| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Loperamide (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.184981 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.181212 |
| FTL | ferritin, light polypeptide | 0.178325 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.144366 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.12478 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.123406 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0920913 |
| RPL23 | ribosomal protein L23 | 0.0804915 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.079714 |
| GRAMD1B | GRAM domain containing 1B | 0.076188 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0669711 |
| PTMA | prothymosin, alpha | 0.0630351 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0626943 |
| RPL19 | ribosomal protein L19 | 0.0623149 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0619181 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0617324 |
| RPS12 | ribosomal protein S12 | 0.0609046 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0603849 |
| TPM3 | tropomyosin 3 | 0.0590784 |
| PFDN2 | prefoldin subunit 2 | 0.0572941 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0552723 |
| TMSB10 | thymosin beta 10 | 0.0545113 |
| RPL36 | ribosomal protein L36 | 0.0526096 |
| TFG | TRK-fused gene | 0.0500516 |
| ZNF292 | zinc finger protein 292 | 0.0490155 |
| RPL37A | ribosomal protein L37a | 0.0489399 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0476791 |
| KIF5B | kinesin family member 5B | 0.0475841 |
| RPLP1 | ribosomal protein, large, P1 | 0.046066 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0452979 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0451775 |
| FGB | fibrinogen beta chain | 0.0420736 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0417056 |
| CANX | calnexin | 0.0410211 |
| YBX1 | Y box binding protein 1 | 0.0407258 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0403676 |
| CYRIB | CYFIP related Rac1 interactor B | 0.040078 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0400461 |
| RPS27A | ribosomal protein S27a | 0.0397936 |
| RPL7 | ribosomal protein L7 | 0.0392258 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0390197 |
| ASPH | aspartate beta-hydroxylase | 0.0385816 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0384945 |
| RPS19 | ribosomal protein S19 | 0.0382827 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0381672 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0377942 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0360769 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0357719 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0349495 |
| CALR | calreticulin | 0.0338617 |
| RPS2 | ribosomal protein S2 | 0.0338614 |
| RPS3 | ribosomal protein S3 | 0.0331705 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0331571 |
| USP3 | ubiquitin specific peptidase 3 | 0.0329529 |
| APP | amyloid beta (A4) precursor protein | 0.0325906 |
| CHN1 | chimerin 1 | 0.0325511 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0324513 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0322715 |
| YBX3 | Y box binding protein 3 | 0.0322574 |
| NUP58 | nucleoporin 58 | 0.0317824 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.03167 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0315884 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0315611 |
| RPS7 | ribosomal protein S7 | 0.0295139 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0293645 |
| RPS27 | ribosomal protein S27 | 0.0290681 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0290601 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0290348 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0285762 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0282758 |
| SERF2 | small EDRK-rich factor 2 | 0.0281231 |
| CAVIN1 | caveolae associated protein 1 | 0.0280183 |
| RPL26 | ribosomal protein L26 | 0.0278313 |
| RTN4 | reticulon 4 | 0.0275431 |
| RNF145 | ring finger protein 145 | 0.0273953 |
| RRM2 | ribonucleotide reductase M2 | 0.0273739 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0273023 |
| MTMR3 | myotubularin related protein 3 | 0.0272762 |
| SET | SET nuclear proto-oncogene | 0.0270309 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0269437 |
| HMGB2 | high mobility group box 2 | 0.0268192 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0266783 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | 0.0266482 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0266085 |
| ANXA2 | annexin A2 | 0.0258444 |
| S100A6 | S100 calcium binding protein A6 | 0.0258163 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0257775 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0257293 |
| RPS25 | ribosomal protein S25 | 0.0255143 |
| ENO1 | enolase 1, (alpha) | 0.0254231 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0249254 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0248361 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0248202 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0246833 |
| SPOPL | speckle-type POZ protein-like | 0.0242717 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0241033 |
| RPS29 | ribosomal protein S29 | 0.0239777 |
| RPL5 | ribosomal protein L5 | 0.0238272 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0238106 |
| ANXA5 | annexin A5 | 0.0236902 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.165872 |
