| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Loperamide (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Loperamide (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.146545 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0986459 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0919701 |
| CANX | calnexin | 0.0802294 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0786808 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0776486 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0722386 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0634165 |
| TPR | translocated promoter region, nuclear basket protein | 0.0630983 |
| RNF145 | ring finger protein 145 | 0.0565232 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0516178 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0512942 |
| PTMA | prothymosin, alpha | 0.0512379 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0499939 |
| CENPF | centromere protein F, 350/400kDa | 0.0484919 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0449708 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0416573 |
| CD109 | CD109 molecule | 0.0408427 |
| GOLGA4 | golgin A4 | 0.0405262 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0404325 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.039975 |
| SUCO | SUN domain containing ossification factor | 0.0399168 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0390143 |
| RAD21 | RAD21 homolog (S. pombe) | 0.038425 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0384 |
| OGA | O-GlcNAcase | 0.0379256 |
| NUP58 | nucleoporin 58 | 0.0373359 |
| AHR | aryl hydrocarbon receptor | 0.0372321 |
| ZNF292 | zinc finger protein 292 | 0.0369983 |
| COPA | coatomer protein complex, subunit alpha | 0.0366488 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0352704 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.034727 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0344817 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0341269 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0341183 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0337767 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0336984 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0336168 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0334083 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0326688 |
| RNF24 | ring finger protein 24 | 0.0322453 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0321582 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0321174 |
| WDR45B | WD repeat domain 45B | 0.0320046 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0315721 |
| SPAG9 | sperm associated antigen 9 | 0.0315013 |
| PGK1 | phosphoglycerate kinase 1 | 0.0314886 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0306999 |
| HELZ | helicase with zinc finger | 0.0303882 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.030352 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0303268 |
| KIF5B | kinesin family member 5B | 0.0299886 |
| NEK7 | NIMA-related kinase 7 | 0.0299412 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0298901 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0294412 |
| RBM25 | RNA binding motif protein 25 | 0.0294026 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0292267 |
| ETNK1 | ethanolamine kinase 1 | 0.0291199 |
| TXNRD1 | thioredoxin reductase 1 | 0.0290839 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0290749 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0287101 |
| CD44 | CD44 molecule (Indian blood group) | 0.0283396 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0278892 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0276597 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0274574 |
| CDC73 | cell division cycle 73 | 0.0272182 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0269851 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0269641 |
| RBM39 | RNA binding motif protein 39 | 0.0268395 |
| RLF | rearranged L-myc fusion | 0.0268303 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0263257 |
| TMSB4X | thymosin beta 4, X-linked | 0.0262336 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0261847 |
| HMGB3 | high mobility group box 3 | 0.0261171 |
| WDR43 | WD repeat domain 43 | 0.0257204 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0254082 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0252528 |
| CEP350 | centrosomal protein 350kDa | 0.0251735 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0251081 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0247657 |
| YME1L1 | YME1-like 1 ATPase | 0.024666 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0246354 |
| CREBRF | CREB3 regulatory factor | 0.0246158 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0244885 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0243686 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0242739 |
| TFG | TRK-fused gene | 0.0240181 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0239548 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0239423 |
| COG5 | component of oligomeric golgi complex 5 | 0.0238805 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0237165 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0235485 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0234265 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0232543 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0231946 |
| SEPTIN7 | septin 7 | 0.0230513 |
| CALR | calreticulin | 0.023035 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0229002 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0228594 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.022856 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.214586 |
| NRG1 | neuregulin 1 | -0.195805 |
| HMGA2 | high mobility group AT-hook 2 | -0.106787 |
| NDRG1 | N-myc downstream regulated 1 | -0.0762493 |
| FN1 | fibronectin 1 | -0.069213 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0623005 |
| EFNA5 | ephrin-A5 | -0.0569711 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0538996 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0537758 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0514077 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0512545 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0503681 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0502142 |
| INTS6 | integrator complex subunit 6 | -0.0502014 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0472217 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0453768 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0452984 |
| VCL | vinculin | -0.044688 |
| STC2 | stanniocalcin 2 | -0.0407027 |
| PALLD | palladin, cytoskeletal associated protein | -0.0391441 |
| AEBP2 | AE binding protein 2 | -0.0381486 |
| ACTG1 | actin gamma 1 | -0.034945 |
| ASPH | aspartate beta-hydroxylase | -0.0323597 |
| EGR1 | early growth response 1 | -0.0311716 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0311522 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0309089 |
| MCL1 | myeloid cell leukemia 1 | -0.0306828 |
| HLA-B | major histocompatibility complex, class I, B | -0.0305802 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0305175 |
| LOXL2 | lysyl oxidase-like 2 | -0.0300887 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0296387 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.029291 |
| LRRC23 | leucine rich repeat containing 23 | -0.0289606 |
| TENM4 | teneurin transmembrane protein 4 | -0.0279737 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0275565 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0275102 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0270237 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0261914 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0257453 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0257218 |
| RASAL2 | RAS protein activator like 2 | -0.0256402 |
| GPC6 | glypican 6 | -0.0246008 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0243887 |
| FLNA | filamin A, alpha | -0.0241217 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0240792 |
| HMGA1 | high mobility group AT-hook 1 | -0.0240126 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0236841 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.0233903 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.02337 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0233353 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0232967 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0232886 |
| VEGFA | vascular endothelial growth factor A | -0.0227468 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0226809 |
| PRKCA | protein kinase C, alpha | -0.0223113 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0222484 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0221253 |
| TMSB10 | thymosin beta 10 | -0.0220856 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0218989 |
| OXR1 | oxidation resistance 1 | -0.0218951 |
| POU2F2 | POU class 2 homeobox 2 | -0.021883 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0207018 |
| ATN1 | atrophin 1 | -0.0203632 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0201963 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0199316 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.019771 |
| SEPTIN9 | septin 9 | -0.0192198 |
| CTSD | cathepsin D | -0.0190286 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0190113 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0189762 |
| FHIT | fragile histidine triad | -0.0187562 |
| IFI44L | interferon-induced protein 44-like | -0.0187111 |
| BRD2 | bromodomain containing 2 | -0.0186664 |
| POTEF | POTE ankyrin domain family, member F | -0.0186658 |
| RAD51B | RAD51 paralog B | -0.0185131 |
| S100A10 | S100 calcium binding protein A10 | -0.0183377 |
| ATXN1 | ataxin 1 | -0.0182178 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0181587 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0180288 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0177272 |
| ABR | active BCR-related | -0.0176497 |
| TUFT1 | tuftelin 1 | -0.0176493 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0176425 |
| CUX1 | cut-like homeobox 1 | -0.017538 |
| EGFR | epidermal growth factor receptor | -0.0175339 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0174771 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0174743 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0174616 |
| GLIS3 | GLIS family zinc finger 3 | -0.0171056 |
| PLEC | plectin | -0.016993 |
| CCDC138 | coiled-coil domain containing 138 | -0.01692 |
| GPATCH2L | G patch domain containing 2-like | -0.0167163 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0167163 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0167102 |
| PKM | pyruvate kinase, muscle | -0.0163061 |
| WDR1 | WD repeat domain 1 | -0.0160907 |
| MAP1B | microtubule-associated protein 1B | -0.0160885 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0160804 |
| RUNX1 | runt-related transcription factor 1 | -0.0160258 |
| UBAP2 | ubiquitin associated protein 2 | -0.0156302 |
