| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.100747 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0803058 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.070311 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0616457 |
| EFNA5 | ephrin-A5 | 0.0570984 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0561133 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0538986 |
| TXNRD1 | thioredoxin reductase 1 | 0.0537492 |
| GDA | guanine deaminase | 0.0532972 |
| NEK7 | NIMA-related kinase 7 | 0.0468403 |
| RPL23 | ribosomal protein L23 | 0.0447214 |
| GRAMD1B | GRAM domain containing 1B | 0.0437197 |
| KYNU | kynureninase | 0.0435791 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0421331 |
| DST | dystonin | 0.041745 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0409504 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0403246 |
| PM20D1 | peptidase M20 domain containing 1 | 0.038046 |
| CTSC | cathepsin C | 0.0343575 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0335466 |
| CENPF | centromere protein F, 350/400kDa | 0.0324411 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0304452 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.030427 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0294115 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0288385 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0285051 |
| TNPO1 | transportin 1 | 0.0284572 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0276949 |
| PTMA | prothymosin, alpha | 0.0275171 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0267873 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0260914 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0260137 |
| MFF | mitochondrial fission factor | 0.0250026 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0245315 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0243125 |
| RPL12 | ribosomal protein L12 | 0.0238541 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0236837 |
| RTN4 | reticulon 4 | 0.0236203 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0229126 |
| ENAH | enabled homolog (Drosophila) | 0.0228205 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0224697 |
| MYOF | myoferlin | 0.0223027 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0218899 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0217145 |
| RPL26 | ribosomal protein L26 | 0.021337 |
| CD109 | CD109 molecule | 0.0212127 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0208373 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0204896 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0200881 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0200552 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0198687 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.019713 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0195369 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0191635 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.018849 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.018775 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0186258 |
| TMSB10 | thymosin beta 10 | 0.0182907 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0181669 |
| MKI67 | marker of proliferation Ki-67 | 0.01795 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0178063 |
| SRGN | serglycin | 0.0177895 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0172222 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0169394 |
| PHF20 | PHD finger protein 20 | 0.0168075 |
| BDNF | brain-derived neurotrophic factor | 0.0166559 |
| FTL | ferritin, light polypeptide | 0.0165707 |
| KIF5B | kinesin family member 5B | 0.0164722 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.016312 |
| WDR43 | WD repeat domain 43 | 0.0160837 |
| RAI1 | retinoic acid induced 1 | 0.0159697 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0159339 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0158761 |
| MT2A | metallothionein 2A | 0.015684 |
| RTN1 | reticulon 1 | 0.0156263 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0153932 |
| OGA | O-GlcNAcase | 0.0153772 |
| PRDX1 | peroxiredoxin 1 | 0.01509 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0149428 |
| CDK6 | cyclin-dependent kinase 6 | 0.0149189 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0149128 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0148928 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0146989 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0146193 |
| ANXA1 | annexin A1 | 0.0145653 |
| NRCAM | neuronal cell adhesion molecule | 0.0145041 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0143939 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0143639 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0143472 |
| WDR26 | WD repeat domain 26 | 0.0142943 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0142217 |
| RGS2 | regulator of G-protein signaling 2 | 0.0141052 |
| CENPE | centromere protein E, 312kDa | 0.0140407 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0140205 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0139461 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0137945 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0137325 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0137207 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0136691 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0136362 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.195351 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.137478 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0735245 |
| CDH13 | cadherin 13 | -0.0718833 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0691057 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0564946 |
| PDE10A | phosphodiesterase 10A | -0.0555638 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0527451 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0494317 |
| AUTS2 | autism susceptibility candidate 2 | -0.0461073 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0458886 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0370515 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0370245 |
| NDRG1 | N-myc downstream regulated 1 | -0.0343582 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0319411 |
| NBEAL1 | neurobeachin-like 1 | -0.0309058 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0307231 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0299535 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0295593 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0295573 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0294152 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0290555 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0283913 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0282549 |
| DENND1A | DENN/MADD domain containing 1A | -0.0279199 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0273525 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0272648 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0268828 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0265098 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0262269 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0260018 |
| CTBP2 | C-terminal binding protein 2 | -0.025748 |
| LAMA5 | laminin, alpha 5 | -0.0256739 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.02472 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0244317 |
| LSAMP | limbic system-associated membrane protein | -0.0242305 |
| XYLT1 | xylosyltransferase I | -0.0232941 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0231675 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0229441 |
| DNER | delta/notch-like EGF repeat containing | -0.0227322 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0226361 |
| IL6 | interleukin 6 | -0.0221468 |
| RAD51B | RAD51 paralog B | -0.0220291 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0216156 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0205899 |
| EGR1 | early growth response 1 | -0.0203705 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0202442 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0201253 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0198298 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0190259 |
| MCL1 | myeloid cell leukemia 1 | -0.0188291 |
| MAP7 | microtubule-associated protein 7 | -0.0187964 |
| PKM | pyruvate kinase, muscle | -0.0181722 |
| HLA-B | major histocompatibility complex, class I, B | -0.0180673 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0178888 |
| FNIP1 | folliculin interacting protein 1 | -0.0175091 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0175039 |
| CA12 | carbonic anhydrase XII | -0.0170167 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0169596 |
| PRELID2 | PRELI domain containing 2 | -0.0167615 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0167028 |
| CUX1 | cut-like homeobox 1 | -0.0165369 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0163199 |
| TENM2 | teneurin transmembrane protein 2 | -0.0162603 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0162599 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0162517 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0162483 |
| HLA-A | major histocompatibility complex, class I, A | -0.0161854 |
| UBC | ubiquitin C | -0.0161367 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0161068 |
| VIM | vimentin | -0.0160135 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0159068 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0158668 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.015695 |
| COPA | coatomer protein complex, subunit alpha | -0.0154662 |
| NCKAP5 | NCK-associated protein 5 | -0.015279 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0152406 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0150785 |
| ZFHX3 | zinc finger homeobox 3 | -0.0149954 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0148543 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0146401 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0144555 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0143825 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0142062 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0141927 |
| FMNL2 | formin-like 2 | -0.0141578 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.014094 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0140705 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0138232 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0135534 |
| FLNA | filamin A, alpha | -0.013461 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0134496 |
| SQSTM1 | sequestosome 1 | -0.0134434 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | -0.013375 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0132802 |
| CHL1 | cell adhesion molecule L1-like | -0.0131815 |
| SPAG9 | sperm associated antigen 9 | -0.0131492 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0130379 |
| C1D | C1D nuclear receptor corepressor | -0.0129715 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0129082 |
