Loperamide (hydrochloride)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0342142
AKAP12 A kinase (PRKA) anchor protein 12 0.0303548
GOLGA4 golgin A4 0.0302596
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0294499
GARS1 glycyl-tRNA synthetase 1 0.020495
CHD1 chromodomain helicase DNA binding protein 1 0.0185085
TRIM33 tripartite motif containing 33 0.0178763
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0174269
BHLHE40 basic helix-loop-helix family, member e40 0.017255
USP3 ubiquitin specific peptidase 3 0.0162671
SNU13 small nuclear ribonucleoprotein 13 0.0160678
FTL ferritin, light polypeptide 0.0159177
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0152891
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0150807
ATP13A3 ATPase type 13A3 0.0143135
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0136184
KMT2E lysine (K)-specific methyltransferase 2E 0.0132093
RPL35A ribosomal protein L35a 0.0125556
TSC22D2 TSC22 domain family, member 2 0.0123126
MSI2 musashi RNA-binding protein 2 0.0120526
LCORL ligand dependent nuclear receptor corepressor-like 0.0120359
ANKRD11 ankyrin repeat domain 11 0.0120251
CD109 CD109 molecule 0.0118122
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.011568
CADM1 cell adhesion molecule 1 0.0113846
TEX10 testis expressed 10 0.0111029
ZC3H15 zinc finger CCCH-type containing 15 0.0110698
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0109674
LARS1 leucyl-tRNA synthetase 1 0.0107176
RBM27 RNA binding motif protein 27 0.0105231
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0102705
TPT1 tumor protein, translationally-controlled 1 0.0100847
QKI QKI, KH domain containing, RNA binding 0.0100773
WDR43 WD repeat domain 43 0.0100407
NUP58 nucleoporin 58 0.00994849
EIF5B eukaryotic translation initiation factor 5B 0.00967393
NAMPT nicotinamide phosphoribosyltransferase 0.00961644
HILPDA hypoxia inducible lipid droplet-associated 0.00959656
TTC3 tetratricopeptide repeat domain 3 0.00953524
RPL10A ribosomal protein L10a 0.00953065
MLEC malectin 0.0094129
FBXO42 F-box protein 42 0.00937614
SEC63 SEC63 homolog (S. cerevisiae) 0.0093359
RPL36 ribosomal protein L36 0.00915021
CDC73 cell division cycle 73 0.00906463
DHFR dihydrofolate reductase 0.008954
MEMO1 mediator of cell motility 1 0.0089539
RPL37 ribosomal protein L37 0.00893377
TIMP3 TIMP metallopeptidase inhibitor 3 0.00893334
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00883245
ZNF292 zinc finger protein 292 0.00874909
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.00864819
HPCAL1 hippocalcin-like 1 0.00862154
ESYT2 extended synaptotagmin-like protein 2 0.00860544
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.00859477
TMF1 TATA element modulatory factor 1 0.00853685
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00853234
SPAG9 sperm associated antigen 9 0.00852162
WDR3 WD repeat domain 3 0.00838423
RPL11 ribosomal protein L11 0.00836649
FAM13A family with sequence similarity 13, member A 0.00832905
RSL1D1 ribosomal L1 domain containing 1 0.00831811
FYN FYN proto-oncogene, Src family tyrosine kinase 0.00829631
RPS7 ribosomal protein S7 0.00815571
EGLN1 egl-9 family hypoxia-inducible factor 1 0.00814692
EIF3H eukaryotic translation initiation factor 3, subunit H 0.00814373
RNF145 ring finger protein 145 0.00799651
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0079754
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.00797265
DENND4C DENN/MADD domain containing 4C 0.00794176
LEF1 lymphoid enhancer-binding factor 1 0.00790533
BRWD3 bromodomain and WD repeat domain containing 3 0.00789476
ANK2 ankyrin 2, neuronal 0.0078859
MIMS1 mitochondrial inner membrane scaffold 1 0.00786162
MAX MYC associated factor X 0.0078223
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.00775712
UBE2B ubiquitin-conjugating enzyme E2B 0.00774433
MXI1 MAX interactor 1, dimerization protein 0.00773015
RBM25 RNA binding motif protein 25 0.00768242
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.00766541
MINDY2 MINDY lysine 48 deubiquitinase 2 0.00765849
IARS1 isoleucyl-tRNA synthetase 1 0.00765503
UBA2 ubiquitin-like modifier activating enzyme 2 0.0076192
DPEP2 dipeptidase 2 0.00757561
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00749158
MARK3 MAP/microtubule affinity-regulating kinase 3 0.00748954
TMEM168 transmembrane protein 168 0.00741223
FMNL2 formin-like 2 0.00739961
CSTB cystatin B (stefin B) 0.00737657
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.00734914
RYK receptor-like tyrosine kinase 0.00734267
INTS6L integrator complex subunit 6 like 0.00733625
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0072668
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.00722465
USP37 ubiquitin specific peptidase 37 0.00711883
BZW1 basic leucine zipper and W2 domains 1 0.00709857
NAP1L1 nucleosome assembly protein 1-like 1 0.00708013
