| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.122263 |
| MT2A | metallothionein 2A | 0.100966 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0914369 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0821633 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0700382 |
| EXT1 | exostosin glycosyltransferase 1 | 0.067588 |
| LDHA | lactate dehydrogenase A | 0.0586783 |
| PTMA | prothymosin, alpha | 0.0564346 |
| EFNA5 | ephrin-A5 | 0.0563437 |
| DTNA | dystrobrevin, alpha | 0.0556888 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0527834 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0520731 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 0.0519772 |
| WDR43 | WD repeat domain 43 | 0.0473129 |
| PKM | pyruvate kinase, muscle | 0.0471944 |
| FTL | ferritin, light polypeptide | 0.0471516 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.04592 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0445826 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0436691 |
| RPL23 | ribosomal protein L23 | 0.0428511 |
| SBF2 | SET binding factor 2 | 0.0415364 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0400069 |
| HELZ | helicase with zinc finger | 0.0374206 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0363248 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0354483 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0353752 |
| MED13 | mediator complex subunit 13 | 0.0346922 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0344899 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0327162 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0320664 |
| RPS23 | ribosomal protein S23 | 0.0316515 |
| XPO1 | exportin 1 | 0.0316058 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0312943 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0306617 |
| MATR3 | matrin 3 | 0.0305051 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0303041 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0300166 |
| QKI | QKI, KH domain containing, RNA binding | 0.0299011 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0296345 |
| RPS3 | ribosomal protein S3 | 0.0282987 |
| FLNB | filamin B, beta | 0.0280114 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0278326 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0277177 |
| S100A6 | S100 calcium binding protein A6 | 0.0272056 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0268816 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0268609 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0268076 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0267663 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0257007 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.025615 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0253452 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0253118 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0251793 |
| VCL | vinculin | 0.025113 |
| RPLP1 | ribosomal protein, large, P1 | 0.0238609 |
| RPLP2 | ribosomal protein, large, P2 | 0.0236431 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0234177 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0229951 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0221002 |
| CLTC | clathrin, heavy chain (Hc) | 0.0221 |
| THOC2 | THO complex 2 | 0.0217521 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0216079 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0215448 |
| WDR45B | WD repeat domain 45B | 0.021312 |
| TPM4 | tropomyosin 4 | 0.0209905 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0209417 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0207316 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0206563 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0200986 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.019555 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0193208 |
| EZR | ezrin | 0.0192775 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0192098 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0191888 |
| YAP1 | Yes-associated protein 1 | 0.0188571 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0183464 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.018261 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0181989 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0179406 |
| CUL3 | cullin 3 | 0.0175889 |
| CD109 | CD109 molecule | 0.0174264 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0171113 |
| RUNX1 | runt-related transcription factor 1 | 0.015779 |
| ASPH | aspartate beta-hydroxylase | 0.0155017 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0152204 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0150032 |
| SPAG9 | sperm associated antigen 9 | 0.0148784 |
| RPL12 | ribosomal protein L12 | 0.0147363 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0143864 |
| ETNK1 | ethanolamine kinase 1 | 0.0143375 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0143148 |
| SEC24D | SEC24 family member D | 0.0142713 |
| TMF1 | TATA element modulatory factor 1 | 0.0142563 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0141774 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0140533 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.01396 |
| FAM107B | family with sequence similarity 107, member B | 0.0138747 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0136312 |
| RASA2 | RAS p21 protein activator 2 | 0.0135469 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0131903 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.0868693 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0634377 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0554149 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0516622 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0498829 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.049552 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0487654 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0419432 |
| MED13L | mediator complex subunit 13-like | -0.0382845 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0380046 |
| ATXN1 | ataxin 1 | -0.0373592 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0353924 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0346605 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0344443 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0343749 |
| PARD3 | par-3 family cell polarity regulator | -0.0341039 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0340348 |
| NBEA | neurobeachin | -0.0335172 |
| AK1 | adenylate kinase 1 | -0.0333508 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0329159 |
| SLTM | SAFB-like, transcription modulator | -0.0316075 |
| FOXO3 | forkhead box O3 | -0.0310621 |
| FOXJ3 | forkhead box J3 | -0.0307663 |
| SUMF1 | sulfatase modifying factor 1 | -0.0307116 |
| OSMR | oncostatin M receptor | -0.0302867 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0297344 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0289838 |
| TXNIP | thioredoxin interacting protein | -0.0286746 |
| ZNF292 | zinc finger protein 292 | -0.0286292 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0284265 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0282601 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0282165 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.027584 |
| FRYL | FRY-like | -0.0275111 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0273543 |
| TMEM123 | transmembrane protein 123 | -0.0271358 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0270175 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0264974 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.026068 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0254481 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.025414 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0242525 |
| PDE8A | phosphodiesterase 8A | -0.0241432 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | -0.0239481 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0236687 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0230927 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0230544 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0228199 |
| ARF4 | ADP-ribosylation factor 4 | -0.0228147 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0226535 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0223205 |
| SMAD3 | SMAD family member 3 | -0.0222456 |
| RPS27A | ribosomal protein S27a | -0.0222398 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0220756 |
| ATP11A | ATPase, class VI, type 11A | -0.0219956 |
| ENO1 | enolase 1, (alpha) | -0.0219353 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0216887 |
| NKTR | natural killer cell triggering receptor | -0.0215656 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.021343 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0213182 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0212454 |
| GPHN | gephyrin | -0.020864 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0207361 |
| VGF | VGF nerve growth factor inducible | -0.0205633 |
| USP3 | ubiquitin specific peptidase 3 | -0.0204461 |
| RYBP | RING1 and YY1 binding protein | -0.0203113 |
| SQSTM1 | sequestosome 1 | -0.0202641 |
| NOP58 | NOP58 ribonucleoprotein | -0.0192421 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0188063 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0185703 |
| MYO1E | myosin IE | -0.0184564 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0183799 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0183782 |
| CNKSR3 | CNKSR family member 3 | -0.0181541 |
| SRSF4 | serine/arginine-rich splicing factor 4 | -0.0181535 |
| CDYL | chromodomain protein, Y-like | -0.0181411 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.018123 |
| NHSL1 | NHS-like 1 | -0.0177672 |
| TES | testin LIM domain protein | -0.0176624 |
| MYO10 | myosin X | -0.017583 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0175548 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0173064 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0172457 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0171626 |
| MORF4L2 | mortality factor 4 like 2 | -0.0165911 |
| RBM25 | RNA binding motif protein 25 | -0.0165305 |
| RFX7 | regulatory factor X, 7 | -0.0164518 |
| DST | dystonin | -0.015752 |
| UBAC2 | UBA domain containing 2 | -0.0157057 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0153845 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0153335 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.015155 |
| MCL1 | myeloid cell leukemia 1 | -0.0149617 |
| GSE1 | Gse1 coiled-coil protein | -0.0148857 |
| SETD5 | SET domain containing 5 | -0.0147288 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0143905 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.014242 |
| ITGA1 | integrin, alpha 1 | -0.0141646 |
| KIAA1217 | KIAA1217 | -0.0140322 |
| FMNL2 | formin-like 2 | -0.0136932 |
