Loperamide (hydrochloride)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.125012
VIM vimentin 0.119807
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.108353
B2M beta-2-microglobulin 0.089161
ENO1 enolase 1, (alpha) 0.0791783
CXCL8 chemokine (C-X-C motif) ligand 8 0.0781455
TIMP3 TIMP metallopeptidase inhibitor 3 0.0750837
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0667831
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.066663
PGK1 phosphoglycerate kinase 1 0.0580734
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.055727
IGFBP3 insulin-like growth factor binding protein 3 0.0542299
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0499113
PDIA6 protein disulfide isomerase family A, member 6 0.0473259
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0467364
IL6 interleukin 6 0.0455343
TNS3 tensin 3 0.0441234
FTL ferritin, light polypeptide 0.0431366
LGALS1 lectin, galactoside-binding, soluble, 1 0.0425712
LOX lysyl oxidase 0.0425234
PTMA prothymosin, alpha 0.0414974
TPT1 tumor protein, translationally-controlled 1 0.0411621
RPL23 ribosomal protein L23 0.0391849
PDIA3 protein disulfide isomerase family A, member 3 0.0375523
CALD1 caldesmon 1 0.0374324
MT2A metallothionein 2A 0.037166
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0368997
OXR1 oxidation resistance 1 0.0358064
ACTG1 actin gamma 1 0.03566
IQGAP1 IQ motif containing GTPase activating protein 1 0.0353152
CDH13 cadherin 13 0.0350893
FRMD4A FERM domain containing 4A 0.0348045
KYNU kynureninase 0.0345152
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0340101
RPL35A ribosomal protein L35a 0.0326114
DPYD dihydropyrimidine dehydrogenase 0.0315648
PDIA4 protein disulfide isomerase family A, member 4 0.031281
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0303518
ZNF395 zinc finger protein 395 0.0301405
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0294381
RBM25 RNA binding motif protein 25 0.0294333
DNAH11 dynein, axonemal, heavy chain 11 0.0293542
CBX3 chromobox homolog 3 0.0284797
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0284307
TPM1 tropomyosin 1 (alpha) 0.0282152
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.028178
CEMIP cell migration inducing protein, hyaluronan binding 0.0280096
KDM6A lysine (K)-specific demethylase 6A 0.0275467
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0273585
RAI14 retinoic acid induced 14 0.0270842
ZMYND8 zinc finger, MYND-type containing 8 0.0267747
DSCAM Down syndrome cell adhesion molecule 0.026694
AKAP12 A kinase (PRKA) anchor protein 12 0.0266736
CLIP1 CAP-GLY domain containing linker protein 1 0.0266554
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0264842
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0258143
RPL34 ribosomal protein L34 0.0256499
DST dystonin 0.0255359
SMAD2 SMAD family member 2 0.0253382
CEP350 centrosomal protein 350kDa 0.0247846
JPH2 junctophilin 2 0.0246711
RPS14 ribosomal protein S14 0.0246026
PICALM phosphatidylinositol binding clathrin assembly protein 0.0243474
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0241634
RPS8 ribosomal protein S8 0.0241194
FBXO11 F-box protein 11 0.0240382
FAM120A family with sequence similarity 120A 0.0239159
MBNL1 muscleblind-like splicing regulator 1 0.0239145
APOLD1 apolipoprotein L domain containing 1 0.0238364
PDS5A PDS5 cohesin associated factor A 0.023809
PRKCA protein kinase C, alpha 0.0237947
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0236593
TENT2 terminal nucleotidyltransferase 2 0.0236193
BBX bobby sox homolog (Drosophila) 0.0235844
RAD51B RAD51 paralog B 0.023565
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0234271
MXI1 MAX interactor 1, dimerization protein 0.023427
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0233474
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.023031
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0229861
TFPI2 tissue factor pathway inhibitor 2 0.0229025
TGFBI transforming growth factor, beta-induced, 68kDa 0.0228928
DENND4C DENN/MADD domain containing 4C 0.0228696
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0228445
SENP6 SUMO1/sentrin specific peptidase 6 0.022718
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0226586
PRSS23 protease, serine, 23 0.0226224
TPM4 tropomyosin 4 0.0220883
NAP1L1 nucleosome assembly protein 1-like 1 0.022084
RPL5 ribosomal protein L5 0.0220786
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0220619
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0219114
DSPP dentin sialophosphoprotein 0.0216553
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0216129
RBM27 RNA binding motif protein 27 0.0215956
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.0214673
NBAS neuroblastoma amplified sequence 0.0211603
CLMP CXADR-like membrane protein 0.0211584
UBE2B ubiquitin-conjugating enzyme E2B 0.0210787
PTPRK protein tyrosine phosphatase, receptor type, K 0.0210275

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.251675
COL6A3 collagen, type VI, alpha 3 -0.169488
