| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.015908 |
| RPL35A | ribosomal protein L35a | 0.011709 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 0.0102837 |
| CENPF | centromere protein F, 350/400kDa | 0.00981887 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.00865186 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00802995 |
| CA8 | carbonic anhydrase VIII | 0.00794821 |
| HDAC9 | histone deacetylase 9 | 0.00703568 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.00700112 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.0068964 |
| VIM | vimentin | 0.00646629 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.00634545 |
| RPS6 | ribosomal protein S6 | 0.00627512 |
| AGMO | alkylglycerol monooxygenase | 0.00621207 |
| FAM162A | family with sequence similarity 162, member A | 0.00606722 |
| RIT2 | Ras-like without CAAX 2 | 0.00601874 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.00591517 |
| PARK7 | parkinson protein 7 | 0.00565399 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.00542862 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.00542423 |
| DNAJC8 | DnaJ (Hsp40) homolog, subfamily C, member 8 | 0.00540373 |
| EGR1 | early growth response 1 | 0.00527749 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00514642 |
| MGAT4C | MGAT4 family, member C | 0.00501753 |
| CSTB | cystatin B (stefin B) | 0.00500574 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.00487879 |
| BDKRB2 | bradykinin receptor B2 | 0.00480354 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.00477808 |
| DHFR | dihydrofolate reductase | 0.00476795 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.00450092 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00445019 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00438495 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0043742 |
| ANKRD26 | ankyrin repeat domain 26 | 0.00435463 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | 0.00434035 |
| LAMB3 | laminin, beta 3 | 0.00432767 |
| RP9 | retinitis pigmentosa 9 (autosomal dominant) | 0.00432196 |
| CWC22 | CWC22 spliceosome-associated protein | 0.00431916 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0042498 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.00417112 |
| RPS7 | ribosomal protein S7 | 0.00414816 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.00412774 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.00410011 |
| LIMA1 | LIM domain and actin binding 1 | 0.00406877 |
| COX7C | cytochrome c oxidase subunit VIIc | 0.00405391 |
| DPM2 | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit | 0.00399947 |
| CCDC112 | coiled-coil domain containing 112 | 0.00399042 |
| MRPL21 | mitochondrial ribosomal protein L21 | 0.0039169 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.00390042 |
| CRB1 | crumbs family member 1, photoreceptor morphogenesis associated | 0.00385451 |
| VCL | vinculin | 0.00381869 |
| ITGA6 | integrin, alpha 6 | 0.00381335 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.00379691 |
| SRP9 | signal recognition particle 9kDa | 0.00378305 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.00377221 |
| YAP1 | Yes-associated protein 1 | 0.00375413 |
| PPIP5K1 | diphosphoinositol pentakisphosphate kinase 1 | 0.00375073 |
| SLC17A5 | solute carrier family 17 (acidic sugar transporter), member 5 | 0.00373822 |
| HES6 | hes family bHLH transcription factor 6 | 0.00371274 |
| ANKRD33B | ankyrin repeat domain 33B | 0.00369779 |
| RPLP0 | ribosomal protein, large, P0 | 0.0036928 |
| PFDN4 | prefoldin subunit 4 | 0.00368727 |
| TSC22D2 | TSC22 domain family, member 2 | 0.00364612 |
| MED30 | mediator complex subunit 30 | 0.00364553 |
| CA9 | carbonic anhydrase IX | 0.00364458 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.00360997 |
| PARG | poly (ADP-ribose) glycohydrolase | 0.00360576 |
| TPCN1 | two pore segment channel 1 | 0.0036035 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.00358132 |
| PTGR1 | prostaglandin reductase 1 | 0.00354319 |
| BCAS2 | breast carcinoma amplified sequence 2 | 0.00354054 |
| PLS3 | plastin 3 | 0.00353312 |
| THAP6 | THAP domain containing 6 | 0.00352437 |
| ANKRD37 | ankyrin repeat domain 37 | 0.00352321 |
| PHACTR2 | phosphatase and actin regulator 2 | 0.00351088 |
| RPL21 | ribosomal protein L21 | 0.00350951 |
| RAB3IP | RAB3A interacting protein | 0.0035031 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.00350094 |
| ZNF143 | zinc finger protein 143 | 0.0034617 |
| LAMC2 | laminin, gamma 2 | 0.00346156 |
| KLHL23 | kelch-like family member 23 | 0.00345695 |
| S100A10 | S100 calcium binding protein A10 | 0.003437 |
| GADD45GIP1 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 | 0.0034341 |
| SAMD11 | sterile alpha motif domain containing 11 | 0.00342921 |
| DCTN3 | dynactin 3 (p22) | 0.00342904 |
| CD44 | CD44 molecule (Indian blood group) | 0.00342468 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00341932 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.00341534 |
| GPR63 | G protein-coupled receptor 63 | 0.00341492 |
| BAG3 | BCL2-associated athanogene 3 | 0.00340956 |
| TTF1 | transcription termination factor, RNA polymerase I | 0.00339952 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | 0.00339809 |
| OSMR | oncostatin M receptor | 0.00339201 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 0.00339126 |
| SEC24D | SEC24 family member D | 0.00338719 |
| HLA-B | major histocompatibility complex, class I, B | 0.00336898 |
| CABP7 | calcium binding protein 7 | 0.00336788 |
| RAI14 | retinoic acid induced 14 | 0.00336573 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.00333833 |
