Loperamide (hydrochloride)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.100154
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.07311
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0578824
PGK1 phosphoglycerate kinase 1 0.055387
ZNF292 zinc finger protein 292 0.0494934
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0394075
GOLGA4 golgin A4 0.0390911
KDM3A lysine (K)-specific demethylase 3A 0.0380719
XPO1 exportin 1 0.0364414
CXCL8 chemokine (C-X-C motif) ligand 8 0.0346988
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0340184
CANX calnexin 0.0338505
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0331294
FAM13A family with sequence similarity 13, member A 0.0327593
ATP13A3 ATPase type 13A3 0.0313107
GARS1 glycyl-tRNA synthetase 1 0.0294819
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0293656
CD109 CD109 molecule 0.0290795
HELZ helicase with zinc finger 0.0283315
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0281495
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0272901
HMGB2 high mobility group box 2 0.0272584
RLF rearranged L-myc fusion 0.0269782
MEF2A myocyte enhancer factor 2A 0.0269761
CDC73 cell division cycle 73 0.0266209
ERRFI1 ERBB receptor feedback inhibitor 1 0.0260964
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0258718
BHLHE40 basic helix-loop-helix family, member e40 0.0254526
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0254461
CENPF centromere protein F, 350/400kDa 0.0249223
SRP54 signal recognition particle 54kDa 0.0248131
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0248042
LDHA lactate dehydrogenase A 0.02469
HILPDA hypoxia inducible lipid droplet-associated 0.0246648
FXR1 fragile X mental retardation, autosomal homolog 1 0.0245288
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0244718
SERINC1 serine incorporator 1 0.0242821
NUP58 nucleoporin 58 0.0242246
LCORL ligand dependent nuclear receptor corepressor-like 0.0234471
OGA O-GlcNAcase 0.023285
INSIG2 insulin induced gene 2 0.0232447
YME1L1 YME1-like 1 ATPase 0.0227454
RAD21 RAD21 homolog (S. pombe) 0.0226039
RAB8B RAB8B, member RAS oncogene family 0.0222352
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0222203
RAB1A RAB1A, member RAS oncogene family 0.0215848
DDIT4 DNA-damage-inducible transcript 4 0.0215401
RBM39 RNA binding motif protein 39 0.0214012
MYH9 myosin, heavy chain 9, non-muscle 0.0212786
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0211865
FAM162A family with sequence similarity 162, member A 0.0211822
USP37 ubiquitin specific peptidase 37 0.0208294
ELL2 elongation factor, RNA polymerase II, 2 0.020655
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0203885
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.020235
PPME1 protein phosphatase methylesterase 1 0.0202246
ESYT2 extended synaptotagmin-like protein 2 0.0201866
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0199998
SUCO SUN domain containing ossification factor 0.0198785
TRA2A transformer 2 alpha homolog (Drosophila) 0.01961
MYOF myoferlin 0.0189193
SET SET nuclear proto-oncogene 0.0186393
MXI1 MAX interactor 1, dimerization protein 0.018608
UBA6 ubiquitin-like modifier activating enzyme 6 0.0184003
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0183709
ENO1 enolase 1, (alpha) 0.0183536
KIF5B kinesin family member 5B 0.0182577
QKI QKI, KH domain containing, RNA binding 0.0182196
TFG TRK-fused gene 0.0181926
FAM168A family with sequence similarity 168, member A 0.0181129
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0179383
TMEM39A transmembrane protein 39A 0.0177674
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0177368
RAB6A RAB6A, member RAS oncogene family 0.0177173
USP3 ubiquitin specific peptidase 3 0.0177002
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0175368
MIMS1 mitochondrial inner membrane scaffold 1 0.0175181
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0173224
NCKAP1 NCK-associated protein 1 0.0171717
NBAS neuroblastoma amplified sequence 0.0170238
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0169002
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0167932
BZW1 basic leucine zipper and W2 domains 1 0.0167649
RAD23B RAD23 homolog B (S. cerevisiae) 0.0166488
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.016398
NAP1L1 nucleosome assembly protein 1-like 1 0.0163296
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0162914
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0162518
TP53BP1 tumor protein p53 binding protein 1 0.0161239
RNF145 ring finger protein 145 0.0160834
BRWD3 bromodomain and WD repeat domain containing 3 0.0160133
WDR43 WD repeat domain 43 0.0157352
SEC23A Sec23 homolog A (S. cerevisiae) 0.0156776
TPM3 tropomyosin 3 0.0156604
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0155709
COPA coatomer protein complex, subunit alpha 0.0155587
ANXA2 annexin A2 0.0154736