| IGF2 | insulin-like growth factor 2 | -0.112515 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.054852 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0533945 |
| EGR1 | early growth response 1 | -0.0527487 |
| ACTG1 | actin gamma 1 | -0.0514825 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0500356 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0452796 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0405017 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0385074 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0379986 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0379175 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0358186 |
| ANKRD12 | ankyrin repeat domain 12 | -0.035549 |
| USP34 | ubiquitin specific peptidase 34 | -0.0352951 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0349641 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0347029 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0341079 |
| STC1 | stanniocalcin 1 | -0.0299528 |
| BICC1 | BicC family RNA binding protein 1 | -0.028951 |
| NDRG1 | N-myc downstream regulated 1 | -0.0288357 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.028514 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0282784 |
| INO80 | INO80 complex subunit | -0.0267675 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.025547 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0246667 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0241503 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0233259 |
| HMGA1 | high mobility group AT-hook 1 | -0.0224443 |
| ERBIN | erbb2 interacting protein | -0.02217 |
| HLA-B | major histocompatibility complex, class I, B | -0.0217357 |
| BRD2 | bromodomain containing 2 | -0.0215988 |
| HDAC9 | histone deacetylase 9 | -0.0212957 |
| EXOC6B | exocyst complex component 6B | -0.020879 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0206243 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0204406 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0195334 |
| IER3 | immediate early response 3 | -0.0193741 |
| UTRN | utrophin | -0.0193526 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0187534 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0187165 |
| NRG1 | neuregulin 1 | -0.0187001 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0186961 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0186955 |
| TXNRD1 | thioredoxin reductase 1 | -0.018657 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0186408 |
| SPIDR | scaffolding protein involved in DNA repair | -0.018559 |
| NF1 | neurofibromin 1 | -0.0184767 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.018422 |
| CDK12 | cyclin-dependent kinase 12 | -0.0183537 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0182344 |
| NNMT | nicotinamide N-methyltransferase | -0.0179666 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0178905 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0178029 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0177417 |
| MORF4L2 | mortality factor 4 like 2 | -0.0176947 |
| GLIS3 | GLIS family zinc finger 3 | -0.0175453 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0173134 |
| KYNU | kynureninase | -0.0172821 |
| VIM | vimentin | -0.0170499 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0166843 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.016599 |
| SON | SON DNA binding protein | -0.0165571 |
| FUS | FUS RNA binding protein | -0.0165486 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0163671 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0162876 |
| GLG1 | golgi glycoprotein 1 | -0.0162863 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0161334 |
| MCL1 | myeloid cell leukemia 1 | -0.0159782 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0159631 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0159019 |
| ATM | ATM serine/threonine kinase | -0.0156201 |
| SVIL | supervillin | -0.0155277 |
| TMEM131 | transmembrane protein 131 | -0.0154857 |
| FNIP1 | folliculin interacting protein 1 | -0.0153908 |
| SCFD1 | sec1 family domain containing 1 | -0.0153796 |
| BPTF | bromodomain PHD finger transcription factor | -0.0153297 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0152868 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.01527 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.015049 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0146925 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.014381 |
| LAMA5 | laminin, alpha 5 | -0.0143447 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0141979 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0141469 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0140609 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0140599 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0140315 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0139532 |
| POTEF | POTE ankyrin domain family, member F | -0.0138668 |
| EPG5 | ectopic P-granules autophagy protein 5 homolog (C. elegans) | -0.013824 |
| NTN4 | netrin 4 | -0.0134519 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0132878 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0131522 |
| NLK | nemo-like kinase | -0.0131193 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0130973 |
| PSEN1 | presenilin 1 | -0.0130814 |
| CCDC91 | coiled-coil domain containing 91 | -0.0130334 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0129496 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0128767 |
