Loperamide (hydrochloride)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.125664
MT2A metallothionein 2A 0.118725
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0881905
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.085943
RPL35A ribosomal protein L35a 0.083718
FRMD6 FERM domain containing 6 0.0787402
RPS8 ribosomal protein S8 0.0781937
ZNF438 zinc finger protein 438 0.0745468
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0741938
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0733833
RPL12 ribosomal protein L12 0.0711154
RPLP0 ribosomal protein, large, P0 0.0674502
RPL7 ribosomal protein L7 0.0640312
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0640289
FTL ferritin, light polypeptide 0.0534246
RPL37A ribosomal protein L37a 0.0491005
RPS2 ribosomal protein S2 0.0486613
RPLP1 ribosomal protein, large, P1 0.0485522
RPL35 ribosomal protein L35 0.048204
RAD51B RAD51 paralog B 0.0467753
RPL11 ribosomal protein L11 0.0466879
RPLP2 ribosomal protein, large, P2 0.0418477
RPS12 ribosomal protein S12 0.0406285
RPL7A ribosomal protein L7a 0.0406058
RPL19 ribosomal protein L19 0.0397966
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0390156
TPT1 tumor protein, translationally-controlled 1 0.0388113
PTMA prothymosin, alpha 0.0387452
RPS25 ribosomal protein S25 0.0384447
RPS14 ribosomal protein S14 0.0381048
RPS19 ribosomal protein S19 0.0379123
RACK1 receptor for activated C kinase 1 0.0365895
RPS20 ribosomal protein S20 0.0364017
RPS17 ribosomal protein S17 0.0358138
RPL23 ribosomal protein L23 0.035031
RPL26 ribosomal protein L26 0.0348138
RPL34 ribosomal protein L34 0.0334596
RPS3 ribosomal protein S3 0.0330623
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0329621
AKAP9 A kinase (PRKA) anchor protein 9 0.0327038
RPL10A ribosomal protein L10a 0.0325901
RPL27A ribosomal protein L27a 0.0323491
RPL36 ribosomal protein L36 0.0312208
RPL37 ribosomal protein L37 0.0306121
RPL9 ribosomal protein L9 0.0298876
KPNB1 karyopherin (importin) beta 1 0.0295519
NAV3 neuron navigator 3 0.0291703
PA2G4 proliferation-associated 2G4, 38kDa 0.0290966
PDIA3 protein disulfide isomerase family A, member 3 0.0289205
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.028772
RPS26 ribosomal protein S26 0.028621
BNC2 basonuclin 2 0.0286197
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0282179
RPS21 ribosomal protein S21 0.0281838
RPS16 ribosomal protein S16 0.0270834
ANK2 ankyrin 2, neuronal 0.0262916
RPL13A ribosomal protein L13a 0.0261676
ASPH aspartate beta-hydroxylase 0.0261599
MTAP methylthioadenosine phosphorylase 0.0259348
RPL27 ribosomal protein L27 0.0256169
RPL21 ribosomal protein L21 0.0255115
RPL31 ribosomal protein L31 0.0250285
RPL8 ribosomal protein L8 0.0243551
IFI16 interferon, gamma-inducible protein 16 0.0241929
RSL24D1 ribosomal L24 domain containing 1 0.0228293
RPS13 ribosomal protein S13 0.0226064
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0225749
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0223379
ZSWIM6 zinc finger, SWIM-type containing 6 0.0222646
RPS29 ribosomal protein S29 0.0222518
FRMD4A FERM domain containing 4A 0.0218712
RPS27 ribosomal protein S27 0.0212813
RPL18 ribosomal protein L18 0.0211949
S100A9 S100 calcium binding protein A9 0.0207905
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0207764
RPL28 ribosomal protein L28 0.0206347
RPL5 ribosomal protein L5 0.0205907
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0205655
MXI1 MAX interactor 1, dimerization protein 0.0205358
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.020423
RPS10 ribosomal protein S10 0.020402
RPL39 ribosomal protein L39 0.020319
SET SET nuclear proto-oncogene 0.0202508
RSL1D1 ribosomal L1 domain containing 1 0.0193468
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0191126
PHF3 PHD finger protein 3 0.0191101
DDR2 discoidin domain receptor tyrosine kinase 2 0.0191053
SCAF11 SR-related CTD-associated factor 11 0.0190332
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0190321
MYRFL myelin regulatory factor-like 0.01886
HMGA2 high mobility group AT-hook 2 0.0184477
RPS7 ribosomal protein S7 0.0183279
NACA nascent polypeptide-associated complex alpha subunit 0.0182915
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0182411
YBX1 Y box binding protein 1 0.017723
LDHB lactate dehydrogenase B 0.0176138
GLRX glutaredoxin (thioltransferase) 0.0176135
KTN1 kinectin 1 (kinesin receptor) 0.0176064
RPL38 ribosomal protein L38 0.0175669
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.0175505

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.131377
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.121801
ACTG1 actin gamma 1 -0.116461
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.091398
TXNRD1 thioredoxin reductase 1 -0.0873211
