| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF292 | zinc finger protein 292 | 0.0774428 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.064085 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0548409 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.052724 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0456221 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.043352 |
| MEMO1 | mediator of cell motility 1 | 0.0418068 |
| RPL23 | ribosomal protein L23 | 0.0416828 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0382714 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0365944 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0359266 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.035379 |
| PAXBP1 | PAX3 and PAX7 binding protein 1 | 0.0348282 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0344776 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.034323 |
| RPL11 | ribosomal protein L11 | 0.0342675 |
| RPS12 | ribosomal protein S12 | 0.0330881 |
| RPS8 | ribosomal protein S8 | 0.0329793 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0327038 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0322578 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0311491 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0309146 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0308253 |
| NPAS3 | neuronal PAS domain protein 3 | 0.0306165 |
| RPS16 | ribosomal protein S16 | 0.0302534 |
| ENO1 | enolase 1, (alpha) | 0.0296005 |
| RPS3 | ribosomal protein S3 | 0.0295955 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0295053 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.0288892 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0279006 |
| ANK2 | ankyrin 2, neuronal | 0.0278815 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0274181 |
| GNAS | GNAS complex locus | 0.0271999 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.027147 |
| SFRP4 | secreted frizzled-related protein 4 | 0.0270675 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0267732 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0264991 |
| PTMA | prothymosin, alpha | 0.0262796 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0262669 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0259623 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0256908 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0255771 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0253005 |
| MT2A | metallothionein 2A | 0.0252107 |
| NDRG1 | N-myc downstream regulated 1 | 0.0250855 |
| RPL7A | ribosomal protein L7a | 0.0250652 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0249594 |
| RPL35A | ribosomal protein L35a | 0.0246666 |
| RPL36A | ribosomal protein L36a | 0.0243879 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0243754 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0242282 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0239201 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0235807 |
| RPS25 | ribosomal protein S25 | 0.0235679 |
| PHIP | pleckstrin homology domain interacting protein | 0.0235652 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0233731 |
| JMJD1C | jumonji domain containing 1C | 0.0232669 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0232195 |
| USP3 | ubiquitin specific peptidase 3 | 0.0231874 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0231096 |
| RPLP1 | ribosomal protein, large, P1 | 0.0229712 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0228602 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0227792 |
| RTN3 | reticulon 3 | 0.0222366 |
| RPS6 | ribosomal protein S6 | 0.0222016 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0220993 |
| KIF13A | kinesin family member 13A | 0.0220233 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0217696 |
| RPS27 | ribosomal protein S27 | 0.0216112 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0215687 |
| FTL | ferritin, light polypeptide | 0.020658 |
| CAVIN1 | caveolae associated protein 1 | 0.0206113 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0205397 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0204941 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0204688 |
| GRB2 | growth factor receptor-bound protein 2 | 0.0204314 |
| GPC3 | glypican 3 | 0.0204139 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0202383 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.020178 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0201566 |
| RPL26 | ribosomal protein L26 | 0.0201155 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0200501 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.019972 |
| SNU13 | small nuclear ribonucleoprotein 13 | 0.0199289 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0199245 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.019679 |
| SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein) | 0.0196336 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0194756 |
| APOE | apolipoprotein E | 0.0191858 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0191484 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | 0.0191082 |
| TPM4 | tropomyosin 4 | 0.0190483 |
| BEX3 | brain expressed X-linked 3 | 0.0189633 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0188876 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0187636 |
| H2AC6 | H2A clustered histone 6 | 0.0187265 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0187128 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | 0.0184611 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | 0.0184509 |
