Loperamide (hydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0454362
UBA6 ubiquitin-like modifier activating enzyme 6 0.0401507
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0374602
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0352651
RNF145 ring finger protein 145 0.0349832
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0346245
FXR1 fragile X mental retardation, autosomal homolog 1 0.0290111
MSN moesin 0.0288804
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0287351
HMGB2 high mobility group box 2 0.0275952
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0235451
ASPH aspartate beta-hydroxylase 0.0225746
TFG TRK-fused gene 0.0210916
MT2A metallothionein 2A 0.0200412
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0200373
NUP58 nucleoporin 58 0.019444
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0186117
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0183276
FAM162A family with sequence similarity 162, member A 0.0177872
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0171376
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0170985
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0168842
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0168205
ATP13A3 ATPase type 13A3 0.0166472
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0163397
ANXA5 annexin A5 0.0159763
SET SET nuclear proto-oncogene 0.0158386
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0147936
NCKAP1 NCK-associated protein 1 0.0147606
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0146657
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.014442
TRA2B transformer 2 beta homolog (Drosophila) 0.0143567
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0138669
DHFR dihydrofolate reductase 0.0137872
DSPP dentin sialophosphoprotein 0.0135406
EZR ezrin 0.0134245
PDIA6 protein disulfide isomerase family A, member 6 0.0129482
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0127317
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0125957
USP3 ubiquitin specific peptidase 3 0.0123277
TSC22D2 TSC22 domain family, member 2 0.0122567
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0122342
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0117932
UGCG UDP-glucose ceramide glucosyltransferase 0.0116703
BHLHE40 basic helix-loop-helix family, member e40 0.0114931
HILPDA hypoxia inducible lipid droplet-associated 0.0114618
SLMAP sarcolemma associated protein 0.0113408
OSBPL9 oxysterol binding protein-like 9 0.0113099
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0110365
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0109493
SSBP2 single-stranded DNA binding protein 2 0.0109382
RAD23B RAD23 homolog B (S. cerevisiae) 0.010888
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0108671
PABPN1 poly(A) binding protein, nuclear 1 0.0107906
KDM1A lysine (K)-specific demethylase 1A 0.0107498
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0106544
TPM3 tropomyosin 3 0.010398
U2SURP U2 snRNP-associated SURP domain containing 0.0103258
SCAF4 SR-related CTD-associated factor 4 0.0102477
PNISR PNN-interacting serine/arginine-rich protein 0.00995904
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.00990996
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.00984266
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.00960024
ZNF292 zinc finger protein 292 0.00952338
MSMO1 methylsterol monooxygenase 1 0.00943544
OTUD4 OTU deubiquitinase 4 0.00940493
SRRM1 serine/arginine repetitive matrix 1 0.0094023
SPOPL speckle-type POZ protein-like 0.00927094
FAM13A family with sequence similarity 13, member A 0.00927039
FOSL1 FOS-like antigen 1 0.00923258
HMGN2 high mobility group nucleosomal binding domain 2 0.00916182
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.00915047
PNN pinin, desmosome associated protein 0.00912353
FEM1C fem-1 homolog c (C. elegans) 0.00906125
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.00890862
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.00874835
SREK1IP1 SREK1-interacting protein 1 0.00871528
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 0.00860427
TNIP1 TNFAIP3 interacting protein 1 0.00859659
SSB Sjogren syndrome antigen B (autoantigen La) 0.00849501
MYO1B myosin IB 0.00848048
HDAC3 histone deacetylase 3 0.00848035
SLK STE20-like kinase 0.00839222
SFPQ splicing factor proline/glutamine-rich 0.00837819
THSD4 thrombospondin, type I, domain containing 4 0.00828075
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.00822957
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.00822014
ZRANB2 zinc finger, RAN-binding domain containing 2 0.00820442
NALF1 NALCN channel auxiliary factor 1 0.00811724
RPL21 ribosomal protein L21 0.00806332
AGFG1 ArfGAP with FG repeats 1 0.00805671
USP12 ubiquitin specific peptidase 12 0.00799355
SMC3 structural maintenance of chromosomes 3 0.0079826
KCTD3 potassium channel tetramerization domain containing 3 0.00796703
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.00790042
BCLAF1 BCL2-associated transcription factor 1 0.00789302
