Loperamide (hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.208767
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.128922
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.101626
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0949548
GOLGA4 golgin A4 0.0862917
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0845678
RPS6 ribosomal protein S6 0.0722428
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0722269
S100A6 S100 calcium binding protein A6 0.0688667
ZNF292 zinc finger protein 292 0.0644286
TMSB4X thymosin beta 4, X-linked 0.063174
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0608056
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0595673
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.057768
NAMPT nicotinamide phosphoribosyltransferase 0.0552714
B2M beta-2-microglobulin 0.0534568
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0532071
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0518082
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0517175
RPS8 ribosomal protein S8 0.0515442
TPT1 tumor protein, translationally-controlled 1 0.05074
TXNIP thioredoxin interacting protein 0.0503742
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0477896
PGK1 phosphoglycerate kinase 1 0.047616
ADAM10 ADAM metallopeptidase domain 10 0.0470665
KMT2E lysine (K)-specific methyltransferase 2E 0.0463381
EZR ezrin 0.0457192
DSCAM Down syndrome cell adhesion molecule 0.0450146
LDHA lactate dehydrogenase A 0.0448451
RPL11 ribosomal protein L11 0.0439909
RPS19 ribosomal protein S19 0.043865
KDM3A lysine (K)-specific demethylase 3A 0.0438021
RPL23 ribosomal protein L23 0.0421404
PNISR PNN-interacting serine/arginine-rich protein 0.0418512
RNF145 ring finger protein 145 0.0417239
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0414809
RTN4 reticulon 4 0.040174
ENO1 enolase 1, (alpha) 0.0398598
TMEM41B transmembrane protein 41B 0.0398378
RPL35A ribosomal protein L35a 0.0397279
NAP1L1 nucleosome assembly protein 1-like 1 0.0395057
RBM39 RNA binding motif protein 39 0.0392376
EIF1 eukaryotic translation initiation factor 1 0.039174
NUP58 nucleoporin 58 0.03907
SMC3 structural maintenance of chromosomes 3 0.0386538
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0384792
PRRC2C proline-rich coiled-coil 2C 0.0382061
RPL26 ribosomal protein L26 0.0376773
RPLP0 ribosomal protein, large, P0 0.0372464
ZFAND3 zinc finger, AN1-type domain 3 0.0363904
RPS3 ribosomal protein S3 0.0363648
DSTN destrin (actin depolymerizing factor) 0.0355758
MT2A metallothionein 2A 0.0354938
RBM25 RNA binding motif protein 25 0.0352653
GARS1 glycyl-tRNA synthetase 1 0.0350423
QKI QKI, KH domain containing, RNA binding 0.0346663
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0341632
RPL12 ribosomal protein L12 0.034067
RPL37A ribosomal protein L37a 0.0339045
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.03317
SET SET nuclear proto-oncogene 0.0328954
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.032358
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0320117
FTL ferritin, light polypeptide 0.0319568
RPLP2 ribosomal protein, large, P2 0.0311252
EEF2 eukaryotic translation elongation factor 2 0.0307519
TXNRD1 thioredoxin reductase 1 0.0304981
PFN1 profilin 1 0.0297188
RPLP1 ribosomal protein, large, P1 0.0296278
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.029582
WAC WW domain containing adaptor with coiled-coil 0.029561
SMNDC1 survival motor neuron domain containing 1 0.02954
MATR3 matrin 3 0.0293726
RPS12 ribosomal protein S12 0.0293698
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0291934
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0286344
CDC73 cell division cycle 73 0.0281254
RPL19 ribosomal protein L19 0.0281191
SQSTM1 sequestosome 1 0.0280937
RLF rearranged L-myc fusion 0.0280661
UBA6 ubiquitin-like modifier activating enzyme 6 0.0275481
TFG TRK-fused gene 0.0272942
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0272251
RPL13A ribosomal protein L13a 0.0272114
RPL31 ribosomal protein L31 0.0272052
RPL36 ribosomal protein L36 0.0268722
FXR1 fragile X mental retardation, autosomal homolog 1 0.0267045
RPS13 ribosomal protein S13 0.0264284
SLMAP sarcolemma associated protein 0.0264089
ADAM9 ADAM metallopeptidase domain 9 0.0263644
SRP54 signal recognition particle 54kDa 0.0263525
KIF5B kinesin family member 5B 0.0263327
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0261835
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0261088
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0261055
RPS25 ribosomal protein S25 0.0259801
RPL27A ribosomal protein L27a 0.0259459
S100A9 S100 calcium binding protein A9 0.025549
HILPDA hypoxia inducible lipid droplet-associated 0.0252434
AKAP9 A kinase (PRKA) anchor protein 9 0.0251642

decreased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific -0.126195
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0878721
