| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.153614 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0995748 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0824133 |
| PRELID2 | PRELI domain containing 2 | 0.06833 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0648677 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0482571 |
| RAD51B | RAD51 paralog B | 0.047718 |
| ATXN1 | ataxin 1 | 0.0449023 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0366469 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.035618 |
| WWOX | WW domain containing oxidoreductase | 0.0343567 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0339203 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0333909 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0332296 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0326997 |
| CANX | calnexin | 0.0322558 |
| AEBP2 | AE binding protein 2 | 0.032164 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0310349 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.028253 |
| ENO1 | enolase 1, (alpha) | 0.0280388 |
| RYR3 | ryanodine receptor 3 | 0.0270389 |
| PTMA | prothymosin, alpha | 0.0267152 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0248725 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0244222 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0240585 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0238646 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0238091 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0235791 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0234858 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.022961 |
| BBX | bobby sox homolog (Drosophila) | 0.0229294 |
| SET | SET nuclear proto-oncogene | 0.0227394 |
| RPS3 | ribosomal protein S3 | 0.0223968 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.020591 |
| RYK | receptor-like tyrosine kinase | 0.0204068 |
| FMN1 | formin 1 | 0.0202763 |
| HELZ | helicase with zinc finger | 0.0200334 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0197651 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0196361 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0195116 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0193074 |
| HDGF | hepatoma-derived growth factor | 0.0189938 |
| PHF21A | PHD finger protein 21A | 0.0189061 |
| TMEM14B | transmembrane protein 14B | 0.0185951 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0185311 |
| STYK1 | serine/threonine/tyrosine kinase 1 | 0.0183532 |
| RSF1 | remodeling and spacing factor 1 | 0.0181963 |
| CALR | calreticulin | 0.0181192 |
| TPM3 | tropomyosin 3 | 0.0177329 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0177307 |
| H2AC6 | H2A clustered histone 6 | 0.0176146 |
| FAM168A | family with sequence similarity 168, member A | 0.0174971 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0171956 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0170983 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0166249 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0165596 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0163616 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0161435 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0160555 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0159557 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0157902 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.015701 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0156683 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.015568 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0153724 |
| ANKRD36B | ankyrin repeat domain 36B | 0.0152514 |
| MCL1 | myeloid cell leukemia 1 | 0.0152147 |
| HYOU1 | hypoxia up-regulated 1 | 0.0150992 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0150519 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0149593 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0149281 |
| DIAPH2 | diaphanous-related formin 2 | 0.0147672 |
| RPL23 | ribosomal protein L23 | 0.0147492 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0145024 |
| TRIM9 | tripartite motif containing 9 | 0.0144264 |
| RPL37A | ribosomal protein L37a | 0.0144195 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0143565 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0143191 |
| TPR | translocated promoter region, nuclear basket protein | 0.0142986 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0142556 |
| NXN | nucleoredoxin | 0.0142549 |
| PREPL | prolyl endopeptidase-like | 0.0141759 |
| RPS7 | ribosomal protein S7 | 0.0140161 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0139843 |
| NEK10 | NIMA-related kinase 10 | 0.0139776 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0139195 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0138662 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0137238 |
| RPS12 | ribosomal protein S12 | 0.0136224 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0135344 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0134865 |
| CEP192 | centrosomal protein 192kDa | 0.0133482 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0133046 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0131572 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0131452 |
| DIPK2A | divergent protein kinase domain 2A | 0.0129559 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0128203 |
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | 0.0128168 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0128099 |
| SFMBT2 | Scm-like with four mbt domains 2 | 0.0127904 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.211528 |
| TXNRD1 | thioredoxin reductase 1 | -0.18779 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.15208 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0896132 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0691306 |
| GRAMD1B | GRAM domain containing 1B | -0.0665896 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0656884 |
| OSMR | oncostatin M receptor | -0.0651995 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0624081 |
| EGR1 | early growth response 1 | -0.0622172 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.061058 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0595252 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0520172 |
| RTN4 | reticulon 4 | -0.0448671 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0438956 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.041382 |
| RAB7A | RAB7A, member RAS oncogene family | -0.040939 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0404149 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0399254 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0397168 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.038871 |
| NABP1 | nucleic acid binding protein 1 | -0.0386091 |
| CDK17 | cyclin-dependent kinase 17 | -0.0377888 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0376995 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0373579 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.036227 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0357339 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0355946 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.035381 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0353384 |
| STC1 | stanniocalcin 1 | -0.0352881 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0350318 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0349345 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0342741 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0326699 |
| ADAR | adenosine deaminase, RNA-specific | -0.0324804 |
| VIM | vimentin | -0.0323186 |
| KLF6 | Kruppel-like factor 6 | -0.0322157 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0321574 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0319155 |
| RASAL2 | RAS protein activator like 2 | -0.0305978 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0302428 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0300024 |
| PLSCR1 | phospholipid scramblase 1 | -0.0299238 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0294741 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0288088 |
| YBX3 | Y box binding protein 3 | -0.0285269 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.027935 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0276705 |
| JMJD1C | jumonji domain containing 1C | -0.0269215 |
| ACTG1 | actin gamma 1 | -0.0263692 |
| LATS2 | large tumor suppressor kinase 2 | -0.0257109 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0256851 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0249945 |
| GPHN | gephyrin | -0.0243829 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0241861 |
| MKI67 | marker of proliferation Ki-67 | -0.0236861 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0233653 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0232104 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0226944 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0223751 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.022224 |
| CLTC | clathrin, heavy chain (Hc) | -0.0222148 |
| ACTN1 | actinin, alpha 1 | -0.0221365 |
| FUS | FUS RNA binding protein | -0.021944 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0218331 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0213853 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0212309 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0211593 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0210848 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0207376 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0207227 |
| DOCK3 | dedicator of cytokinesis 3 | -0.0206572 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0204947 |
| MYPN | myopalladin | -0.0202879 |
| SNX9 | sorting nexin 9 | -0.0202707 |
| NRG1 | neuregulin 1 | -0.0202596 |
| ATP11A | ATPase, class VI, type 11A | -0.0201247 |
| TMEM41B | transmembrane protein 41B | -0.0201094 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0200165 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0199603 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0199007 |
| AHNAK | AHNAK nucleoprotein | -0.0197722 |
| RIGI | RNA sensor RIG-I | -0.0196822 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0196528 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0195763 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0195691 |
| CCND1 | cyclin D1 | -0.0195553 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0192057 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0190488 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0190064 |
| FBXO11 | F-box protein 11 | -0.0189831 |
| FHL2 | four and a half LIM domains 2 | -0.0185617 |
| MMP12 | matrix metallopeptidase 12 | -0.0184024 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0183701 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.018327 |
| IL6ST | interleukin 6 signal transducer | -0.0181573 |
| ATAD1 | ATPase family, AAA domain containing 1 | -0.0180768 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0180363 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0179119 |