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.121135
FTH1 ferritin, heavy polypeptide 1 -0.0739209
NDRG1 N-myc downstream regulated 1 -0.0691535
ELL2 elongation factor, RNA polymerase II, 2 -0.0677478
LOC112694756 uncharaterized LOC112694756 -0.0605562
AKAP9 A kinase (PRKA) anchor protein 9 -0.0588413
CD44 CD44 molecule (Indian blood group) -0.0570207
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0533278
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.052689
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0525607
SOD2 superoxide dismutase 2, mitochondrial -0.0491408
LOXL2 lysyl oxidase-like 2 -0.0490712
SDC4 syndecan 4 -0.0463657
RTN4 reticulon 4 -0.0456749
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0412171
NAMPT nicotinamide phosphoribosyltransferase -0.0401742
OGA O-GlcNAcase -0.0401043
RAP1A RAP1A, member of RAS oncogene family -0.0400815
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0396887
PKM pyruvate kinase, muscle -0.0390779
SRP54 signal recognition particle 54kDa -0.0383598
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0375281
HIP1 huntingtin interacting protein 1 -0.0371206
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0365322
NRXN3 neurexin 3 -0.0364617
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0341789
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0335765
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0335482
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0333827
COG5 component of oligomeric golgi complex 5 -0.0330021
UGCG UDP-glucose ceramide glucosyltransferase -0.0328008
TOP1 topoisomerase (DNA) I -0.0326638
ANXA2 annexin A2 -0.032293
WASF2 WAS protein family, member 2 -0.0316266
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0315794
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0315033
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0314935
UBC ubiquitin C -0.0308345
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.030769
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0305419
FNDC3B fibronectin type III domain containing 3B -0.0305074
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0304882
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0302709
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0300986
ARRDC3 arrestin domain containing 3 -0.030025
F3 coagulation factor III (thromboplastin, tissue factor) -0.0291573
BHLHE40 basic helix-loop-helix family, member e40 -0.0291547
FN1 fibronectin 1 -0.0290784
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0289924
RSRC2 arginine/serine-rich coiled-coil 2 -0.0289133
HOOK2 hook microtubule-tethering protein 2 -0.0286001
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0282491
WWTR1 WW domain containing transcription regulator 1 -0.028008
COL1A1 collagen, type I, alpha 1 -0.0279972
RBM39 RNA binding motif protein 39 -0.0278367
HBP1 HMG-box transcription factor 1 -0.0276829
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0274795
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0273651
FOSL1 FOS-like antigen 1 -0.0272085
INSIG1 insulin induced gene 1 -0.0268701
SMAD3 SMAD family member 3 -0.0266607
JARID2 jumonji, AT rich interactive domain 2 -0.0266545
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0265609
ASPH aspartate beta-hydroxylase -0.0264635
CLIP2 CAP-GLY domain containing linker protein 2 -0.0263984
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.026383
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0262248
RND3 Rho family GTPase 3 -0.026095
SCFD2 sec1 family domain containing 2 -0.0254587
ANO6 anoctamin 6 -0.0251629
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0250318
KMT2E lysine (K)-specific methyltransferase 2E -0.0249786
ZBTB20 zinc finger and BTB domain containing 20 -0.0248986
TENT5A terminal nucleotidyltransferase 5A -0.024796
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.024782
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.024491
ITGAV integrin, alpha V -0.0244236
ESYT2 extended synaptotagmin-like protein 2 -0.0242777
MT1X metallothionein 1X -0.0242166
TSC22D2 TSC22 domain family, member 2 -0.0240963
GLIS3 GLIS family zinc finger 3 -0.023904
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0238736
PCM1 pericentriolar material 1 -0.0238566
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0237844
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0236777
EGR1 early growth response 1 -0.0236392
PRRC1 proline-rich coiled-coil 1 -0.0236172
HLA-C major histocompatibility complex, class I, C -0.0235375
S100A10 S100 calcium binding protein A10 -0.0232289
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.022987
IRF1 interferon regulatory factor 1 -0.0228484
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0228145
SLC38A2 solute carrier family 38, member 2 -0.0226671
EMP1 epithelial membrane protein 1 -0.0226149
CD99 CD99 molecule -0.0225246
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0223721
ERBIN erbb2 interacting protein -0.0222986
NCOR2 nuclear receptor corepressor 2 -0.0222792