| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Loperamide (hydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0975472 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0950413 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0697341 |
| RPL23 | ribosomal protein L23 | 0.0645108 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0610233 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0503931 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0497557 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0487953 |
| GOLGA4 | golgin A4 | 0.0477773 |
| RPS12 | ribosomal protein S12 | 0.0469557 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.043958 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0420935 |
| FTL | ferritin, light polypeptide | 0.0401872 |
| HELZ | helicase with zinc finger | 0.0341219 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0336424 |
| B2M | beta-2-microglobulin | 0.0336193 |
| SQSTM1 | sequestosome 1 | 0.0334682 |
| ZNF292 | zinc finger protein 292 | 0.0331872 |
| RPS8 | ribosomal protein S8 | 0.032876 |
| CANX | calnexin | 0.0325793 |
| RPL37A | ribosomal protein L37a | 0.0325137 |
| CDH13 | cadherin 13 | 0.0320652 |
| PTMA | prothymosin, alpha | 0.0307211 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0300519 |
| MYOF | myoferlin | 0.0298297 |
| MT2A | metallothionein 2A | 0.0293446 |
| RPS3 | ribosomal protein S3 | 0.0291991 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0282963 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0274695 |
| FRMPD4 | FERM and PDZ domain containing 4 | 0.0274365 |
| FMNL2 | formin-like 2 | 0.0258361 |
| RPL26 | ribosomal protein L26 | 0.0250997 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0249885 |
| SERINC1 | serine incorporator 1 | 0.0248977 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0247198 |
| CADM1 | cell adhesion molecule 1 | 0.0241172 |
| IER3 | immediate early response 3 | 0.0240109 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | 0.0239788 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0239165 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0238946 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.023482 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0234274 |
| PCBP3 | poly(rC) binding protein 3 | 0.023293 |
| RPS6 | ribosomal protein S6 | 0.0229522 |
| OGA | O-GlcNAcase | 0.022498 |
| RYBP | RING1 and YY1 binding protein | 0.0224386 |
| SPAG9 | sperm associated antigen 9 | 0.0222044 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0221034 |
| RPL12 | ribosomal protein L12 | 0.0220618 |
| RPL11 | ribosomal protein L11 | 0.0218901 |
| ENO1 | enolase 1, (alpha) | 0.0217987 |
| RPLP2 | ribosomal protein, large, P2 | 0.0216849 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0215193 |
| INTS6 | integrator complex subunit 6 | 0.0215121 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0212734 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0210985 |
| RPS25 | ribosomal protein S25 | 0.0208711 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0207509 |
| RPS19 | ribosomal protein S19 | 0.0205708 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0201805 |
| FAM13A | family with sequence similarity 13, member A | 0.020114 |
| IRS2 | insulin receptor substrate 2 | 0.0200649 |
| RPL7 | ribosomal protein L7 | 0.0196078 |
| RPLP1 | ribosomal protein, large, P1 | 0.0195684 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0194302 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0191026 |
| RPL10A | ribosomal protein L10a | 0.0190806 |
| ATP13A3 | ATPase type 13A3 | 0.0184805 |
| ADM | adrenomedullin | 0.0183399 |
| PRELID2 | PRELI domain containing 2 | 0.0179792 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0176731 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0176386 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.017631 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0174117 |
| RPL31 | ribosomal protein L31 | 0.0173641 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0172687 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0171886 |
| USP37 | ubiquitin specific peptidase 37 | 0.0171399 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0169593 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0168529 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0166512 |
| DTNA | dystrobrevin, alpha | 0.0165966 |
| PHF3 | PHD finger protein 3 | 0.0164917 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0160496 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0160082 |
| RPS27A | ribosomal protein S27a | 0.0158804 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0156153 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0155846 |
| RPS13 | ribosomal protein S13 | 0.0155689 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0155646 |
| CALR | calreticulin | 0.0154777 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0154611 |
| RACK1 | receptor for activated C kinase 1 | 0.0153536 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0153022 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0152422 |
| WTAP | Wilms tumor 1 associated protein | 0.0151681 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0150893 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0150674 |
| ASPH | aspartate beta-hydroxylase | 0.0150111 |
