Loperamide (hydrochloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 0.289429
AKAP12 A kinase (PRKA) anchor protein 12 0.276923
VIM vimentin 0.227843
PTMA prothymosin, alpha 0.142659
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.118401
FBL fibrillarin 0.110882
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.110608
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0782917
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0758845
ENO1 enolase 1, (alpha) 0.0588017
S100A6 S100 calcium binding protein A6 0.0551136
TMSB10 thymosin beta 10 0.0546235
FTL ferritin, light polypeptide 0.0533881
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0532442
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0523278
RPS3 ribosomal protein S3 0.0521856
RPLP2 ribosomal protein, large, P2 0.0505207
RPL35A ribosomal protein L35a 0.0500359
RPS8 ribosomal protein S8 0.0479566
RPLP0 ribosomal protein, large, P0 0.0469837
KTN1 kinectin 1 (kinesin receptor) 0.0466047
RPLP1 ribosomal protein, large, P1 0.0463566
NAP1L1 nucleosome assembly protein 1-like 1 0.0458808
RPS12 ribosomal protein S12 0.0442783
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0437308
MT2A metallothionein 2A 0.0431615
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0406651
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0405958
CANX calnexin 0.0392165
RPL37A ribosomal protein L37a 0.0364125
PDIA3 protein disulfide isomerase family A, member 3 0.0358507
RPS25 ribosomal protein S25 0.0356297
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0351472
RPL11 ribosomal protein L11 0.0347781
LDHA lactate dehydrogenase A 0.034451
RPL23 ribosomal protein L23 0.0326456
RACK1 receptor for activated C kinase 1 0.0323767
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0315023
RPS27A ribosomal protein S27a 0.0310304
EIF1 eukaryotic translation initiation factor 1 0.0310012
B2M beta-2-microglobulin 0.029421
GOLGA4 golgin A4 0.029216
PGK1 phosphoglycerate kinase 1 0.0289376
RPL12 ribosomal protein L12 0.0282605
SET SET nuclear proto-oncogene 0.0280518
RPS17 ribosomal protein S17 0.0279298
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0276457
CALR calreticulin 0.0275979
RPS13 ribosomal protein S13 0.0275403
RPS6 ribosomal protein S6 0.0272248
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0271955
YBX1 Y box binding protein 1 0.027184
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0266822
RPL27A ribosomal protein L27a 0.0265418
DDIT4 DNA-damage-inducible transcript 4 0.0262764
SEPTIN7 septin 7 0.0262557
ANGPTL4 angiopoietin-like 4 0.0260999
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0256959
RPS24 ribosomal protein S24 0.025584
TPT1 tumor protein, translationally-controlled 1 0.0255137
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0254692
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0253239
RPS19 ribosomal protein S19 0.0253226
RPS14 ribosomal protein S14 0.0252332
RPS5 ribosomal protein S5 0.0252229
APLP2 amyloid beta (A4) precursor-like protein 2 0.0250251
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0249733
RPL26 ribosomal protein L26 0.0249706
EIF3K eukaryotic translation initiation factor 3, subunit K 0.0244601
PKM pyruvate kinase, muscle 0.0243118
SPAG9 sperm associated antigen 9 0.0239498
SFTPA2 surfactant protein A2 0.0233701
RPL31 ribosomal protein L31 0.0231088
SQSTM1 sequestosome 1 0.0228399
PDIA6 protein disulfide isomerase family A, member 6 0.0227115
IFITM3 interferon induced transmembrane protein 3 0.0223233
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0222749
RPL7 ribosomal protein L7 0.0221632
BIRC3 baculoviral IAP repeat containing 3 0.0220239
FMNL2 formin-like 2 0.0219844
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0219103
RPL36A ribosomal protein L36a 0.0217479
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0214972
MYOF myoferlin 0.0214148
RPL37 ribosomal protein L37 0.0205963
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.020029
ADM adrenomedullin 0.0199746
DSTN destrin (actin depolymerizing factor) 0.0197071
KIF5B kinesin family member 5B 0.0196221
RPS23 ribosomal protein S23 0.0195359
CENPF centromere protein F, 350/400kDa 0.0189228
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0188589
ZNF292 zinc finger protein 292 0.0185737
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0183894
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0183859
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 0.0183583
RPL10A ribosomal protein L10a 0.0183257
KDM2A lysine (K)-specific demethylase 2A 0.018131
LGALS1 lectin, galactoside-binding, soluble, 1 0.0179093
SNX14 sorting nexin 14 0.0178846

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.150474
ACTN4 actinin, alpha 4 -0.0569958
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.0432876
ZFP36 ZFP36 ring finger protein -0.0386089
WWTR1 WW domain containing transcription regulator 1 -0.0378518
