0162005
ARL5B ADP-ribosylation factor-like 5B 0.0161828
VMP1 vacuole membrane protein 1 0.0159068
ANO6 anoctamin 6 0.0158983
EP300 E1A binding protein p300 0.0157943
BRWD1 bromodomain and WD repeat domain containing 1 0.0155827
AGO2 argonaute RISC catalytic component 2 0.0150766
RUNX1 runt-related transcription factor 1 0.0149431
WDR26 WD repeat domain 26 0.0149174
RTN4 reticulon 4 0.0148046
GSK3B glycogen synthase kinase 3 beta 0.014548
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0144515
MRPS6 mitochondrial ribosomal protein S6 0.0142771
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.014248
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0141895
NEK7 NIMA-related kinase 7 0.01408
KMT5B lysine methyltransferase 5B 0.0140623
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0140499
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0140157
SYAP1 synapse associated protein 1 0.0138799
TMEM165 transmembrane protein 165 0.0137767
CHD1 chromodomain helicase DNA binding protein 1 0.0133665
BLZF1 basic leucine zipper nuclear factor 1 0.013289
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0131654
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.0131301
ANXA5 annexin A5 0.013105
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0130096
ATP13A3 ATPase type 13A3 0.0129821
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 0.0126131
RICTOR RPTOR independent companion of MTOR, complex 2 0.012607
SPRED1 sprouty-related, EVH1 domain containing 1 0.0124561
CARD16 caspase recruitment domain family, member 16 0.0124377
WDFY3 WD repeat and FYVE domain containing 3 0.0123844
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0123626
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0123278
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.0120928
RB1CC1 RB1-inducible coiled-coil 1 0.0120167
CENPF centromere protein F, 350/400kDa 0.0120024
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0115031
TET2 tet methylcytosine dioxygenase 2 0.0114973
ATP11B ATPase, class VI, type 11B 0.0113985
SUCO SUN domain containing ossification factor 0.0112252
DHFR dihydrofolate reductase 0.0112016
MYO1B myosin IB 0.0111991
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0111007
ZFC3H1 zinc finger, C3H1-type containing 0.011099
UBA6 ubiquitin-like modifier activating enzyme 6 0.0110523
VEGFC vascular endothelial growth factor C 0.0110141
UBE3A ubiquitin protein ligase E3A 0.0110131
SGO2 shugoshin 2 0.0108838
NCKAP1 NCK-associated protein 1 0.010838
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0108181
TMEM87A transmembrane protein 87A 0.0107526
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0107143
KIAA1328 KIAA1328 0.0106955
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.010611
RC3H1 ring finger and CCCH-type domains 1 0.0103432
CKAP2 cytoskeleton associated protein 2 0.0103383
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0101971
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0101622
BIRC2 baculoviral IAP repeat containing 2 0.0100982
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.010006

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.389117
TMSB10 thymosin beta 10 -0.215401
EGFR epidermal growth factor receptor -0.151532
PTMA prothymosin, alpha -0.138452
ACTG1 actin gamma 1 -0.132061
TPT1 tumor protein, translationally-controlled 1 -0.108376
S100A10 S100 calcium binding protein A10 -0.0910364
ASPH aspartate beta-hydroxylase -0.0866894
PTPRM protein tyrosine phosphatase, receptor type, M -0.0838436
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0799516
PKM pyruvate kinase, muscle -0.0778713
RPL35A ribosomal protein L35a -0.0749761
CST3 cystatin C -0.0730626
NDRG1 N-myc downstream regulated 1 -0.0712812
EGR1 early growth response 1 -0.0700608
RPLP1 ribosomal protein, large, P1 -0.0659907
FTL ferritin, light polypeptide -0.0648653
RPL37A ribosomal protein L37a -0.0642824
RPS25 ribosomal protein S25 -0.0625672
RPS24 ribosomal protein S24 -0.0615517
THSD4 thrombospondin, type I, domain containing 4 -0.0614887
MCL1 myeloid cell leukemia 1 -0.0585186
INTS6 integrator complex subunit 6 -0.0581696
HLA-B major histocompatibility complex, class I, B -0.0566256
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0562572
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0551999
RPL31 ribosomal protein L31 -0.0540249
RPS3 ribosomal protein S3 -0.0539636
SEC61G Sec61 gamma subunit -0.0518878
RPL34 ribosomal protein L34 -0.0487718
RPS6 ribosomal protein S6 -0.0480637
IFI6 interferon, alpha-inducible protein 6 -0.048023
KRT7 keratin 7, type II -0.047329
RPS8 ribosomal protein S8 -0.0463346
RPS29 ribosomal protein S29 -0.0459363
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0457479
RPS27A ribosomal protein S27a -0.0457236
AKR1C1 aldo-keto reductase family 1, member C1 -0.0446185
RPL11 ribosomal protein L11 -0.0437648
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0424271
AREG amphiregulin -0.0413363
B2M beta-2-microglobulin -0.0411443
FUS FUS RNA binding protein -0.0402274
IER3 immediate early response 3 -0.0395576
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0384196
RPL37 ribosomal protein L37 -0.0383991
ANXA2 annexin A2 -0.0373853
RPS12 ribosomal protein S12 -0.0370823
CUX1 cut-like homeobox 1 -0.036751
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0363161
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0354989
ENO1 enolase 1, (alpha) -0.0354584
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.035448
RPS23 ribosomal protein S23 -0.03536
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0352944
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0351204
RPL19 ribosomal protein L19 -0.0347695
RPLP2 ribosomal protein, large, P2 -0.0345654
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0343311
STC1 stanniocalcin 1 -0.0340951
CCND1 cyclin D1 -0.0339452
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0339222
WSB1 WD repeat and SOCS box containing 1 -0.0339143
SLC38A1 solute carrier family 38, member 1 -0.0338433
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0334642
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0334353
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0330895
S100A11 S100 calcium binding protein A11 -0.032765
PGK1 phosphoglycerate kinase 1 -0.0323599
FBXO11 F-box protein 11 -0.0319415
S100P S100 calcium binding protein P -0.0318739
S100A9 S100 calcium binding protein A9 -0.0314261
LPP LIM domain containing preferred translocation partner in lipoma -0.0314189
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0311285
ZMYND8 zinc finger, MYND-type containing 8 -0.0310067
RPS27 ribosomal protein S27 -0.0305113
FLNB filamin B, beta -0.0303579
SP100 SP100 nuclear antigen -0.0300352
AHNAK AHNAK nucleoprotein -0.0297655
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0296549
RPS19 ribosomal protein S19 -0.0296396
EFNA5 ephrin-A5 -0.029612
WASF2 WAS protein family, member 2 -0.0289626
RPS17 ribosomal protein S17 -0.0289555
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0289352
KRT18 keratin 18, type I -0.0286736
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0284299
MYO1E myosin IE -0.0281217
RPL8 ribosomal protein L8 -0.0280423
RPS13 ribosomal protein S13 -0.0278906
KPNB1 karyopherin (importin) beta 1 -0.0278806
KRT8 keratin 8, type II -0.0277865
EIF1 eukaryotic translation initiation factor 1 -0.0275233
RPS21 ribosomal protein S21 -0.0275106
RNF213 ring finger protein 213 -0.0275103
RPL38 ribosomal protein L38 -0.0274458
TPM4 tropomyosin 4 -0.0272022
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0267614
RPL30 ribosomal protein L30 -0.0264353
CAV1 caveolin 1, caveolae protein, 22kDa -0.0263786