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0830524
PDE4D phosphodiesterase 4D, cAMP-specific -0.0724424
BMP10 bone morphogenetic protein 10 -0.0640595
FOXP1 forkhead box P1 -0.0580595
CPED1 cadherin-like and PC-esterase domain containing 1 -0.055678
GLI3 GLI family zinc finger 3 -0.0455356
AHNAK AHNAK nucleoprotein -0.0419063
EGFR epidermal growth factor receptor -0.0394725
VCL vinculin -0.0347695
SOX6 SRY (sex determining region Y)-box 6 -0.0342404
NBEA neurobeachin -0.0330788
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0329147
GLI2 GLI family zinc finger 2 -0.0304811
NPAS2 neuronal PAS domain protein 2 -0.0303437
TTC28 tetratricopeptide repeat domain 28 -0.0288941
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0246081
MYO5C myosin VC -0.0241989
GSE1 Gse1 coiled-coil protein -0.0236999
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0231973
DLG1 discs, large homolog 1 (Drosophila) -0.0229038
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0228471
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0220602
PDE7B phosphodiesterase 7B -0.0218469
INTS6 integrator complex subunit 6 -0.0213132
DPYD dihydropyrimidine dehydrogenase -0.0211096
BMP2K BMP2 inducible kinase -0.0194293
CAMKMT calmodulin-lysine N-methyltransferase -0.0192581
PRUNE2 prune homolog 2 (Drosophila) -0.0189972
FER1L6 fer-1-like family member 6 -0.0187947
ZNF438 zinc finger protein 438 -0.018638
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0180518
RFC3 replication factor C (activator 1) 3, 38kDa -0.01786
TSC22D1 TSC22 domain family, member 1 -0.0175707
TAS2R14 taste receptor, type 2, member 14 -0.0175243
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0174498
UNC13A unc-13 homolog A (C. elegans) -0.0171936
DIAPH3 diaphanous-related formin 3 -0.0171482
SDK1 sidekick cell adhesion molecule 1 -0.0169602
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0167393
EFNA5 ephrin-A5 -0.0166513
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0166215
HDAC9 histone deacetylase 9 -0.0160699
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0155026
PDGFC platelet derived growth factor C -0.0151719
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0140194
CUX1 cut-like homeobox 1 -0.0139398
AEBP2 AE binding protein 2 -0.0138853
NAV2 neuron navigator 2 -0.0138146
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.013803
PRELID2 PRELI domain containing 2 -0.0133968
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -0.0132124
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0131125
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0126714
SPRY4 sprouty homolog 4 (Drosophila) -0.0123224
BCOR BCL6 corepressor -0.0121831
PKP4 plakophilin 4 -0.0120405
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0120085
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0118803
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.011547
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0113652
SCLT1 sodium channel and clathrin linker 1 -0.0113234
PARD3B par-3 family cell polarity regulator beta -0.01124
LARP4B La ribonucleoprotein domain family, member 4B -0.011235
APLF aprataxin and PNKP like factor -0.0112089
COMMD10 COMM domain containing 10 -0.0111916
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0110638
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -0.011061
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.010937
RAD51B RAD51 paralog B -0.0108698
MACROD2 MACRO domain containing 2 -0.0108021
CREB5 cAMP responsive element binding protein 5 -0.010661
FHIT fragile histidine triad -0.0105391
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0104939
MKI67 marker of proliferation Ki-67 -0.0104877
ITGA10 integrin, alpha 10 -0.0104231
CCND1 cyclin D1 -0.0100723
SEPTIN9 septin 9 -0.00990708
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.00988449
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.00970595
AFG2A AFG2 AAA ATPase homolog A -0.00924267
PBX3 pre-B-cell leukemia homeobox 3 -0.00923703
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.00918874
FAF1 Fas (TNFRSF6) associated factor 1 -0.0090558
FUS FUS RNA binding protein -0.00905535
ZEB1 zinc finger E-box binding homeobox 1 -0.00904332
BCL2 B-cell CLL/lymphoma 2 -0.0090314
TRIOBP TRIO and F-actin binding protein -0.00902408
ONECUT2 one cut homeobox 2 -0.00899149
SLC38A2 solute carrier family 38, member 2 -0.00893037
RAB27B RAB27B, member RAS oncogene family -0.00891102
LPP LIM domain containing preferred translocation partner in lipoma -0.00886945
CEP112 centrosomal protein 112kDa -0.00877771
ZSWIM6 zinc finger, SWIM-type containing 6 -0.00867093
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.00865514
PLXNA2 plexin A2 -0.00864224
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.00862834
HEG1 heart development protein with EGF-like domains 1 -0.00859495
ATP9B ATPase, class II, type 9B -0.00850217