GPX4 glutathione peroxidase 4 0.00786651
TEX10 testis expressed 10 0.00786201
HSPA8 heat shock 70kDa protein 8 0.00782671
ATG3 autophagy related 3 0.00777694

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.26643
ACTG1 actin gamma 1 -0.21231
FN1 fibronectin 1 -0.210471
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.136923
EXT1 exostosin glycosyltransferase 1 -0.121034
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.100292
FNDC3B fibronectin type III domain containing 3B -0.0900973
EFNA5 ephrin-A5 -0.0898212
TMSB10 thymosin beta 10 -0.0885203
LIMCH1 LIM and calponin homology domains 1 -0.0864477
POTEF POTE ankyrin domain family, member F -0.0796687
SAMD4A sterile alpha motif domain containing 4A -0.0757163
EIF1 eukaryotic translation initiation factor 1 -0.0734309
LMO7 LIM domain 7 -0.07106
LPP LIM domain containing preferred translocation partner in lipoma -0.0695916
TPT1 tumor protein, translationally-controlled 1 -0.0686055
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0685001
FBXO32 F-box protein 32 -0.0665384
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0651404
RPL34 ribosomal protein L34 -0.0624224
ALCAM activated leukocyte cell adhesion molecule -0.0617853
IGFBP3 insulin-like growth factor binding protein 3 -0.0606211
ERBIN erbb2 interacting protein -0.0601827
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0590397
UBC ubiquitin C -0.0577438
VCL vinculin -0.0564101
RPL35A ribosomal protein L35a -0.0555001
MYO1E myosin IE -0.0540343
GNAS GNAS complex locus -0.0533434
SH3KBP1 SH3-domain kinase binding protein 1 -0.0529694
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0524356
PTMA prothymosin, alpha -0.0522432
SEC31A SEC31 homolog A (S. cerevisiae) -0.0516812
TM4SF1 transmembrane 4 L six family member 1 -0.0515351
FNIP1 folliculin interacting protein 1 -0.0505106
ARHGAP5 Rho GTPase activating protein 5 -0.0487041
RCOR1 REST corepressor 1 -0.0481747
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.047975
RPS23 ribosomal protein S23 -0.0476047
CD2AP CD2-associated protein -0.0473821
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0468509
TPM4 tropomyosin 4 -0.04676
GOLGA4 golgin A4 -0.0466569
LAMB3 laminin, beta 3 -0.0463899
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0454749
RAB7A RAB7A, member RAS oncogene family -0.0451822
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0450555
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0446252
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.044386
PALLD palladin, cytoskeletal associated protein -0.0439577
TRIO trio Rho guanine nucleotide exchange factor -0.0438958
HLA-A major histocompatibility complex, class I, A -0.0429481
FBXO34 F-box protein 34 -0.0426559
NPEPPS aminopeptidase puromycin sensitive -0.0422661
TMSB4X thymosin beta 4, X-linked -0.0421513
NF1 neurofibromin 1 -0.0420363
NDRG1 N-myc downstream regulated 1 -0.0419628
S100A6 S100 calcium binding protein A6 -0.041808
NIPBL Nipped-B homolog (Drosophila) -0.041529
UBE2H ubiquitin-conjugating enzyme E2H -0.0409569
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0408394
SOX4 SRY (sex determining region Y)-box 4 -0.0407429
FTH1 ferritin, heavy polypeptide 1 -0.0396797
TMEM165 transmembrane protein 165 -0.0395419
RPS24 ribosomal protein S24 -0.0390588
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.038996
IFI6 interferon, alpha-inducible protein 6 -0.0389024
MYO6 myosin VI -0.0388784
ELL2 elongation factor, RNA polymerase II, 2 -0.0386996
RPL30 ribosomal protein L30 -0.0383697
MAP4 microtubule-associated protein 4 -0.0378125
BASP1 brain abundant, membrane attached signal protein 1 -0.0373726
CTNND1 catenin (cadherin-associated protein), delta 1 -0.03736
LOC112694756 uncharaterized LOC112694756 -0.0373454
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.037317
OCLN occludin -0.0372862
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0370161
CAPN2 calpain 2, (m/II) large subunit -0.0370133
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0362216
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0360358
RPS13 ribosomal protein S13 -0.0359975
OSMR oncostatin M receptor -0.0356859
CCND1 cyclin D1 -0.0354791
ITCH itchy E3 ubiquitin protein ligase -0.0353661
VGLL3 vestigial-like family member 3 -0.0352424
RPS25 ribosomal protein S25 -0.0348025
UBAP1 ubiquitin associated protein 1 -0.0347539
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0346529
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0346434
PARD3 par-3 family cell polarity regulator -0.034537
KMT2C lysine (K)-specific methyltransferase 2C -0.0344276
S100A10 S100 calcium binding protein A10 -0.0342862
HLA-B major histocompatibility complex, class I, B -0.0340588
KRT7 keratin 7, type II -0.0338068
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0337144
ARHGAP20 Rho GTPase activating protein 20 -0.0336544
CEP350 centrosomal protein 350kDa -0.0329573
GRB10 growth factor receptor-bound protein 10 -0.0328867
BLZF1 basic leucine zipper nuclear factor 1 -0.032804
ARF1 ADP-ribosylation factor 1 -0.0326768