CD44 CD44 molecule (Indian blood group) -0.0375478
EGR1 early growth response 1 -0.037161
CARD18 caspase recruitment domain family, member 18 -0.0340435
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0307482
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0286126
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0262776
SPRED2 sprouty-related, EVH1 domain containing 2 -0.026192
NCEH1 neutral cholesterol ester hydrolase 1 -0.0255864
TM4SF1 transmembrane 4 L six family member 1 -0.0247374
SLC38A2 solute carrier family 38, member 2 -0.023307
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0225791
EXT1 exostosin glycosyltransferase 1 -0.0224491
OSMR oncostatin M receptor -0.0222004
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0221131
UBASH3B ubiquitin associated and SH3 domain containing B -0.0220029
FHL2 four and a half LIM domains 2 -0.0218927
VMP1 vacuole membrane protein 1 -0.0216209
THSD4 thrombospondin, type I, domain containing 4 -0.0214699
SLC35F3 solute carrier family 35, member F3 -0.0212809
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0210507
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0206851
RASAL2 RAS protein activator like 2 -0.0206311
ZNF780B zinc finger protein 780B -0.020326
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0200688
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0199516
BMAL2 basic helix-loop-helix ARNT like 2 -0.019642
ZNF644 zinc finger protein 644 -0.0189328
SDK1 sidekick cell adhesion molecule 1 -0.0188863
NUP98 nucleoporin 98kDa -0.0182048
SMYD3 SET and MYND domain containing 3 -0.0181253
SAMD4B sterile alpha motif domain containing 4B -0.0177599
SMAD3 SMAD family member 3 -0.0176669
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0174056
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0171494
RTN4 reticulon 4 -0.0170351
JMJD1C jumonji domain containing 1C -0.0168158
DSCAM Down syndrome cell adhesion molecule -0.0166626
ITGB5 integrin, beta 5 -0.0162568
PHF14 PHD finger protein 14 -0.0161237
ARHGAP29 Rho GTPase activating protein 29 -0.0160868
BMP6 bone morphogenetic protein 6 -0.0157852
AKT2 v-akt murine thymoma viral oncogene homolog 2 -0.0157809
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0157284
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0156069
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0155401
NABP1 nucleic acid binding protein 1 -0.0154802
NPAS2 neuronal PAS domain protein 2 -0.0154634
TPM1 tropomyosin 1 (alpha) -0.0145403
RAP1B RAP1B, member of RAS oncogene family -0.0145118
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0143496
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.014106
NPC1 Niemann-Pick disease, type C1 -0.0140718
ITGAV integrin, alpha V -0.0140516
MCTP1 multiple C2 domains, transmembrane 1 -0.0139553
ZBTB20 zinc finger and BTB domain containing 20 -0.0138377
ADGRG6 adhesion G protein-coupled receptor G6 -0.0138184
MSRB3 methionine sulfoxide reductase B3 -0.0137552
ELL2 elongation factor, RNA polymerase II, 2 -0.0131121
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0130907
EFNA5 ephrin-A5 -0.0130088
RSU1 Ras suppressor protein 1 -0.012927
ATP9B ATPase, class II, type 9B -0.0128964
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0128138
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0127386
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0126742
MOSMO modulator of smoothened -0.0126713
EPAS1 endothelial PAS domain protein 1 -0.0123326
BCL2L1 BCL2-like 1 -0.0122104
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0121223
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0120809
MCL1 myeloid cell leukemia 1 -0.0119556
ZC3H12B zinc finger CCCH-type containing 12B -0.0117394
EGFR epidermal growth factor receptor -0.0116409
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0114845
PDE10A phosphodiesterase 10A -0.0113655
SPIDR scaffolding protein involved in DNA repair -0.0110397
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0107917
TNRC18 trinucleotide repeat containing 18 -0.0107517
WDR27 WD repeat domain 27 -0.0107245
RABGAP1L RAB GTPase activating protein 1-like -0.0104212
ANKRD28 ankyrin repeat domain 28 -0.0104164
RAB7A RAB7A, member RAS oncogene family -0.0103741
AOPEP aminopeptidase O (putative) -0.0103006
LPP LIM domain containing preferred translocation partner in lipoma -0.0102451
CCN2 cellular communication network factor 2 -0.0100913
FAM3C family with sequence similarity 3, member C -0.0100913
NT5E 5'-nucleotidase, ecto (CD73) -0.0100847
TTC28 tetratricopeptide repeat domain 28 -0.0100739
FRMD5 FERM domain containing 5 -0.0100498
EXOC4 exocyst complex component 4 -0.0100413
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.0100106
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.00991791
ATF6 activating transcription factor 6 -0.00986439
DNMBP dynamin binding protein -0.00986415
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.00967889