ADAM17 ADAM metallopeptidase domain 17 0.0154609
PDIA6 protein disulfide isomerase family A, member 6 0.0154545
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0154033

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.252489
FN1 fibronectin 1 -0.189997
MT2A metallothionein 2A -0.159545
STC1 stanniocalcin 1 -0.154219
NDRG1 N-myc downstream regulated 1 -0.14674
HLA-B major histocompatibility complex, class I, B -0.120972
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.109824
TMSB10 thymosin beta 10 -0.0965504
CD44 CD44 molecule (Indian blood group) -0.0909414
VIM vimentin -0.0761298
B2M beta-2-microglobulin -0.0751282
FTL ferritin, light polypeptide -0.0697192
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0656476
PKM pyruvate kinase, muscle -0.0618567
COL1A1 collagen, type I, alpha 1 -0.0602349
NRP1 neuropilin 1 -0.0592099
COL6A1 collagen, type VI, alpha 1 -0.0535232
PSD3 pleckstrin and Sec7 domain containing 3 -0.0527255
FRMD4A FERM domain containing 4A -0.051975
EGR1 early growth response 1 -0.0512614
NAV1 neuron navigator 1 -0.0506627
POTEF POTE ankyrin domain family, member F -0.0494268
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0464157
TGFBI transforming growth factor, beta-induced, 68kDa -0.0460344
VEGFA vascular endothelial growth factor A -0.0429253
IFI6 interferon, alpha-inducible protein 6 -0.041495
RPL35A ribosomal protein L35a -0.0407171
PTPRG protein tyrosine phosphatase, receptor type, G -0.0401586
RPLP1 ribosomal protein, large, P1 -0.0399655
HLA-A major histocompatibility complex, class I, A -0.0395394
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0378574
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0376383
SP100 SP100 nuclear antigen -0.0374258
NPAS2 neuronal PAS domain protein 2 -0.0371332
IFITM3 interferon induced transmembrane protein 3 -0.0370246
ZBTB38 zinc finger and BTB domain containing 38 -0.0370246
TPM1 tropomyosin 1 (alpha) -0.0366896
RPS19 ribosomal protein S19 -0.0365159
RAB7A RAB7A, member RAS oncogene family -0.0354607
ZBTB20 zinc finger and BTB domain containing 20 -0.0349934
HLA-C major histocompatibility complex, class I, C -0.0344871
ACTG1 actin gamma 1 -0.0342402
LOC112694756 uncharaterized LOC112694756 -0.0339522
FNDC3B fibronectin type III domain containing 3B -0.0336892
CST3 cystatin C -0.0328477
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.032795
COL5A1 collagen, type V, alpha 1 -0.0319588
COL6A2 collagen, type VI, alpha 2 -0.0316146
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0315419
TFPI2 tissue factor pathway inhibitor 2 -0.0315342
FHIT fragile histidine triad -0.03152
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.0311531
GLIS3 GLIS family zinc finger 3 -0.0310596
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0306585
ICAM1 intercellular adhesion molecule 1 -0.0300229
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0297075
FTH1 ferritin, heavy polypeptide 1 -0.0290163
RPL28 ribosomal protein L28 -0.0288188
FOSL1 FOS-like antigen 1 -0.0287433
TPM4 tropomyosin 4 -0.028626
CDH13 cadherin 13 -0.0282539
EXT1 exostosin glycosyltransferase 1 -0.0281084
IFI16 interferon, gamma-inducible protein 16 -0.0280314
RPS6 ribosomal protein S6 -0.0274473
S100A9 S100 calcium binding protein A9 -0.0268076
SVIL supervillin -0.0267474
RPS21 ribosomal protein S21 -0.0266959
LOXL2 lysyl oxidase-like 2 -0.0266898
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0265165
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0263923
PFN1 profilin 1 -0.0256771
IL1B interleukin 1, beta -0.0255632
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0253687
IFI44L interferon-induced protein 44-like -0.0252418
LOC102724023 ES1 protein homolog, mitochondrial -0.0248605
RPS11 ribosomal protein S11 -0.0246025
CDCP1 CUB domain containing protein 1 -0.02448
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0244491
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0244222
ANGPTL4 angiopoietin-like 4 -0.024396
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0243481
HMGA1 high mobility group AT-hook 1 -0.0242347
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0238555
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0234907
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0233634
PMP22 peripheral myelin protein 22 -0.0232575
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0229869
RPL31 ribosomal protein L31 -0.0226521
HDAC9 histone deacetylase 9 -0.0219406
GNAS GNAS complex locus -0.0219247
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.021794
SMIM44 small integral membrane protein 44 -0.0216537
VCL vinculin -0.0216092
ENO2 enolase 2 (gamma, neuronal) -0.021478
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0214446
RPS8 ribosomal protein S8 -0.0214086
PLSCR1 phospholipid scramblase 1 -0.0213951
EXOC4 exocyst complex component 4 -0.0213432
ECE1 endothelin converting enzyme 1 -0.0213403
ACTN4 actinin, alpha 4 -0.0212687