AHNAK AHNAK nucleoprotein -0.0829683
JUN jun proto-oncogene -0.0807156
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0691146
PTK2 protein tyrosine kinase 2 -0.0660192
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0598206
PRRC2B proline-rich coiled-coil 2B -0.0580204
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0576141
RBM25 RNA binding motif protein 25 -0.0526967
EEF2 eukaryotic translation elongation factor 2 -0.0519016
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0512141
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0507988
JMJD1C jumonji domain containing 1C -0.0507829
CALU calumenin -0.0493301
DSCAM Down syndrome cell adhesion molecule -0.0473645
ANKRD17 ankyrin repeat domain 17 -0.0461337
C2CD2 C2 calcium-dependent domain containing 2 -0.0458049
ZFAND3 zinc finger, AN1-type domain 3 -0.0444479
LOC112694756 uncharaterized LOC112694756 -0.0441932
ZEB1 zinc finger E-box binding homeobox 1 -0.0440422
SFPQ splicing factor proline/glutamine-rich -0.0415141
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0394749
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0393899
MCL1 myeloid cell leukemia 1 -0.0392243
CD44 CD44 molecule (Indian blood group) -0.0380824
DLC1 DLC1 Rho GTPase activating protein -0.0374896
IARS1 isoleucyl-tRNA synthetase 1 -0.037124
CORO1C coronin, actin binding protein, 1C -0.035978
PCBP2 poly(rC) binding protein 2 -0.0359154
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0358771
RBM39 RNA binding motif protein 39 -0.035508
OGA O-GlcNAcase -0.0350797
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0344954
FUBP3 far upstream element (FUSE) binding protein 3 -0.0344415
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0340551
ANTXR2 anthrax toxin receptor 2 -0.0338021
RTN4 reticulon 4 -0.0332581
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0330257
NF1 neurofibromin 1 -0.0321493
SETX senataxin -0.0317764
RASA2 RAS p21 protein activator 2 -0.031596
APP amyloid beta (A4) precursor protein -0.0310766
RBM33 RNA binding motif protein 33 -0.0306467
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0301874
CAPN2 calpain 2, (m/II) large subunit -0.030116
USP34 ubiquitin specific peptidase 34 -0.0297019
RPS27A ribosomal protein S27a -0.0293823
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0292664
EXT1 exostosin glycosyltransferase 1 -0.0288728
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0288367
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0284271
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0283747
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0283468
TRIO trio Rho guanine nucleotide exchange factor -0.0283331
FLNB filamin B, beta -0.0281888
SEC16A SEC16 homolog A (S. cerevisiae) -0.0276947
MYH9 myosin, heavy chain 9, non-muscle -0.0276037
FLNA filamin A, alpha -0.0275105
BIRC6 baculoviral IAP repeat containing 6 -0.0274395
STK4 serine/threonine kinase 4 -0.0267236
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0265396
BRD4 bromodomain containing 4 -0.0265343
COG5 component of oligomeric golgi complex 5 -0.026348
FER fer (fps/fes related) tyrosine kinase -0.0262319
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -0.0261327
ACTN1 actinin, alpha 1 -0.0260768
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0258687
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0257638
MAP4 microtubule-associated protein 4 -0.0257056
PUM1 pumilio RNA-binding family member 1 -0.0257017
ATP13A3 ATPase type 13A3 -0.0256492
NIPBL Nipped-B homolog (Drosophila) -0.0253463
SPRY4 sprouty homolog 4 (Drosophila) -0.0252298
TM9SF3 transmembrane 9 superfamily member 3 -0.0251269
STAU2 staufen double-stranded RNA binding protein 2 -0.0250147
USP9X ubiquitin specific peptidase 9, X-linked -0.0246874
ADAM17 ADAM metallopeptidase domain 17 -0.0246031
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0245755
TOP1 topoisomerase (DNA) I -0.0245653
SRPK2 SRSF protein kinase 2 -0.0242223
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0237591
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0237306
KDM5C lysine (K)-specific demethylase 5C -0.023192
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0231665
TUT7 terminal uridylyl transferase 7 -0.0230048
G0S2 G0/G1 switch 2 -0.0229966
PARD3 par-3 family cell polarity regulator -0.0228951
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0227881
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0227787
CDK17 cyclin-dependent kinase 17 -0.0227232
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0227016
RUNX1 runt-related transcription factor 1 -0.0226914
FUS FUS RNA binding protein -0.0226438
FAM91A1 family with sequence similarity 91, member A1 -0.0226318
ERBIN erbb2 interacting protein -0.0223974
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.022236