| RPL37 | ribosomal protein L37 | 0.0150041 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.215758 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.187568 |
| CD44 | CD44 molecule (Indian blood group) | -0.103565 |
| GLIS3 | GLIS family zinc finger 3 | -0.102904 |
| BICC1 | BicC family RNA binding protein 1 | -0.0981469 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0966532 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0827082 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0811226 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0774676 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0772142 |
| VCL | vinculin | -0.0706342 |
| SMAD3 | SMAD family member 3 | -0.0696985 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0683247 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0672979 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0630325 |
| EGR1 | early growth response 1 | -0.0627794 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0572551 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0526345 |
| NDRG1 | N-myc downstream regulated 1 | -0.0472169 |
| C3 | complement component 3 | -0.045897 |
| THBS1 | thrombospondin 1 | -0.0456252 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0454078 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0443827 |
| TAPBP | TAP binding protein (tapasin) | -0.0434557 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0431548 |
| VMP1 | vacuole membrane protein 1 | -0.0421093 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0419519 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0408579 |
| KYNU | kynureninase | -0.0397648 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0388716 |
| MKI67 | marker of proliferation Ki-67 | -0.0377846 |
| ATXN1 | ataxin 1 | -0.0375992 |
| VEGFA | vascular endothelial growth factor A | -0.0372504 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0371049 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0350705 |
| FLNB | filamin B, beta | -0.0349252 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0347172 |
| OSMR | oncostatin M receptor | -0.0338735 |
| FRMD4A | FERM domain containing 4A | -0.0335517 |
| RTN4 | reticulon 4 | -0.0324089 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0322594 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0320965 |
| VIM | vimentin | -0.0320014 |
| NABP1 | nucleic acid binding protein 1 | -0.0314588 |
| NRP1 | neuropilin 1 | -0.0313449 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0311883 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0304252 |
| RAI14 | retinoic acid induced 14 | -0.0292874 |
| MX1 | MX dynamin-like GTPase 1 | -0.0284161 |
| TXNRD1 | thioredoxin reductase 1 | -0.0283957 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0283117 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0282382 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0281413 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0272145 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0269835 |
| VCAN | versican | -0.0265923 |
| HDAC8 | histone deacetylase 8 | -0.0263965 |
| MSN | moesin | -0.0262891 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0259641 |
| TPM4 | tropomyosin 4 | -0.025926 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0257914 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0254497 |
| TUBB | tubulin, beta class I | -0.0252201 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0250279 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0247872 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0244859 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0244844 |
| MAP1B | microtubule-associated protein 1B | -0.0244434 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0244142 |
| TNS3 | tensin 3 | -0.0242992 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0242707 |
| CTSD | cathepsin D | -0.0240461 |
| PALLD | palladin, cytoskeletal associated protein | -0.0238256 |
| PLPP6 | phospholipid phosphatase 6 | -0.0237944 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.0236979 |
| HMGA2 | high mobility group AT-hook 2 | -0.0234693 |
| RNF213 | ring finger protein 213 | -0.0232555 |
| AHNAK | AHNAK nucleoprotein | -0.0232037 |
| LOX | lysyl oxidase | -0.023171 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0229164 |
| ACTG1 | actin gamma 1 | -0.0227599 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0224354 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0223815 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0217514 |
| HLA-B | major histocompatibility complex, class I, B | -0.0217194 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0215859 |
| BPTF | bromodomain PHD finger transcription factor | -0.0214779 |
| EHBP1 | EH domain binding protein 1 | -0.0214678 |
| CDCP1 | CUB domain containing protein 1 | -0.0214333 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0211669 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0211024 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0210758 |
| ACTN1 | actinin, alpha 1 | -0.020853 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0206187 |
| JAK2 | Janus kinase 2 | -0.0204213 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0202857 |
| FLNA | filamin A, alpha | -0.0202756 |
| FOXP1 | forkhead box P1 | -0.0200645 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0197958 |
| CLIC4 | chloride intracellular channel 4 | -0.0197865 |