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.00700411
FNBP1L formin binding protein 1-like 0.00697818
SSBP2 single-stranded DNA binding protein 2 0.00695834

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.162662
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.147402
UBC ubiquitin C -0.0881196
FMN1 formin 1 -0.0872498
FNDC3B fibronectin type III domain containing 3B -0.0697106
ICAM1 intercellular adhesion molecule 1 -0.0656265
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0603955
PKM pyruvate kinase, muscle -0.0585911
SQSTM1 sequestosome 1 -0.0518829
FLNA filamin A, alpha -0.0481415
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0480836
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0476985
EEF2 eukaryotic translation elongation factor 2 -0.047674
CCND1 cyclin D1 -0.047581
ENO1 enolase 1, (alpha) -0.0460803
NDRG1 N-myc downstream regulated 1 -0.0440076
TM4SF1 transmembrane 4 L six family member 1 -0.042449
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0419757
POTEF POTE ankyrin domain family, member F -0.0394482
NAV2 neuron navigator 2 -0.0392939
TXNRD1 thioredoxin reductase 1 -0.0381654
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0375954
TMSB10 thymosin beta 10 -0.0370611
CD44 CD44 molecule (Indian blood group) -0.0353942
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0339311
PCBP2 poly(rC) binding protein 2 -0.0338773
LDHA lactate dehydrogenase A -0.0318212
LOC112694756 uncharaterized LOC112694756 -0.0317631
AHNAK AHNAK nucleoprotein -0.0309961
FRMD4A FERM domain containing 4A -0.0304301
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0302938
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0281732
RPS27A ribosomal protein S27a -0.0277873
RUNX1 runt-related transcription factor 1 -0.0274922
ACTG1 actin gamma 1 -0.0267315
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0265693
MT2A metallothionein 2A -0.0263665
FLNB filamin B, beta -0.0260789
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0260138
MYH9 myosin, heavy chain 9, non-muscle -0.0259912
NOTCH2 notch 2 -0.0255966
ZBTB20 zinc finger and BTB domain containing 20 -0.0255571
ACTN4 actinin, alpha 4 -0.0252791
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0252191
WWTR1 WW domain containing transcription regulator 1 -0.0247111
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0233246
FHIT fragile histidine triad -0.0232106
EMP1 epithelial membrane protein 1 -0.0229746
FN1 fibronectin 1 -0.0228882
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0224037
ATXN1 ataxin 1 -0.0217223
PRELID2 PRELI domain containing 2 -0.0214978
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0214965
ACTN1 actinin, alpha 1 -0.0209499
BPTF bromodomain PHD finger transcription factor -0.0206888
MAP4 microtubule-associated protein 4 -0.0204916
SFTPA2 surfactant protein A2 -0.0204803
ASPH aspartate beta-hydroxylase -0.0204556
FRMD5 FERM domain containing 5 -0.0203448
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0203097
ANKRD28 ankyrin repeat domain 28 -0.0202236
HMGA1 high mobility group AT-hook 1 -0.020141
ANXA2 annexin A2 -0.0201181
ANGPTL4 angiopoietin-like 4 -0.0200444
IFI16 interferon, gamma-inducible protein 16 -0.0200115
BCAS3 breast carcinoma amplified sequence 3 -0.019955
TBC1D5 TBC1 domain family, member 5 -0.0197428
ADAR adenosine deaminase, RNA-specific -0.019715
HDAC9 histone deacetylase 9 -0.0196238
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0190107
B2M beta-2-microglobulin -0.0187161
FUS FUS RNA binding protein -0.018593
IFI6 interferon, alpha-inducible protein 6 -0.0184224
CTSB cathepsin B -0.0183485
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0178912
SLC39A11 solute carrier family 39, member 11 -0.0177713
FOXP1 forkhead box P1 -0.0176108
PLEC plectin -0.017368
RBM39 RNA binding motif protein 39 -0.0171805
MSN moesin -0.0171285
RASAL2 RAS protein activator like 2 -0.0170239
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0167088
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0166722
RNF213 ring finger protein 213 -0.0166494
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0164155
BRD4 bromodomain containing 4 -0.0164065
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.016278
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0160676
PRRC2B proline-rich coiled-coil 2B -0.0160352
BBX bobby sox homolog (Drosophila) -0.0160306
SOD2 superoxide dismutase 2, mitochondrial -0.0159177
MCL1 myeloid cell leukemia 1 -0.0158339
CORO1C coronin, actin binding protein, 1C -0.0156356
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0155704
OSBPL10 oxysterol binding protein-like 10 -0.0154353
EXOC6B exocyst complex component 6B -0.0153255
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0150056
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0149956
TENM3 teneurin transmembrane protein 3 -0.0149166
RHOA ras homolog family member A -0.0148107