| RAB31 | RAB31, member RAS oncogene family | 0.00333459 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | -0.208452 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0987713 |
| VGF | VGF nerve growth factor inducible | -0.0981877 |
| ENO1 | enolase 1, (alpha) | -0.088597 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0557999 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0513234 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0507119 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0488456 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0470787 |
| UBC | ubiquitin C | -0.0461719 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.045875 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0452224 |
| RPS27A | ribosomal protein S27a | -0.0451034 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0450324 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0449258 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0445718 |
| GPC6 | glypican 6 | -0.0444983 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.042763 |
| MCL1 | myeloid cell leukemia 1 | -0.0396084 |
| TENM1 | teneurin transmembrane protein 1 | -0.0391144 |
| SMYD3 | SET and MYND domain containing 3 | -0.0388208 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0386309 |
| PTMA | prothymosin, alpha | -0.0369541 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0369464 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0361793 |
| PEG10 | paternally expressed 10 | -0.0341557 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0340463 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0317324 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0311299 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0308444 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.030788 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0307266 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0303807 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0302042 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.029749 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0294749 |
| PCBP2 | poly(rC) binding protein 2 | -0.029394 |
| PKM | pyruvate kinase, muscle | -0.0293009 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0284541 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0273948 |
| ACTG1 | actin gamma 1 | -0.0267248 |
| MATR3 | matrin 3 | -0.0266138 |
| TPM3 | tropomyosin 3 | -0.0265273 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.0261514 |
| FGF14 | fibroblast growth factor 14 | -0.0260834 |
| CALCA | calcitonin-related polypeptide alpha | -0.0259702 |
| FUS | FUS RNA binding protein | -0.0259233 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0256225 |
| SMC1A | structural maintenance of chromosomes 1A | -0.0254985 |
| RPS3 | ribosomal protein S3 | -0.0254129 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0253049 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0251718 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0250265 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0249722 |
| NCKAP5 | NCK-associated protein 5 | -0.024844 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0248282 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0246301 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0246097 |
| AUTS2 | autism susceptibility candidate 2 | -0.0244389 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0242438 |
| MED13L | mediator complex subunit 13-like | -0.0239091 |
| NDRG1 | N-myc downstream regulated 1 | -0.0236368 |
| NRG1 | neuregulin 1 | -0.0235647 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.023469 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0230762 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0228607 |
| STC1 | stanniocalcin 1 | -0.0228367 |
| FAT1 | FAT atypical cadherin 1 | -0.0227795 |
| XRN2 | 5'-3' exoribonuclease 2 | -0.0227122 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0222601 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0222103 |
| IGF1R | insulin-like growth factor 1 receptor | -0.022159 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0221112 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0220068 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0219394 |
| PTK2 | protein tyrosine kinase 2 | -0.0218479 |
| DST | dystonin | -0.0217763 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0217462 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | -0.0214847 |
| CADM1 | cell adhesion molecule 1 | -0.0214595 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0211784 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0208546 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.02073 |
| PRPF8 | pre-mRNA processing factor 8 | -0.0206241 |
| RORA | RAR-related orphan receptor A | -0.019895 |
| NBAS | neuroblastoma amplified sequence | -0.0197885 |
| PCBP3 | poly(rC) binding protein 3 | -0.0196403 |
| SET | SET nuclear proto-oncogene | -0.0195702 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.0195536 |
| GPHN | gephyrin | -0.0194057 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0191409 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.019068 |
| CALR | calreticulin | -0.0190514 |
| APP | amyloid beta (A4) precursor protein | -0.0190073 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0188769 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0188762 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0188382 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.018616 |
| RNF213 | ring finger protein 213 | -0.0185757 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0185105 |
