| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.226536 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.102848 |
| PTMA | prothymosin, alpha | 0.0908058 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0899158 |
| FAM13A | family with sequence similarity 13, member A | 0.0803313 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0765701 |
| RPS6 | ribosomal protein S6 | 0.0686227 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0673687 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0671367 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0669258 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0668073 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0605932 |
| RPL26 | ribosomal protein L26 | 0.0605116 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.059217 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0589961 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0584663 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0579861 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0579857 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0576537 |
| MED13 | mediator complex subunit 13 | 0.0573561 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0571914 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0562589 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.055554 |
| CANX | calnexin | 0.0552963 |
| QKI | QKI, KH domain containing, RNA binding | 0.055062 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0535398 |
| RPS3 | ribosomal protein S3 | 0.0514401 |
| XPO1 | exportin 1 | 0.0513704 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.051282 |
| OGA | O-GlcNAcase | 0.0510793 |
| PTK2 | protein tyrosine kinase 2 | 0.0504284 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0502936 |
| MORF4L2 | mortality factor 4 like 2 | 0.0499401 |
| TPD52 | tumor protein D52 | 0.0491034 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0488533 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.048601 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0485354 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0479949 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0477606 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0476113 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0465623 |
| MATR3 | matrin 3 | 0.0454685 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0452407 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0443476 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0435012 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0433944 |
| RPLP1 | ribosomal protein, large, P1 | 0.0430142 |
| ZNF292 | zinc finger protein 292 | 0.0428886 |
| SRPK2 | SRSF protein kinase 2 | 0.0425621 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0413094 |
| TOP1 | topoisomerase (DNA) I | 0.0411939 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0410636 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0409662 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0400994 |
| HELZ | helicase with zinc finger | 0.0394421 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0393615 |
| PTEN | phosphatase and tensin homolog | 0.0393443 |
| LDHA | lactate dehydrogenase A | 0.038836 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0387783 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0386106 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0382842 |
| STAG2 | stromal antigen 2 | 0.0381639 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0381024 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0375748 |
| TPR | translocated promoter region, nuclear basket protein | 0.0375345 |
| ACTN4 | actinin, alpha 4 | 0.0374522 |
| OXSR1 | oxidative stress responsive 1 | 0.0370352 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0364012 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0360753 |
| DST | dystonin | 0.0359437 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0357428 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0357404 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0354313 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0353384 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0351275 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.034374 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0342833 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0341138 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0339033 |
| ATP13A3 | ATPase type 13A3 | 0.0338773 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0333203 |
| TFG | TRK-fused gene | 0.0331733 |
| COG5 | component of oligomeric golgi complex 5 | 0.0328535 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0328054 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0327777 |
| TXNIP | thioredoxin interacting protein | 0.0323678 |
| PGK1 | phosphoglycerate kinase 1 | 0.0322338 |
| RNF145 | ring finger protein 145 | 0.0316575 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0315848 |
| RPS8 | ribosomal protein S8 | 0.0310327 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0310143 |
| NCKAP1 | NCK-associated protein 1 | 0.0293503 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0292485 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0292452 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0290937 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0286016 |
| RPL23 | ribosomal protein L23 | 0.0282875 |
| RPL7 | ribosomal protein L7 | 0.0282064 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0281941 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0279676 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.175987 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.140497 |
| FTL | ferritin, light polypeptide | -0.103921 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0972161 |
| VIM | vimentin | -0.0947552 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.094072 |
| SLTM | SAFB-like, transcription modulator | -0.0925489 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0877039 |
| EGFR | epidermal growth factor receptor | -0.0839972 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0797504 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0784222 |
| FBXO11 | F-box protein 11 | -0.0774707 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0768966 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0763608 |
| FN1 | fibronectin 1 | -0.0748221 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0720539 |
| LOXL2 | lysyl oxidase-like 2 | -0.0715699 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0690523 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0689837 |
| MT2A | metallothionein 2A | -0.062747 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.061615 |
| SMYD3 | SET and MYND domain containing 3 | -0.0607265 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0594888 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.054639 |
| EFNA5 | ephrin-A5 | -0.0538016 |
| PDE10A | phosphodiesterase 10A | -0.0533494 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0512407 |
| FLNB | filamin B, beta | -0.050971 |
| TXNRD1 | thioredoxin reductase 1 | -0.0503635 |
| STC1 | stanniocalcin 1 | -0.0487611 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.047446 |
| RNF213 | ring finger protein 213 | -0.0473392 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0471708 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0467585 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0467382 |
| GLIS3 | GLIS family zinc finger 3 | -0.0460343 |
| C3 | complement component 3 | -0.0453268 |
| RAB10 | RAB10, member RAS oncogene family | -0.0441547 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0439789 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0430479 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0427578 |
| ANO6 | anoctamin 6 | -0.0426705 |
| SBF2 | SET binding factor 2 | -0.0426178 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0423659 |
| ASPH | aspartate beta-hydroxylase | -0.0414197 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0411321 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0404172 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0395277 |
| MMP12 | matrix metallopeptidase 12 | -0.0394691 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0382757 |
| RPS16 | ribosomal protein S16 | -0.037988 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0379598 |
| MYO1E | myosin IE | -0.0372872 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0368728 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0368598 |
| INHBA | inhibin, beta A | -0.0366726 |
| JMJD1C | jumonji domain containing 1C | -0.0360614 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0356813 |
| POTEF | POTE ankyrin domain family, member F | -0.0355219 |
| USP47 | ubiquitin specific peptidase 47 | -0.0349129 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0348479 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0347109 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0346792 |
| SVIL | supervillin | -0.0346262 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0345364 |
| TPI1 | triosephosphate isomerase 1 | -0.0338556 |
| GPC6 | glypican 6 | -0.0338392 |
| KIAA1217 | KIAA1217 | -0.0337435 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0336634 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0329682 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0321993 |
| CCDC88A | coiled-coil domain containing 88A | -0.0317304 |
| CD44 | CD44 molecule (Indian blood group) | -0.0313205 |
| DIAPH3 | diaphanous-related formin 3 | -0.0312465 |
| CCND1 | cyclin D1 | -0.0307558 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0306489 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0302076 |
| KYNU | kynureninase | -0.0298435 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0293278 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0291434 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0290485 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0288338 |
| C1D | C1D nuclear receptor corepressor | -0.0288266 |
| CDK17 | cyclin-dependent kinase 17 | -0.028772 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0287317 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.028726 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0285924 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.028536 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0284135 |
| PEG10 | paternally expressed 10 | -0.0276208 |
| DSPP | dentin sialophosphoprotein | -0.0274804 |
| NBAS | neuroblastoma amplified sequence | -0.0274659 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0274526 |
| OSMR | oncostatin M receptor | -0.0271588 |
| RSF1 | remodeling and spacing factor 1 | -0.0269025 |
| OLA1 | Obg-like ATPase 1 | -0.0264546 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.02623 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0262232 |
| B2M | beta-2-microglobulin | -0.0261168 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0257882 |