| MPG | N-methylpurine-DNA glycosylase | 0.0184242 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PEG10 | paternally expressed 10 | -0.100598 |
| ITGAV | integrin, alpha V | -0.0853772 |
| SPAG9 | sperm associated antigen 9 | -0.0739253 |
| TMSB10 | thymosin beta 10 | -0.0582551 |
| MKI67 | marker of proliferation Ki-67 | -0.0544567 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0475902 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0466279 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0457131 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0448698 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0448042 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0446841 |
| SMYD3 | SET and MYND domain containing 3 | -0.0446702 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0440456 |
| POTEF | POTE ankyrin domain family, member F | -0.0422021 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0408465 |
| TXNRD1 | thioredoxin reductase 1 | -0.0407265 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0395206 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0377416 |
| DST | dystonin | -0.0376075 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0365794 |
| ECT2 | epithelial cell transforming 2 | -0.0365062 |
| CKAP2 | cytoskeleton associated protein 2 | -0.036076 |
| VIM | vimentin | -0.0356687 |
| METAP2 | methionyl aminopeptidase 2 | -0.034695 |
| RIGI | RNA sensor RIG-I | -0.0346662 |
| BRD2 | bromodomain containing 2 | -0.0337268 |
| ENAH | enabled homolog (Drosophila) | -0.033483 |
| ACTG1 | actin gamma 1 | -0.0329158 |
| THBS1 | thrombospondin 1 | -0.0329038 |
| COL3A1 | collagen, type III, alpha 1 | -0.0328526 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0328514 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0322653 |
| MAP4 | microtubule-associated protein 4 | -0.0320173 |
| NRG1 | neuregulin 1 | -0.0319887 |
| UBC | ubiquitin C | -0.0319755 |
| AHNAK | AHNAK nucleoprotein | -0.0317341 |
| CADM2 | cell adhesion molecule 2 | -0.0311888 |
| WDR43 | WD repeat domain 43 | -0.0311561 |
| PCBP2 | poly(rC) binding protein 2 | -0.0311273 |
| TPX2 | TPX2, microtubule-associated | -0.0309793 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0309624 |
| OLA1 | Obg-like ATPase 1 | -0.0308303 |
| SMC4 | structural maintenance of chromosomes 4 | -0.030568 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0305021 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0303968 |
| CENPF | centromere protein F, 350/400kDa | -0.0302512 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0298056 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0297795 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0295954 |
| COL5A2 | collagen, type V, alpha 2 | -0.0287253 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0285672 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.028184 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.027816 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | -0.0276235 |
| USP25 | ubiquitin specific peptidase 25 | -0.0272053 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.0271673 |
| FGF13 | fibroblast growth factor 13 | -0.0270335 |
| UTRN | utrophin | -0.0268151 |
| CCN2 | cellular communication network factor 2 | -0.0264161 |
| TEX11 | testis expressed 11 | -0.0256596 |
| SFPQ | splicing factor proline/glutamine-rich | -0.02552 |
| SGO2 | shugoshin 2 | -0.0254808 |
| RSF1 | remodeling and spacing factor 1 | -0.0253816 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0252054 |
| NOP58 | NOP58 ribonucleoprotein | -0.0248877 |
| ANLN | anillin, actin binding protein | -0.0247799 |
| RTTN | rotatin | -0.0243773 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0242116 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.024173 |
| COL1A2 | collagen, type I, alpha 2 | -0.0241573 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0238318 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0236502 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0236223 |
| FNIP1 | folliculin interacting protein 1 | -0.0236205 |
| MEIS2 | Meis homeobox 2 | -0.0235752 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.023571 |
| HDLBP | high density lipoprotein binding protein | -0.0235307 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0232976 |
| TMEM123 | transmembrane protein 123 | -0.0231262 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0228573 |
| FAT1 | FAT atypical cadherin 1 | -0.0228294 |
| SP3 | Sp3 transcription factor | -0.0227618 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0226002 |
| ANXA2 | annexin A2 | -0.022593 |
| EMP1 | epithelial membrane protein 1 | -0.0223504 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0221156 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0218736 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0216385 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0216199 |
| CTPS1 | CTP synthase 1 | -0.0216074 |
| SERTAD2 | SERTA domain containing 2 | -0.0215896 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.0215105 |
| NDC80 | NDC80 kinetochore complex component | -0.0214914 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.021399 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | -0.0213831 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0213629 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0211264 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0209831 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0208179 |
| TBC1D22B | TBC1 domain family, member 22B | -0.0208177 |
